Conditioning medicine最新文献_第3页

Chronic remote ischemic conditioning for cardiovascular protection. 慢性远端缺血调节对心血管的保护作用。

Conditioning medicine Pub Date : 2019-08-01

Jun Chong, Heerajnarain Bulluck, Andrew Fw Ho, William A Boisvert, Derek J Hausenloy

引用次数: 0

Mechanisms of innate preconditioning towards ischemia/anoxia tolerance: Lessons from mammalian hibernators. 先天预适应对缺血/缺氧耐受的机制:来自哺乳动物冬眠的经验教训。

Conditioning medicine Pub Date : 2019-06-01

Saurav Bhowmick, Kelly L Drew

{"title":"Mechanisms of innate preconditioning towards ischemia/anoxia tolerance: Lessons from mammalian hibernators.","authors":"Saurav Bhowmick, Kelly L Drew","doi":"","DOIUrl":"","url":null,"abstract":"Hibernating mammals exhibit an innate physiological ability to withstand dramatic fluctuations in blood flow that occurs during hibernation and arousal or experimental models of ischemia reperfusion without significant damage. These innate adaptations are of significance particularly to organs that are highly susceptible to energy deprivation, such as the brain and the heart. Among vertebrates, the arctic ground squirrel (AGS) is a species that tolerates ischemic/anoxic insult. During the process of entering hibernation, a state of prolonged torpor, the AGS undergoes a profound decrease in respiratory rate, heart rate, blood flow, cerebral perfusion, and body temperature (Tb). The reduced level of blood flow during torpor resembles an ischemic state, albeit without energy deficit. During the process of arousal or emergence from torpor, however, when Tb, respiratory rate, heart rate, and blood flow rapidly returns to pre-torpid levels, the rapid return of cerebral blood flow mimics aspects of reperfusion such as is seen after stroke or cardiac arrest. This sublethal ischemic/reperfusion insult experienced by AGS during the process of arousal may precondition AGS to tolerate otherwise lethal ischemic/reperfusion injury induced in the laboratory. In this review, we will summarize some of the mechanisms implemented by mammalian hibernators to combat ischemia/anoxia tolerance.","PeriodicalId":72686,"journal":{"name":"Conditioning medicine","volume":"2 3","pages":"134-141"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295161/pdf/nihms-1597708.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38049627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative Conditioning of Mitochondrial Dysfunction in Age-related Neurodegenerative Diseases. 年龄相关神经退行性疾病中线粒体功能障碍的负调节。

Conditioning medicine Pub Date : 2019-02-01

Sharmelee Selvaraji, Luting Poh, Venkateswaran Natarajan, Karthik Mallilankaraman, Thiruma V Arumugam

引用次数: 0

Peripheral Mechanisms of Remote Ischemic Conditioning. 远端缺血条件调节的外周机制。

Conditioning medicine Pub Date : 2019-02-01

Jiwon Yang, Faariah Shakil, Sunghee Cho

引用次数: 0

INDUCED PLURIPOTENT STEM CELLS FOR MODELLING ENERGETIC ALTERATIONS IN HYPERTROPHIC CARDIOMYOPATHY. 诱导多能干细胞模拟肥厚性心肌病的能量改变。

Conditioning medicine Pub Date : 2019-01-01

Chrishan J A Ramachandra, K P Myu Mai Ja, Ying-Hsi Lin, Winston Shim, William A Boisvert, Derek J Hausenloy

{"title":"INDUCED PLURIPOTENT STEM CELLS FOR MODELLING ENERGETIC ALTERATIONS IN HYPERTROPHIC CARDIOMYOPATHY.","authors":"Chrishan J A Ramachandra, K P Myu Mai Ja, Ying-Hsi Lin, Winston Shim, William A Boisvert, Derek J Hausenloy","doi":"","DOIUrl":"","url":null,"abstract":"Hypertrophic cardiomyopathy (HCM) is one of the most commonly inherited cardiac disorders that manifests with increased ventricular wall thickening, cardiomyocyte hypertrophy, disarrayed myofibers and interstitial fibrosis. The major pathophysiological features include, diastolic dysfunction, obstruction of the left ventricular outflow tract and cardiac arrhythmias. Mutations in genes that encode mostly for sarcomeric proteins have been associated with HCM but, despite the abundant research conducted to decipher the molecular mechanisms underlying the disease, it remains unclear as to how a primary defect in the sarcomere could lead to secondary phenotypes such as cellular hypertrophy. Mounting evidence suggests energy deficiency could be an important contributor of disease pathogenesis as well. Various animal models of HCM have been generated for gaining deeper insight into disease pathogenesis, however species variation between animals and humans, as well as the limited availability of human myocardial samples, has encouraged researchers to seek alternative 'humanized' models. Using induced pluripotent stem cells (iPSCs), human cardiomyocytes (CMs) have been generated from patients with HCM for investigating disease mechanisms. While these HCM-iPSC models demonstrate most of the phenotypic traits, it is important to ascertain if they recapitulate all pathophysiological features, especially that of energy deficiency. In this review we discuss the currently established HCM-iPSC models with emphasis on altered energetics.","PeriodicalId":72686,"journal":{"name":"Conditioning medicine","volume":"2 4","pages":"142-151"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250397/pdf/nihms-1050560.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37979684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preconditioning with CpG-ODN1826 reduces ischemic brain injury in young male mice: a replication study. 用 CpG-ODN1826 进行预处理可减少年轻雄性小鼠的缺血性脑损伤：一项重复研究。

