Autism research : official journal of the International Society for Autism Research最新文献_第2页

A Cross-Sectional Study on Narrative Microstructure in Tamil-Speaking Autistic and Non-Autistic Children. 泰米尔语自闭症与非自闭症儿童叙事微观结构的横断面研究。

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-28 DOI: 10.1002/aur.70106

Madhumitha Saravanaperumal, Krupa Venkatraman, Aswathy Muraleedharan

{"title":"A Cross-Sectional Study on Narrative Microstructure in Tamil-Speaking Autistic and Non-Autistic Children.","authors":"Madhumitha Saravanaperumal, Krupa Venkatraman, Aswathy Muraleedharan","doi":"10.1002/aur.70106","DOIUrl":"https://doi.org/10.1002/aur.70106","url":null,"abstract":"Narrative skills involve retelling or generating stories, reflecting cognitive and communication development. This use of language is decontextualized and requires a fluent interplay of various components. Autistic children often demonstrate atypical language development and restricted communication tailored to specific needs. This cross-sectional study examines narrative microstructure in language-level-matched Tamil-speaking autistic children and those without autism, aged 3-5 years. Six microstructure parameters were analyzed through story-retelling and story-generation tasks to assess narrative abilities. The research included 38 Tamil-speaking children, divided based on autism diagnosis and matched for language level using standardized tests. The assessment focused on a retelling task and sequencing cards for story retelling (SR) and story generation (SG). The six microstructure variables evaluated were: total number of words (TNW), total number of utterances (TNU), mean length of utterances in words (MLU-W), mean length of utterances in morphemes (MLU-M), number of different words (NDW), and type-token ratio (TTR). The results indicated that autistic children consistently scored lower across all parameters, exhibiting difficulties with fluency and using shorter, simpler sentences. This study highlights the significance of narrative assessment in enhancing our understanding and support of language development in autistic children.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome. 对SHANK的坦率评估：SHANK3致病变异对Phelan McDermid综合征临床前模型的影响。

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-28 DOI: 10.1002/aur.70112

Vic Lin, Samantha M Matta, Julia E Dallman, Suzanne Hosie, Manon Moreau, Ashley E Franks, Thomas Bourgeron, Elisa L Hill-Yardin

{"title":"A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome.","authors":"Vic Lin, Samantha M Matta, Julia E Dallman, Suzanne Hosie, Manon Moreau, Ashley E Franks, Thomas Bourgeron, Elisa L Hill-Yardin","doi":"10.1002/aur.70112","DOIUrl":"https://doi.org/10.1002/aur.70112","url":null,"abstract":"Although there are as many as 40 preclinical models of the neurodevelopmental disorder Phelan McDermid syndrome (PMS, or 22q13.3 deletion syndrome), detailed phenotypic analyses to compare the effects of different pathogenic variants and inform treatment design are lacking. Here, we clarify behavioral traits (social, vocalization, repetitive and anxiety-like behavior), developmental trajectories, and motor activity in addition to changes in brain structure and function in 10 widely available Shank3 transgenic mouse models. Although behavioral deficits in Shank3B-/- and Shank3∆C/∆C mice were most extensively reported, each model reviewed here displayed autism-relevant behavioral traits. Most studies focused on assessing social, anxiety-like, and repetitive behavior, whereas few studies examined changes in vocalization, developmental milestones, motor function, or aggressive behavior. We did not identify any studies of gut function in the ten selected Shank3 models. Alterations in the gastrointestinal microbiome of Shank3-deficient mice are associated with changes in bacterial abundance and composition, which may impact social behavior and gastrointestinal function. Studying preclinical models can provide critical insights into molecular pathways contributing to PMS. Further research is needed to determine how various genetic variations in Shank3 impact the brain, behavior, and potentially the gastrointestinal system.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The National Prevalence of Neurodevelopmental Disorders and Their Associations With Health Conditions Among General Junior High School Students in China: Findings From the China Education Panel Survey. 中国普通初中生神经发育障碍患病率及其与健康状况的关系：来自中国教育小组调查的结果

