Cardiology & vascular research (Wilmington, Del.)最新文献

{"title":"Venous Thromboembolic Diseases: Epidemiological, Clinical, Para clinical, Therapeutic and Evolutionary Aspects: Retrospective Study over a Period of 7.5 Years about 112 Cases collected in the Internal Medicine and Cardiology Department of Lnth","authors":"Toure Ai, S. K, Boncano A, Dodo B, H. M, Haggar S, Z. À, Djonyony S","doi":"10.33425/2639-8486.1093","DOIUrl":"https://doi.org/10.33425/2639-8486.1093","url":null,"abstract":"Introduction: venous thromboembolism (VTE) is a real public health problem in the world due to its frequency and severity since the mortality from an untreated thromboembolic episode is around 30%. Because of its chronic and disabling complications (post-thrombotic disease and chronic thromboembolic pulmonary hypertension), it is responsible for a deterioration in the quality of life of patients. Objective: The aim of this work was to contribute to the study of the epidemiological , clinical, Para clinical, therapeutic and evolutive aspects of venous thromboembolism disease in the internal medicine and cardiology department of the Amirou Boubacar Diallo National Hospital. Patients and Methods: It's a prospective study from July 1st, 2019 to June 30th, 2020 and retrospective from January 1st, 2013 to June 30th, 2019 (7 years and 6 months) about 112 patients with whom the diagnostic of deep venous thrombosis (DVT ) and / or pulmonary embolism (PE) had been done. Results: In our study, the prevalence of venous thromboembolism has been estimated at 3.9% of hospitalized patients with cardiovascular diseases. There was a female predominance (sex ratio 1.38). The average age of patients was 52 years. Teabed-rest prolonged was the frequent risk factor (66%). The clinical symptomatology was dominated by oedema of the lower limb (83.3%) and pain in limb palpation (82.1%) in case of DVT, the dyspnea (23.02%) and thoracic pain (11.6%) in case of PE. The attack of the left lower limb prevailed (45.5%). The sinus tachycardia (25.9%) was the predominant electrical sign at the ECG. Through the Doppler of the lower limbs, the popliteal and femoral veins were the most involved with 22.3% and 17.8% respectively. According to the chest angio-CT, the left pulmonary artery was obstructed in 100% of case. The treatment was essentially made of low molecular weight heparins (90.1%) replaced quickly by vitamin k antagonist (began the first day of the heparin therapy) and / or of unfractionated heparin (9%). The most common complication was PE due to DVT and the overall mortality was 12.5%. Conclusion: VTE is pathology in young adults and elderly characterized by the formation of a clot in a vein responsible for the obstruction of the latter causing local inflammatory signs and / or its pulmonary migration which could be fatal. The prevention and treatment of VTE are based on anticoagulants.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42415120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients Living with HIV and Coronary Disease: Are we Using Appropriate Anti platelets as Part of Dual Antiplatelet Therapy?","authors":"O. Archer, J. Perram, J. Nadel, S. Emmanuel, G. Matthews, R. Beresford, C. Holloway","doi":"10.33425/2639-8486.1094","DOIUrl":"https://doi.org/10.33425/2639-8486.1094","url":null,"abstract":"Background: People living with HIV (PLHIV) have a higher incidence of cardiovascular disease and complications after intervention, including in-stent thrombosis. The frequency of potential drug-drug interactions in the setting of acute coronary syndrome (ACS) with antiretroviral therapy (ART) and dual-antiplatelet therapy (DAPT) regimens remains unclear. We sought to determine the frequency of potential drug-drug interactions in a cohort of people living with HIV who were investigated for coronary disease and initiated on DAPT as per Australian ACS Guidelines. Methods: A retrospective audit was performed in a single tertiary hospital in PLHIV presenting with symptomatic coronary artery disease (CAD) receiving DAPT. Patients were grouped based on exposure to a protease inhibitor or efavirenz and etravirine, given that these were found to have the greatest potential interactions with DAPT. Results: Fifty-three patients received DAPT, of which 31 (58%) had a potential drug-drug interaction. Clopidogrel was the most frequent P2Y12 inhibitor prescribed, accounting for 47 (87%) of the interactions. Twenty-six patients were on a protease inhibitor, of which 21 (81%) had a potential drug-drug interaction. There were 11 instances of efavirenz and 3 of etravirine use, of which all resulted in potential drug-drug interactions (100%, respectively). Conclusion: Potential drug-drug interactions were very common in PLHIV needing DAPT. The widespread use of clopidogrel in DAPT regimens resulted in a high rate of drug-drug interactions. An awareness of interactions and guidelines around P2Y12 inhibitor selection may help reduce the rate of in-stent thrombosis for PLHIV and improve clinical outcomes.