Cholesterol最新文献_第2页

Banana Blossom (Musa acuminate Colla) Incorporated Experimental Diets Modulate Serum Cholesterol and Serum Glucose Level in Wistar Rats Fed with Cholesterol 香蕉花(Musa acuminate Colla)添加实验饲料对高胆固醇Wistar大鼠血清胆固醇和血糖水平的调节作用

Cholesterol Pub Date : 2016-11-30 DOI: 10.1155/2016/9747412

R. Liyanage, Saranya Gunasegaram, R. Visvanathan, Chathuni Jayathilake, P. Weththasinghe, B. Jayawardana, J. Vidanarachchi

引用次数: 20

In Vivo Antihypercholesterolemic Potential of Swietenia mahagoni Leaf Extract 苦参叶提取物体内抗高胆固醇潜能研究

Cholesterol Pub Date : 2016-10-13 DOI: 10.1155/2016/2048341

Naveen Yelaware Puttaswamy, A. Urooj

{"title":"In Vivo Antihypercholesterolemic Potential of Swietenia mahagoni Leaf Extract","authors":"Naveen Yelaware Puttaswamy, A. Urooj","doi":"10.1155/2016/2048341","DOIUrl":"https://doi.org/10.1155/2016/2048341","url":null,"abstract":"The present investigation aims to evaluate antihypercholesterolemic potential of Swietenia mahagoni leaf aqueous extract (MAE) in diet-induced hypercholesterolemic rat model. In the study, Wistar albino rats (170–220 g) were segregated into 5 groups; all the groups except normal control group were given high fat diet to induce hypercholesterolemia. After induction of cholesterolemia, normal control and positive control groups were treated with saline, statin group was treated with atorvastatin, and remaining two groups received MAE in two doses (250 and 500 mg kg−1 BW) for a treatment period of one month. After the treatment period, weight of rats was recorded and they were anesthetized and decapitated. Blood samples were taken and triglycerides, total cholesterol, LDL-C, HDL-C, malondialdehyde (MDA), and urea were determined. Liver and kidney were taken for the estimation of lipid peroxides. The positive control group showed higher values of triglycerides (109 ± 5.1 mg/dL), total cholesterol (134 ± 4.6 mg/dL), LDL-C (44 ± 1.2 mg/dL), MDA, and bile acid content when compared to a normal control group (triglycerides (89 ± 3.2 mg/dL), total cholesterol (72 ± 3.4 mg/dL), and LDL-C (28 ± 1.2 mg/dL)). Treatment with MAE decreased the cholesterol levels, HDL-C, ALT, AST, and bilirubin levels and the effect was dependent on the dose. The results of this study indicated that MAE possesses hypolipidemic potential and thus could be useful in the treatment of hypercholesterolemic condition.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82364412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Cholesterol Lowering Effect of Plant Stanol Ester Yoghurt Drinks with Added Camelina Oil 添加亚麻荠油植物甾醇酯酸奶饮料的降胆固醇效果

Cholesterol Pub Date : 2016-02-21 DOI: 10.1155/2016/5349389

P. Salo, P. Kuusisto

{"title":"Cholesterol Lowering Effect of Plant Stanol Ester Yoghurt Drinks with Added Camelina Oil","authors":"P. Salo, P. Kuusisto","doi":"10.1155/2016/5349389","DOIUrl":"https://doi.org/10.1155/2016/5349389","url":null,"abstract":"The aim of this study was to investigate the effects of yoghurt minidrinks containing two doses of plant stanol ester either with or without added camelina oil on the serum cholesterol levels in moderately hypercholesterolemic subjects. In this randomised, double-blind, parallel group study, 143 subjects consumed a 65 mL minidrink together with a meal daily for four weeks. The minidrink contained 1.6 or 2.0 grams of plant stanols with or without 2 grams of alpha-linolenic acid-rich camelina oil. The placebo minidrink did not contain plant stanols or camelina oil. All plant stanol treated groups showed statistically significant total, LDL, and non-HDL cholesterol lowering relative to baseline and relative to placebo. Compared to placebo, LDL cholesterol was lowered by 9.4% (p < 0.01) and 8.1% (p < 0.01) with 1.6 g and 2 g plant stanols, respectively. With addition of Camelina oil, 1.6 g plant stanols resulted in 11.0% (p < 0.01) and 2 g plant stanols in 8.4% (p < 0.01) reduction in LDL cholesterol compared to placebo. In conclusion, yoghurt minidrinks with plant stanol ester reduced serum LDL cholesterol significantly and addition of a small amount of camelina oil did not significantly enhance the cholesterol lowering effect. This trial was registered with ClinicalTrials.gov NCT02628990.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86426394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats. 苦参种子对糖尿病大鼠的降糖、降血脂作用的评价。