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-25 DOI: 10.1002/aur.70111

Shu-Li Shen, Ning Pan, Jun-Shan Lin, Ying-Qian Chen, Li-Zi Lin, Li Cai, Zhao-Yan Liu, Qiang Feng, Jin Jing, Xin Wang

{"title":"The National Prevalence of Neurodevelopmental Disorders and Their Associations With Health Conditions Among General Junior High School Students in China: Findings From the China Education Panel Survey.","authors":"Shu-Li Shen, Ning Pan, Jun-Shan Lin, Ying-Qian Chen, Li-Zi Lin, Li Cai, Zhao-Yan Liu, Qiang Feng, Jin Jing, Xin Wang","doi":"10.1002/aur.70111","DOIUrl":"https://doi.org/10.1002/aur.70111","url":null,"abstract":"Neurodevelopmental disorders (NDDs) remain poorly understood in adolescents, particularly in middle-income countries like China. To assess NDDs prevalence and their associations with health conditions among Chinese general junior high school students, data from the China Education Panel Survey (CEPS, 2013-2015) were used. A total of 8324 junior high school students were included. Validated questionnaires and tests assessed NDDs (autism spectrum disorder [ASD], language disorder [LD], and attention-deficit/hyperactivity disorder [ADHD]) and health conditions (physical health through overweight/obesity and myopia; mental health through anxiety symptoms and depression symptoms; cognitive functioning through academic performance and cognitive ability; adherence to social norms). Of 8324 participants, 299 (4.59%) had NDDs. Students with NDDs showed higher rates of anxiety symptoms and poor cognitive ability compared to those without NDDs. Specific NDD associations included anxiety symptoms with LD and ADHD, depression symptoms with ASD and ADHD, and poor cognitive ability with ASD and LD. Sex-specific disparities were observed in the associations: the link between NDDs and depression symptoms was evident solely in boys, whereas the association between NDDs and academic performance was significant only in girls. Increased surveillance of NDDs prevalence nationwide and improved support services through better integration of families, schools, and society are needed.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Paradigm for Autism Spectrum Disorder Discrimination in Children Utilizing EEG Data Collected During Cartoon Viewing With a Focus on Atypical Semantic Processing. 儿童自闭症谱系障碍识别的新范式：基于非典型语义加工的儿童脑电分析。

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-23 DOI: 10.1002/aur.70105

Lin Deng, Meng-Jie Lu, Le-Tong Yang, Yue Zhang, Hang-Yu Tan, Miao Cao, Fei Li

{"title":"A New Paradigm for Autism Spectrum Disorder Discrimination in Children Utilizing EEG Data Collected During Cartoon Viewing With a Focus on Atypical Semantic Processing.","authors":"Lin Deng, Meng-Jie Lu, Le-Tong Yang, Yue Zhang, Hang-Yu Tan, Miao Cao, Fei Li","doi":"10.1002/aur.70105","DOIUrl":"https://doi.org/10.1002/aur.70105","url":null,"abstract":"Autism spectrum disorder (ASD) is characterized by impaired social interaction and communication skills, with semantic processing difficulties being a hallmark feature that significantly impacts social communication. While traditional neuroimaging studies have provided insights into language processing in ASD, ecological validity remains a challenge, particularly when assessing young children. This study introduces a novel approach to evaluate atypical semantic processing in children with ASD (aged 4-10 years) through electroencephalography (EEG) data collection during cartoon viewing, offering a more natural assessment environment. We developed an innovative methodology combining pretrained language models with regression techniques in a machine learning framework. The analysis incorporated the Six-dimensional Semantic Database system and EEG topographical mapping to investigate semantic processing preferences and neural mechanisms across various word dimensions. Our semantic processing model demonstrated robust performance with high sensitivity (91.3%) and moderate specificity (61.0%); findings successfully replicated in validation analysis. These results reveal distinct patterns in how children with ASD process semantic information, particularly in their integration and response to emotional semantic dimensions. These findings help us understand the language processing patterns in ASD and provide potential applications for auxiliary diagnosis in more natural settings, meeting important needs in clinical practice.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autistic Listeners Demonstrate Robust Lexically Guided Perceptual Learning. 自闭症听众表现出强大的词汇引导感知学习。

