Cardiovascular endocrinology最新文献_第7页

Relevance of low testosterone to non-alcoholic fatty liver disease. 低睾酮与非酒精性脂肪肝的相关性

Cardiovascular endocrinology Pub Date : 2015-09-01 DOI: 10.1097/XCE.0000000000000057

Avni Mody, Donna White, Fasiha Kanwal, Jose M Garcia

引用次数: 39

Effects of testosterone replacement on glucose and lipid metabolism 睾酮替代对糖脂代谢的影响

Cardiovascular endocrinology Pub Date : 2015-09-01 DOI: 10.1097/XCE.0000000000000061

I. Errázuriz, S. Dube, A. Basu, R. Basu

引用次数: 3

Testosterone replacement therapy: the controversies of cardiovascular risk 睾酮替代疗法:心血管风险的争议

Cardiovascular endocrinology Pub Date : 2015-09-01 DOI: 10.1097/XCE.0000000000000058

V. Surampudi, R. Swerdloff

引用次数: 0

Testosterone, metabolism, and cardiovascular disease 睾丸素，新陈代谢和心血管疾病

Cardiovascular endocrinology Pub Date : 2015-09-01 DOI: 10.1097/XCE.0000000000000054

K. Yuen, A. Krentz

引用次数: 0

Testosterone replacement and cardiovascular disease risk: what do endocrinologists need to know? 睾酮替代与心血管疾病风险:内分泌学家需要知道什么?

Cardiovascular endocrinology Pub Date : 2015-09-01 DOI: 10.1097/XCE.0000000000000051

Joshua R. Gonzalez, I. Goldstein

引用次数: 1

The components of metabolic syndrome in women: ‘Is the whole really greater than the sum of its parts?’ 女性代谢综合征的组成部分:“整体真的大于部分之和吗?””

Cardiovascular endocrinology Pub Date : 2015-06-01 DOI: 10.1097/XCE.0000000000000052

P. Patel, Shaista Malik

引用次数: 0

Blood pressure and body size preference in traditional communities of Ilorin metropolis, Nigeria 尼日利亚伊洛林大都市传统社区的血压和体型偏好

Cardiovascular endocrinology Pub Date : 2015-06-01 DOI: 10.1097/XCE.0000000000000048

E. Okoro, E. Etebu, B. Oyejola

{"title":"Blood pressure and body size preference in traditional communities of Ilorin metropolis, Nigeria","authors":"E. Okoro, E. Etebu, B. Oyejola","doi":"10.1097/XCE.0000000000000048","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000048","url":null,"abstract":"BackgroundOur previous work showed that many individuals with type 2 diabetes and in the background population may prefer larger body sizes. This prompted us to study the interaction between body size, body size perception and blood pressure. MethodsAnthropometric variables, body size perception and blood pressure were measured in adults of three Nigerian communities. The results were subjected to tests of correlation and regression to determine any association/functional relationship between predictor variables and blood pressure. ResultsParticipants with elevated blood pressure were older (52.75 vs. 39.58 years) and had a higher BMI (24.50 vs. 22.84), waist circumference (86.69 vs. 81.57) and hip circumference (95.23 vs. 92.49) compared with normotensives. There were significant (P<0.05) correlations between systolic blood pressure and age (0.401), weight (0.13), BMI (0.182), waist circumference (0.231), hip circumference (0.132), height (0.15), current body size perception (0.181), preferred body size (0.119) and preferred body size of the opposite gender (0.14). For normotensives, a 1 cm increment in waist circumference was associated with an increase in systolic blood pressure by 0.35 mmHg in those younger than 50 years of age. In older participants, an increase in BMI by 1 kg/m2 led to an increase in systolic blood pressure by 1.1 mmHg. Thirty-two per cent of the participants had hypertension. Less than 10% of the interindividual differences in blood pressure resulted from variations in body dimensions/or body size perception. Significantly, 66.5 versus 51.9% of hypertensive and normotensive individuals, respectively, desired a larger body size for self/spouse. ConclusionThe results indicated a dominant preference for larger body sizes, whereas body dimension predicted blood pressure only to a very limited degree.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"9 1","pages":"53–59"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81957812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bariatric surgery in obese older people: useful or not? 肥胖老年人的减肥手术:有用还是没用?

Cardiovascular endocrinology Pub Date : 2015-06-01 DOI: 10.1097/XCE.0000000000000045

