BoneKEy reportsPub Date : 2016-10-19DOI: 10.1038/bonekey.2016.72
Huifang Lu, R. Champlin, U. Popat, X. Pundole, C. Escalante, Xuemei Wang, W. Qiao, W. Murphy, R. Gagel
{"title":"Ibandronate for the prevention of bone loss after allogeneic stem cell transplantation for hematologic malignancies: a randomized-controlled trial.","authors":"Huifang Lu, R. Champlin, U. Popat, X. Pundole, C. Escalante, Xuemei Wang, W. Qiao, W. Murphy, R. Gagel","doi":"10.1038/bonekey.2016.72","DOIUrl":"https://doi.org/10.1038/bonekey.2016.72","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"843"},"PeriodicalIF":0.0,"publicationDate":"2016-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58485013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BoneKEy reportsPub Date : 2016-10-19DOI: 10.1038/BONEKEY.2016.75
U. Dadwal, C. Falank, H. Fairfield, Sarah Linehan, C. Rosen, D. Kaplan, J. Sterling, M. Reagan
{"title":"Tissue-engineered 3D cancer-in-bone modeling: silk and PUR protocols.","authors":"U. Dadwal, C. Falank, H. Fairfield, Sarah Linehan, C. Rosen, D. Kaplan, J. Sterling, M. Reagan","doi":"10.1038/BONEKEY.2016.75","DOIUrl":"https://doi.org/10.1038/BONEKEY.2016.75","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"842"},"PeriodicalIF":0.0,"publicationDate":"2016-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/BONEKEY.2016.75","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58485198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BoneKEy reportsPub Date : 2016-09-21DOI: 10.1038/bonekey.2016.69
Mark L. Johnson
{"title":"How rare bone diseases have informed our knowledge of complex diseases.","authors":"Mark L. Johnson","doi":"10.1038/bonekey.2016.69","DOIUrl":"https://doi.org/10.1038/bonekey.2016.69","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"839"},"PeriodicalIF":0.0,"publicationDate":"2016-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BoneKEy reportsPub Date : 2016-09-14DOI: 10.1038/bonekey.2016.65
Karan M. Shah, M. Stern, A. Stern, J. Pathak, N. Bravenboer, A. Bakker
{"title":"Osteocyte isolation and culture methods.","authors":"Karan M. Shah, M. Stern, A. Stern, J. Pathak, N. Bravenboer, A. Bakker","doi":"10.1038/bonekey.2016.65","DOIUrl":"https://doi.org/10.1038/bonekey.2016.65","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"838"},"PeriodicalIF":0.0,"publicationDate":"2016-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2016.65","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BoneKEy reportsPub Date : 2016-09-07DOI: 10.1038/bonekey.2016.61
Meghan M. Moran, K. Sena, M. McNulty, D. R. Sumner, A. Virdi
{"title":"Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models.","authors":"Meghan M. Moran, K. Sena, M. McNulty, D. R. Sumner, A. Virdi","doi":"10.1038/bonekey.2016.61","DOIUrl":"https://doi.org/10.1038/bonekey.2016.61","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"28 1","pages":"837"},"PeriodicalIF":0.0,"publicationDate":"2016-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BoneKEy reportsPub Date : 2016-08-31DOI: 10.1038/bonekey.2016.59
E. Lespessailles, R. Hambli, S. Ferrari
{"title":"Osteoporosis drug effects on cortical and trabecular bone microstructure: a review of HR-pQCT analyses.","authors":"E. Lespessailles, R. Hambli, S. Ferrari","doi":"10.1038/bonekey.2016.59","DOIUrl":"https://doi.org/10.1038/bonekey.2016.59","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":"836"},"PeriodicalIF":0.0,"publicationDate":"2016-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BoneKEy reportsPub Date : 2016-08-24eCollection Date: 2016-01-01DOI: 10.1038/bonekey.2016.60
Uwe Wolfram, Jakob Schwiedrzik
{"title":"Post-yield and failure properties of cortical bone.","authors":"Uwe Wolfram, Jakob Schwiedrzik","doi":"10.1038/bonekey.2016.60","DOIUrl":"https://doi.org/10.1038/bonekey.2016.60","url":null,"abstract":"<p><p>Ageing and associated skeletal diseases pose a significant challenge for health care systems worldwide. Age-related fractures have a serious impact on personal, social and economic wellbeing. A significant proportion of physiological loading is carried by the cortical shell. Its role in the fracture resistance and strength of whole bones in the ageing skeleton is of utmost importance. Even though a large body of knowledge has been accumulated on this topic on the macroscale, the underlying micromechanical material behaviour and the scale transition of bone's mechanical properties are yet to be uncovered. Therefore, this review aims at providing an overview of the state-of-the-art of the post-yield and failure properties of cortical bone at the extracellular matrix and the tissue level. </p>","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 ","pages":"829"},"PeriodicalIF":0.0,"publicationDate":"2016-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2016.60","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34350876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BoneKEy reportsPub Date : 2016-08-17eCollection Date: 2016-01-01DOI: 10.1038/bonekey.2016.55