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47851777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Sudden Cardiac Death: Necropsic Studies at Aristide Le Dantec Hospital","authors":"Bodian M, Akanni Scg, Beye Sm, Mingou Js, Diouf Y, Niass Ad, A. F., Sarr Sa, Diop Cmbm, Ndiaye Pg, Ngaide Aa, D. M, Lèye M, Ralaizandry U, Ndiaye Mb, M. A, Kane Ad, K. A, D. M","doi":"10.33425/2639-8486.1095","DOIUrl":"https://doi.org/10.33425/2639-8486.1095","url":null,"abstract":"Introduction: Sudden cardiac death (SCD) remains a major public health issue. In Senegal, there is a lack of data on this phenomenon; this underlies the relevance of this study whose objective is to study the epidemiological profile of victims experiencing unrecovered sudden cardiac arrest at Aristide LE DANTEC Hospital. Patients and Methods: This is a transverse study with retrospective data collection from January 1, 2016 to January 31, 2017. Included, in the study were all victims of sudden cardiac death in Dakar who had a necropsy in the morgues of Aristide Le Dantec Hospital. Results: We recorded 69 cases of sudden death of cardiovascular origin from 169 forensic autopsy reports, or 40.8% of autopsies. The average age was 44 years with a male predominance in 76.81%. The large majority of death occurred at home (26%), without witnesses (48%) and at rest (36%). Two cases of sudden death, or 3%, occurred at exertion. These deaths were recorded in 16% of cases in the middle of the day. The highest death rate was recorded during the month of December (15.9%). Malaise was the predominant symptom (13%) followed by emotional stress (6%). The existence of a history could only be clarified in 4% of cases. The electrocardiogram was only performed in 1 case. At necropsy, ischemic heart disease was the leading disease (46%), 26% of which was due to myocardial infarction, followed by hypertrophic cardiomyopathy (16%) and mixed cardiomyopathy (13%). Tamponade, dilated cardiomyopathy and aortic dissection were found in 9%, 6% and 4% of cases, respectively. Conclusion: Sudden cardiac death is a major public health problem. In the Senegalese population, victims of unrecovered SCD are relatively young with a predominance of men. Coronary artery disease is the most frequently implicated pathology. Faced with this observation, a national program for the integrated control of cardiovascular risk factors is necessary.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43525432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Selective Endothelin Receptor Antagonist on Vegf Signaling System in Diabetic Penis: A Possible Clinical Implication for Diabetes Induced Erectile Dysfunction","authors":"A. Maqbool, S. Jesmin, Chishimba N Mowa, S. N. Sultana, N. Shimojo, Y. Matsuishi, Takeru Shima, N. Yamaguchi, T. Miyauchi, S. Kawano, M. Moroi","doi":"10.33425/2639-8486.1096","DOIUrl":"https://doi.org/10.33425/2639-8486.1096","url":null,"abstract":"Erectile dysfunction (ED) affects around 50 percent of male diabetic patients due to vascular and neuropathic complications arising from diabetes. Vascular endothelial growth factor (VEGF) has been extensively investigated for its pathogenic relevance in various diabetes complications, and we have already noted that VEGF signaling is significantly reduced at the insulin-resistant stage in the penis of type II diabetic rat model. The present research used a three-week streptozotocin (STZ)-induced diabetic (DM) rat model to determine the expression of VEGF with NO mechanism in penile tissue and subsequently investigated its impact endothelin antagonism on these shifts. Citrate saline vehicle or STZ (65 mg/kg IP) was administered to male Sprague-Dawley rats (weight 453 ± 23 g). Hyperglycemia confirmed diabetes, and then after 1 week of diabetes, animals were divided into receiving endothelin-A (ET-A) receptor antagonists (TA-0201, 1 mg/kg) or saline by osmotic minipump for 2 weeks and then sacrificed. Significantly improved glucose levels in DM rats (405 ± 103 mg/dL) relative to non-DM rats (120 ± 8 mg/dL) and higher local ET-1 levels in DM penis by 20% are observed. A 30 percent decline in penile tissue expression of VEGF was observed in DM rats and improved by an antagonist with ET. Penile NO and eNOS levels in DM rats decreased, while ET-A receptor antagonist significantly increased. Therefore, we infer that ET antagonism seemed able to restore the down-regulated VEGF and was possibly efficient in restoring the decreased levels of NO and eNOS in DM.