Biomarkers in cancer最新文献_第8页

Deep Sequencing of Serum Small RNAs Identifies Patterns of 5' tRNA Half and YRNA Fragment Expression Associated with Breast Cancer. 血清小rna深度测序鉴定与乳腺癌相关的5' tRNA半和YRNA片段表达模式

Biomarkers in cancer Pub Date : 2014-12-08 eCollection Date: 2014-01-01 DOI: 10.4137/BIC.S20764

Joseph M Dhahbi, Stephen R Spindler, Hani Atamna, Dario Boffelli, David Ik Martin

{"title":"Deep Sequencing of Serum Small RNAs Identifies Patterns of 5' tRNA Half and YRNA Fragment Expression Associated with Breast Cancer.","authors":"Joseph M Dhahbi, Stephen R Spindler, Hani Atamna, Dario Boffelli, David Ik Martin","doi":"10.4137/BIC.S20764","DOIUrl":"https://doi.org/10.4137/BIC.S20764","url":null,"abstract":"Small noncoding RNAs circulating in the blood may serve as signaling molecules because of their ability to carry out a variety of cellular functions. We have previously described tRNA- and YRNA-derived small RNAs circulating as components of larger complexes in the blood of humans and mice; the characteristics of these small RNAs imply specific processing, secretion, and physiological regulation. In this study, we have asked if changes in the serum abundance of these tRNA and YRNA fragments are associated with a diagnosis of cancer. We used deep sequencing and informatics analysis to catalog small RNAs in the sera of breast cancer cases and normal controls. 5' tRNA halves and YRNA fragments are abundant in both groups, but we found that a breast cancer diagnosis is associated with changes in levels of specific subtypes. This prompted us to look at existing sequence datasets of serum small RNAs from 42 breast cancer cases, taken at the time of diagnosis. We find significant changes in the levels of specific 5' tRNA halves and YRNA fragments associated with clinicopathologic characteristics of the cancer. Although these findings do not establish causality, they suggest that circulating 5' tRNA halves and YRNA fragments with known cellular functions may participate in breast cancer syndromes and have potential as circulating biomarkers. Larger studies with multiple types of cancer are needed to adequately evaluate their potential use for the development of noninvasive cancer screening. ","PeriodicalId":72377,"journal":{"name":"Biomarkers in cancer","volume":"6 ","pages":"37-47"},"PeriodicalIF":0.0,"publicationDate":"2014-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BIC.S20764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32918921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 145

Allele and genotype distributions of DNA repair gene polymorphisms in South Indian healthy population. 南印度健康人群DNA修复基因多态性的等位基因和基因型分布。

Biomarkers in cancer Pub Date : 2014-12-07 eCollection Date: 2014-01-01 DOI: 10.4137/BIC.S19681

Katiboina Srinivasa Rao, Abialbon Paul, Annan Sudarsan Arun Kumar, Gurusamy Umamaheswaran, Biswajit Dubashi, Karunanithi Gunaseelan, Steven Aibor Dkhar

{"title":"Allele and genotype distributions of DNA repair gene polymorphisms in South Indian healthy population.","authors":"Katiboina Srinivasa Rao, Abialbon Paul, Annan Sudarsan Arun Kumar, Gurusamy Umamaheswaran, Biswajit Dubashi, Karunanithi Gunaseelan, Steven Aibor Dkhar","doi":"10.4137/BIC.S19681","DOIUrl":"https://doi.org/10.4137/BIC.S19681","url":null,"abstract":"Various DNA repair pathways protect the structural and chemical integrity of the human genome from environmental and endogenous threats. Polymorphisms of genes encoding the proteins involved in DNA repair have been found to be associated with cancer risk and chemotherapeutic response. In this study, we aim to establish the normative frequencies of DNA repair genes in South Indian healthy population and compare with HapMap populations. Genotyping was done on 128 healthy volunteers from South India, and the allele and genotype distributions were established. The minor allele frequency of Xeroderma pigmentosum group A (XPA) G23A, Excision repair cross-complementing 2 (ERCC2)/Xeroderma pigmentosum group D (XPD) Lys751Gln, Xeroderma pigmentosum group G (XPG) His46His, XPG Asp1104His, and X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphisms were 49.2%, 36.3%, 48.0%, 23.0%, and 34.0% respectively. Ethnic variations were observed in the frequency distribution of these polymorphisms between the South Indians and other HapMap populations. The present work forms the groundwork for cancer association studies and biomarker identification for treatment response and prognosis. ","PeriodicalId":72377,"journal":{"name":"Biomarkers in cancer","volume":"6 ","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2014-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BIC.S19681","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32918920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

