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Cold Spring Harbor symposia on quantitative biology最新文献

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Author Index. 作者索引。
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 DOI: 10.1101/sqb.2018.83.AI
{"title":"Author Index.","authors":"","doi":"10.1101/sqb.2018.83.AI","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.AI","url":null,"abstract":"","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"34 1","pages":"297"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87699577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Conversation with Edward Boyden. 与爱德华·博伊登的对话。
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-02-25 DOI: 10.1101/sqb.2018.83.037325
{"title":"A Conversation with Edward Boyden.","authors":"","doi":"10.1101/sqb.2018.83.037325","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.037325","url":null,"abstract":"Dr. Boyden: If we want to understand the brain, we have three technological needs: to see what’s going on in the brain with high-speed precision, to map the molecules and the organization of the brain, and to control the high-speed dynamics.We’ve been working a lot on extending tool sets into these three directions. For control, we’ve been trying to perfect optogenetic control of neurons and also to develop noninvasiveways to focus the effects of electricity deep in the brain. Formapping the brain, we’ve beenworking onways to physically blow up the brain until it’s up to a thousand times bigger in volume so that you can map the very finest connections.","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"239-242"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.037325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37173108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hippocampus and Social Impairment in Psychiatric Disorders. 精神障碍患者的海马体与社交障碍。
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-02-20 DOI: 10.1101/sqb.2018.83.037614
Matthew Schafer, Daniela Schiller
{"title":"The Hippocampus and Social Impairment in Psychiatric Disorders.","authors":"Matthew Schafer,&nbsp;Daniela Schiller","doi":"10.1101/sqb.2018.83.037614","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.037614","url":null,"abstract":"<p><p>Social deficits, such as poor social skills (i.e., the inability to engage in appropriate and effective social interactions) and social withdrawal, are prevalent across psychiatric disorders and often co-occur with hippocampal structural and functional abnormalities. The centrality of both social and hippocampal dysfunction in psychiatric research prompts the question: Are they linked? The social cognitive map framework provides a clue: The hippocampus tracks social information in the physical environment, maps others along social dimensions, and supports social memory and decision-making. Hippocampal dysfunction might disrupt social map representation and contribute to commonly seen social behavioral symptoms. This review summarizes evidence for the role of the hippocampus in social cognitive mapping, followed by evidence that hippocampal dysfunction and social dysfunction co-occur in psychiatric disorders. We argue that the co-occurrence of hippocampal and social impairment may be related via hippocampal social cognitive mapping.</p>","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"105-118"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.037614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36984484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Current Status of Deep Brain Stimulation for Alzheimer's Disease: From Chance Observation to Clinical Trials. 深部脑刺激治疗阿尔茨海默病的现状:从偶然观察到临床试验。
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-03-08 DOI: 10.1101/sqb.2018.83.037440
Darrin J Lee, Andres M Lozano
{"title":"Current Status of Deep Brain Stimulation for Alzheimer's Disease: From Chance Observation to Clinical Trials.","authors":"Darrin J Lee,&nbsp;Andres M Lozano","doi":"10.1101/sqb.2018.83.037440","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.037440","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a neurodegenerative disorder that results in significant memory impairment and cognitive decline. Current medical treatment is aimed at treating AD symptoms but does not alter the disease course. The use of deep brain stimulation (DBS) for the treatment of AD is in its nascent phase. Here, we describe the evolution of DBS as a potential treatment modality for AD, including previous and current trials, as well as the behavioral and histological preclinical data that help to better understand and inform future clinical trials. As such, a phase 3 clinical trial studying the effects of forniceal DBS for AD is currently underway.</p>","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"201-205"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.037440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37038587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
A Conversation with Helen Mayberg. Helen Mayberg的对话。
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-03-18 DOI: 10.1101/sqb.2018.83.037598
{"title":"A Conversation with Helen Mayberg.","authors":"","doi":"10.1101/sqb.2018.83.037598","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.037598","url":null,"abstract":"Dr. Mayberg: Depression is a very common psychiatric condition, one of the most common that we have. It’s diagnosed by an interview, not by a laboratory test or a scan. It’s a condition that’s characterized by a disturbance in one’s mood, generally a profoundly and distressing low mood that’s accompanied, in most cases, by a sense of not feeling pleasure: anhedonia. It has an admixture of many other symptoms that affect our drives—like sleep, or appetite, or one’s libido—and activities, as well as interests and thought. Thinking can get slow or confused. People feel like doing less. They may feel anxiety. They may have sensations in the body that, at their core, are disturbances in drive states, emotion, and putting thought to action. Despite being extremely common and accounting for much of the world’s disability, the good news is that there are many treatments, and have been. There are a number of evidence-based psychotherapies like interpersonal psychotherapy or cognitive behavioral therapy that can be quite effective. There’s a multitude of medications and have been since the late ’50s, heralded now by the serotonin reuptake inhibitors, but also drugs like tricyclics or mixed serotonin and norepinephrine drugs. We have new medications like ketamine that are being tested that are not even of the old classes. And we have somatic treatments, like using magnetic therapies like TMS [transcranial magnetic stimulation]. Most importantly, the best treatment that there is is actually electroconvulsive therapy, but it’s generally reserved for people who are extremely ill and have not responded to medication or psychotherapy.","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"264-267"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.037598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37069576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Mechanisms Underlying Sleep. 睡眠的遗传机制。