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-23 DOI: 10.1002/aur.70078

Shawn N Cummings, Brooke Duda, Rachel M Theodore

{"title":"Autistic Listeners Demonstrate Robust Lexically Guided Perceptual Learning.","authors":"Shawn N Cummings, Brooke Duda, Rachel M Theodore","doi":"10.1002/aur.70078","DOIUrl":"https://doi.org/10.1002/aur.70078","url":null,"abstract":"Listeners accommodate rampant variability in speech input, at least in part, by adapting to structured phonetic variation. However, most work demonstrating this type of perceptual learning has focused on group-level effects in modal populations. This approach masks potentially meaningful differences-present among all listeners but particularly associated with autism-in sensory perception, social functioning, and language processing. These differences may be expected to influence adaptation, but their roles remain unclear. The present investigation aimed to clarify the relationships between autism, perceptual acuity, and adaptation. Listeners (n = 80, of which 40 were diagnosed with autism) were exposed to spectral energy ambiguous between /s/ and /ʃ/ in lexical contexts designed to elicit adaptation. Learning was assessed by comparing categorization of an ashi-asi test continuum before and after the critical lexically guided exposure. Autistic traits and pitch pattern sensitivity were also assessed. Robust learning was observed by both the general population and autistic listeners, with no evidence to suggest that learning was associated with autistic traits or pitch pattern sensitivity. These results advance theories of speech adaptation by constraining determinants of lexically guided perceptual learning to suggest that the social language traits of autism may be orthogonal to adaptation in speech perception.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Anxiety in Autistic and Non-Autistic Youth: Validation of the German Parent Version of the Anxiety Scale for Children With Autism Spectrum Disorder. 评估自闭症与非自闭症青少年的焦虑：德文家长版自闭症谱系障碍儿童焦虑量表的验证。

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-21 DOI: 10.1002/aur.70107

Magdalena Gruner, Veit Roessner, Melanie Ring

{"title":"Assessing Anxiety in Autistic and Non-Autistic Youth: Validation of the German Parent Version of the Anxiety Scale for Children With Autism Spectrum Disorder.","authors":"Magdalena Gruner, Veit Roessner, Melanie Ring","doi":"10.1002/aur.70107","DOIUrl":"https://doi.org/10.1002/aur.70107","url":null,"abstract":"Anxiety is a prevalent co-occurring disorder in autistic youth, yet its accurate assessment remains challenging due to symptom overlap with autism. The Anxiety Scale for Children with Autism Spectrum Disorder-Parent Version (ASC-ASD-P) was designed to address this issue, but its utility in German clinical settings has not been established. This study validated the German translation of the ASC-ASD-P in a clinical sample of 317 participants presenting at a clinic for autism assessment, including 120 autistic youth. Internal consistency was excellent (Cronbach's α = 0.92), and convergent validity was demonstrated through significant correlations with established psychopathology measures such as the Child Behavior Checklist (CBCL) and Strengths and Difficulties Questionnaire (SDQ). Factor analyses preferred a 4-factor structure in the autism group, but indicated difficulties replicating the Separation Anxiety Subscale. Autistic youth showed higher total anxiety and uncertainty scores compared to non-autistic youth, underlining the scale's sensitivity to autism-specific anxiety patterns. By including youth with intellectual disabilities, often underrepresented in research, this study provides a more comprehensive evaluation of the ASC-ASD-P's applicability across the autism spectrum. These findings support the ASC-ASD-P as a reliable tool for assessing anxiety in German-speaking autistic youth while highlighting areas where refinement could strengthen its utility.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Brain Network Connectivity and Cognitive Measures in Autism Spectrum Disorder: A Post Hoc Analysis of a Parent Study "Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder". 自闭症谱系障碍中脑网络连通性与认知测量之间的关系：一项“评估经颅脉冲刺激治疗自闭症谱系障碍的安全性和有效性”的父母研究的事后分析。

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-21 DOI: 10.1002/aur.70093

Chun Liang Hsu, Eva Matt, Tommy Kwan Hin Fong, Joyce Yuen Ting Lam, Bolton Chau, Calvin Pak Wing Cheng, Roland Beisteiner, Teris Cheung

