Cold Spring Harbor symposia on quantitative biology最新文献_第7页

A Conversation with Daniela Schiller. 《与丹妮拉·席勒的对话》

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-02-25 DOI: 10.1101/sqb.2018.83.037606

引用次数: 0

A Conversation with Huda Zoghbi. 与Huda Zoghbi的对话。

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-04-23 DOI: 10.1101/sqb.2018.83.037721

引用次数: 0

A Conversation with Li-Huei Tsai. 与蔡丽慧的对话。

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-04-01 DOI: 10.1101/sqb.2018.83.038042

引用次数: 0

Epigenetic Priming in Drug Addiction. 药物成瘾的表观遗传启动。

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-04-01 DOI: 10.1101/sqb.2018.83.037663

Philipp Mews, Deena M Walker, Eric J Nestler

引用次数: 19

Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Cell (iPSC)-Based Model of Dravet Syndrome. 研究大麻二酚在人类诱导多能干细胞(iPSC)模型中的治疗机制。

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-06-11 DOI: 10.1101/sqb.2018.83.038174

Yishan Sun, Ricardo E Dolmetsch

{"title":"Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Cell (iPSC)-Based Model of Dravet Syndrome.","authors":"Yishan Sun, Ricardo E Dolmetsch","doi":"10.1101/sqb.2018.83.038174","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.038174","url":null,"abstract":"Dravet syndrome is an infantile epileptic encephalopathy primarily caused by loss-of-function variants of the gene SCN1A Standard treatment regimens have very limited efficacy to combat the life-threatening seizures in Dravet syndrome or the behavioral-cognitive comorbidities of the disease. Recently there has been encouraging progress in developing new treatments for this disorder. One of the clinical advances is cannabidiol (CBD), a compound naturally found in cannabis and shown to further reduce convulsive seizures in patients when used together with existing drug regimens. Like many other natural products, the exact therapeutic mechanism of CBD remains undefined. Previously we have established a human cellular model of Dravet syndrome by differentiating patient-derived induced pluripotent stem cells (iPSCs) into telencephalic inhibitory and excitatory neurons. Here we have applied this model to investigate the antiepileptic mechanism(s) of CBD at the cellular level. We first determined the effect of escalating the concentrations of CBD on neuronal excitability, using primary culture of rat cortical neurons. We found modulatory effects on excitability at submicromolar concentrations and toxic effects at high concentrations (15 µM). We then tested CBD at 50 nM, a concentration that corresponds to the estimated human clinical exposure, in telencephalic neurons derived from a patient iPSC line and control cell line H9. This 50 nM of CBD increased the excitability of inhibitory neurons but decreased the excitability of excitatory neurons, without changing the amplitude of sodium currents in either cell type. Our findings suggest a cell type-dependent mechanism for the therapeutic action of CBD in Dravet syndrome that is independent of sodium channel activity.","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"185-191"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.038174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37318565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

A Conversation with Mehmet Fatih Yanik. 与穆罕默德·法提赫·亚尼克的对话。

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-04-23 DOI: 10.1101/sqb.2018.83.038018

引用次数: 0

The Neurobiology of Confidence: From Beliefs to Neurons. 信心的神经生物学:从信念到神经元。

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-07-03 DOI: 10.1101/sqb.2018.83.038794

Torben Ott, Paul Masset, Adam Kepecs

{"title":"The Neurobiology of Confidence: From Beliefs to Neurons.","authors":"Torben Ott, Paul Masset, Adam Kepecs","doi":"10.1101/sqb.2018.83.038794","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.038794","url":null,"abstract":"How confident are you? As humans, aware of our subjective sense of confidence, we can readily answer. Knowing your level of confidence helps to optimize both routine decisions such as whether to go back and check if the front door was locked and momentous ones like finding a partner for life. Yet the inherently subjective nature of confidence has limited investigations by neurobiologists. Here, we provide an overview of recent advances in this field and lay out a conceptual framework that lets us translate psychological questions about subjective confidence into the language of neuroscience. We show how statistical notions of confidence provide a bridge between our subjective sense of confidence and confidence-guided behaviors in nonhuman animals, thus enabling the study of the underlying neurobiology. We discuss confidence as a core cognitive process that enables organisms to optimize behavior such as learning or resource allocation and that serves as the basis of metacognitive reasoning. These approaches place confidence on a solid footing and pave the way for a mechanistic understanding of how the brain implements confidence-based algorithms to guide behavior.","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.038794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37388083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

