Advances in Clinical Medical Research and Healthcare Delivery最新文献

{"title":"COVID-19 Vaccination Hesitancy in Pregnancy: A Retrospective Cohort Study of Patients’ Perceptions","authors":"Molly Schassberger, Charlotte Kirk, Samantha Fields, Carol Brenner, Andrea M Bodine","doi":"10.53785/2769-2779.1143","DOIUrl":"https://doi.org/10.53785/2769-2779.1143","url":null,"abstract":"","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82112392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Shoulder Ultrasound for Diagnosis of Rotator Cuff Pathologies","authors":"E. Ahmed","doi":"10.48112/acmr.v4i1.48","DOIUrl":"https://doi.org/10.48112/acmr.v4i1.48","url":null,"abstract":"To assess accuracy of shoulder ultrasound (USG) for diagnosis of rotator cuff pathologies. Seventy- four adult patients in age range of 30-80 years with rotator cuff pathologies of either gender were subjected to USG taken with Philips IU22 and a 5-12 MHz linear array transducer. All tendons were examined and grayscale 2D USG images were stored. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) was measured. USG findings showed intact supraspinatus tendons in 36 and 32, full tear in 8 and 10, partial tear in 2 and 7 and tendinosis in 28 and 25 cases respectively. Statistical analysis showed non- significant difference (P>0.05). USG findings showed intact infraraspinatus tendons in 45 and 41, full tear in 0 and 7, partial tear in 3 and 10 and tendinosis in 26 and 16 cases respectively. Statistical analysis showed significant difference (P<0.05). USG findings showed intact biceps tendons in 50 and 48, full tear in 2 and 3, partial tear in 4 and 4 and tendinosis in 18 and 19 cases respectively. Statistical analysis showed non- significant difference (P>0.05). A high accuracy, sensitivity, specificity, PPV and NPV was observed with USG in diagnosis of supraspinatus tendon, infraspinatus tendon, biceps tendons, subcapularis tendons. USG found to be effective in assessment of rotator cuff pathologies having high sensitivity, specificity, positive predictive and negative predictive values.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80499089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Landmarks in the Traumatic Brain Injury A Retrospective Study","authors":"Omar Al-Awar","doi":"10.48112/acmr.v4i1.45","DOIUrl":"https://doi.org/10.48112/acmr.v4i1.45","url":null,"abstract":"As one might expect, prehistoric brain surgery lacked knowledge of the anatomy, concept recognition of the disease, and comprehension of the disease’s origin. Unfortunately, failure to deeply understand these important principles delayed the progression of medical and surgical practice. Trepanation may be one of the oldest surgical interventions for which archaeological evidence is present. In the 1990s, standardized guidelines were developed and established for the management of traumatic brain injury. They included protocols regarding the pharmaceutical therapy and the management of increased ICP. Since then, research has improved TBI survival. Evidence of trepanation practice and other techniques in pre-Columbian Mesoamerica is demonstrated by the cranial remains in pre-Columbian burials, iconographic artworks, and post-colonial reports. The intellectual understanding of neurosurgery developed during the golden age of ancient Greece where no surgeon restricted oneself in strict to neurosurgery. Head injuries on the other hand appear to have been abundant; an expected result of wars and internecine conflict, as recorded by Herodotus, Thucydides, and Homer. Then and now, war remains the primary source of study material for the improvement of knowledge regarding head injuries. Surgical procedures for the management of even minimal lesions of the theca cranica, continued throughout the 16 th and 17 th Century. The surgical technique, with cross-shaped skin incision and the instruments used (trephine, lever, scalpel, gouge, protector of the meninx, etc.) would remain unchanged with respect to the past, but one should take notice at the improved quality of the materials and the ameliorated precision with which the instruments were made. Some instruments appeared to be real work of art, as shown by the findings now displayed in museums and in illustrations of the times. The most ancient technique of craniotomy involved using abrasive instruments to thin down the bony wall. Subsequently, circular incisions were progressively made deeper, or a series of small holes were made in a circular fashion. The remaining bony bridges between these small holes would be broken down. The two latter methods that continued to be used for a very long period depended on using metal instruments.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"49 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77322210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Immunological Considerations of Monoclonal Antibody Therapy in COVID-19 A Review","authors":"S. Bazarova, Z. Saatov, M. Nazirova","doi":"10.48112/acmr.v4i1.47","DOIUrl":"https://doi.org/10.48112/acmr.v4i1.47","url":null,"abstract":"Currently, effective methods for the prevention and treatment of coronavirus infections have not been developed. This could be attributed to the unique pathogenesis of the coronavirus infection and the rapid global spread of the pandemic, which have posed challenges to ongoing research efforts. Similar to other viral infections, coronavirus infection leads to the development and dissemination of the inflammatory process, resulting in viremia or the systemic spread of the infection. This uncontrolled inflammatory response is characterized by elevated levels of cytokines such as IFNy, IL-1, IL-6, and IL-12 in the bloodstream, transitioning the initial inflammatory reaction into a phase known as the cytokine storm. The cytokine storm is marked by severe clinical and laboratory manifestations. Consequently, it is crucial to implement appropriate therapies that target the uncontrolled inflammation induced by the virus rather than viremia itself. Hence, the aim of our study was to investigate the impact of monoclonal antibodies, specifically the medication \"Kazirivimab + Imdevimab,\" which is a combination of recombinant monoclonal antibodies targeting the S-protein, on the clinical progression and laboratory parameters in patients with COVID-19.