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Получение трансгенных эмбриональных стволовых клеток крысы с использованием системы CRISPR/Cpf1 для индуцируемого нокаута генов 利用CRISPR/Cpf1系统获取转基因胚胎干细胞，诱导基因淘汰赛
Biokhimiia (Moscow, Russia) Pub Date : 2021-07-01 DOI: 10.31857/S0320972521070046
В. В. Шерстюк, С. М. Закиян
{"title":"Получение трансгенных эмбриональных стволовых клеток крысы с использованием системы CRISPR/Cpf1 для индуцируемого нокаута генов","authors":"В. В. Шерстюк, С. М. Закиян","doi":"10.31857/S0320972521070046","DOIUrl":"https://doi.org/10.31857/S0320972521070046","url":null,"abstract":"","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43206827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Дефицит PTIP в В-лимфоцитах снижает запасание подкожного жира у мышей B淋巴细胞中PTIP缺乏减少小鼠皮下脂肪储存
Biokhimiia (Moscow, Russia) Pub Date : 2021-07-01 DOI: 10.31857/S0320972521070083
Y. Xu, D. Zhu, Q. Yang, D. Su, Y. Q. Chen
{"title":"Дефицит PTIP в В-лимфоцитах снижает запасание подкожного жира у мышей","authors":"Y. Xu, D. Zhu, Q. Yang, D. Su, Y. Q. Chen","doi":"10.31857/S0320972521070083","DOIUrl":"https://doi.org/10.31857/S0320972521070083","url":null,"abstract":"","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46109550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Эффекты ингибиторов супероксиддисмутазы и глюкозы на гибель клеток и образование активных форм кислорода в листьях гороха 超氧化物和葡萄糖抑制剂的作用会导致细胞死亡，并在豌豆叶中形成活性形式的氧气。
Biokhimiia (Moscow, Russia) Pub Date : 2021-07-01 DOI: 10.31857/S032097252107006X
В. Д. Самуилов, Д. Б. Киселевский, Е.В. Дзюбинская, О. И. Фролова
{"title":"Эффекты ингибиторов супероксиддисмутазы и глюкозы на гибель клеток и образование активных форм кислорода в листьях гороха","authors":"В. Д. Самуилов, Д. Б. Киселевский, Е.В. Дзюбинская, О. И. Фролова","doi":"10.31857/S032097252107006X","DOIUrl":"https://doi.org/10.31857/S032097252107006X","url":null,"abstract":"","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47034830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Пространственная структура и РНК-связывающие свойства Lsm-белка из Halobacterium salinarum Halobacterium salinarum Lsm蛋白的空间结构和rna结合特性
Biokhimiia (Moscow, Russia) Pub Date : 2021-07-01 DOI: 10.31857/S0320972521070034
М. С. Фандо, А. О. Михайлина, Н. В. Леконцева, С. В. Тищенко, А. Д. Никулин
{"title":"Пространственная структура и РНК-связывающие свойства Lsm-белка из Halobacterium salinarum","authors":"М. С. Фандо, А. О. Михайлина, Н. В. Леконцева, С. В. Тищенко, А. Д. Никулин","doi":"10.31857/S0320972521070034","DOIUrl":"https://doi.org/10.31857/S0320972521070034","url":null,"abstract":"","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45785334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Дофаминовый нейротрофический фактор мозга (CDNF): структура, функции и терапевтический потенциал 多巴胺神经营养因子(CDNF):结构、功能和治疗潜力
Biokhimiia (Moscow, Russia) Pub Date : 2021-07-01 DOI: 10.31857/S0320972521070071
Д В Ерёмин, Т. В. Ильчибаева, А. С. Цыбко
{"title":"Дофаминовый нейротрофический фактор мозга (CDNF): структура, функции и терапевтический потенциал","authors":"Д В Ерёмин, Т. В. Ильчибаева, А. С. Цыбко","doi":"10.31857/S0320972521070071","DOIUrl":"https://doi.org/10.31857/S0320972521070071","url":null,"abstract":"","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42805732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Моноаминоксидаза как потенциальный биологический маркер эффективности терапии психических заболеваний 单胺氧化酶作为精神疾病治疗有效性的潜在生物标志物
Biokhimiia (Moscow, Russia) Pub Date : 2021-06-01 DOI: 10.31857/s0320972521060142
Т.И. Сырейщикова, Ю. А. Грызунов, Н.В. Смолина, Г. Е. Добрецов, А.А. Комар, М. Г. Узбеков, Э. Ю. Мисионжник, А. В. Молодецких, Н. М. Максимова