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42122183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Cardiopulmonary Complications after Revascularization in Patients with Severe Mental Health Disorders.","authors":"Leah Gober,&nbsp;Adam Brown,&nbsp;Avianne P Bunnell,&nbsp;Brian E Bunnell,&nbsp;Jean Marie Ruddy","doi":"10.33425/2639-8486.1122","DOIUrl":"https://doi.org/10.33425/2639-8486.1122","url":null,"abstract":"<p><strong>Introduction: </strong>Mental health disorders (MHD) are prevalent within surgical patient populations and can be associated with poorer postoperative outcomes, particularly in those with more severe MHD (schizophrenia and bipolar disorder). However, these associations have not been examined in vascular surgery patients. This study investigated patients undergoing lower extremity revascularization, hypothesizing that those with severe MHD would experience worse health and postoperative outcomes.</p><p><strong>Methods: </strong>A retrospective chart review of patients from 2010-2015 with peripheral arterial disease (PAD) requiring revascularization was conducted, with subsequent narrowing to those with concurrent MHD diagnoses, including severe MHD (sMHD) defined as bipolar disorder or schizophrenia and non-severe MHD (nsMHD), defined as anxiety or depression. The primary endpoints were 30-day mortality; Major Adverse Limb Events (MALE) including amputation at the above or below knee level; and Major Adverse Cardiac Events (MACE) including myocardial infarction (MI), congestive heart failure (CHF) exacerbation, and arrhythmia. Secondary endpoints were readmission within 30 days, pulmonary complications, and wound infection. Statistical analyses included Fisher Exact Test and Student's T-test.</p><p><strong>Results: </strong>Eighteen patients with MHD (sMHD, n=10; nsMHD, n=8) were identified and stratified. Twenty-four limbs were revascularized (sMHD, n=13; nsMHD, n=11). Overall incidence of 30-day mortality, MALE, and MACE were 4.2%, 33.3%, and 50.0%, respectively. Readmission rate, pneumonia, and wound infection occurred in 41.7%, 20.8%, and 16.7% of the population. Stratifying by MHD severity, no significant differences were observed for medical comorbidities, MALE, intervention type (open vs. endovascular), or treatment indication (claudication vs. critical limb ischemia). Patients with sMHD had significantly higher rates of MACE compared to patients with nsMHD (30.8% vs. 18.2%, p<.05). Pneumonia was also more prevalent in this group (38.5% vs. 0.0%, p<.05).</p><p><strong>Conclusion: </strong>While patients with concurrent diagnoses of MHD and PAD presented with similar comorbidities, comparable disease severity, and were equally treated by open versus endovascular techniques, those with severe MHD suffered significantly elevated rates of cardiopulmonary complications, specifically MACE and pneumonia. Further investigation is warranted to identify opportunities to optimize post-operative care for these complex patients.</p>","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":"5 5","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306221/pdf/nihms-1774875.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40619897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Atrial Mass: Thrombus? Myxoma? Or Both? Myxoma surrounded by thrombus","authors":"M. Taşar, Fatih Ada","doi":"10.33425/2639-8486.1089","DOIUrl":"https://doi.org/10.33425/2639-8486.1089","url":null,"abstract":"Left atrial masses are generally myxomas or thrombus formations. When the operation of the mass is inevitable, preoperative radiological techniques are used for understanding the properties. When a mass in left atrium is seen, it thought to be solely myxoma or thrombus. In this case, we aimed to present a patient that underwent open cardiac surgery for a left atrial mass and it was a myxoma which was surrounded by thrombus formation. *Correspondence: Dr. Mehmet Taşar, Dr.Sami Ulus Maternity, Child Health Education and Research Hospital, Cardiovascular Surgery Department, Ankara, Turkey, Tel: +90 505 442 47 80. Received: 02 December 2020; Accepted: 22 December 2020","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42884665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cocaine Induced Peripheral Artery Occlusion Resulting in Critical Limb Ischemia","authors":"K. Collins, R. Senese, A. Ramanathan","doi":"10.33425/2639-8486.1090","DOIUrl":"https://doi.org/10.33425/2639-8486.1090","url":null,"abstract":"Introduction: Cocaine addiction is a common health problem. While Cocaine’s effects on the heart and the cerebrovascular system are well documented and studied, cases of peripheral arterial occlusion from Cocaine use are uncommon in the literature. Case: A case of a forty six year old man with cocaine induced common iliac artery thrombosis