Cholesterol Pub Date : 2016-01-01 Epub Date: 2016-04-14 DOI: 10.1155/2016/7389864

Gholamreza Komeili, Mohammad Hashemi, Mohsen Bameri-Niafar

{"title":"Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats.","authors":"Gholamreza Komeili, Mohammad Hashemi, Mohsen Bameri-Niafar","doi":"10.1155/2016/7389864","DOIUrl":"https://doi.org/10.1155/2016/7389864","url":null,"abstract":"The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200-230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and 120 mg/kg) of hydroalcoholic extract of Peganum harmala seeds for 4 weeks orally. At the end of treatment, blood samples were taken and glucose, triglycerides, total cholesterol, LDL-c, HDL-c, malondialdehyde (MDA), total antioxidant capacity (TCA), ALT, AST, GGT, bilirubin, and glycosylated hemoglobin (HbA1C) were determined. STZ-induced diabetic rats showed significant changes in the values of glucose, triglycerides, total cholesterol, LDL-c, MDA, TAC, ALT, AST, GGT, bilirubin, and HbA1C in comparison with normal rats. Administration of the extract to diabetic rats resulted in a remarkable decrease in glucose, lipid profiles, MDA, ALT, AST, GGT, bilirubin, and HbA1C levels and increase in TAC relative to diabetic group. The results of this study indicated that hydroalcoholic extract of Peganum harmala seeds possesses antidiabetic and hypolipidemic activities and could be useful in treatment of diabetes. ","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2016 ","pages":"7389864"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7389864","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34390133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Trends of Prevalence of Uncontrolled Risk Factors for Cerebrocardiovascular Disease: Southern Italy from 1988/9 to 2008/9. 1988/9至2008/9年意大利南部脑血管疾病未控制危险因素流行趋势

Cholesterol Pub Date : 2016-01-01 Epub Date: 2016-04-24 DOI: 10.1155/2016/6087981

Vincenzo Capuano, Norman Lamaida, Ernesto Capuano, Rocco Capuano, Eduardo Capuano, Gianfranco Mazzotta

{"title":"Trends of Prevalence of Uncontrolled Risk Factors for Cerebrocardiovascular Disease: Southern Italy from 1988/9 to 2008/9.","authors":"Vincenzo Capuano, Norman Lamaida, Ernesto Capuano, Rocco Capuano, Eduardo Capuano, Gianfranco Mazzotta","doi":"10.1155/2016/6087981","DOIUrl":"https://doi.org/10.1155/2016/6087981","url":null,"abstract":"The aim of this study was to determine the trends of cardiovascular risk factor prevalence between 1988/9 and 2008/9 in the 25-74-year-old population in an area of Southern Italy. We compared three cross-sectional studies conducted in random population samples, in 1988/9, 1998/9, and 2008/9 in Salerno, Italy. The methodology of data collection (lipid profile, systolic and diastolic blood pressure, glycaemia, and smoking) and conducting tests which the population underwent during the three phases was standardized and comparable. Prevalence of diabetes, hypertension, hypercholesterolemia, and smoking was calculated and standardized for age. A total of 3491 subjects were included. From 1988/9 to 2008/9, in males, the prevalence of all four risk factors was reduced. In women, there was a clear reduction of hypertension, a similar prevalence of hypercholesterolemia, and an increase of smoking and diabetes. In the area of Salerno, our data confirm that the global prevalence of the major risk factors is decreasing in men, but their absolute values are still far from optimization. In women, diabetes and smoking showed a negative trend, therefore requiring targeted interventions. These data are now used as a base for executive targeted programs to improve prevention of cardiovascular disease in our community. ","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2016 ","pages":"6087981"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6087981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34574059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Lowering Effects of Hydroalcoholic Extract of Anethum graveolens L. and Dill Tablet in High Cholesterol Fed Hamsters 茴香水醇提取物和莳萝片对高胆固醇饲养仓鼠的降脂作用

Cholesterol Pub Date : 2015-12-28 DOI: 10.1155/2015/958560

Ebrahim Abbasi Oshaghi, I. Khodadadi, M. Saidijam, Reza Yadegarazari, N. Shabab, H. Tavilani, M. Goodarzi

