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Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density. Fam3c调节成骨细胞分化，影响骨体积和皮质骨矿物质密度。
BoneKEy reports Pub Date : 2016-04-06 eCollection Date: 2016-01-01 DOI: 10.1038/bonekey.2016.14
Jorma A Määttä, Ameya Bendre, Mervi Laanti, Kalman G Büki, Pia Rantakari, Päivi Tervola, Johanna Saarimäki, Matti Poutanen, Pirkko Härkönen, Kalervo Väänänen
{"title":"Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density.","authors":"Jorma A Määttä,&nbsp;Ameya Bendre,&nbsp;Mervi Laanti,&nbsp;Kalman G Büki,&nbsp;Pia Rantakari,&nbsp;Päivi Tervola,&nbsp;Johanna Saarimäki,&nbsp;Matti Poutanen,&nbsp;Pirkko Härkönen,&nbsp;Kalervo Väänänen","doi":"10.1038/bonekey.2016.14","DOIUrl":"https://doi.org/10.1038/bonekey.2016.14","url":null,"abstract":"<p><p>Fam3c, a cytokine-like growth factor, has been suggested to have a role in epithelial-to-mesenchymal transition (EMT), tumor growth and metastasis. A single-nucleotide polymorphism affecting bone mineral density has been found in the first intron of the Fam3c gene in a study analyzing an Asian population cohort. Other independent studies on different population cohorts have found the fam3c locus to be associated with bone mineral density and fractures. In order to investigate the role of Fam3c in bone biology, we have generated a Fam3c knock-out (KO) mouse strain. The Fam3c KO mice were found to have normal appearance, behavior and fertility, but small changes in bone morphology and content were also observed. Micro-CT analysis of tibiae of the female mice revealed decreased number of trabeculae. In male mice the changes in the bone phenotype were smaller, but hematological changes were observed. Furthermore, there was a negative correlation between body weight and tibial trabecular and cortical bone volume in the male KO mice. There was a small increase in cortical bone mineral density, but in the lateral direction of tibiae the breaking strength was reduced. Fam3c KO bone marrow cells showed accelerated osteogenic differentiation and mineralization in vitro. The reduced number of bone trabeculae in Fam3c KO mice and the stimulated osteogenic differentiation indicate a role for Fam3c in osteoblast differentiation and bone homeostasis. </p>","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 ","pages":"787"},"PeriodicalIF":0.0,"publicationDate":"2016-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822344/pdf/bonekey201614.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34469613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Periostin-deficient mice, a relevant animal model to investigate periodontitis or not? 缺牙周素小鼠是否是研究牙周炎的相关动物模型?
BoneKEy reports Pub Date : 2016-04-06 eCollection Date: 2016-01-01 DOI: 10.1038/bonekey.2016.21
Olivier Lapérine, Jérôme Guicheux, Philippe Lesclous
{"title":"Periostin-deficient mice, a relevant animal model to investigate periodontitis or not?","authors":"Olivier Lapérine,&nbsp;Jérôme Guicheux,&nbsp;Philippe Lesclous","doi":"10.1038/bonekey.2016.21","DOIUrl":"https://doi.org/10.1038/bonekey.2016.21","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 ","pages":"794"},"PeriodicalIF":0.0,"publicationDate":"2016-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822343/pdf/bonekey201621.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34469612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
TBS and bone strength. TBS和骨骼强度。
BoneKEy reports Pub Date : 2016-03-02 DOI: 10.1038/bonekey.2016.19
B. Cortet, V. Bousson
{"title":"TBS and bone strength.","authors":"B. Cortet, V. Bousson","doi":"10.1038/bonekey.2016.19","DOIUrl":"https://doi.org/10.1038/bonekey.2016.19","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"792"},"PeriodicalIF":0.0,"publicationDate":"2016-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Therapeutic actions of curcumin in bone disorders. 姜黄素对骨疾病的治疗作用。
BoneKEy reports Pub Date : 2016-03-02 DOI: 10.1038/bonekey.2016.20
R. Rohanizadeh, Yi Deng, E. Verron
