Cholesterol最新文献_第7页

Metabolic risk factors, leisure time physical activity, and nutrition in german children and adolescents. 德国儿童和青少年的代谢危险因素、闲暇时间体力活动和营养。

Cholesterol Pub Date : 2012-01-01 DOI: 10.1155/2012/370850

Gerda-Maria Haas, Evelyn Liepold, Peter Schwandt

{"title":"Metabolic risk factors, leisure time physical activity, and nutrition in german children and adolescents.","authors":"Gerda-Maria Haas, Evelyn Liepold, Peter Schwandt","doi":"10.1155/2012/370850","DOIUrl":"https://doi.org/10.1155/2012/370850","url":null,"abstract":"Purpose. We assessed the five components of the metabolic syndrome (MetS) as defined by the International Diabetes Federation (IDF) in 6040 (3158 males) youths aged 6-16 years who participated in the Präventions-Erziehungs-Programm (PEP Family Heart Study) in Nuernberg between 2000 and 2007. The purpose of this cross-sectional study was to examine associations with lifestyle habits. Results and Discussion. The prevalence of MetS was low in children (1.6%) and adolescents (2.3%). High waist circumference (WC) and low HDL-C were slightly higher in females (9.5% and 7.5%, resp.) than in males (8.8% and 5.7%, resp.). Low leisure time physical activity (LTPA) was significantly associated with low HDL-C (odds ratio [OR] 2.4; 95% CI 1.2-5.0) and inversely associated with hypertension (r = -0.146), hypertriglyceridemia (r = -0.141), and central adiposity (r = -0.258). The risk for low HDL-C (≤1.3 mmol/L) was 1.7-fold (CI 1.0-2.6) higher in youth with high (≥33%) saturated fat consumption. A low polyunsaturated/saturated fat ratio (P/S ratio) was significantly associated with fasting hyperglycemia (OR 1.4; 95% CI 1.0-1.2).","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2012 ","pages":"370850"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/370850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9375102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Ezetimibe and simvastatin reduce cholesterol levels in zebrafish larvae fed a high-cholesterol diet. 依折替贝和辛伐他汀可以降低高胆固醇饲料喂养的斑马鱼幼虫的胆固醇水平。

Cholesterol Pub Date : 2012-01-01 DOI: 10.1155/2012/564705

Ji Sun Baek, Longhou Fang, Andrew C Li, Yury I Miller

{"title":"Ezetimibe and simvastatin reduce cholesterol levels in zebrafish larvae fed a high-cholesterol diet.","authors":"Ji Sun Baek, Longhou Fang, Andrew C Li, Yury I Miller","doi":"10.1155/2012/564705","DOIUrl":"https://doi.org/10.1155/2012/564705","url":null,"abstract":"Cholesterol-fed zebrafish is an emerging animal model to study metabolic, oxidative, and inflammatory vascular processes relevant to pathogenesis of human atherosclerosis. Zebrafish fed a high-cholesterol diet (HCD) develop hypercholesterolemia and are characterized by profound lipoprotein oxidation and vascular lipid accumulation. Using optically translucent zebrafish larvae has the advantage of monitoring vascular pathology and assessing the efficacy of drug candidates in live animals. Thus, we investigated whether simvastatin and ezetimibe, the principal drugs used in management of hypercholesterolemia in humans, would also reduce cholesterol levels in HCD-fed zebrafish larvae. We found that ezetimibe was well tolerated by zebrafish and effectively reduced cholesterol levels in HCD-fed larvae. In contrast, simvastatin added to water was poorly tolerated by zebrafish larvae and, when added to food, had little effect on cholesterol levels in HCD-fed larvae. Combination of low doses of ezetimibe and simvastatin had an additive effect in reducing cholesterol levels in zebrafish. These results suggest that ezetimibe exerts in zebrafish a therapeutic effect similar to that in humans and that the hypercholesterolemic zebrafish can be used as a low-cost and informative model for testing new drug candidates and for investigating mechanisms of action for existing drugs targeting dyslipidemia.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2012 ","pages":"564705"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/564705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9728898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Are dietary cholesterol intake and serum cholesterol levels related to nonalcoholic Fatty liver disease in obese children? 膳食胆固醇摄入量和血清胆固醇水平与肥胖儿童非酒精性脂肪肝有关吗?

