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Cancer chemotherapy and biological response modifiers最新文献

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Breast cancer. 乳腺癌。
Cancer chemotherapy and biological response modifiers Pub Date : 2005-01-01
Alistair Ring, Catherine Harper-Wynne, Ian Smith
{"title":"Breast cancer.","authors":"Alistair Ring, Catherine Harper-Wynne, Ian Smith","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":" ","pages":"545-61"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25258154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Native and genetically engineered anti-disialoganglioside monoclonal antibody treatment of melanoma. 天然和基因工程抗双胞脂苷单克隆抗体治疗黑色素瘤。
Cancer chemotherapy and biological response modifiers Pub Date : 2005-01-01 DOI: 10.1016/s0921-4410(04)22037-3
Mark R Albertini, Jacquelyn A Hank, Paul M Sondel
{"title":"Native and genetically engineered anti-disialoganglioside monoclonal antibody treatment of melanoma.","authors":"Mark R Albertini, Jacquelyn A Hank, Paul M Sondel","doi":"10.1016/s0921-4410(04)22037-3","DOIUrl":"https://doi.org/10.1016/s0921-4410(04)22037-3","url":null,"abstract":"","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":" ","pages":"789-97"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25258167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Chemotherapy, cytokines, and biochemotherapy for melanoma. 化疗，细胞因子和黑色素瘤的生物化疗。
Cancer chemotherapy and biological response modifiers Pub Date : 2005-01-01
Omar Eton
{"title":"Chemotherapy, cytokines, and biochemotherapy for melanoma.","authors":"Omar Eton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":" ","pages":"739-48"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25258163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermal growth factor receptor pathway inhibitors. 表皮生长因子受体途径抑制剂。
Cancer chemotherapy and biological response modifiers Pub Date : 2005-01-01 DOI: 10.1016/s0921-4410(04)22009-9
Jose Baselga, Javier Cortes
{"title":"Epidermal growth factor receptor pathway inhibitors.","authors":"Jose Baselga, Javier Cortes","doi":"10.1016/s0921-4410(04)22009-9","DOIUrl":"https://doi.org/10.1016/s0921-4410(04)22009-9","url":null,"abstract":"","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":" ","pages":"205-23"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25258139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroendocrine tumours. 神经内分泌肿瘤。
Cancer chemotherapy and biological response modifiers Pub Date : 2005-01-01
Dan Granberg, Kjell Oberg
{"title":"Neuroendocrine tumours.","authors":"Dan Granberg, Kjell Oberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":" ","pages":"471-83"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25258151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemotherapy, cytokines, and biochemotherapy for melanoma. 化疗，细胞因子和黑色素瘤的生物化疗。
Cancer chemotherapy and biological response modifiers Pub Date : 2005-01-01 DOI: 10.1016/s0921-4410(04)22033-6
O. Eton
{"title":"Chemotherapy, cytokines, and biochemotherapy for melanoma.","authors":"O. Eton","doi":"10.1016/s0921-4410(04)22033-6","DOIUrl":"https://doi.org/10.1016/s0921-4410(04)22033-6","url":null,"abstract":"","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":"22 1","pages":"739-48"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56279885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Systemic therapy for renal cell carcinoma. 肾细胞癌的全身治疗。
Cancer chemotherapy and biological response modifiers Pub Date : 2005-01-01 DOI: 10.1016/s0921-4410(04)22012-9
Yoo-Joung Ko, Michael B Atkins
{"title":"Systemic therapy for renal cell carcinoma.","authors":"Yoo-Joung Ko, Michael B Atkins","doi":"10.1016/s0921-4410(04)22012-9","DOIUrl":"https://doi.org/10.1016/s0921-4410(04)22012-9","url":null,"abstract":"","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":" ","pages":"263-72"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25258142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 337
Retargeting T cells and immune effector cells with bispecific antibodies. 用双特异性抗体重靶向T细胞和免疫效应细胞。
Cancer chemotherapy and biological response modifiers Pub Date : 2005-01-01 DOI: 10.1016/s0921-4410(04)22013-0
Lawrence G Lum, Pamela A Davol
