Conditioning medicine最新文献_第5页

The underlying mechanisms involved in the protective effects of ischemic postconditioning. 缺血后适应保护作用的潜在机制。

Conditioning medicine Pub Date : 2018-01-01

Rong Xie, Jinquan Li, Heng Zhao

{"title":"The underlying mechanisms involved in the protective effects of ischemic postconditioning.","authors":"Rong Xie, Jinquan Li, Heng Zhao","doi":"","DOIUrl":"","url":null,"abstract":"Cerebral ischemic postconditioning (PostC) refers to a series of brief ischemia and reperfusion (I/R) cycles applied at the onset of reperfusion following an ischemic event. PostC has been shown to have neuroprotective effects, and represents a promising clinical strategy against cerebral ischemia-reperfusion injury. Many studies have indicated that cerebral PostC can effectively reduce neural cell death, cerebral edema and infarct size, improve cerebral circulation, and relieve inflammation, apoptosis and oxidative stress. In addition, several protective molecular pathways such as Akt, mTOR and MAPK have been shown to play a role in PostC-induced neuroprotection. PostC represents an attractive therapeutic option because of its ability to be induced rapidly or in a delayed fashion, as well as being inducible by pharmacological agents. As a potential clinical treatment, PostC is therapeutically translatable as it can be induced remotely. The underlying mechanisms of PostC have been systematically investigated, but still need to be comprehensively analyzed. As most PostC studies to date were conducted preclinically using animal models, future studies are needed to optimize protocols in order to accelerate the clinical translation of PostC.","PeriodicalId":72686,"journal":{"name":"Conditioning medicine","volume":" ","pages":"73-79"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959054/pdf/nihms966514.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40527150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ischemic Conditioning and neonatal hypoxic ischemic encephalopathy: a literature review. 缺血性调节与新生儿缺氧缺血性脑病:文献综述。

Conditioning medicine Pub Date : 2017-12-01 Epub Date: 2017-12-15

Dusit Adstamongkonkul, David C Hess

{"title":"Ischemic Conditioning and neonatal hypoxic ischemic encephalopathy: a literature review.","authors":"Dusit Adstamongkonkul, David C Hess","doi":"","DOIUrl":"","url":null,"abstract":"Hypoxic Ischemic Encephalopathy (HIE) is the result of severe anoxic brain injury during the neonatal period and causes life-long morbidity and premature mortality. Currently, therapeutic hypothermia immediately after birth is the standard of care for clinically relevant HIE. However, therapeutic hypothermia alone does not provide complete neuroprotection and there is an urgent need for adjunctive therapies. Ischemic conditioning is an adaptive process of endogenous protection in which small doses of sub-lethal ischemia can provide a protection against a lethal ischemic event. Remote Ischemic Post-conditioning (RIPC), a form of ischemic conditioning, is highly translatable for HIE diagnosed immediately after birth as the conditioned ischemic stimulus is applied at the limb after the lethal ischemic episode. A number of studies in neonatal rats have demonstrated that RIPC is effective at reducing injury in focal cerebral ischemia models and improves neurological outcomes. In this review, we focus on the available data on HIE and its current treatment, models in HIE studies, ischemic conditioning/RIPC and its mechanism. We discuss in particular the effect of RIPC on neonatal brain with HIE. We postulate that combining RIPC with standard therapeutic hypothermia can be an attractive therapeutic approach for HIE.","PeriodicalId":72686,"journal":{"name":"Conditioning medicine","volume":"1 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131706/pdf/nihms-987710.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36491039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The microRNA miR-21 conditions the brain to protect against ischemic and traumatic injuries. microRNA miR-21调节大脑免受缺血性和创伤性损伤。

Conditioning medicine Pub Date : 2017-12-01 Epub Date: 2017-12-15

Mary S Lopez, Robert J Dempsey, Raghu Vemuganti

引用次数: 0

Ischemic preconditioning treatment of astrocytes transfers ischemic tolerance to neurons. 对星形胶质细胞进行缺血预处理可将缺血耐受性转移到神经元。

Conditioning medicine Pub Date : 2017-12-01

Srinivasan V Narayanan, Miguel A Perez-Pinzon

{"title":"Ischemic preconditioning treatment of astrocytes transfers ischemic tolerance to neurons.","authors":"Srinivasan V Narayanan, Miguel A Perez-Pinzon","doi":"","DOIUrl":"","url":null,"abstract":"Ischemic preconditioning (IPC) represents a potential therapy against cerebral ischemia. While our group has previously shown IPC to induce neuroprotection through various pathways, the role of astrocytes in supporting IPC-induced neuroprotection has not been extensively studied. Astrocyte-derived lactate has gained attention as a potential soluble mediator through which astrocytes could impart ischemic tolerance to neurons. Therefore, the goal of this study was to determine if i) IPC-treatment of astrocytes alone could transfer ischemic tolerance to neurons; ii) if IPC-treatment of astrocytes increases lactate production; and if iii) exogenous lactate administration to neurons could induce neuroprotection against lethal ischemia in vitro. For this purpose, a co-culture system was used and modified from a previous method. This system allows astrocytes and neurons to be separated by a physical barrier, while allowing secreted substances from either cell type to interact with each other. Oxygen-glucose deprivation was used as a model of cerebral ischemia and IPC in cultured rodent astrocytes and neurons. Neurons incubated with IPC-treated astrocytes were significantly protected against lethal ischemic injury compared to neurons incubated with sham-treated astrocytes. In addition, IPC-treatment of astrocytes significantly increased lactate secretion into the extracellular media. Finally, exogenous lactate administration can significantly attenuate cell death in neuronal cultures following exposure to lethal OGD. Our results suggest that IPC-treatment of astrocytes alone can transfer ischemic tolerance to neurons. In addition, the ability of IPC to increase lactate production in astrocytes suggest that lactate could represent a neuroprotective agent to protect neurons against lethal ischemic injury.","PeriodicalId":72686,"journal":{"name":"Conditioning medicine","volume":"1 1","pages":"2-8"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777620/pdf/nihms934949.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35764754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to Conditioning Medicine. 调理医学导论。

Conditioning medicine Pub Date : 2017-12-01 Epub Date: 2017-12-15

Miguel A Perez-Pinzon, Xunming Ji

引用次数: 0

Regulation of gene expression in ischemic preconditioning in the brain. 脑缺血预处理中基因表达的调控。

Conditioning medicine Pub Date : 2017-12-01 Epub Date: 2017-12-15

Tuo Yang, Qianqian Li, Feng Zhang

引用次数: 0

Neuroprotective potential of exercise preconditioning in stroke. 运动预处理对脑卒中的神经保护作用。

Conditioning medicine Pub Date : 2017-01-01

Mohammad Rashedul Islam, Michael F Young, Christiane D Wrann

引用次数: 0