Susan Reijntjes, A. Viljoen, A. Wierzbicki, T. Hardman

{"title":"Bariatric surgery in obese older people: useful or not?","authors":"Susan Reijntjes, A. Viljoen, A. Wierzbicki, T. Hardman","doi":"10.1097/XCE.0000000000000045","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000045","url":null,"abstract":"ObjectiveThe aim of this study was to determine whether older (≥65 years) obese people would benefit from bariatric surgery, considering the prevalence of multiple comorbidities and frailty in this group. MethodsA PubMed search was carried out for studies on the use of bariatric surgery in older obese people published in the database from 1980 to the present (August 2014). ResultsA total of 244 citations were obtained on searching; 182 of these publications were selected for manual checking and 10 studies were identified as containing useable data on this patient cohort. Published data were available for efficacy in 641 patients. Substantial improvement was observed in diabetes (76%), hypertension (68%) and sleep apnoea (67%) following bariatric surgery. Laparoscopic adjustable gastric banding (n=456) was the most frequently reported procedure. Similar findings but with greater weight loss and fewer complications were found in the small numbers of patients undergoing other procedures. Data from four large registry studies (n=6837) showed mortality and complications associated with bariatric surgery to be increased in older compared with younger people especially in those undergoing gastric bypass surgery. The elderly had longer hospital stays, and patients with cardiac, pulmonary or renal comorbidities generally had a worse prognosis. ConclusionBariatric surgery in older people is effective in reducing complications of obesity, but is also associated with increased rates of complications compared with those seen in younger patients. The few reported studies in the elderly are retrospective, generally small, primarily describe findings of laparoscopic adjustable gastric banding as the surgical intervention option and lack long-term follow-up. More trials and registry data, especially for sleeve gastrectomy and gastric bypass, are required to better address the utility of bariatric surgery in the elderly and to define long-term clinical outcomes.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"1 1","pages":"60–66"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75529294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diiodothyropropionic acid in the management of cardiovascular disease 二碘甲丙酸在心血管疾病治疗中的应用

Cardiovascular endocrinology Pub Date : 2015-05-26 DOI: 10.1097/XCE.0000000000000046

S. Arora, M. Agrawal, J. Iqbal, P. Bhandari, J. Mechanick

{"title":"Diiodothyropropionic acid in the management of cardiovascular disease","authors":"S. Arora, M. Agrawal, J. Iqbal, P. Bhandari, J. Mechanick","doi":"10.1097/XCE.0000000000000046","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000046","url":null,"abstract":"ObjectiveCardiovascular disease is the leading cause of morbidity and mortality in the USA. Thyroid analogs have emerged as a potential new therapeutic agent for cardiovascular disease. Thyroid hormones beneficially influence cardiac contractility and serum lipids but can also confer harmful effects on cardiac tissue and bone. To circumvent these harmful effects of thyroid hormones, several thyroid analogs have been studied since the 1960s. This review focuses on one such thyroid analog, diiodothyropropionic acid (DITPA), which has shown promise in the management of heart failure. Materials and methodsWe conducted a systematic review of the literature using evidence-based criteria. ResultsStrong laboratory data exist supporting the role of DITPA in heart failure by improving systolic and diastolic heart function. DITPA significantly alters the myosin heavy chain ratio in the heart muscle to improve ventricular contractility. There is increasing evidence in support of the improvement in lipid profile in patients on DITPA. No proarrhythmogenic adverse effects were noted with the use of DITPA. ConclusionDITPA appears to be promising in enhancing cardiac output and hemodynamic stability for heart failure patients, with possible synergistic implications when combined with other heart failure medications. However, extensive human trials are needed to establish its role in the management of heart failure and establish its safety profile.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"60 1","pages":"67–73"},"PeriodicalIF":0.0,"publicationDate":"2015-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88017839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A novel application of salivary testosterone in systolic heart failure: relationship with exercise capacity, quality of life and cardiac mechanics 唾液睾酮在收缩期心力衰竭中的新应用:与运动能力、生活质量和心脏力学的关系

Cardiovascular endocrinology Pub Date : 2015-03-01 DOI: 10.1097/XCE.0000000000000047

M. Stout, K. Pearce, S. Williams

{"title":"A novel application of salivary testosterone in systolic heart failure: relationship with exercise capacity, quality of life and cardiac mechanics","authors":"M. Stout, K. Pearce, S. Williams","doi":"10.1097/XCE.0000000000000047","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000047","url":null,"abstract":"Introduction There is an association between heart failure (HF) and testosterone deficiency. Salivary testosterone (ST) has been described as a marker of the free fraction of testosterone in healthy populations and has not commonly been utilized clinically. This study aimed to assess the clinical utility of ST in a HF population with a broad range of testosterone concentrations compared with more traditional serum parameters. Methods A total of 40 men with HF were recruited. Traditional serum testosterone measures and ST measures were collected on two separate occasions. Patients performed a 6-min walk, underwent echocardiography and completed quality of life questionnaires. Bland–Altman plots were constructed to assess the agreement between ST and free testosterone (FT) levels, and to assess the repeatability between traditional and ST measures. Pearson’s correlation was used to determine the relationship between ST levels, traditional serum testosterone parameters and important health outcomes. Results There was excellent agreement between ST and FT measures [bias 0.087 nmol/l, SD 0.056 nmol/l, 95% limits of agreement (LoA) of +2 SD 0.104 nmol/l and −2 SD −0.122 nmol/l]. ST and FT measures show excellent reproducibility (bias 0.0137 nmol/l, SD 0.021 nmol/l, 95% LoA +2 SD 0.041 nmol/l and −2 SD −0.041 nmol/l for ST, and bias 0.004 nmol/l, SD ±0.0025 nmol/l, 95% LoA ±2 SD +0.055 nmol/l and −0.046 nmol/l). There are similar levels of moderately strong positive correlation between ST levels, other testosterone fractions and endurance capacity/physical domains of quality of life assessed using the Short Form-36 questionnaire. Conclusion ST can be used as an alternative marker of traditional testosterone parameters in HF without semi-invasive blood sampling. There is a correlation between exercise capacity and physical quality of life domains with all testosterone fractions.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"51 1","pages":"28–38"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86154918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0