Conditioning medicine Pub Date : 2019-01-01

Kunjan R Dave, Isabel Saul, Ami P Raval, Miguel A Perez-Pinzon

{"title":"Preconditioning with CpG-ODN1826 reduces ischemic brain injury in young male mice: a replication study.","authors":"Kunjan R Dave, Isabel Saul, Ami P Raval, Miguel A Perez-Pinzon","doi":"","DOIUrl":"","url":null,"abstract":"Earlier studies established that ischemic tolerance can be induced in the brain using various strategies. An earlier study demonstrated that preconditioning with the toll-like receptor 9 ligand, CpG oligodeoxynucleotides (ODN), protects the brain against ischemic damage. To increase the potential translational value of the previous study, the goal of the present study was to replicate this earlier finding in a different animal cohort at a different site. In addition to these replication studies, following the Stroke Treatment Academic Industry Roundtable (STAIR) guidelines, we also conducted studies to evaluate the protective effect of CpG-ODN 1826 preconditioning on cerebral ischemic damage in ovariectomized (Ovx) female animals. Young male and female mice were treated with CpG-ODN 1826 or control ligand 3 days prior to the induction of transient (60 min) cerebral ischemia using a middle cerebral artery occlusion (MCAO) model. Infarct size was evaluated at ~24 h post-MCAO. We were able to replicate earlier findings that preconditioning with a low dose (20 μg/mouse) of CpG-ODN 1826 was able to lower cerebral ischemic damage in young male mice. However, we did not see any protective effect of low dose CpG-ODN 1826 preconditioning against cerebral ischemic damage in young Ovx female mice. Our study independently confirms the protective effect of CpG-ODN 1826 in inducing cerebral ischemia tolerance in male but not in Ovx female mice. Our study also demonstrates the feasibility of conducting such replication studies in rodent models of transient stroke.","PeriodicalId":72686,"journal":{"name":"Conditioning medicine","volume":"2 4","pages":"178-184"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274220/pdf/nihms-1051299.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38023752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estrogen preconditioning: A promising strategy to reduce inflammation in the ischemic brain. 雌激素预处理:减少缺血性脑炎症的一个有希望的策略。

Conditioning medicine Pub Date : 2019-01-01 Epub Date: 2019-06-30

Juan Pablo de Rivero Vaccari, Helen M Bramlett, Miguel A Perez-Pinzon, Ami P Raval

{"title":"Estrogen preconditioning: A promising strategy to reduce inflammation in the ischemic brain.","authors":"Juan Pablo de Rivero Vaccari, Helen M Bramlett, Miguel A Perez-Pinzon, Ami P Raval","doi":"","DOIUrl":"","url":null,"abstract":"During the premenopausal phase of a woman's life, estrogen naturally protects against ischemic brain damage and its debilitating consequence of cognitive decline. However, the decline in estrogen at menopause exponentially increases a women's risk for cerebral ischemia and its severity. Supplementation of estrogen during menopause is the most logical solution to abate this increased risk for cerebral ischemia; however, continuous therapy has proven to be contraindicative. Studies from our laboratory over the past decade have shown that a single bolus or long-term periodic 17β-estradiol treatment(s) two days prior to ischemia mimics ischemic preconditioning-conferred protection of the brain in ovariectomized or reproductively senescent female rats. These studies also demonstrated that 17β-estradiol-induced preconditioning (EPC) requires estrogen receptor (ER)-subtype beta (ER-β) activation. ER-β is expressed throughout the brain, including in the hippocampus, which plays a key role in learning and memory. Because periodic activation of ER-β mitigates post-ischemic cognitive decline in ovariectomized female rats, it can be surmised that EPC has the potential to reduce post-ischemic damage and cognitive decline in females. Estrogens are key anti-inflammatory agents; therefore this review discusses the effects of EPC on the inflammasome. Furthermore, as we now clearly know, the brain acts differently in males and females. Indeed, neurodegenerative diseases, including cerebral ischemia, and pharmacological drugs affect males and females in different ways. Thus, inasmuch as the National Institutes of Health and the Stroke Treatment Academic Industry Roundtable (STAIR) consortium mandate inclusion of female experimental animals, this review also discusses the need to close the gap in our knowledge in future studies of EPC in female animal models of cerebral ischemia.","PeriodicalId":72686,"journal":{"name":"Conditioning medicine","volume":"2 3","pages":"106-113"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331970/pdf/nihms-1603312.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38112113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive and negative conditioning in the neonatal brain. 新生儿大脑中的积极和消极条件反射