{"title":"Associations Between Brain Network Connectivity and Cognitive Measures in Autism Spectrum Disorder: A Post Hoc Analysis of a Parent Study \"Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder\".","authors":"Chun Liang Hsu, Eva Matt, Tommy Kwan Hin Fong, Joyce Yuen Ting Lam, Bolton Chau, Calvin Pak Wing Cheng, Roland Beisteiner, Teris Cheung","doi":"10.1002/aur.70093","DOIUrl":"https://doi.org/10.1002/aur.70093","url":null,"abstract":"This study presents a post hoc analysis of our parent study \"Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder\" study which was a double-blind, sham-controlled, randomized controlled trial. In this study, we examined associations between changes in brain network connectivity and cognitive performance in young adolescents (12-17 years) with autism spectrum disorder (ASD) following the administration of transcranial pulse stimulation (TPS) which is considered non-invasive, evidenced-based brain stimulation for neurodegenerative disorders and neuropsychiatric disorders. Our findings indicate that increased connectivity in specific brain networks is associated with improvements in cognitive measures, suggesting that connectivity changes may underpin cognitive changes observed after six TPS intervention. These results highlight potential neural mechanisms underlying cognitive improvements in ASD, although causality cannot be inferred from these associations. Trial Registration: ClinicalTrials.gov identifier: NCT05408793.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining Associations Between Social Experiences and Loneliness Among Autistic Youth. 研究自闭症青少年的社会经历与孤独之间的关系。

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-20 DOI: 10.1002/aur.70115

Natalie Libster, Julie Lounds Taylor, Shuting Zheng, Somer Bishop, Ryan Adams

{"title":"Examining Associations Between Social Experiences and Loneliness Among Autistic Youth.","authors":"Natalie Libster, Julie Lounds Taylor, Shuting Zheng, Somer Bishop, Ryan Adams","doi":"10.1002/aur.70115","DOIUrl":"10.1002/aur.70115","url":null,"abstract":"To develop targeted interventions aimed at reducing loneliness among autistic youth, it is critical to understand which social experiences are associated with loneliness in this population. The current study examined associations between loneliness, social interaction/solitary experiences (i.e., time spent interacting and alone, feelings during time spent interacting and alone) and peer experiences (i.e., victimization, being ignored, and being included) among autistic youth. Autistic youth (N = 241) between 15 and 26 years old (M = 18.7) completed online surveys that measured their levels of loneliness and the degrees to which they were victimized, ignored, and included by peers. Furthermore, at 9 PM each day for 7 consecutive days, participants were prompted via a smartphone app to report events that occurred within five specific time frames throughout that day. Youth reported how long they participated in each event, whether they were interacting with others or alone, and for the longest lasting activity in each time frame, the degree to which they experienced positive and negative feelings. Results revealed that more negative feelings when interacting and when alone were associated with increased loneliness, whereas more positive feelings when alone were associated with reduced loneliness. Neither time spent interacting nor time spent alone was significantly associated with loneliness. Greater frequency of being ignored was also associated with increased loneliness. Therefore, rather than focusing on the amount of time autistic youth spend interacting and alone, it is equally important for future interventions to consider ways to increase youth's satisfaction with the quantity and quality of their social interactions.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Risk of Autism Spectrum Disorder in Descendants of Women With Gestational Diabetes and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis". 妊娠期糖尿病和多囊卵巢综合征妇女后代自闭症谱系障碍的风险：一项系统综述和荟萃分析。

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-20 DOI: 10.1002/aur.70110

Francisca Bravo-Muñoz, Isidora Bustos, Diana Muñoz-Fierro, Sofía San-Martín, Catalina Tabilo, Macarena Véliz, Taide Zaror, Paulina Ormazabal, Nele Brusselaers, Romina Fornes