which was successfully treated by stenting is presented. Discussion: Cocaine induced peripheral arterial disease is discussed along with possible mechanisms. Conclusion: Physicians should be aware of Cocaine use as one of the possible risk factors for peripheral arterial occlusion. *Correspondence: Anantha Ramanathan, Dept of Surgery, Nassau University Medical Center, Hempstead Tpke, East Meadow, NY, Tel: +1929 365 7501. Received: 04 December 2020; Accepted: 29 December 2020","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47672186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Assessing Myocardial Deformation at Recovery after Dobutamine Stress Echocardiography in Predicting Coronary Artery Disease","authors":"Abdulaziz Aboshahba, H. Khalaf, Ali Alamin, S. Nouh, Abdulaziz Rezq, Ahmed H Dawood, Ibrahim Altaj, G. Abdelhady, Mohamed Elbordy, R. Solomon, Abdelmohsen Mostafa","doi":"10.33425/2639-8486.1086","DOIUrl":"https://doi.org/10.33425/2639-8486.1086","url":null,"abstract":"","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47711992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underuse of Injectable Penicillin in Secondary Prophylaxis of Rheumatic Heart Disease in Nepal","authors":"S. Laudari, Tiwari K. Kaushal, A. Subedi, Sanjib K Sharma","doi":"10.33425/2639-8486.1087","DOIUrl":"https://doi.org/10.33425/2639-8486.1087","url":null,"abstract":"Background and Aims: Secondary prophylaxis has remained the mainstay of rheumatic fever and rheumatic heart disease management. Despite the proven efficacy and superiority of injectable penicillin in rheumatic heart disease patients, it has been underused in Nepal. Materials and Methods: This is a hospital based cross-sectional study during June 2014 to October 2018 over a period of 52 months at College of Medical Sciences-Bharatpur including 350 patients with clinical and/or echocardiographic evidence of definite rheumatic heart disease. Data was collected from both cardiology outpatients and inpatients (admitted in cardio ward/coronary care unit). Relevant data and information were entered into the pre-structured proforma and then analyzed by SPSS-16 software. Results: The age of the patients ranged from 6 to 80 years with mean age 36.76±4.6years with female preponderance (F:M=1.26:1). The predominantly involved isolated valve was mitral in 152 patients (44.43 %) followed by aortic valve in 70 patients (20.00 %) and rest 90 (25.71 %) had dual valvular involvement. The common complications encountered were heart failure in 200(57.14 %) and arrhythmias in 155(44.29 %) patients. Two hundred ten (60.00 %) of the patients received penicillin (oral and injectable) and erythromycin. Majority (180/210=85.71 %) were prescribed on oral penicillin whereas only 46/210=21.90 % received injectable penicillin; the ratio being 3.35:1. Conclusion: RHD is a leading cause of heart failure and death among young population. There is underuse of penicillin with very minimal focus on use of injectable penicillins currently. Hence, Nepal government and other non-governmental organizations should consider implementation of use of penicillin broadly and moreover focus on use and adherence of injectable penicillin. *Correspondence: Dr. Shankar Laudari, MD, DM, FESC, FACC Cardiology, Consultant Cardiologist, Department of Cardiology, College of Medical Sciences-TH, Bharatpur, Nepal, Tel: 977-9845112909. Received: 20 November 2020; Accepted: 02 December 2020","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45487025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoker’s Polycythemia: Is It a Cardiovascular Risk?","authors":"Abeer M. Shawky","doi":"10.33425/2639-8486.1085","DOIUrl":"https://doi.org/10.33425/2639-8486.1085","url":null,"abstract":"Increase red blood cell mass and decrease plasma volume can elevate blood viscosity, which can impair blood flow, making individuals susceptible to vaso-occlusive events. Smoking that results in secondary polycythemia and erythrocytosis can cause additional harms in smokers. It can be defined by an expansion of red cell mass with elevated haemoglobin and hematocrit as a physiologic response to increased erythropoietin production secondary to generalized tissue hypoxia. Hypoxia in smoker’s polycythemia is present with normal or falsely elevated oxygen saturation value. This article stressing the importance of being aware of cardiovascular risk in patients with polycythemia as a result of chronic smoking exposure. *Correspondence: Abeer Mohamed Shawky, Cardiology Department, Faculty of medicine, Al-Azhar university, Cairo, Egypt, E-mail: abeer_ shawky@hotmail.com. Received: 02 October 2020; Accepted: 30 October 2020","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48103801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}