{"title":"Lipid Lowering Effects of Hydroalcoholic Extract of Anethum graveolens L. and Dill Tablet in High Cholesterol Fed Hamsters","authors":"Ebrahim Abbasi Oshaghi, I. Khodadadi, M. Saidijam, Reza Yadegarazari, N. Shabab, H. Tavilani, M. Goodarzi","doi":"10.1155/2015/958560","DOIUrl":"https://doi.org/10.1155/2015/958560","url":null,"abstract":"Objective. This study was aimed to determine the effect of Anethum graveolens extract and Anethum graveolens (dill) tablet on lipid profile, liver enzymes, and gene expression and enzymatic activity of HMG-CoA reductase in high cholesterol fed hamsters. Materials and Methods. Golden Syrian male hamsters (130 ± 10 g) were randomly divided into 6 groups (n = 6) and received daily the following: group 1 received chow + 2% cholesterol + 0.5% cholic acid (HCD), groups 2 and 3 received HCD diet plus 100 and 200 mg/kg hydroalcoholic extract of dill, respectively, and groups 4 and 5 received HCD diet plus 100 and 200 mg/kg dill tablet, respectively. Group 6 received only chow. After 1 month feeding serum biochemical factors were determined. HMG-CoA reductase mRNA level was measured (real-time PCR) and its activity was determined spectrophotometrically. Results. Compared with hypercholesterolemic group 1, lipid profile, blood glucose, and liver enzymes significantly decreased in all dill tablet or dill extract treated groups (p < 0.05). The changes in HMG-CoA reductase gene expression level and enzyme activity significantly reduced in animals that received 200 mg/kg of extract or tablet. Conclusion. Dill extract and dill tablet showed potential hypocholesterolemic properties in hamsters by inhibition of HMG-CoA reductase activity.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82637258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Cholesterol Transporters ABCA1 and ABCG1 Gene Expression in Peripheral Blood Mononuclear Cells in Patients with Metabolic Syndrome 代谢综合征患者外周血单个核细胞中胆固醇转运体ABCA1和ABCG1基因的表达

Cholesterol Pub Date : 2015-12-15 DOI: 10.1155/2015/682904

Zahra Tavoosi, Hemen Moradi-sardareh, M. Saidijam, Reza Yadegarazari, S. Borzuei, A. Soltanian, M. Goodarzi

{"title":"Cholesterol Transporters ABCA1 and ABCG1 Gene Expression in Peripheral Blood Mononuclear Cells in Patients with Metabolic Syndrome","authors":"Zahra Tavoosi, Hemen Moradi-sardareh, M. Saidijam, Reza Yadegarazari, S. Borzuei, A. Soltanian, M. Goodarzi","doi":"10.1155/2015/682904","DOIUrl":"https://doi.org/10.1155/2015/682904","url":null,"abstract":"ABCA1 and ABCG1 genes encode the cholesterol transporter proteins that play a key role in cholesterol and phospholipids homeostasis. This study was aimed at evaluating and comparing ABCA1 and ABCG1 genes expression in metabolic syndrome patients and healthy individuals. This case-control study was performed on 36 patients with metabolic syndrome and the same number of healthy individuals in Hamadan (west of Iran) during 2013-2014. Total RNA was extracted from mononuclear cells and purified using RNeasy Mini Kit column. The expression of ABCA1 and ABCG1 genes was performed by qRT-PCR. Lipid profile and fasting blood glucose were measured using colorimetric procedures. ABCG1 expression in metabolic syndrome patients was significantly lower (about 75%) compared to that of control group, while for ABCA1 expression, there was no significant difference between the two studied groups. Comparison of other parameters such as HDL-C, FBS, BMI, waist circumference, and systolic and diastolic blood pressure between metabolic syndrome patients and healthy individuals showed significant differences (P < 0.05). Decrease in ABCG1 expression in metabolic syndrome patients compared to healthy individuals suggests that hyperglycemia, related metabolites, and hyperlipidemia over the transporter capacity resulted in decreased expression of ABCG1. Absence of a significant change in ABCA1 gene expression between two groups can indicate a different regulation mechanism for ABCA1 expression.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"239 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89159888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics 功能失调高密度脂蛋白:蛋白质组学和脂质组学的创新靶点

Cholesterol Pub Date : 2015-11-08 DOI: 10.1155/2015/296417

J. Salazar, L. Olivar, E. Ramos, Mervin Chávez-Castillo, Joselyn Rojas, Valmore Bermúdez

{"title":"Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics","authors":"J. Salazar, L. Olivar, E. Ramos, Mervin Chávez-Castillo, Joselyn Rojas, Valmore Bermúdez","doi":"10.1155/2015/296417","DOIUrl":"https://doi.org/10.1155/2015/296417","url":null,"abstract":"High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflammatory properties. Nevertheless, observations of hereditary syndromes featuring scant HDL-C concentration in absence of premature atherosclerotic disease suggest HDL-C levels may not be the best predictor of cardiovascular disease. Indeed, the beneficial effects of HDL may not depend solely on their concentration, but also on their quality. Distinct subfractions of this lipoprotein appear to be constituted by specific protein-lipid conglomerates necessary for different physiologic and pathophysiologic functions. However, in a chronic inflammatory microenvironment, diverse components of the HDL proteome and lipid core suffer alterations, which propel a shift towards a dysfunctional state, where HDL-C becomes proatherogenic, prooxidant, and proinflammatory. This heterogeneity highlights the need for further specialized molecular studies in this aspect, in order to achieve a better understanding of this dysfunctional state; with an emphasis on the potential role for proteomics and lipidomics as valuable methods in the search of novel therapeutic approaches for cardiovascular disease.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84864520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

