BJA open最新文献_第7页

Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium 脑脊液纤维蛋白原从术前到术后的变化与术后谵妄的关系

BJA open Pub Date : 2024-10-05 DOI: 10.1016/j.bjao.2024.100349

Thomas Payne , Jennifer Taylor , David Kunkel , Katherine Konieczka , Frankie Ingram , Kaj Blennow , Henrik Zetterberg , Robert A. Pearce , Anke Meyer-Franke , Niccolò Terrando , Katerina Akassoglou , Robert D. Sanders , Richard C. Lennertz

{"title":"Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium","authors":"Thomas Payne , Jennifer Taylor , David Kunkel , Katherine Konieczka , Frankie Ingram , Kaj Blennow , Henrik Zetterberg , Robert A. Pearce , Anke Meyer-Franke , Niccolò Terrando , Katerina Akassoglou , Robert D. Sanders , Richard C. Lennertz","doi":"10.1016/j.bjao.2024.100349","DOIUrl":"10.1016/j.bjao.2024.100349","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to assess perioperative changes in fibrinogen in the cerebrospinal fluid (CSF), their association with markers of blood–brain barrier breakdown and neuroinflammation, and their association with postoperative delirium severity.</div></div><div><h3>Methods</h3><div>We conducted a secondary analysis of the Interventions for Postoperative Delirium-Biomarker 2 (IPOD-B2, NCT02926417) study, a prospective observational cohort study. We included 24 patients aged >21 yr undergoing aortic aneurysm repair. CSF samples were obtained before (<em>n</em>=24) and after surgery (<em>n</em>=13), with some participants having multiple postoperative samples. Our primary outcome was the perioperative change in CSF fibrinogen. Delirium was assessed using the Delirium Rating Scale-Revised-98.</div></div><div><h3>Results</h3><div>CSF fibrinogen increased after surgery (<em>P</em><0.001), and this was associated with an increase in CSF/plasma albumin ratio (β=1.09, 95% CI 0.47–1.71, <em>P</em>=0.004). The peak change in CSF fibrinogen was associated with the change in CSF interleukin (IL)-10 and IL-12p70. The peak change in CSF fibrinogen was associated with the change in CSF total tau (β=0.47, 95% CI 0.24–0.71, <em>P</em>=0.002); however, we did not observe an association with postoperative delirium severity (incidence rate ratio = 1.20, 95% CI 0.66–2.17, <em>P</em>=0.540).</div></div><div><h3>Conclusions</h3><div>Our preliminary findings support the hypothesis that fibrinogen enters the brain via blood-brain barrier disruption, promoting neuroinflammation and neuronal injury. However, we did not observe an association between cerebrospinal fluid fibrinogen and peak delirium severity in this limited cohort.</div></div>","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"12 ","pages":"Article 100349"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of introduction of point-of-care viscoelastic testing on transfusion practice in major obstetric haemorrhage 引入护理点粘弹性测试对产科大出血输血实践的影响

BJA open Pub Date : 2024-10-01 DOI: 10.1016/j.bjao.2024.100316

A. Phillips, F. Breckenridge

引用次数: 0

Incidence of early postoperative cognitive dysfunction and overall patient and surgical risks in older patients undergoing cardiac surgery 接受心脏手术的老年患者术后早期认知功能障碍的发生率以及患者和手术的总体风险

BJA open Pub Date : 2024-10-01 DOI: 10.1016/j.bjao.2024.100317

Chyanis Vongseenin, Nicha Wongratanakarn, Wacharin Sindhvananda

引用次数: 0

Major haemorrhage: fluid communication to stem the flow 大出血：输液止血

BJA open Pub Date : 2024-10-01 DOI: 10.1016/j.bjao.2024.100321

A. Bundy, C. Rooney, C. Henderson, S. Meredith, G. Scotland

引用次数: 0

Innovative use of elective admission unit to deliver preoperative intravenous iron infusions 创新性地利用择期入院病房提供术前静脉注射铁剂

BJA open Pub Date : 2024-10-01 DOI: 10.1016/j.bjao.2024.100335

C. Bird, C. Pitchford, J. Simpson

引用次数: 0

Opioid stewardship amongst patients undergoing major robotic surgery at Eastbourne District General Hospital: an audit and quality improvement project 伊斯特本地区综合医院接受大型机器人手术患者的阿片类药物管理：审计与质量改进项目

BJA open Pub Date : 2024-10-01 DOI: 10.1016/j.bjao.2024.100336

J. Cowman, L. Beckett, J. Spiteri

引用次数: 0

Preoperative assessment and obstructive sleep apnoea: where and when to screen? 术前评估与阻塞性睡眠呼吸暂停：何时何地进行筛查？

BJA open Pub Date : 2024-10-01 DOI: 10.1016/j.bjao.2024.100328

Sef Carter, Thai Ha Dinh, Alfred Ball, Ishrat Hussain, Chanaka Karunaratne

引用次数: 0

Development of a Bayesian Deep Learning algorithm using multicentre pre-anaesthesia assessment data to predict surgical duration, blood loss, and patient placement (the Pre-Anesthesia AI Tool) 利用多中心麻醉前评估数据开发贝叶斯深度学习算法，以预测手术时间、失血量和患者安置情况（麻醉前人工智能工具）

BJA open Pub Date : 2024-10-01 DOI: 10.1016/j.bjao.2024.100315

Sujoy Kar, Saikat Sengupta, Bharath Potla, Jospin Dhivya, Chetana Korrapati, Triyanka Tiu, Sangita Reddy

引用次数: 0

Evaluation of anaesthesiologists’ knowledge about fluid therapy in paediatric anaesthesia 评估麻醉师对儿科麻醉液体疗法的了解程度

BJA open Pub Date : 2024-10-01 DOI: 10.1016/j.bjao.2024.100320

Patrick F.S. Machado , Bernardo L. da Nóbrega , Márcia A.D.M. Moreira , Idrys H.L. Guedes , Aline M.M.S. Neiva , Cleumy M.A. Gama , Arthur Moreira Meirelles

引用次数: 0

‘F-1 Pit crew’ multidisciplinary theatre team emergency front-of-neck access training programme F-1 Pit crew "多学科手术室团队颈前入路急救培训计划

BJA open Pub Date : 2024-10-01 DOI: 10.1016/j.bjao.2024.100333

Tamryn Miller, Clare Buffery, Tom Miller, Peter Groom

引用次数: 0