Cardiovascular endocrinology最新文献_第9页

Hitode heart: a report of two cases of midventricular takotsubo cardiomyopathy Hitode心脏:中心室takotsubo型心肌病2例报告

Cardiovascular endocrinology Pub Date : 2014-12-01 DOI: 10.1097/XCE.0000000000000035

Leigh Clanton, Daniel B. Cobb, Misha Huang, M. Krantz

引用次数: 1

Conference report: European Association for the Study of Diabetes 会议报告:欧洲糖尿病研究协会

Cardiovascular endocrinology Pub Date : 2014-11-01 DOI: 10.1097/XCE.0000000000000041

A. Krentz

引用次数: 0

Hemoglobin A1c less than 6.5% on admission increases risk for in-hospital and 1-year mortality in patients with diabetes and chest pain 入院时糖化血红蛋白低于6.5%会增加糖尿病和胸痛患者住院和1年内死亡的风险

Cardiovascular endocrinology Pub Date : 2014-09-01 DOI: 10.1097/XCE.0000000000000033

S. Hailpern, Fabienne Santel, J. Mazurek, Sheila Ramirez, Joshua Remick, Joshua Klein, U. Schubart, Charles W. Nordin

{"title":"Hemoglobin A1c less than 6.5% on admission increases risk for in-hospital and 1-year mortality in patients with diabetes and chest pain","authors":"S. Hailpern, Fabienne Santel, J. Mazurek, Sheila Ramirez, Joshua Remick, Joshua Klein, U. Schubart, Charles W. Nordin","doi":"10.1097/XCE.0000000000000033","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000033","url":null,"abstract":"BackgroundAs the association between low hemoglobin A1c (HbA1c) and adverse clinical outcomes in patients with chest pain and myocardial infarction has not been extensively examined, a prospective cohort study was conducted to examine whether low HbA1c magnifies mortality risk. Patients and methodsA total of 717 consecutive patients (284 with diabetes and 433 without known diabetes) admitted to a public hospital over a 6-month period with chest pain and troponin measurement were included. HbA1c was obtained upon admission. Mortality was confirmed by National Death Index search. Cox proportional hazards models were constructed for the sample stratified by diabetes status. ResultsThe unadjusted incidence of mortality during hospitalization in patients with diabetes and HbA1c less than 6.5% (n=55) was 3.84 compared with those with HbA1c of 6.5% or more (n=229). In Cox proportional hazard models, patients with diabetes and HbA1c less than 6.5% had higher risk for in-hospital (hazard ratio 3.51, 95% confidence interval 1.25–9.83, P=0.02) and 1-year mortality (hazard ratio 3.50, 95% confidence interval 1.84–6.64, P<0.001) compared with those with HbA1c of 6.5% or more. No increase in risk was seen for those without diabetes and HbA1c less than 6.5%. Hypoglycemia (serum glucose<3.89 mmol/l) was more frequent in patients with diabetes and HbA1c less than 6.5% (44%) than those with HbA1c of 6.5% or more (22%) (P=0.001). Patients with hypoglycemia and diabetes had significantly higher rate of in-hospital mortality than those without [13.33% (10/75) vs. 2.87% (6/209), P<0.001]. ConclusionPatients with diabetes admitted for chest pain with HbA1c less than 6.5% may be at increased risk for in-hospital and 1-year mortality. The mechanism for death may be mediated in part by hypoglycemia.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"59 1","pages":"85–91"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89484402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acute cardiometabolic responses facilitating a state of chronic hyperglycemia and renal impairment: the SABPA study 急性心脏代谢反应促进慢性高血糖和肾功能损害:SABPA研究

Cardiovascular endocrinology Pub Date : 2014-09-01 DOI: 10.1097/XCE.0000000000000019