Cholesterol Pub Date : 2012-01-01 DOI: 10.1155/2012/572820

Dimitrios Papandreou, Zaharoula Karabouta, Israel Rousso

{"title":"Are dietary cholesterol intake and serum cholesterol levels related to nonalcoholic Fatty liver disease in obese children?","authors":"Dimitrios Papandreou, Zaharoula Karabouta, Israel Rousso","doi":"10.1155/2012/572820","DOIUrl":"https://doi.org/10.1155/2012/572820","url":null,"abstract":"Background. Nonalcoholic fatty liver disease (NAFLD) in children has been recognized as a major health burden. Serum lipids as well as dietary cholesterol (DC) intake may positively relate to development of NAFLD. The purpose of this study was to investigate anthropometric, biochemical, and dietary intake parameters of obese Greek children with and without NAFLD. Materials and Methods. Eighty-five obese children aged 8-15 (45 boys/40 girls) participated in the study. NAFLD was diagnosed by ultrasonography (US) in all subjects. Liver indexes were measured in all children. A 3-day dietary was recorded for all subjects. Results. 38 out of 85 children (44.7%) were found to have fatty liver. Obese children with increased levels of TC (95% CI: 1.721-3.191), low density lipoprotein (LDL) (95% CI: 1.829-3.058), and increased dietary cholesterol intakes (95% CI: 1.511-2.719) were 2.541, 2.612, and 2.041 times more likely to develop NAFLD compared with the children without NAFLD. Conclusion. The present study showed that TC, LDL, and DC were the strongest risk factors of development of NAFLD. Reducing body weight and dietary cholesterol intakes as well as decreasing serum TC and LDL levels are urgently necessary in order to prevent NAFLD and possible other health implications later in life.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2012 ","pages":"572820"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/572820","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

The effects of unripe grape juice on lipid profile improvement. 生葡萄汁对血脂改善的影响。

Cholesterol Pub Date : 2012-01-01 DOI: 10.1155/2012/890262

Mohammad Javad Zibaeenezhad, Esmael Mohammadi, Mohammad Ali Babaie Beigi, Fatemeh Mirzamohammadi, Oveis Salehi

引用次数: 28

Changes in Lipids and Lipoproteins after Selective LDL Apheresis (7-Year Experience). 选择性低密度脂蛋白分离后血脂和脂蛋白的变化(7年经验)。

Cholesterol Pub Date : 2012-01-01 DOI: 10.1155/2012/976578

Genovefa Kolovou, Georgios Hatzigeorgiou, Constantinos Mihas, Nikos Gontoras, Panagiotis Litras, Dimitris Devekousos, Panagiota Kontodima, Constantina Sorontila, Helen Bilianou, Sophie Mavrogeni

{"title":"Changes in Lipids and Lipoproteins after Selective LDL Apheresis (7-Year Experience).","authors":"Genovefa Kolovou, Georgios Hatzigeorgiou, Constantinos Mihas, Nikos Gontoras, Panagiotis Litras, Dimitris Devekousos, Panagiota Kontodima, Constantina Sorontila, Helen Bilianou, Sophie Mavrogeni","doi":"10.1155/2012/976578","DOIUrl":"https://doi.org/10.1155/2012/976578","url":null,"abstract":"Background. The aim of the study was to investigate the changes in plasma lipids and lipoproteins and the cardiovascular events after selective LDL apheresis. Methods and Results. Two pediatric patients with familial hypercholesterolemia aged 11 and 13 years and 19 dyslipidemic adults aged 41 ± 14 years underwent direct adsorption of lipoproteins (DALI) sessions. The mean follow-up period was 47 ± 23 months. The total cholesterol (TC) values before and after treatment were 8.2 ± 2.2 and 3.1 ± 1.6 mmol/l (318 ± 86 and 122 ± 62 mg/dL), respectively. The interval mean of TC was 6.9 ± 1.9 mmol/l (268 ± 75 mg/dL). The LDL cholesterol concentrations before and after treatment were 6.6 ± 2.1 and 1.7 ± 1.1 mmol/l, (256 ± 82 mg/dL and 65 ± 41 mg/dL), respectively. The percentage of acute LDL cholesterol reduction was 75 ± 11%. Cardiovascular events were observed in seven patients. The average annual event rate was 5.51%. Conclusion. LDL apheresis is a very important therapeutic tool in managing patients at high risk for premature CAD or with aggressive CAD, despite adequate medical treatment.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2012 ","pages":"976578"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/976578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Rosiglitazone and fenofibrate additive effects on lipids. 罗格列酮和非诺贝特对血脂的累加作用。

Cholesterol Pub Date : 2011-01-01 Epub Date: 2011-11-24 DOI: 10.1155/2011/286875

Ahmad Slim, Laudino Castillo-Rojas, Eddie Hulten, Jennifer N Slim, Dorette Pearce Moore, Todd C Villines