Conditioning medicine Pub Date : 2018-10-01

Zinaida S Vexler, Carina Mallard, Henrik Hagberg

{"title":"Positive and negative conditioning in the neonatal brain.","authors":"Zinaida S Vexler, Carina Mallard, Henrik Hagberg","doi":"","DOIUrl":"","url":null,"abstract":"Brain injury in the perinatal period occurs in many clinical settings, e.g. hypoxic-ischemic encephalopathy (HIE) in term infants, neonatal stroke, encephalopathy of prematurity, and infections. These insults often result in life-long disabilities including cerebral palsy, cognitive deficits, visual dysfunction, hearing impairments, and epilepsy. However, the success of clinical implementation of a broad array of potential neuroprotective strategies tested experimentally has been limited with the exception of therapeutic hypothermia (TH) used within hours of birth in term human babies with mild to moderate HIE. There is an extensive search for adjuvant therapeutic approaches to enhance the outcomes. One strategy is to modify susceptibility in the developing CNS by means of preconditioning or postconditioning using sublethal stress. The pre-clinical and clinical literature has shown that CNS immaturity at the time of ischemic insult plays a central role in the response to injury. Thus, better understanding of the molecular regulation of the endogenous vulnerability of the immature brain is needed. Further, the use of sublethal stressors of different origin may help shed light on mechanistic similarities and distinctions beween conditioning strategies. In this review we discuss the mechanisms of protection that are achieved by an interplay of changes on the systemic level and brain level, and via changes of intracellular and mitochondrial signaling. We also discuss the barriers to improving our understanding of how brain immaturity and the type of insult-hypoxic, ischemic or inflammatory-affect the efficacy of conditioning efforts in the immature brain.","PeriodicalId":72686,"journal":{"name":"Conditioning medicine","volume":"1 6","pages":"279-293"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581457/pdf/nihms-997619.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37082662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Platelets in Ischemic Conditioning. 血小板在缺血条件下的作用。

Conditioning medicine Pub Date : 2018-10-01

Juan Alpuche, Luz Quírino, José T Sánchez-Vega, Jonathan Yap, Eduardo Pérez-Campos, Hector A Cabrera-Fuentes

引用次数: 0

Remote ischemic conditioning in ST-segment elevation myocardial infarction - an update. st段抬高型心肌梗死的远程缺血调节研究进展。

Conditioning medicine Pub Date : 2018-08-01

Jun Chong, Heerajnarain Bulluck, En Ping Yap, Andrew Fw Ho, William A Boisvert, Derek J Hausenloy

{"title":"Remote ischemic conditioning in ST-segment elevation myocardial infarction - an update.","authors":"Jun Chong, Heerajnarain Bulluck, En Ping Yap, Andrew Fw Ho, William A Boisvert, Derek J Hausenloy","doi":"","DOIUrl":"","url":null,"abstract":"Acute myocardial infarction (AMI) and the heart failure (HF) that often results are among the leading causes of death and disability in the world. As such, novel strategies are required to protect the heart against the detrimental effects of acute ischemia/reperfusion injury (IRI), in order to reduce myocardial infarct (MI) size and prevent the onset of HF. The endogenous cardioprotective strategy of remote ischemic conditioning (RIC), in which cycles of brief ischemia and reperfusion are applied to a tissue or organ away from the heart, has been reported in experimental studies to reduce MI size in animal models of acute IRI. In the clinical setting, RIC can be induced by simply inflating and deflating a cuff placed on the upper arm or thigh to induce brief cycles of ischemia and reperfusion, a strategy which has been shown to reduce MI size in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI). The results of the ongoing CONDI2/ERIC-PPCI trial are eagerly awaited, and will provide definitive answers with regards to the cardioprotective effect and clinical outcome benefits of RIC in STEMI.","PeriodicalId":72686,"journal":{"name":"Conditioning medicine","volume":"1 5","pages":"13-22"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191186/pdf/nihms-988793.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36597750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0