BJA open最新文献

{"title":"Sugammadex for preventIoN oF pOst-operative pulmoNary complIcAtions (SINFONIA): protocol for an embedded mixed-methods process evaluation","authors":"Charlotte Dunn,&nbsp;Bronwen Connolly,&nbsp;Bronagh Blackwood,&nbsp;Jonathan A. Silversides,&nbsp;Lydia M. Emerson","doi":"10.1016/j.bjao.2026.100856","DOIUrl":"10.1016/j.bjao.2026.100856","url":null,"abstract":"<div><h3>Background</h3><div>The Sugammadex for preventIoN oF pOst-operative pulmoNary complIcAtions (SINFONIA) trial is a multi-centre, pragmatic, randomised superiority trial comparing sugammadex with neostigmine to reverse neuromuscular block after major abdominal or thoracic surgery. Neuromuscular blocking agents are routinely administered during general anaesthesia to facilitate intubation, ventilation, and surgical access. Residual neuromuscular block remains common despite reversal and is associated with increased risk of post-operative pulmonary complications. Sugammadex reduces residual paralysis compared with neostigmine, but its effect on patient-centred outcomes remains uncertain, and clinical equipoise persists. As intervention delivery is embedded within complex intra-operative decision-making, variation in implementation may influence trial outcomes. An embedded process evaluation will characterise intervention delivery and identify contextual and organisational factors influencing implementation across sites. This protocol describes the rationale, aims, and methods of the SINFONIA process evaluation.</div></div><div><h3>Methods</h3><div>This embedded mixed-methods process evaluation is informed by the PrOcess Evaluation of Trials In Critical care (POETIC) framework, examining Context, Fidelity, Dose, Reach, and Quality of Delivery. A logic model was developed, describing relationships between contextual factors, intervention delivery and trial outcomes. An explanatory sequential design will first analyse quantitative data describing intervention delivery, followed by qualitative data explaining observed variation. Data will be collected via electronic survey and semi-structured interviews, with findings integrated with the main trial results.</div></div><div><h3>Discussion</h3><div>This embedded process evaluation will characterise SINFONIA intervention delivery across sites, explain how contextual factors shape implementation, and support interpretation of trial findings through integrated process evaluation evidence.</div></div><div><h3>Clinical trial registration</h3><div><span><span>ISRCTN.com</span><svg><path></path></svg></span> ISRCTN15109717. Registered on 21 December 2022.</div></div>","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100856"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective feasibility study of sleep, fatigue, and psychomotor performance in anaesthetic residents","authors":"Josh Davies,&nbsp;Daniel Butler,&nbsp;Alex Hunter,&nbsp;Jeremy Fabes","doi":"10.1016/j.bjao.2026.100634","DOIUrl":"10.1016/j.bjao.2026.100634","url":null,"abstract":"","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100634"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing spurious magnesium monitoring and prescribing in critically ill patients: completion of an audit cycle","authors":"Lydia Chong,&nbsp;Iain Ballantine,&nbsp;Kate E. Shipman","doi":"10.1016/j.bjao.2026.100600","DOIUrl":"10.1016/j.bjao.2026.100600","url":null,"abstract":"","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100600"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149004187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An evaluation of perioperative cardiopulmonary exercise testing services in University Hospitals Sussex East from September 2024 to January 2025","authors":"Ghajan Kugathaasan,&nbsp;Sri Bulathgama,&nbsp;Jia Stevens","doi":"10.1016/j.bjao.2026.100616","DOIUrl":"10.1016/j.bjao.2026.100616","url":null,"abstract":"","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100616"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149004370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational sessions for enhancing awareness about Perioperative Quality Improvement Programme among recovery nurses","authors":"Muhammad Ali,&nbsp;Mashail Zahra","doi":"10.1016/j.bjao.2026.100606","DOIUrl":"10.1016/j.bjao.2026.100606","url":null,"abstract":"","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100606"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149004513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-filled diamorphine syringes: optimising resource allocation and standardising practice in theatres","authors":"Kevin O’Neill,&nbsp;Alix Murphy,&nbsp;Catherine Poots","doi":"10.1016/j.bjao.2026.100621","DOIUrl":"10.1016/j.bjao.2026.100621","url":null,"abstract":"","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100621"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality improvement project: location of emergency anaesthetic drugs in operating theatres","authors":"Amber Saleem,&nbsp;Andrew Taylor,&nbsp;Christine James","doi":"10.1016/j.bjao.2026.100622","DOIUrl":"10.1016/j.bjao.2026.100622","url":null,"abstract":"","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100622"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149004515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative diabetes mellitus assessment for elective surgery","authors":"Holly James,&nbsp;Sundar Ashok","doi":"10.1016/j.bjao.2026.100603","DOIUrl":"10.1016/j.bjao.2026.100603","url":null,"abstract":"","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100603"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding preoperative workload: a traffic-light framework to quantify clinic complexity beyond the American Society of Anesthesiologists","authors":"Shreyas Shikaripura,&nbsp;Vippan Gongireddy,&nbsp;Chandrakanth Bijjal","doi":"10.1016/j.bjao.2026.100589","DOIUrl":"10.1016/j.bjao.2026.100589","url":null,"abstract":"","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100589"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of EasyWarm blankets and forced-air warming in the prevention of inadvertent perioperative hypothermia: a quality improvement audit","authors":"Abhishiek Samson,&nbsp;Stuart Fludger","doi":"10.1016/j.bjao.2026.100593","DOIUrl":"10.1016/j.bjao.2026.100593","url":null,"abstract":"","PeriodicalId":72418,"journal":{"name":"BJA open","volume":"19 ","pages":"Article 100593"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}