{"title":"Rosiglitazone and fenofibrate additive effects on lipids.","authors":"Ahmad Slim, Laudino Castillo-Rojas, Eddie Hulten, Jennifer N Slim, Dorette Pearce Moore, Todd C Villines","doi":"10.1155/2011/286875","DOIUrl":"https://doi.org/10.1155/2011/286875","url":null,"abstract":"Background. To evaluate the effect of rosiglitazone, fenofibrate, or their combined use on plasma lipids in normoglycemic healthy adults. Methods and Results. Subjects were randomized in a double-blind fashion to rosiglitazone + placebo, fenofibrate + placebo, rosiglitazone + fenofibrate, or matching double placebo. The between-group difference in the change in fasting TG, high-density lipoprotein cholesterol (HDL-C), LDL-C, and plasma apolipoproteins A-I, A-II, and C-III level were compared after 12 weeks of treatment. A total of 548 subjects were screened and 41 met the inclusion criteria. After 12 weeks of therapy, the median change in the triglyceride levels showed a significant reduction ranging from 47 to 55 mg per deciliter in the fenofibrate only and rosiglitazone/fenofibrate groups compared with placebo (P = 0.0496). However, the rosiglitazone only group did not show significant change in triglyceride level. The change in the Apo AII showed increase in all the treatment groups compared with placebo (P = 0.009). There was also significant change in the Apo CIII that showed reduction of its level in the fenofibrate only and rosiglitazone/fenofibrate groups (P = 0.0003). Conclusion. Rosiglitazone does not appear to modulate hypertriglyceridemia in patients with elevated triglycerides independent of glucose metabolism.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2011 ","pages":"286875"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/286875","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30319266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease. APOE和FABP2多态性与心肌梗死、中风、糖尿病和胆囊疾病的历史

Cholesterol Pub Date : 2011-01-01 Epub Date: 2011-09-18 DOI: 10.1155/2011/896360

Ikuko Kato, Susan Land, Jill Barnholtz-Sloan, Richard K Severson

引用次数: 8

Modulators of Protein Kinase C Affect SR-BI-Dependent HDL Lipid Uptake in Transfected HepG2 Cells. 蛋白激酶C调节剂影响转染HepG2细胞sr - bi依赖性HDL脂质摄取

Cholesterol Pub Date : 2011-01-01 Epub Date: 2011-01-05 DOI: 10.1155/2011/687939

Rachelle Brunet, Maxine How, Bernardo L Trigatti

引用次数: 11

Dietary, anthropometric, and biochemical determinants of plasma high-density lipoprotein-cholesterol in free-living adults. 自由生活成人血浆高密度脂蛋白-胆固醇的饮食、人体测量和生化决定因素。

Cholesterol Pub Date : 2011-01-01 Epub Date: 2010-12-15 DOI: 10.1155/2011/851750

Erick Prado de Oliveira, Rodrigo Minoru Manda, Gabriel Augusto Torezan, José Eduardo Corrente, Roberto Carlos Burini

{"title":"Dietary, anthropometric, and biochemical determinants of plasma high-density lipoprotein-cholesterol in free-living adults.","authors":"Erick Prado de Oliveira, Rodrigo Minoru Manda, Gabriel Augusto Torezan, José Eduardo Corrente, Roberto Carlos Burini","doi":"10.1155/2011/851750","DOIUrl":"https://doi.org/10.1155/2011/851750","url":null,"abstract":"The level of high-density lipoprotein is thought to be critical in inhibiting lesion formation as well as reducing the lipid load of preexisting atherosclerotic lesions. With the aim of determining the main determinants of plasma HDL-cholesterol (HDL-c) in free-living adults, 997 individuals (52.3 ± 10 years, 67% females) were selected for a descriptive cross-sectional study. The used data corresponded to the baseline obtained from participants clinically selected for a lifestyle modification program. Covariables of clinical, anthropometry, food intake, aerobic fitness, and plasma biochemistry were analyzed against plasma HDL-c either as continuous or categorized variables. After adjustments for age, gender, and BMI the excess of abdominal fat along with high carbohydrate-energy intake and altered plasma triglycerides were the stronger predictors of reduced plasma HDL-c. In conclusion lifestyle interventions aiming to normalize abdominal fatness and plasma triglycerides are recommended to restore normal levels of HDL-c in these free-living adults.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2011 ","pages":"851750"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/851750","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29814273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Friend Turns Foe: Transformation of Anti-Inflammatory HDL to Proinflammatory HDL during Acute-Phase Response. 朋友变成敌人:急性期反应中抗炎HDL向促炎HDL的转化。

Cholesterol Pub Date : 2011-01-01 Epub Date: 2010-11-25 DOI: 10.1155/2011/274629

Hima Bindu G, Veena S Rao, Vijay V Kakkar

引用次数: 94