Chinese medical journal pulmonary and critical care medicine最新文献

{"title":"Small cell lung cancer transformations from non-small cell lung cancer: Biological mechanism and clinical relevance","authors":"Yang Yang, Songqing Fan","doi":"10.1016/j.pccm.2023.10.005","DOIUrl":"https://doi.org/10.1016/j.pccm.2023.10.005","url":null,"abstract":"","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139885888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelial stem cells and niches in lung alveolar regeneration and diseases","authors":"Jilei Zhang, Yuru Liu","doi":"10.1016/j.pccm.2023.10.007","DOIUrl":"https://doi.org/10.1016/j.pccm.2023.10.007","url":null,"abstract":"","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"184 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139831480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A crucial role of neutrophil extracellular traps in pulmonary infectious diseases","authors":"Ting Pan, Jae Woo Lee","doi":"10.1016/j.pccm.2023.10.004","DOIUrl":"https://doi.org/10.1016/j.pccm.2023.10.004","url":null,"abstract":"","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"387 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139824253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in metabolomics of chronic obstructive pulmonary disease","authors":"Wenqian Wu ,&nbsp;Zhiwei Li ,&nbsp;Yongqiang Wang ,&nbsp;Chuan Huang ,&nbsp;Tiantian Zhang ,&nbsp;Hongmei Zhao","doi":"10.1016/j.pccm.2023.10.001","DOIUrl":"10.1016/j.pccm.2023.10.001","url":null,"abstract":"<div><p>Chronic obstructive pulmonary disease (COPD) is a chronic lung disease with limited airflow. COPD is characterized by chronic bronchitis and emphysema, and is often accompanied by malnutrition with fatigue, muscle weakness, and an increased risk of infection. Although the pulmonary function test is used as the gold criterion for diagnosing COPD, it is unable to identify early COPD or classify the subtypes, thereby impeding early intervention and the precise diagnosis of COPD. Recent evidence suggests that metabolic dysfunction, such as changes in lipids, amino acids, glucose, nucleotides, and microbial metabolites in the lungs and intestine, have a great potential for diagnosing COPD in the early stage. However, a comprehensive summary of these metabolites and their effects on COPD is still lacking. This review summarizes the metabolites that are changed in COPD and highlights some promising early diagnostic markers and therapeutic targets. We emphasize that intensified dietary management may be among the most feasible methods to improve metabolism in the body.</p></div>","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"1 4","pages":"Pages 223-230"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772558823000579/pdfft?md5=fc85a7ce2f8ddd4153b300cf3555847b&pid=1-s2.0-S2772558823000579-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138619931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis, pathological characteristics and individualized therapy for immune-related adverse effects","authors":"Kang Miao,&nbsp;Li Zhang","doi":"10.1016/j.pccm.2023.08.002","DOIUrl":"10.1016/j.pccm.2023.08.002","url":null,"abstract":"<div><p>Immune checkpoint inhibitors (ICIs) are a class of antitumor medications that target immune checkpoints, which induce the activation of lymphocytes. These treatments effectively prolong the survival of patients with advanced tumors, especially lung cancer. However, in addition to tumor killing effects, ICIs may also cause an imbalance between immune tolerance and immunity. Over-activated lymphocytes may cause various types of damage to multiple organs throughout the body, called immune-related adverse events. In this review, we summarize the pathogenesis, pathological characteristics, biomarkers, and therapeutic agents for immune-related adverse events.</p></div>","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"1 4","pages":"Pages 215-222"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772558823000439/pdfft?md5=b645e4fe53553904fc760c57a79d5dc4&pid=1-s2.0-S2772558823000439-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135255523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating tumor DNA (ctDNA)-based minimal residual disease in non-small cell lung cancer","authors":"Libo Tang ,&nbsp;Ruiyang Li ,&nbsp;Huahai Wen ,&nbsp;Qing Zhou ,&nbsp;Chongrui Xu","doi":"10.1016/j.pccm.2023.04.001","DOIUrl":"10.1016/j.pccm.2023.04.001","url":null,"abstract":"<div><p>Lung cancer is the second most common cancer worldwide and the