A Conversation with Paul Glimcher. 与保罗·格里姆彻的对话。

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-02-11 DOI: 10.1101/sqb.2018.83.037317

{"title":"A Conversation with Paul Glimcher.","authors":"","doi":"10.1101/sqb.2018.83.037317","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.037317","url":null,"abstract":"Dr. Glimcher: My lab’s really focused on understanding the core underlying biological basis of how we make decisions. That’s an area that we knew very little about 20, 30 years ago.We knew a lot about Pavlovian conditioning but really didn’t think about how people make choices and what the neural architecture for that looks like. Over the course of the last 25 years, as a community we’ve made tremendous strides in making fundamental insights into that. I think at this point we can say that we understand the basic neural architecture for making decisions. We understand how parts of the frontal cortex generate values, store them, how we learn what we like and what we don’t like, and then how those values are passed to areas of the frontal and parietal cortex for decision-making, for weighing options in a very formal, mathematical sense. It’s been a really exciting field to be in for the last 25 years, because it’s really a field that was born pretty much 25, 30 years ago. At this point we really have laid the groundwork for understanding how to change policy, how to understand things like drug addiction, how to understand decisionmaking.","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"249-251"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.037317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36953505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding Depression: Insights from Glial and Ketamine Regulation of Neuronal Burst Firing in Lateral Habenula. 解码抑郁症:从神经胶质和氯胺酮调节外侧缰神经突放电的见解。

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-02-04 DOI: 10.1101/sqb.2018.83.036871

Yihui Cui, Yan Yang, Yiyan Dong, Hailan Hu

引用次数: 13

A Conversation with Michael Platt. 与迈克尔·普拉特的对话。

Cold Spring Harbor symposia on quantitative biology Pub Date : 2018-01-01 Epub Date: 2019-02-04 DOI: 10.1101/sqb.2018.83.037473

{"title":"A Conversation with Michael Platt.","authors":"","doi":"10.1101/sqb.2018.83.037473","DOIUrl":"https://doi.org/10.1101/sqb.2018.83.037473","url":null,"abstract":"Dr. Platt: It is a bold claim to say something is a homology, because that really means that it basically arises from the same biological substrate. It emerges developmentally in the same way, it serves a similar function, and in terms of behavior it looks the same, as well. My statement isn’t just based on our work, but of course many other people as well. We have been fascinated by nonhuman primates and macaques in particular because their behavior, especially their social behavior, bears somany hallmarks of our own. They, like people, live in large groups that havemales and females. They live a long time. They identify each other on sight, they know who is related to whom, they know who outranks whom. They understand third-party relationships. One of the things that I think is really important about these animals is that they engage in behaviors that are very similar to ours to form cooperative alliances that they use to advance their own causes. Some monkeys invest a lot of time and energy in developing friendships. Friends come to their aid. We know that—just like for people—the deeper, more numerous connections that a monkey has, the better he or she is going to do. They’re going to live longer, they’ll be healthier, less stressed out, have more offspring. With people, it’s more or less the same thing: live longer, happier, healthier life, evenmakemore money. The functions and the behaviors themselves are very similar and what we, and others, have begun to discover is that essentially the system in the brain—the circuitry that allows us to manage our connections with others—is exactly the same as what the monkey has in his or her brain. It’s the same bits of stuff wired up in very similar ways. We have identified by comparison between monkeys and people that when we engage in various kinds of social interactions like this, the way that our brains process that information looks virtually identical to what we see in monkeys using complementary techniques.","PeriodicalId":72635,"journal":{"name":"Cold Spring Harbor symposia on quantitative biology","volume":"83 ","pages":"272-274"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/sqb.2018.83.037473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36976920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0