{"title":"Моноаминоксидаза как потенциальный биологический маркер эффективности терапии психических заболеваний","authors":"Т.И. Сырейщикова, Ю. А. Грызунов, Н.В. Смолина, Г. Е. Добрецов, А.А. Комар, М. Г. Узбеков, Э. Ю. Мисионжник, А. В. Молодецких, Н. М. Максимова","doi":"10.31857/s0320972521060142","DOIUrl":"https://doi.org/10.31857/s0320972521060142","url":null,"abstract":"Conformational changes of the proteins participating in metabolic processes in human body may indicate the presence of serious pathological changes in it. The present work is devoted to evaluation of the state of patients with mental disorders by analyzing conformational changes of human serum albumin (HSA) by fluorescent methods. HSA is the important transport protein of blood plasma, binding various ligands, formed at metabolic processes. Changes in the structure of albumin molecule was detected by measuring of decay of fluorescent probe, K-35, bound to albumin globule and acting as a ligand-reporter. The measurements were carried out on serum albumin of the patients relating to different groups of mental pathology (29 patients with depression, 8 patients with schizophrenia). The data obtained while measuring serum albumin fluorescence for 7 healthy donors, were used as a control. It was shown, that the applied fluorescent method allowed us to distinguish statistically significantly average values of the parameters characterizing three time components of K-35 probe fluorescence decay for sick patients and healthy donors. The amplitude analysis of K-35 decay in fluorescence quenching (by nitrate anions) and ionic strength changes allowed us to differentiate the patients before and after treatment. Statistics of measurements collected so far is not sufficient to make early prognosis of the efficiency of therapy in the framework of the suggested fluorescent method. To prove the clinical significance of the obtained data the further investigation is carried out.","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48195922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Роль изменений экспрессии Homer1 в чувствительности к стрессу Homer1表达变化在压力敏感性中的作用
Biokhimiia (Moscow, Russia) Pub Date : 2021-06-01 DOI: 10.31857/s0320972521060014
В. В. Решетников, Наталья Петровна Бондарь
{"title":"Роль изменений экспрессии Homer1 в чувствительности к стрессу","authors":"В. В. Решетников, Наталья Петровна Бондарь","doi":"10.31857/s0320972521060014","DOIUrl":"https://doi.org/10.31857/s0320972521060014","url":null,"abstract":"","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42610033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Изменение экспрессии генов и нейровоспаление в гиппокампе после фокальной ишемии мозга: участие в индукции длительных когнитивных и психоэмоциональных нарушений 基因表达变化和海马体脑尖突缺血后的神经炎症:长期认知和精神疾病诱导
Biokhimiia (Moscow, Russia) Pub Date : 2021-06-01 DOI: 10.31857/s032097252106004x
Г. Т. Шишкина, Татьяна Сергеевна Калинина, Н. В. Гуляева, Д. А. Ланшаков, Николай Николаевич Дыгало
{"title":"Изменение экспрессии генов и нейровоспаление в гиппокампе после фокальной ишемии мозга: участие в индукции длительных когнитивных и психоэмоциональных нарушений","authors":"Г. Т. Шишкина, Татьяна Сергеевна Калинина, Н. В. Гуляева, Д. А. Ланшаков, Николай Николаевич Дыгало","doi":"10.31857/s032097252106004x","DOIUrl":"https://doi.org/10.31857/s032097252106004x","url":null,"abstract":"","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47342831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Длительная социальная изоляция приводит к снижению экспрессии предшественника BDNF и пролилэндопептидазы в структурах мозга крыс 长期的社会孤立导致了BDNF前身的表达和老鼠大脑中多肽增多酶的减少。
Biokhimiia (Moscow, Russia) Pub Date : 2021-06-01 DOI: 10.31857/s0320972521060087
С.Д. Ширенова, Надежда Николаевна Хлебникова, Наталия Александровна Крупина
{"title":"Длительная социальная изоляция приводит к снижению экспрессии предшественника BDNF и пролилэндопептидазы в структурах мозга крыс","authors":"С.Д. Ширенова, Надежда Николаевна Хлебникова, Наталия Александровна Крупина","doi":"10.31857/s0320972521060087","DOIUrl":"https://doi.org/10.31857/s0320972521060087","url":null,"abstract":"","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43340030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Современные представления о роли стресса в патогенезе хронических нейродегенеративных заболеваний 关于压力在慢性神经退行性疾病病原体中的作用的现代观点
Biokhimiia (Moscow, Russia) Pub Date : 2021-06-01 DOI: 10.31857/s0320972521060117
Л. Г. Хаспеков
{"title":"Современные представления о роли стресса в патогенезе хронических нейродегенеративных заболеваний","authors":"Л. Г. Хаспеков","doi":"10.31857/s0320972521060117","DOIUrl":"https://doi.org/10.31857/s0320972521060117","url":null,"abstract":"","PeriodicalId":72370,"journal":{"name":"Biokhimiia (Moscow, Russia)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41645188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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