The Effect of Elevated Triglycerides on the Onset and Progression of Coronary Artery Disease: A Retrospective Chart Review 甘油三酯升高对冠状动脉疾病发生和发展的影响:回顾性图表回顾

Cholesterol Pub Date : 2015-11-04 DOI: 10.1155/2015/292935

D. Daniel, P. Hardigan, Asif Jawaid, Rohit K Bhandari, M. Daniel

{"title":"The Effect of Elevated Triglycerides on the Onset and Progression of Coronary Artery Disease: A Retrospective Chart Review","authors":"D. Daniel, P. Hardigan, Asif Jawaid, Rohit K Bhandari, M. Daniel","doi":"10.1155/2015/292935","DOIUrl":"https://doi.org/10.1155/2015/292935","url":null,"abstract":"Background. The American College of Cardiology and American Heart Association did not indicate a correlation between treating hypertriglyceridemia and reducing cardiovascular events. Objective. This study investigated whether patients with hypertriglyceridemia were more prone to worse outcomes during cardiac catheterization. Methods. Data collected over a one-year period analyzed lipid panels obtained at the time of cardiac catheterization. Triglyceride levels were categorized into three groups: <150 mg/dL, 150 mg/dL–300 mg/dL, and >300 mg/dL. Controlled variables included age, gender, the presence of hypertension, diabetes, hyperlipidemia, and history of coronary artery disease. Results. Subjects with a triglyceride level <150 mg/dL have a 54% likelihood of being treated medically compared to 38% and 41% in the 150 mg/dL–300 mg/dL and >300 mg/dL groups, respectively (p < 0.01). Subjects with a triglyceride level >300 mg/dL have a 20% percent chance of being treated with a coronary artery bypass graft compared to 12% and 15% in the <150 mg/dL and 150 mg/dL–300 mg/dL groups, respectively (p < 0.01). Subjects with a triglyceride level between 150 and 300 mg/dL have a 44% percent of being treated with a percutaneous coronary intervention compared to 34% and 43% in the <150 mg/dL and >300 mg/dL groups, respectively (p < 0.01). Conclusion. Hypertriglyceridemia was associated with worse outcomes in percutaneous coronary intervention or surgery.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74118147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Serum cholesterol reduction efficacy of biscuits with added plant stanol ester. 添加植物甾醇酯的饼干降低血清胆固醇的效果。

Cholesterol Pub Date : 2015-01-01 Epub Date: 2015-03-10 DOI: 10.1155/2015/353164

Wantanee Kriengsinyos, Ajima Wangtong, Surat Komindr

{"title":"Serum cholesterol reduction efficacy of biscuits with added plant stanol ester.","authors":"Wantanee Kriengsinyos, Ajima Wangtong, Surat Komindr","doi":"10.1155/2015/353164","DOIUrl":"https://doi.org/10.1155/2015/353164","url":null,"abstract":"This study's aim was to test the low-density lipoprotein cholesterol- (LDL-c-) lowering efficacy of biscuits containing 2 g of plant stanols, which corresponded to 3.4 g of plant stanol esters. The biscuit is a new food format that can be consumed as a snack. In a double-blind, placebo-controlled parallel design study, 119 mildly to moderately hypercholesterolemic volunteers were randomized to plant stanol or control groups. Subjects were comparable in age, gender, lipid profiles, and body mass index. They consumed a control biscuit once a day for a two-week period, followed by a four-week intervention period that either had a plant stanol ester biscuit or a control. During the habitual diet, one biscuit per day was consumed at any time that subjects wished. Serum lipid profiles were measured at the first day of run-in, at baseline, and at the study's end. Compared to the control, the total cholesterol (TC), LDL-c, and the LDL-to-high-density lipoprotein (LDL/HDL) ratio had serum reductions of 4.9%, 6.1%, and 4.3%, respectively, and were observed after 4 weeks of biscuit consumption with added plant stanols (P < 0.05). A significantly higher reduction in LDL-c (8.9%) and LDL/HDL ratio (11.4%) was measured in those taking a plant stanol biscuit with a meal compared to those who consumed a plant stanol biscuit without other food. In conclusion, incorporating plant stanols into a biscuit is an attractive, convenient, and acceptable way to modestly lower elevated cholesterol concentrations. For optimal efficacy, biscuits should be consumed with a meal as part of a healthy diet. ","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2015 ","pages":"353164"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/353164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33206384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15