L. Joosten, L. Malan, A. S. Uys, A. Alkerwi, N. Malan

{"title":"Acute cardiometabolic responses facilitating a state of chronic hyperglycemia and renal impairment: the SABPA study","authors":"L. Joosten, L. Malan, A. S. Uys, A. Alkerwi, N. Malan","doi":"10.1097/XCE.0000000000000019","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000019","url":null,"abstract":"BackgroundAugmented &agr;-adrenergic response patterns are associated with vascular risk in Africans. Therefore, the aims of this study were (a) to assess ethnic differences related to glucose and cardiovascular responses during acute laboratory stress, and (b) to assess whether these responses are associated with chronic hyperglycemia (HbA1c≥5.7%) and albumin : creatinine ratio (ACR). Materials and methodsAmbulatory blood pressure of 81 African and 100 Caucasian men was recorded. Beat-to-beat blood pressure was obtained during exposure to the Color Word Conflict (STROOP) and Cold Pressor Tests (CPT). Overnight 8 h fasting urine, basal and post-stress blood samples were collected for biochemical analyses. ResultsAugmented glucose responses (P<0.001) were shown by the African men in response to the STROOP and CPT, in contrast to their Caucasian counterparts, who showed attenuated responses. In hyperglycemic African men, an enhanced &agr;-adrenergic profile was revealed, with decreased stroke volume (P=0.07) and cardiac output responses (P=0.05). Augmented systolic blood pressure changes during the CPT predicted elevated ACR in African men [adjusted R2 0.31: &bgr;, 0.54 (0.23, 0.85), P=0.002]. In hyperglycemic Caucasian men, however, metabolic changes, that is augmented glucose changes to the STROOP test, predicted elevated ACR [adjusted R2 0.19: &bgr;, 0.33 (0.02, 0.64), P=0.04]. ConclusionAn &agr;-adrenergic-driven cardiovascular response profile acted in tandem with augmented glucose responses in African men when exposed to acute laboratory stress. Pressure overload in Africans in contrast to metabolic responses in Caucasians may suggest different underlying mechanisms for ACR, a marker of renal impairment, when in a state of chronic hyperglycemia.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"32 1","pages":"98–106"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78872173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effect of atrial natriuretic peptide on lipolysis in the mouse heart 心房利钠肽对小鼠心脏脂肪分解的影响

Cardiovascular endocrinology Pub Date : 2014-09-01 DOI: 10.1097/XCE.0000000000000029

E. Bartels, L. Bisgaard, C. Christoffersen, L. Nielsen

{"title":"Effect of atrial natriuretic peptide on lipolysis in the mouse heart","authors":"E. Bartels, L. Bisgaard, C. Christoffersen, L. Nielsen","doi":"10.1097/XCE.0000000000000029","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000029","url":null,"abstract":"Overweight is associated with triglyceride accumulation in cardiomyocytes, which can cause cardiac dysfunction. It is also associated with reduced synthesis and plasma concentration of atrial natriuretic peptide (ANP). In adipocytes, ANP stimulates lipolysis through natriuretic peptide receptor-A (NPR-A), leading to cGMP-dependent phosphorylation of hormone-sensitive lipase. Cardiac myocytes express NPR-A and hormone-sensitive lipase. In the present study, we investigated whether ANP affects triglyceride stores in the heart. Subcutaneously implanted osmotic minipumps were used to administer ANP (125 or 500 ng/kg/min) or saline to obese leptin-deficient (ob/ob) mice or lean control mice (ob/+) for a week. ANP (500 ng/kg/min) reduced blood pressure but did not affect the cardiac triglyceride stores or mRNA expression of NPR-A and NPR-C. Also, deficiency of NPR-A did not affect the cardiac triglyceride content. Finally, addition of ANP to the culture medium (10−7 mol/l) increased cellular cGMP content (P=0.009) but did not affect triglyceride stores in HL-1 cardiac myocyte cultures. Hence, ANP does not affect triglyceride stores in the murine heart.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"24 1","pages":"92–97"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85922387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clarithromycin-induced QT prolongation in a patient with incidental parathyroidectomy 克拉霉素致偶发甲状旁腺切除术患者QT间期延长

Cardiovascular endocrinology Pub Date : 2014-09-01 DOI: 10.1097/XCE.0000000000000016

Faruk Kutluturk, S. Yuce, O. Ozeke

引用次数: 0

Glucose in the coronary care unit: some evidence, more questions 冠状动脉监护病房的葡萄糖:一些证据，更多的问题

Cardiovascular endocrinology Pub Date : 2014-09-01 DOI: 10.1097/XCE.0000000000000034

D. Carty, J. Petrie

引用次数: 0

Blunted neuroendocrine responses linking depressive symptoms and ECG-left ventricular hypertrophy in black Africans: the SABPA study 非洲黑人抑郁症状与ecg -左心室肥厚相关的神经内分泌反应迟钝:SABPA研究

Cardiovascular endocrinology Pub Date : 2014-06-01 DOI: 10.1097/XCE.0000000000000014