A standardized and reproducible urine preparation protocol for cancer biomarkers discovery. 一个标准化和可重复的尿液制备方案，用于癌症生物标志物的发现。

Biomarkers in cancer Pub Date : 2014-11-03 eCollection Date: 2014-01-01 DOI: 10.4137/BIC.S17991

Julia Beretov, Valerie C Wasinger, Peter Schwartz, Peter H Graham, Yong Li

引用次数: 16

Biomarkers of HIV-associated Cancer. hiv相关癌症的生物标志物。

Biomarkers in cancer Pub Date : 2014-07-03 eCollection Date: 2014-01-01 DOI: 10.4137/BIC.S15056

Brian Thabile Flepisi, Patrick Bouic, Gerhard Sissolak, Bernd Rosenkranz

引用次数: 16

Differential expression of cysteine dioxygenase 1 in complex karyotype liposarcomas. 半胱氨酸双加氧酶1在复杂核型脂肪肉瘤中的差异表达。

Biomarkers in cancer Pub Date : 2014-04-06 eCollection Date: 2014-01-01 DOI: 10.4137/BIC.S14683

Mohammed Shaker, Kara M Pascarelli, Matthew J Plantinga, Miles A Love, Alexander J Lazar, Davis R Ingram, Margaret von Mehren, Dina Lev, David Kipling, Dominique Broccoli

{"title":"Differential expression of cysteine dioxygenase 1 in complex karyotype liposarcomas.","authors":"Mohammed Shaker, Kara M Pascarelli, Matthew J Plantinga, Miles A Love, Alexander J Lazar, Davis R Ingram, Margaret von Mehren, Dina Lev, David Kipling, Dominique Broccoli","doi":"10.4137/BIC.S14683","DOIUrl":"https://doi.org/10.4137/BIC.S14683","url":null,"abstract":"Altered cysteine dioxygenase 1 (CDO1) gene expression has been observed in several cancers but has not yet been investigated in liposarcomas. The aim of this study was to evaluate CDO1 expression in a cohort of liposarcomas and to determine its association with clinicopathological features. Existing microarray data indicated variable CDO1 expression in liposarcoma subtypes. CDO1 mRNA from a larger cohort of liposarcomas was quantified by real time-PCR, and CDO1 protein expression was determined by immunohistochemistry (IHC) in more than 300 tumor specimens. Well-differentiated liposarcomas (WDLSs) had significantly higher CDO1 gene expression and protein levels than dedifferentiated liposarcomas (DDLSs) (P < 0.001). Location of the tumor was not predictive of the expression level of CDO1 mRNA in any histological subtype of liposarcoma. Recurrent tumors did not show any difference in CDO1 expression when compared to primary tumors. CDO1 expression was upregulated as human mesenchymal stem cells (hMSCs) undergo differentiation into mature adipocytes. Our results suggest that CDO1 is a marker of liposarcoma progression and adipogenic differentiation. ","PeriodicalId":72377,"journal":{"name":"Biomarkers in cancer","volume":"6 ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2014-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BIC.S14683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32271056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

An Antibody-based Blood Test Utilizing a Panel of Biomarkers as a New Method for Improved Breast Cancer Diagnosis. 利用一组生物标志物作为改进乳腺癌诊断的新方法的基于抗体的血液检测。

Biomarkers in cancer Pub Date : 2013-11-19 eCollection Date: 2013-01-01 DOI: 10.4137/BIC.S13236

Galit Yahalom, Daria Weiss, Ilya Novikov, Therese B Bevers, Laszlo G Radvanyi, Mei Liu, Benjamin Piura, Stefano Iacobelli, Maria T Sandri, Enrico Cassano, Tanir M Allweis, Arie Bitterman, Pnina Engelman, Luis M Vence, Marvin M Rosenberg

