Biophysicist (Rockville, Md.)最新文献

Implementation of Specifications Grading in an Upper-Division Chemical Biology Lecture Course 高年级化学生物学讲座课程规范评分的实施

Biophysicist (Rockville, Md.) Pub Date : 2023-08-01 DOI: 10.35459/tbp.2022.000239

Jessica I. Kelz, Jose L. Uribe, M. Rasekh, Gemma R. Takahashi, Wyeth Gibson, Renée D. Link, K. McKnelly, Rachel W. Martin

{"title":"Implementation of Specifications Grading in an Upper-Division Chemical Biology Lecture Course","authors":"Jessica I. Kelz, Jose L. Uribe, M. Rasekh, Gemma R. Takahashi, Wyeth Gibson, Renée D. Link, K. McKnelly, Rachel W. Martin","doi":"10.35459/tbp.2022.000239","DOIUrl":"https://doi.org/10.35459/tbp.2022.000239","url":null,"abstract":"\u0000 Specifications grading is a student-centered assessment method that enables flexibility and opportunities for revision. Here, we describe the first known full implementation of specifications grading in an upper-division chemical biology course. Due to the rapid development of relevant knowledge in this discipline, the overarching goal of this class is to prepare students to interpret and communicate about current research. In the past, a conventional points-based assessment method made it challenging to ensure that satisfactory standards for student work were consistently met, particularly for comprehensive written assignments. Specifications grading was chosen because the core tenet requires students to demonstrate minimum learning objectives to achieve a passing grade and complete more content of increased cognitive complexity to achieve higher grades. This strict adherence to determining grades based on demonstrated skills is balanced by opportunities for revision or flexibility in assignment deadlines. These options are made manageable for the instructors through the use of a token economy with a limited number of tokens that students can choose to use when needed. Over the duration of the course, a validated survey on self-efficacy showed slight positive trends, student comprehension and demonstrated skills qualitatively improved, and final grade distributions were not negatively affected. Instructors noticed that discussions with students were more focused on course concepts and feedback, rather than grades, while overall grading time was reduced. Responses to university-administered student feedback surveys revealed some self-reported reduction in anxiety, as well as increased confidence in managing time and course material. Recommendations are provided on how to continue to improve the overall teaching and learning experience for both instructors and students.","PeriodicalId":72403,"journal":{"name":"Biophysicist (Rockville, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45021314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Undergraduate Tutorial for Simulating Flocking with the Vicsek Model 用Vicsek模型模拟群集的本科生教程

Biophysicist (Rockville, Md.) Pub Date : 2023-08-01 DOI: 10.35459/tbp.2022.000227

A. Tabatabai, Macquarrie Thomson, Reece Keller

引用次数: 0

Teaching Image Processing and Optical Engineering to University Biology Students 高等生物学学生的图像处理与光学工程教学

Biophysicist (Rockville, Md.) Pub Date : 2023-08-01 DOI: 10.35459/tbp.2022.000240

Thomas Zimmerman, R. Esquerra, Y. M. Chan, Anagha Kulkarni, N. Adelstein, Ashley Albright, Jiayu Luo, Ziah Dean, Salma Ahmed, Michelle Phillips, Simone Bianco, S. Capponi

引用次数: 0

Bringing Biophysics Outreach to a Rural County Fair 将生物物理学外展活动带到乡村集市

Biophysicist (Rockville, Md.) Pub Date : 2023-07-07 DOI: 10.35459/tbp.2022.000232

Collette Higgins, Mason Ong, Alexander Sedley, Jacob Brothers, Callie J. Miller, N. Wright

引用次数: 0

Modular, Articulated Models of DNA and Peptide Nucleic Acids for Nanotechnology Education 用于纳米技术教育的DNA和肽核酸的模块化、铰接模型

Biophysicist (Rockville, Md.) Pub Date : 2023-04-11 DOI: 10.35459/tbp.2022.000225

Caleigh M. Goodwin-Schoen, Rebecca E. Taylor

{"title":"Modular, Articulated Models of DNA and Peptide Nucleic Acids for Nanotechnology Education","authors":"Caleigh M. Goodwin-Schoen, Rebecca E. Taylor","doi":"10.35459/tbp.2022.000225","DOIUrl":"https://doi.org/10.35459/tbp.2022.000225","url":null,"abstract":"\u0000 Dynamic and flexible nucleic acid models can provide current and future scientists with physical intuition for the structure of DNA and the ways that DNA and its synthetic mimics can be used to build self-assembling structures and advanced nanomachines. As more research labs and classrooms dive into the field of structural nucleic acid nanotechnology, students and researchers need access to interactive, dynamic, handheld models. Here, we present a 3D-printable kit for the construction of DNA and peptide nucleic acid (PNA). We have engineered a previous modular DNA kit to reduce costs while improving ease of assembly, flexibility, and robustness. We have also expanded the scope of available snap-together models by creating the first 3D-printable models of γPNA, an emerging material for nuclease- and protease-resistance nanotechnology. Building on previous research, representative nucleic acid duplexes were split into logical monomer segments, and atomic coordinates were used to create solid models for 3D printing. We used a human factors approach to customize 3 types of articulated snap-together connectors that allow for physically relevant motion characteristic of each interface in the model. Modules are easy to connect and separate manually but stay together when the model is manipulated. To greatly reduce cost, we bundled these segments for printing, and we created a miniaturized version that uses less than half the printing material to build. Our novel 3D-printed articulated snap-together models capture the flexibility and robustness of DNA and γPNA nanostructures. Resulting handheld helical models replicate the geometries in published structures and can now flex to form crossovers and allow biologically relevant zipping and unzipping to allow complex demonstrations of nanomachines undergoing strand displacement reactions. Finally, the same tools used to create these models can be readily applied to other types of backbones and nucleobases for endless research and education possibilities.","PeriodicalId":72403,"journal":{"name":"Biophysicist (Rockville, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44734290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching 本质无序蛋白质作为研究整合教学的工具