{"title":"Therapeutic actions of curcumin in bone disorders.","authors":"R. Rohanizadeh, Yi Deng, E. Verron","doi":"10.1038/bonekey.2016.20","DOIUrl":"https://doi.org/10.1038/bonekey.2016.20","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"34 1","pages":"793"},"PeriodicalIF":0.0,"publicationDate":"2016-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2016.20","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
Activation of intracellular calcium signaling in osteoblasts colocalizes with the formation of post-yield diffuse microdamage in bone matrix. 成骨细胞细胞内钙信号的激活与骨基质产后弥漫性微损伤的形成是共域的。
BoneKEy reports Pub Date : 2016-03-02 DOI: 10.1038/bonekey.2016.5
Hyungjin Jung, O. Akkus
{"title":"Activation of intracellular calcium signaling in osteoblasts colocalizes with the formation of post-yield diffuse microdamage in bone matrix.","authors":"Hyungjin Jung, O. Akkus","doi":"10.1038/bonekey.2016.5","DOIUrl":"https://doi.org/10.1038/bonekey.2016.5","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"778"},"PeriodicalIF":0.0,"publicationDate":"2016-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Mouse models for studying prostate cancer bone metastasis. 研究前列腺癌骨转移的小鼠模型。
BoneKEy reports Pub Date : 2016-02-17 DOI: 10.1038/bonekey.2016.4
Jinlu Dai, Janine Hensel, Ning Wang, Marianna Kruithof-de Julio, Y. Shiozawa
{"title":"Mouse models for studying prostate cancer bone metastasis.","authors":"Jinlu Dai, Janine Hensel, Ning Wang, Marianna Kruithof-de Julio, Y. Shiozawa","doi":"10.1038/bonekey.2016.4","DOIUrl":"https://doi.org/10.1038/bonekey.2016.4","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"777"},"PeriodicalIF":0.0,"publicationDate":"2016-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2016.4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
Sclerostin serum levels in patients with systemic autoimmune diseases. 系统性自身免疫性疾病患者血清硬化蛋白水平
BoneKEy reports Pub Date : 2016-02-03 DOI: 10.1038/bonekey.2016.2
C. Fernández-Roldán, F. Genre, R. López-Mejías, B. Ubilla, V. Mijares, D. S. Cano, C. Robles, J. Callejas-Rubio, R. R. Fernández, M. Ruiz, M. González-Gay, N. Ortego Centeno
{"title":"Sclerostin serum levels in patients with systemic autoimmune diseases.","authors":"C. Fernández-Roldán, F. Genre, R. López-Mejías, B. Ubilla, V. Mijares, D. S. Cano, C. Robles, J. Callejas-Rubio, R. R. Fernández, M. Ruiz, M. González-Gay, N. Ortego Centeno","doi":"10.1038/bonekey.2016.2","DOIUrl":"https://doi.org/10.1038/bonekey.2016.2","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"775"},"PeriodicalIF":0.0,"publicationDate":"2016-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Glucose: not always the bad guy. 葡萄糖:不总是坏家伙。
BoneKEy reports Pub Date : 2016-02-03 DOI: 10.1038/bonekey.2016.1
T. Brennan-Speranza, I. Levinger
{"title":"Glucose: not always the bad guy.","authors":"T. Brennan-Speranza, I. Levinger","doi":"10.1038/bonekey.2016.1","DOIUrl":"https://doi.org/10.1038/bonekey.2016.1","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"31 1","pages":"774"},"PeriodicalIF":0.0,"publicationDate":"2016-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2016.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical animal models of multiple myeloma. 多发性骨髓瘤的临床前动物模型。
BoneKEy reports Pub Date : 2016-02-03 DOI: 10.1038/bonekey.2015.142
S. Lwin, C. Edwards, R. Silbermann
{"title":"Preclinical animal models of multiple myeloma.","authors":"S. Lwin, C. Edwards, R. Silbermann","doi":"10.1038/bonekey.2015.142","DOIUrl":"https://doi.org/10.1038/bonekey.2015.142","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"772"},"PeriodicalIF":0.0,"publicationDate":"2016-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2015.142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
FGF23 in chronic kidney disease: are we lost in translation? 慢性肾病中的FGF23:我们在翻译中丢失了吗?
BoneKEy reports Pub Date : 2016-01-06 DOI: 10.1038/bonekey.2015.140
J. Bacchetta
{"title":"FGF23 in chronic kidney disease: are we lost in translation?","authors":"J. Bacchetta","doi":"10.1038/bonekey.2015.140","DOIUrl":"https://doi.org/10.1038/bonekey.2015.140","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"770"},"PeriodicalIF":0.0,"publicationDate":"2016-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2015.140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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