{"title":"An Antibody-based Blood Test Utilizing a Panel of Biomarkers as a New Method for Improved Breast Cancer Diagnosis.","authors":"Galit Yahalom, Daria Weiss, Ilya Novikov, Therese B Bevers, Laszlo G Radvanyi, Mei Liu, Benjamin Piura, Stefano Iacobelli, Maria T Sandri, Enrico Cassano, Tanir M Allweis, Arie Bitterman, Pnina Engelman, Luis M Vence, Marvin M Rosenberg","doi":"10.4137/BIC.S13236","DOIUrl":"https://doi.org/10.4137/BIC.S13236","url":null,"abstract":"In order to develop a new tool for diagnosis of breast cancer based on autoantibodies against a panel of biomarkers, a clinical trial including blood samples from 507 subjects was conducted. All subjects showed a breast abnormality on exam or breast imaging and final biopsy pathology of either breast cancer patients or healthy controls. Using an enzyme-linked immunosorbent assay, the samples were tested for autoantibodies against a predetermined number of biomarkers in various models that were used to determine a diagnosis, which was compared to the clinical status. Our new assay achieved a sensitivity of 95.2% [CI = 92.8-96.8%] at a fixed specificity of 49.5%. Receiver-operator characteristic curve analysis showed an area under the curve of 80.1% [CI = 72.6-87.6%]. These results suggest that a blood test which is based on models comprising several autoantibodies to specific biomarkers may be a new and novel tool for improving the diagnostic evaluation of breast cancer. ","PeriodicalId":72377,"journal":{"name":"Biomarkers in cancer","volume":"5 ","pages":"71-80"},"PeriodicalIF":0.0,"publicationDate":"2013-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BIC.S13236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31943643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Molecular profiling for breast cancer: a comprehensive review. 乳腺癌的分子分析:一个全面的综述。

Biomarkers in cancer Pub Date : 2013-10-29 DOI: 10.4137/BIC.S9455

Muaiad Kittaneh, Alberto J Montero, Stefan Glück

引用次数: 161

Can immunohistochemistry serve as an alternative to subjective histopathological diagnosis of oral epithelial dysplasia? 免疫组织化学可以替代口腔上皮发育不良的主观组织病理学诊断吗?

Biomarkers in cancer Pub Date : 2013-10-10 DOI: 10.4137/BIC.S12951

Ahmad A Abdulmajeed, Camile S Farah

引用次数: 23

Susceptibility to Cutaneous Squamous Cell Carcinoma in Renal Transplant Recipients Associates with Genes Regulating Melanogenesis Independent of their Role in Pigmentation. 肾移植受者对皮肤鳞状细胞癌的易感性与调节黑色素形成的基因相关，而与色素沉着无关。

Biomarkers in cancer Pub Date : 2013-10-07 eCollection Date: 2013-01-01 DOI: 10.4137/BIC.S12754

Per A Andresen, Dag A Nymoen, Kristina Kjærheim, Torbjørn Leivestad, Per Helsing

{"title":"Susceptibility to Cutaneous Squamous Cell Carcinoma in Renal Transplant Recipients Associates with Genes Regulating Melanogenesis Independent of their Role in Pigmentation.","authors":"Per A Andresen, Dag A Nymoen, Kristina Kjærheim, Torbjørn Leivestad, Per Helsing","doi":"10.4137/BIC.S12754","DOIUrl":"https://doi.org/10.4137/BIC.S12754","url":null,"abstract":"The highly polymorphic melanocortin 1 receptor (MC1R) gene plays a crucial role in pigmentation. Variants of the gene have been implicated in risk of cutaneous squamous cell carcinoma (SCC) in the general population. In renal transplant (RT) recipients these cancers are more aggressive and very common. To evaluate the risk of SCC relative to MC1R and the pigmentation-associated genes ASIP, TYR, and TYRP1, a group of 217 RT recipients with and without SCC was genotyped. Associations with SCC risk were indicated in carriers of the red hair color associated MC1R variant p.Arg151Cys (OR = 1.99; 1.05-3.75), and in carriers of two of any of the MC1R variants disclosed (OR = 2.36; 1.08-5.15). These associations appeared independent of traditionally protective phenotypes, also supported by the stratifications from skin phototype and hair color. A tendency towards an increased SCC risk was observed for a specific ASIP haplotype (OR = 1.87; 0.91-3.83), while no such associations were observed for the TYR and TYRP1 variants. Thus, the risk of developing SCC in RT patients is modulated by MC1R variation irrespective of phenotypes considered to be protective. Heterozygous combinations of MC1R variants appear to be more relevant in assessing SCC risk than the effects of variants individually. ","PeriodicalId":72377,"journal":{"name":"Biomarkers in cancer","volume":"5 ","pages":"41-7"},"PeriodicalIF":0.0,"publicationDate":"2013-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BIC.S12754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31824208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Circulating HER2 Extracellular Domain: A Specific and Quantitative Biomarker of Prognostic Value in all Breast Cancer Patients? 循环HER2细胞外结构域:所有乳腺癌患者预后价值的特异性定量生物标志物?

Biomarkers in cancer Pub Date : 2013-08-12 DOI: 10.4137/BIC.S12389

Walter P Carney, Dirk Bernhardt, Bharat Jasani

引用次数: 40