Biophysicist (Rockville, Md.) Pub Date : 2023-03-23 DOI: 10.35459/tbp.2022.000221

K. Skriver, Signe A. Sjørup, A. Langkilde, Evanthia Balouka, Caspar S. Christensen, Kathrine Carbel, Jens N. V. Decker, D. N. Essenbæk, Justus F. Gräf, Camilla H. Jessen, Peter Kristensen, Christoffer Merrild, Tobias S. Mortensen, Isabella F. Nalepa, Bjørn W. Nordsteen, Sophie K. Svoren, M. van Hall, Jan Weicher, Malene L. Wind, Danping Zhang, Daniel Saar, Helle Blæsild, M. Stahlhut, K. V. Andersen, R. Dagil, B. Vestergaard, Marie L. Ryberg, B. Kragelund

{"title":"Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching","authors":"K. Skriver, Signe A. Sjørup, A. Langkilde, Evanthia Balouka, Caspar S. Christensen, Kathrine Carbel, Jens N. V. Decker, D. N. Essenbæk, Justus F. Gräf, Camilla H. Jessen, Peter Kristensen, Christoffer Merrild, Tobias S. Mortensen, Isabella F. Nalepa, Bjørn W. Nordsteen, Sophie K. Svoren, M. van Hall, Jan Weicher, Malene L. Wind, Danping Zhang, Daniel Saar, Helle Blæsild, M. Stahlhut, K. V. Andersen, R. Dagil, B. Vestergaard, Marie L. Ryberg, B. Kragelund","doi":"10.35459/tbp.2022.000221","DOIUrl":"https://doi.org/10.35459/tbp.2022.000221","url":null,"abstract":"2,2,2-trifluoroethanol (TFE) as well as SAXS and 1-anilino-8-naphthalene sulphonate (ANS) binding supports a molten globule character. (b) The homology block 1 (HB1) domain of VAR2CSA (VAR2CSA 818–859 ) shows heterogeneity and oligomerization, as seen from the very few peaks in the NMR spectrum and the diversity of peaks originating from the single tryptophan (see figure insert). Addition of crowding agents as polyethylene glycol led to disappearance of the signals and fluorescence quenching, without visible precipitation. (c) A region of the intracellular domain of interleukin 22 receptor A1 (IL22RA1 L447–L532 ) was confirmed to be disordered by NMR and circular dichroism, with distinct cis - trans isomerism. (d) A lipidated, disordered C-terminal tail of KRAS form oligomers leading to broad peaks in the 1 H-NMR spectrum, that can be partly resolved by sodium dodecyl sulfate addition, but with an increasing SAXS Kratky plot indicating the presence of remaining disorder. (e) The N-terminal domain of galectin 3 is disordered as evidenced by the low dispersion in the 15N-HSQC and the increasing SAXS Kratky plot. NMR data indicate that it binds lactose and galactose very weakly at low pH. (f) The NMR signals of dehydrin Rab16c shows a low dispersion in the 15 N-HSQC spectrum, indicative of disorder, and elutes in two populations on a Sephadex S75 column, corresponding in sizes to the presence of a monomer–dimer equilibrium. The results presented in this figure are all preliminary data and would need repetition and validation.","PeriodicalId":72403,"journal":{"name":"Biophysicist (Rockville, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47946602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

So Simple A Beginning: How Four Physical Principles Shape Our Living World by Raghuveer Parthasarathy 如此简单的开始：四项物理原理如何塑造我们的生活世界

Biophysicist (Rockville, Md.) Pub Date : 2023-02-15 DOI: 10.35459/tbp.2022.000230

C. H. Crouch

引用次数: 0

Integrating CURE in Basic Medical Courses: The Perspective of Mexican Medical Students 将CURE融入基础医学课程:墨西哥医学生的视角

Biophysicist (Rockville, Md.) Pub Date : 2023-02-06 DOI: 10.35459/tbp.2022.000220

Hassler Stefan Macías-Sánchez, Irene Gómez-Oropeza, A. Rodríguez-Marín, María Fernanda Romero-Espinoza, Joseline Arroyo-Hernández, Jorge Alberto Guevara-Díaz

引用次数: 0

Hooking Nonscientists on Biophysics 在生物物理学上吸引非科学家

Biophysicist (Rockville, Md.) Pub Date : 2022-12-28 DOI: 10.35459/tbp.2022.000224

R. Parthasarathy

引用次数: 0

National Academies Report and Biophysics Education 国家科学院报告和生物物理教育

Biophysicist (Rockville, Md.) Pub Date : 2022-12-01 DOI: 10.35459/tbp.2022.000229

Sam M. Safran

引用次数: 0