Justine Bacchetta, Marcella Greco, Aurélia Bertholet-Thomas, François Nobili, Jozef Zustin, Pierre Cochat, Francesco Emma, Georges Boivin
{"title":"Skeletal implications and management of cystinosis: three case reports and literature review.","authors":"Justine Bacchetta, Marcella Greco, Aurélia Bertholet-Thomas, François Nobili, Jozef Zustin, Pierre Cochat, Francesco Emma, Georges Boivin","doi":"10.1038/bonekey.2016.55","DOIUrl":"https://doi.org/10.1038/bonekey.2016.55","url":null,"abstract":"<p><p>Hypophosphatemic rickets and short stature are observed in nephropathic cystinosis, an orphan autosomal recessive lysosomal storage disease due to a deficiency of cystinosin (CTNS gene). Although bone impairment is not common, it nevertheless appears to be more and more discussed by experts, even though the exact underlying pathophysiology is unclear. Four hypotheses are currently discussed to explain such impairment: copper deficiency, bone consequences of severe hypophosphatemic rickets during infancy, cysteamine toxicity and abnormal thyroid metabolism. In murine models, the invalidation of the CTNS gene is associated neither with renal phosphate wasting nor with renal failure, but causes severe osteopenia and growth retardation, thus raising the hypothesis of a specific underlying bone defect in cystinosis. Moreover, the in vitro ability of mesenchymal stromal cells isolated from bone marrow to differentiate along the osteoblastic lineage is reduced in patients with cystinosis as compared with cells obtained from healthy controls, this cellular abnormality being reverted after cysteamine treatment. From our experience of three pediatric patients with cystinosis and severe bone deformations having undergone a thorough biochemical evaluation, as well as a bone biopsy, we conclude that even though copper deficiency, high-doses cysteamine regimens and abnormal thyroid metabolism may worsen the bone picture in cystinosis patients, the exact pathophysiology of such impairment remains to be defined. The role of chronic hypoparathyroidism due to chronic phosphate wasting could also be discussed. In the future, larger and prospective studies should focus on this topic because of the potential major impact on patients' quality of life. </p>","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 ","pages":"828"},"PeriodicalIF":0.0,"publicationDate":"2016-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988218/pdf/bonekey201655.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34350934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BoneKEy reportsPub Date : 2016-08-10DOI: 10.1038/bonekey.2016.58
R. Macdonell, M. Hamrick, C. Isales
{"title":"Protein/amino-acid modulation of bone cell function","authors":"R. Macdonell, M. Hamrick, C. Isales","doi":"10.1038/bonekey.2016.58","DOIUrl":"https://doi.org/10.1038/bonekey.2016.58","url":null,"abstract":"","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2016.58","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58484507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BoneKEy reportsPub Date : 2016-07-20eCollection Date: 2016-01-01DOI: 10.1038/bonekey.2016.52
Kathrin Sinningen, Sylvia Thiele, Lorenz C Hofbauer, Martina Rauner
{"title":"Role of milk fat globule-epidermal growth factor 8 in osteoimmunology.","authors":"Kathrin Sinningen, Sylvia Thiele, Lorenz C Hofbauer, Martina Rauner","doi":"10.1038/bonekey.2016.52","DOIUrl":"https://doi.org/10.1038/bonekey.2016.52","url":null,"abstract":"<p><p>Milk fat globule-epidermal growth factor 8 (MFG-E8) is a glycoprotein that is abundantly expressed in various tissues and has a pivotal role in the phagocytic clearance of apoptotic cells. However, MFG-E8 has also gained significant attention because of its wide range of functions in autoimmunity, inflammation and tissue homeostasis. More recently, MFG-E8 has been identified as a critical regulator of bone homeostasis, being expressed in both, osteoblasts and osteoclasts. In addition, it was shown that MFG-E8 fulfils an active role in modulating inflammatory processes, suggesting an anti-inflammatory role of MFG-E8 and proposing it as a novel therapeutic target for inflammatory diseases. This concise review focusses on the expression and regulation of MFG-E8 in the context of inflammatory bone diseases, highlights its role in the pathophysiology of osteoimmune diseases and discusses the therapeutic potential of MFG-E8. </p>","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":"5 ","pages":"820"},"PeriodicalIF":0.0,"publicationDate":"2016-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954605/pdf/bonekey201652.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34350931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}