{"title":"\"Risk of Autism Spectrum Disorder in Descendants of Women With Gestational Diabetes and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis\".","authors":"Francisca Bravo-Muñoz, Isidora Bustos, Diana Muñoz-Fierro, Sofía San-Martín, Catalina Tabilo, Macarena Véliz, Taide Zaror, Paulina Ormazabal, Nele Brusselaers, Romina Fornes","doi":"10.1002/aur.70110","DOIUrl":"https://doi.org/10.1002/aur.70110","url":null,"abstract":"Some reports show that children exposed to hyperandrogenemia or hyperglycemic states in utero are more prone to be diagnosed with autism spectrum disorder (ASD). This systematic review and meta-analysis aim to assess the association between Polycystic Ovary Syndrome (PCOS) or gestational diabetes (GD) and ASD. A systematic review (1980-2023) in Web of Science, PubMed and Scopus, using specific search terms \"gestational diabetes\", \"polycystic ovary syndrome,\" \"neurodevelopmental disorder\" and \"autism spectrum disorder\" was performed. Generic inverse-variance method was used to pool the adjusted or crude effect measures with a random-effects model. Results were presented as relative risk (RR) with 95% confidence interval (CI). Only studies from the northern hemisphere were found. All the articles evaluated the association between either GD (n = 16) or PCOS (8) and ASD separately. The overall analysis revealed that there is an increased risk of ASD in the offspring of women diagnosed with GD [RR = 1.23 (95% CI 1.13-1.34), n = 14] and in women diagnosed with PCOS [RR = 1.35 (95% CI 1.17-1.56), n = 6]. In a sensitivity analysis, the risk of ASD was particularly higher in mothers with GD and obesity. Although both GD and PCOS have been associated with ASD in offspring, studies in other geographical regions are needed. Future research should investigate how varying androgen levels in PCOS and the timing of GD diagnosis might influence the observed associations. Additional studies are needed to confirm these associations, address potential confounding variables, and explore whether these maternal conditions contribute directly or indirectly to autism risk.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life in Autistic Children: Discrepancies Between Self- and Caregiver-Proxy Reports and Associations With Individual Characteristics. 自闭症儿童的生活质量：自我和照顾者代理报告之间的差异以及与个体特征的关联。

IF 5.6

Autism research : official journal of the International Society for Autism Research Pub Date : 2025-08-18 DOI: 10.1002/aur.70108

Emily C Skaletski, Rebekah M Rodriguez, Sharon G Gartland, Karla K Ausderau, Lauren Bishop, James J Li, Brittany G Travers

{"title":"Quality of Life in Autistic Children: Discrepancies Between Self- and Caregiver-Proxy Reports and Associations With Individual Characteristics.","authors":"Emily C Skaletski, Rebekah M Rodriguez, Sharon G Gartland, Karla K Ausderau, Lauren Bishop, James J Li, Brittany G Travers","doi":"10.1002/aur.70108","DOIUrl":"10.1002/aur.70108","url":null,"abstract":"Quality of life (QoL) is important for everyone and has been identified as a priority for autistic people. However, studies typically focus on caregiver-proxy-reported QoL and its related individual characteristics, even though self- and caregiver-proxy-reported QoL may differ in autistic children. In 74 autistic children (5.04-10.99 years old, intelligence quotient [IQ] 47-141), we sought to determine the level of agreement between self- and caregiver-proxy-reported QoL and determine if self- and caregiver-proxy-reported QoL are differently related to personal characteristics such as age, IQ, autism features, attention-deficit/hyperactivity disorder (ADHD) features, sleep difficulties, and sensory features. Findings suggested poor inter-rater agreement (ICC = 0.16) between self- and caregiver-proxy-reported QoL. Across both self- and caregiver-proxy reports, sensory features and sleep difficulties related to QoL, but age and IQ did not. We also found an interaction effect of reporter on the relation between QoL and both autism and ADHD features, with these associations driven by caregiver-proxy-reported QoL. These findings emphasize the importance of measuring both self- and caregiver-proxy-reported QoL to provide complementary perspectives. Moreover, these results underscore the importance of understanding a child's sensory features and sleep difficulties, as these two areas were similarly related to both self- and caregiver-proxy-reported QoL.","PeriodicalId":72339,"journal":{"name":"Autism research : official journal of the International Society for Autism Research","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0