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-04-01 DOI: 10.1101/sqb.2018.83.037705
Hirofumi Toda, Mi Shi, Julie A Williams, Amita Sehgal
{"title":"Genetic Mechanisms Underlying Sleep.","authors":"Hirofumi Toda,&nbsp;Mi Shi,&nbsp;Julie A Williams,&nbsp;Amita Sehgal","doi":"10.1101/sqb.2018.83.037705","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.037705","url":null,"abstract":"<p><p>Sleep is important for cognitive ability, and perturbations of sleep are associated with a myriad of brain disorders. However, how sleep promotes health and function during wake is poorly understood. To address the cellular and molecular mechanisms underlying sleep, we use the fruit fly <i>Drosophila melanogaster</i> as a genetic model. Forward genetic approaches in flies were critical for deciphering molecular mechanisms of the circadian clock. Using similar approaches, we and others are gaining insights into the pathways that control sleep amount.</p>","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"57-61"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.037705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37112409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Rewiring the Addicted Brain: Circuits-Based Treatment for Addiction. 重新连接成瘾的大脑:基于电路的成瘾治疗。
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-05-16 DOI: 10.1101/sqb.2018.83.038158
Graziella Madeo, Antonello Bonci
{"title":"Rewiring the Addicted Brain: Circuits-Based Treatment for Addiction.","authors":"Graziella Madeo,&nbsp;Antonello Bonci","doi":"10.1101/sqb.2018.83.038158","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.038158","url":null,"abstract":"<p><p>The advent of the noninvasive brain stimulation (NIBS) technique has paved the way for neural circuit-based treatments for addiction. Recently, evidence from both preclinical and clinical studies has evaluated the use of transcranial magnetic stimulation (TMS) as a safe and cost-effective therapeutic tool for substance use disorders (SUDs). Indeed, repetitive TMS impacts on neural activity inducing short- and long-term effects involving neuroplasticity mechanisms locally within the target area of stimulation and the network level throughout the brain. Here, we provide an integrated view of evidence highlighting the mechanisms of TMS-induced effects on modulating the maladaptive brain circuitry of addiction. We then review the preclinical and clinical findings suggesting rTMS as an effective interventional tool for the treatment of SUDs.</p>","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"173-184"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.038158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37248356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
A Conversation with Adam Kepecs. 与Adam Kepecs对话。
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-06-11 DOI: 10.1101/sqb.2018.83.038133
{"title":"A Conversation with Adam Kepecs.","authors":"","doi":"10.1101/sqb.2018.83.038133","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.038133","url":null,"abstract":"Dr. Kepecs: I’m very interested in how brains make decisions. I’m interested in the computational mechanism: what makes brains able to do feats that computers, even in the age of amazing AI [artificial intelligence], cannot do? On the other hand, I’m also very interested in the cellular mechanisms at the level of neural circuits: Where’s the “magic” in brains? What about them, in terms of the biological machinery, makes them able to do these things?","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"258-260"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37318564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Conversation with Yang Dan. 对话杨丹
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-05-16 DOI: 10.1101/sqb.2018.83.037564
{"title":"A Conversation with Yang Dan.","authors":"","doi":"10.1101/sqb.2018.83.037564","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.037564","url":null,"abstract":"Dr. Dan: Absolutely. Both things that you said are crucial for our research program. Optogenetics is crucial. Without it, I probably would never have even moved into sleep. Because that tool was available and I started using it in the visual system, I realized how powerful it is and I see this new opportunity to apply it to sleep research. More recently, we’ve also been doing a lot of sequencing, gene profiling. Without it being cheap, we would not be able to afford it.","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"243-245"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37248357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Conversation with Robert C. Malenka. 与Robert C. Malenka的对话。
Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-02-04 DOI: 10.1101/sqb.2018.83.037481
{"title":"A Conversation with Robert C. Malenka.","authors":"","doi":"10.1101/sqb.2018.83.037481","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.037481","url":null,"abstract":"Gary Stix: Your work is a major hub of research on synaptic plasticity. In addition to all the basic work you do, your work is also focused on how that applies to realworld disorders like drug addiction. You’ve also presented work that focuses on social reward and the fact that serotonin release in the nucleus accumbens promotes prosocial behavior. Could you tell us about this study and relate it to the larger picture of what you’re doing?","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"261-263"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.037481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36976921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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