leading cause of cancer-related fatalities, with non-small cell lung cancer (NSCLC) accounting for 85% of all lung cancers. Over the past forty years, patients with NSCLC have had a 5-year survival rate of only 16%, despite improvements in chemotherapy, targeted therapy, and immunotherapy. Circulating tumor DNA (ctDNA) in blood can be used to identify minimal residual disease (MRD), and ctDNA-based MRD has been shown to be of significance in prognostic assessment, recurrence monitoring, risk of recurrence assessment, efficacy monitoring, and therapeutic intervention decisions in NSCLC. The level of MRD can be obtained by monitoring ctDNA to provide guidance for more precise and personalized treatment, the scientific feasibility of which could dramatically modify lung cancer treatment paradigm. In this review, we present a comprehensive review of MRD studies in NSCLC and focus on the application of ctDNA-based MRD in different stages of NSCLC in current clinical practice.</p></div>","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"1 4","pages":"Pages 207-214"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772558823000129/pdfft?md5=dbdab7a7fdf255576247f6d117000da1&pid=1-s2.0-S2772558823000129-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82602979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of long COVID: An updated review","authors":"Yan Liu ,&nbsp;Xiaoying Gu ,&nbsp;Haibo Li ,&nbsp;Hui Zhang ,&nbsp;Jiuyang Xu","doi":"10.1016/j.pccm.2023.10.003","DOIUrl":"10.1016/j.pccm.2023.10.003","url":null,"abstract":"<div><p>The coronavirus disease 2019 (COVID-19) pandemic has been ongoing for more than 3 years, with an enormous impact on global health and economies. In some patients, symptoms and signs may remain after recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which cannot be explained by an alternate diagnosis; this condition has been defined as long COVID. Long COVID may exist in patients with both mild and severe disease and is prevalent after infection with different SARS-CoV-2 variants. The most common symptoms include fatigue, dyspnea, and other symptoms involving multiple organs. Vaccination results in lower rates of long COVID. To date, the mechanisms of long COVID remain unclear. In this narrative review, we summarized the clinical presentations and current evidence regarding the pathogenesis of long COVID.</p></div>","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"1 4","pages":"Pages 231-240"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772558823000580/pdfft?md5=ded9c3419df768b990e1a9091532f16d&pid=1-s2.0-S2772558823000580-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138612413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of extended viral shedding of Omicron BA.2 in Shanghai: Implications for vaccination strategy optimization","authors":"Jingwen Huang ,&nbsp;Lin Huang ,&nbsp;Jing Xi ,&nbsp;Yong Li ,&nbsp;Jianping Zhou ,&nbsp;Zhiyao Bao ,&nbsp;Qijian Cheng ,&nbsp;Qingyun Li ,&nbsp;Min Zhou ,&nbsp;Ren Zhao ,&nbsp;Yanan Li","doi":"10.1016/j.pccm.2023.11.001","DOIUrl":"10.1016/j.pccm.2023.11.001","url":null,"abstract":"<div><h3>Background</h3><p>In late March 2022, an outbreak of coronavirus disease 2019 (COVID-19) caused by the Omicron BA.2 strain occurred in Shanghai, China. This retrospective study aimed to investigate the clinical characteristics, laboratory parameters, and vaccine protectiveness related to this disease in China.</p></div><div><h3>Methods</h3><p>We conducted a single-center retrospective study on 735 patients with COVID-19 hospitalized from March 17 to May 14, 2022. Clinical characteristics were analyzed based on vaccination status and viral shedding time (VST). The least absolute shrinkage and selection operator (LASSO) regression and 5-fold cross-validation were applied to screen factors linked to the rate of the VST. Generalized linear models were further applied to estimate the odds ratios for factors influencing the VST.