{"title":"Retargeting T cells and immune effector cells with bispecific antibodies.","authors":"Lawrence G Lum,&nbsp;Pamela A Davol","doi":"10.1016/s0921-4410(04)22013-0","DOIUrl":"https://doi.org/10.1016/s0921-4410(04)22013-0","url":null,"abstract":"<p><p>The development of BiAbs for therapeutic applications in cancer shows promise. As our understanding of effector cell receptor biology for triggering of cytotoxic functions improves and the behavior of TAA and the targeting antibody engagement is elucidated, customized BiAb reagents can be engineered to optimize in vivo or ex vivo arming of T cells for targeting tumors. Additionally, other variables that require consideration in the equation for successful T cell immunotherapy include: the type of effector cells, their state of activation, the type of effector receptor being activated or tareeted. the presence of Tregs, the affinity of the anti-effector cell antibody and the anti-TAA antibody, the type of BiAb (mouse, humanized, or human), the number of binding sites for the T cells or TAA, the presence or absence of decoy antigen, whether the TAA modulates after being engaged by antibody, the type of tumor, the tumor burden, and last, but not least, the amount of 'immunologic' space available for the adoptively transferred cells to expand and function.</p>","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":" ","pages":"273-91"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25258143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Mucins in gastrointestinal cancers. 胃肠道肿瘤中的粘蛋白。
Cancer chemotherapy and biological response modifiers Pub Date : 2003-01-01 DOI: 10.1016/s0921-4410(03)21012-7
Michael S Turner, John R McKolanis, Ramesh K Ramanathan, David C Whitcomb, Olivera J Finn
{"title":"Mucins in gastrointestinal cancers.","authors":"Michael S Turner,&nbsp;John R McKolanis,&nbsp;Ramesh K Ramanathan,&nbsp;David C Whitcomb,&nbsp;Olivera J Finn","doi":"10.1016/s0921-4410(03)21012-7","DOIUrl":"https://doi.org/10.1016/s0921-4410(03)21012-7","url":null,"abstract":"<p><p>The mucin family has been under study by molecular biologists, biochemists, pathologists and immunologists interested in cancer because of the role these molecules can play in the diagnosis and treatment of cancer. Immense knowledge has been accumulated, but the high speed of progress in the laboratory has not been matched by the progress towards applying this knowledge in the clinic. For example, specific knowledge of cancer-associated changes in the expression and glycosylation of various mucins, which can aid in the diagnosis as well as prognosis of GI cancers, has not yet led to the use of a panel of anti-mucin antibodies as a standard diagnostic tool. Similarly, many more opportunities exist for using mucin-based therapies than are currently being considered in the clinic. This chapter aimed to highlight some of these opportunities and to interest clinician scientists in exploring them in the near future.</p>","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":"21 ","pages":"259-74"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24660523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Mechanisms of tumor evasion from the immune response. 肿瘤逃避免疫反应的机制。
Cancer chemotherapy and biological response modifiers Pub Date : 2003-01-01 DOI: 10.1016/s0921-4410(03)21018-8
Paulo C Rodríguez, Arnold H Zea, Augusto C Ochoa
{"title":"Mechanisms of tumor evasion from the immune response.","authors":"Paulo C Rodríguez,&nbsp;Arnold H Zea,&nbsp;Augusto C Ochoa","doi":"10.1016/s0921-4410(03)21018-8","DOIUrl":"https://doi.org/10.1016/s0921-4410(03)21018-8","url":null,"abstract":"<p><p>The results from in vitro immunological experiments, murine tumor models and patients with cancer clearly demonstrate that tumors have multiple mechanisms to evade the immune response. During the early stages of tumor development malignant cells can be poor stimulators, present poor targets or become resistant to the innate immune response, while at later stages, progressively growing tumors impair the adaptive immune response by blocking the maturation and function of APCs and causing alterations in T-cell signal transduction and function. Preliminary results also suggest a correlation between some of these changes and an increased metastatic potential of the tumor cells, a diminished response to immunotherapy, and poor prognosis. Carefully coordinated basic research studies and clinical immunotherapy trials will be required to fully determine the impact of these mechanisms of tumor evasion on the outcome of the disease and the response to treatment. However, understanding the mechanisms used by tumor cells to evade the immune system could result in new therapeutic approaches for preventing and/or reversing these immune alterations and could have the potential of improving the current results of immunotherapy trials.</p>","PeriodicalId":72508,"journal":{"name":"Cancer chemotherapy and biological response modifiers","volume":"21 ","pages":"351-64"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24660529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
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