N. Mashele, L. Malan, J. V. van Rooyen, B. Harvey, J. Potgieter, M. Hamer

{"title":"Blunted neuroendocrine responses linking depressive symptoms and ECG-left ventricular hypertrophy in black Africans: the SABPA study","authors":"N. Mashele, L. Malan, J. V. van Rooyen, B. Harvey, J. Potgieter, M. Hamer","doi":"10.1097/XCE.0000000000000014","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000014","url":null,"abstract":"ObjectiveChronic psychosocial stress as experienced in an urban environment plays an important role in the aetiology of depression-related cardiovascular risk. It is uncertain whether acute mental stress responses aggravate this risk. Therefore, we aimed to explore the associations between depressive symptoms, neuroendocrine acute mental stress responses and cardiovascular risk, that is ECG-left ventricular hypertrophy (ECG-LVH), in a black South African cohort. Materials and methodsThe substudy sample consisted of 179 black African men and women from the Sympathetic Activity and Ambulatory Blood Pressure in Africans study. Depressive symptoms were evaluated using the nine-item Patient Health Questionnaire and the participants were stratified into black Africans with depressive symptoms and without. Cortisol and 3-methoxy-phenylglycol (MHPG) responses were analysed during rest and exposure to the Stroop mental stressor. Cortisol median split responses were determined and stratified sex groups accordingly into above (>1.5 ng/ml) and below (⩽1.5 ng/ml) responders. Blood pressure and ECG-LVH data were obtained from 24-h ambulatory monitoring and 12-lead ECG. ResultsThe Africans with depressive symptoms demonstrated mean hypertensive status, blunted cortisol and MHPG acute mental stress responses (P⩽0.05). In Africans with depressive symptoms and low cortisol stress responses, blunted MHPG acute mental stress responses were associated with ECG-LVH in Africans [adjusted R2=0.20; &bgr;=0.92 (95% confidence interval 0.74, 1.10); P⩽0.02]. ConclusionBlunted neuroendocrine responses were linked to depressive symptoms and ECG-LVH in black Africans. When coupled to their hypertensive status, these vasoconstrictive agent responses may underpin the increased long-term depression and vascular disease risk in urban Africans.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"80 1","pages":"59–65"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/XCE.0000000000000014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72449483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The effect of vitamin D supplementation on plasma leptin/adiponectin ratio in diabetic individuals with different haptoglobin phenotypes 补充维生素D对不同触珠蛋白表型糖尿病患者血浆瘦素/脂联素比值的影响

Cardiovascular endocrinology Pub Date : 2014-06-01 DOI: 10.1097/XCE.0000000000000018

A. Breslavsky, H. Oz, Z. Matas, M. Shargorodsky

引用次数: 4

Acute enzymatic glycocalyx degradation results in reduced insulin sensitivity but normal glucose tolerance in conscious rats 急性酶解糖萼降解导致清醒大鼠胰岛素敏感性降低，但葡萄糖耐量正常

Cardiovascular endocrinology Pub Date : 2014-06-01 DOI: 10.1097/XCE.0000000000000017

Bart J. M. Eskens, Hanneke Cobelens, H. Vink, J. VanTeeffelen

{"title":"Acute enzymatic glycocalyx degradation results in reduced insulin sensitivity but normal glucose tolerance in conscious rats","authors":"Bart J. M. Eskens, Hanneke Cobelens, H. Vink, J. VanTeeffelen","doi":"10.1097/XCE.0000000000000017","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000017","url":null,"abstract":"Perturbation of the endothelial glycocalyx has been suggested to be an early event in the development of endothelial dysfunction during increased cardiovascular risk exposure. Previously, we showed in anesthetized rats that acute enzymatic degradation of the endothelial glycocalyx was associated with impaired insulin-mediated glucose disposal, suggesting a role of the glycocalyx in regulation of glucose homeostasis. In the current study, we tested the acute effect of enzymatic glycocalyx treatment on glucose tolerance and insulin sensitivity in conscious rats. In rats that had had their femoral artery and vein cannulated 1 week before the experiment, intravenous glucose and insulin tolerance tests were performed before and after acute degradation of the endothelial glycocalyx using an intravenous bolus of hyaluronidase. During the intravenous glucose tolerance test, glucose tolerance did not differ between the hyaluronidase-treated and control animals, but was associated with a 1.5-fold higher plasma insulin level in the former group. Further, glycocalyx treatment significantly decreased insulin-mediated glucose disposal during intravenous insulin tolerance tests, as observed from the reduced insulin-mediated glucose disposal rate from 3.3±0.1%/min in control rats to 2.6±0.2%/min in the hyaluronidase-treated rats. These results support a role for the endothelial glycocalyx in the regulation of peripheral insulin sensitivity. The reduction in insulin sensitivity during acute glycocalyx damage, however, does not have an immediate effect on glucose tolerance because of a compensatory increase in plasma insulin levels.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"27 1","pages":"66–73"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83195969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2