</p></div><div><h3>Results</h3><p>The median VST of unvaccinated patients was 13 (11–16) days, which was longer than that of patients vaccinated with one or two doses (11 [9–13] days) and with completed booster doses (11 [8–12] days). A LASSO regression model and 5-fold cross-validation showed that age of ≥60 years (β = 0.01), pneumonia (β = 0.53), and higher number of comorbidities (β = 0.69) were positively associated with the VST, whereas the platelet count (β = −8.0×10⁻⁵) was inversely associated with the VST. Subgroup analysis revealed that the number of vaccinations was significantly associated with a decreased VST among patients with renal dysfunction (odds ratio [OR], 0.65; 95% confidence interval [CI], 0.44–0.97; <em>P</em> = 0.034) and patients with two or more comorbidities (OR, 0.09; 95% CI, 0.03–0.28; <em>P</em> &lt; 0.001). The lymphocyte count was significantly associated with a decreased VST among patients aged &lt;60 years (OR, 0.51; 95% CI, 0.30–0.85; <em>P</em> = 0.011), patients with normal renal function (OR, 0.41; 95% CI, 0.21–0.80; <em>P</em> = 0.009), and patients with fewer than two comorbidities (OR, 0.49; 95% CI, 0.30–0.80; <em>P</em> = 0.005).</p></div><div><h3>Conclusion</h3><p>Our preliminary results suggest that the complete and booster vaccination contributes to the viral clearance of Omicron BA.2 variants, while the protectiveness of vaccination is most imperative in patients with impaired renal function and more comorbidities.</p></div>","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"1 4","pages":"Pages 241-248"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772558823000634/pdfft?md5=7ad8827068b905e2dc31e09e0709fc7c&pid=1-s2.0-S2772558823000634-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoor air pollution: An important risk factor for lung cancer among Asian women without a history of smoking","authors":"Xiangling Chu ,&nbsp;Qi Wang ,&nbsp;Chunxia Su","doi":"10.1016/j.pccm.2023.10.002","DOIUrl":"10.1016/j.pccm.2023.10.002","url":null,"abstract":"","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"1 4","pages":"Pages 198-199"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772558823000567/pdfft?md5=0b5d2dd8c5ab60a5588e9ffc0d4513f2&pid=1-s2.0-S2772558823000567-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138615548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asian, regional, and national burdens of respiratory tract cancers and associated risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019","authors":"Ran Zhong ,&nbsp;Xiuyu Cai ,&nbsp;Jianfu Li ,&nbsp;Peiling Chen ,&nbsp;Runchen Wang ,&nbsp;Xinting Li ,&nbsp;Feng Li ,&nbsp;Shan Xiong ,&nbsp;Caichen Li ,&nbsp;Huiting Wang ,&nbsp;Yang Xiang ,&nbsp;Shuting Zhan ,&nbsp;Ziwen Yu ,&nbsp;Haixuan Wang ,&nbsp;Chunyan Li ,&nbsp;Lixuan Lin ,&nbsp;Wenhai Fu ,&nbsp;Xin Zheng ,&nbsp;Shen Zhao ,&nbsp;Kang Zhang ,&nbsp;Jianxing He","doi":"10.1016/j.pccm.2023.11.002","DOIUrl":"10.1016/j.pccm.2023.11.002","url":null,"abstract":"<div><h3>Background</h3><p>Respiratory cancer is the leading cause of cancer-related deaths worldwide, but its statistics vary between the East and West. This study aimed to estimate the burdens of tracheal, bronchus, and lung (TBL) cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia, and at regional and national levels.</p></div><div><h3>Methods</h3><p>This research evaluated the incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) for respiratory tract cancers using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 database. Age-standardized rates were calculated for TBL cancer from 1990 to 2019, adjusted for smoking and socio-demographic index (SDI). Deaths from TBL cancer and larynx cancer attributable to each risk factor were estimated for 33 Asian countries.</p></div><div><h3>Results</h3><p>The age-standardized incidence and death rates for TBL cancer in Asia declined from 2010 to 2019, while the incidence rate of larynx cancer increased. Smoking was the leading specific risk factor for deaths from both TBL and larynx cancers. The burden of TBL cancer in Asian countries was influenced by SDI and smoking, particularly among males in Central Asia. Deaths, DALYs, and incidences of larynx cancer in East Asia had not changed significantly over the past 30 years, but showed slight downward trends in males and both sexes combined, and an upward trend in females in recent years.</p></div><div><h3>Conclusions</h3><p>The past decade saw increases in numbers of incident cases and deaths from TBL cancer and larynx cancer in Asia. SDI and smoking were the main factors influencing the disease burden of TBL cancer in Asian countries. This study highlights the need for tailored cancer control programs to address the burden of respiratory tract cancers in different Asian countries.</p></div>","PeriodicalId":72583,"journal":{"name":"Chinese medical journal pulmonary and critical care medicine","volume":"1 4","pages":"Pages 249-258"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772558823000609/pdfft?md5=56b65051a793fd98b73424797e07df85&pid=1-s2.0-S2772558823000609-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}