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79947831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Treatment Outcomes for Traumatic Intracranial Hematomas During Early Traumatic Brain Injury","authors":"R.B. Khazratkulov","doi":"10.48112/acmr.v4i1.46","DOIUrl":"https://doi.org/10.48112/acmr.v4i1.46","url":null,"abstract":"The main objective of this research study was to examine the treatment outcomes of traumatic intracranial hematomas through the application of algorithms for complex diagnosis and differentiated tactics for treating various types of traumatic hematomas. Between 2014 and 2019, a total of 635 patients with traumatic intracranial hematomas were evaluated and treated at the Republican Specialized Scientific and Practical Medical Center of Neurosurgery. In addressing indications for surgical or conservative treatment, a unique approach was adopted based on the principles of urgency, complexity, and interconnection at all stages of treatment in the hospital. The results of the treatment of traumatic intracranial hematomas, both surgical and conservative, significantly varied not only in different periods and phases of the course of traumatic brain injury but also depending on the patient's age, type, location, and prevalence of the hematoma. The application of algorithms for complex diagnosis and differentiated treatment was found to be beneficial.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88231049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile and Outcome of Obstetric Fistula Surgeries in a Fistula Care Centre in South-East Nigeria","authors":"Yakubu En","doi":"10.48112/acmr.v4i1.49","DOIUrl":"https://doi.org/10.48112/acmr.v4i1.49","url":null,"abstract":"Prolonged obstructed labour is the main cause of obstetric vesico-vaginal fistula, however there is growing perception that a proportion of cases may be arising from surgical complications and errors. This study intends to evaluate this observation. A retrospective study of 378 eligible cases of obstetric VVF repaired over a five-year period. Requisite information was retrieved from hospital case records. Dataentry and analysis was done using SPSS version 20. Means and SD, Chi square test and the level of significance set at p<0.05 were calculated. The mean age was 33.9±10.1 years, mostly multipara, majority following caesarean sections in 62.3% followed by prolonged obstructed labour in 28.6% of patients. The most common type of VVF was Intra-cervical fistula in 55.8% of patients. At the time of hospital discharge following repair, 76.5% were closed and dry, 18.5% had post-repair incontinence and 5.0% had a failed repair within the studied period. Half of our patients (50.3%) were referred from private hospitals, 40.3% had no referral letter and the remaining were referred from government hospitals. The outcomes of surgeries were not influenced by the type of VVF repaired. Chi square test was 0.38 at 95% CI (p>0.05). There is a worrisome proportion of obstetric VVF from caesarean sections. Our success rates in obstetric VVF repair appears satisfactory; more effort be made in strengthening the referral system and impacting correct surgical skills especially in areas of caesarean section.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87877746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial disparities in access to pain management services during COVID pandemic at an urban safety-net hospital","authors":"Mohammad Ghorbanhoseini, Akhil V Uppalapati, Allen Yang, Rafael Ortega, E. Vaynberg","doi":"10.53785/2769-2779.1133","DOIUrl":"https://doi.org/10.53785/2769-2779.1133","url":null,"abstract":"","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90760182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Maintenance Prednisone in ANCA Glomerulonephritis","authors":"Arjun Sekar, Pulkit Gandhi, Vijay Sheldon, A. Reddy, Ruth E. Campbell","doi":"10.53785/2769-2779.1140","DOIUrl":"https://doi.org/10.53785/2769-2779.1140","url":null,"abstract":"","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88491298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Wave of the Overdose Epidemic arises during the COVID-19 Pandemic","authors":"T. Suvar, A. Buvanendran, Stephen C. Music, Wilson M Compton","doi":"10.53785/2769-2779.1127","DOIUrl":"https://doi.org/10.53785/2769-2779.1127","url":null,"abstract":"","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73362353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Research Framework for Strengthening Health Care and Public Health Engagement in Neighborhood Change as a Social Determinant of Health","authors":"Christopher Williams, N. Woodard, Charlene Chao-Li Kuo","doi":"10.53785/2769-2779.1135","DOIUrl":"https://doi.org/10.53785/2769-2779.1135","url":null,"abstract":"","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88665838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}