AsiaIntervention最新文献

{"title":"A randomised clinical trial investigating robotic-assisted percutaneous coronary intervention: the PARTY trial.","authors":"James Leung, John French, James Xu, Kathryn Wales, Hashim Kachwalla, Krishna Kaddapu, Sarah Fares, Viet Dang, Tamer Badie, Christian Mussap, Rohan Rajaratnam, Dominic Leung, Sidney Lo, Craig Juergens","doi":"10.4244/AIJ-D-25-00066","DOIUrl":"10.4244/AIJ-D-25-00066","url":null,"abstract":"<p><strong>Background: </strong>Robotic-assisted percutaneous coronary intervention (R-PCI) allows precise control of percutaneous coronary intervention (PCI) equipment with the operator in a radiation-shielded cockpit.</p><p><strong>Aims: </strong>We aimed to address the lack of randomised studies investigating this emerging technology.</p><p><strong>Methods: </strong>In this single-centre, randomised controlled trial, patients with symptomatic coronary disease underwent either R-PCI or manual PCI (M-PCI). The primary endpoint was patient radiation exposure. Secondary outcomes included radiation exposure to the medical team, overall subjective workload, and other procedural characteristics.</p><p><strong>Results: </strong>A total of 148 patients were randomised (72 R-PCI, 76 M-PCI), with a median age of 63.2 years (interquartile range [IQR] 55.5-69.5), and 82.4% were male. In the intention-to-treat analysis, R-PCI numerically reduced patient radiation exposure (230.7 microsieverts [μSv; IQR 104.0-443.7] vs 261.4 µSv [IQR 136.5-531.2]; p=0.14). This reduction became statistically significant in the as-treated analysis (218.5 µSv [IQR 100.0-375.3] vs 264.7 µSv [IQR 136.3-534.8]; p=0.03). R-PCI significantly reduced operator radiation exposure (0.1 µSv [IQR 0.1-0.3] vs 13.6 µSv [IQR 6.0-29.2]; p<0.0001) and contrast usage (75 mL [IQR 50-120] vs 100 mL [IQR 70-130]; p=0.001). R-PCI did not prolong PCI time (40 mins [IQR 25.3-58.8] vs 46 mins [IQR 31.0-55.8]; p=0.23). Seven R-PCI cases (9.7%) required manual conversion. R-PCI reduced operator workload (NASA Task Load Index 12.5 [IQR 9.4-30] vs 25 [IQR 11.3-45]; p<0.01). There were no major adverse cardiac events at 30 days.</p><p><strong>Conclusions: </strong>Patient radiation exposure was numerically reduced with R-PCI, while operator radiation exposure was significantly reduced, without prolonging PCI time. Furthermore, R-PCI reduced contrast use and was found to be less onerous for the operator. These results are encouraging; however, there are important limitations that must be addressed before wider adoption.</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 2","pages":"e136-e145"},"PeriodicalIF":0.0,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13397417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACEF score and its predictive performance in coronary artery disease patients undergoing PCI: a systematic review and meta-analysis of the C-statistic.","authors":"Shinta Dewi Rasti, Rosi Amrilla Fagi, Militanisa Zamzara Arvianti, Adra Achirultan Ramainaldo Sugiarto, Audia Putri Amalia Nuryandi, Rizky Istifarina, Chiquita Febby Pragitara, Romadhana Trisnha Yomara, Yudi Her Oktaviono","doi":"10.4244/AIJ-D-25-00031","DOIUrl":"10.4244/AIJ-D-25-00031","url":null,"abstract":"<p><strong>Background: </strong>Despite being minimally invasive, percutaneous coronary intervention (PCI) presents challenges, especially regarding major adverse cardiovascular events (MACE), which typically occur within the first year after intervention. Furthermore, many existing MACE prediction models are complex and challenging to apply in clinical practice.</p><p><strong>Aims: </strong>This study evaluated the simple Age, Creatinine, Ejection Fraction (ACEF) score for predicting outcomes in coronary artery disease patients undergoing PCI.</p><p><strong>Methods: </strong>A meta-analysis of randomised controlled trials (RCTs) and cohort studies was conducted using six prominent databases. Predictive performance was assessed with the C-statistic, with MACE as the primary endpoint and mortality and ACEF modifications as secondary endpoints. Outcomes reported in at least two studies were included.</p><p><strong>Results: </strong>Twenty studies involving 41,255 patients were analysed, including three RCTs and eight multicentre studies. Key findings include the following: (1) the ACEF score showed good discrimination for <=30-day MACE (area under the curve [AUC] 0.71), (2) it demonstrated stronger predictive ability for both cardiac mortality (AUC 0.75 at 2 years) and all-cause mortality (AUC 0.82 at <=30 days), and (3) its performance was comparable to more complex scores, such as the modified ACEF (mACEF), the Age, Glomerular filtration rate, Ejection Fraction (AGEF), and the clinical SYNTAX scores.</p><p><strong>Conclusions: </strong>Adhering to the law of parsimony, the ACEF score is a straightforward tool based on objectively measured variables. The ACEF score effectively predicts MACE and mortality at <=30 days in PCI patients. Its simplicity and accessibility highlight its value as a practical tool for clinical risk stratification. (PROSPERO Identifier CRD42024558580).</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 2","pages":"e146-e155"},"PeriodicalIF":0.0,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13397422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraluminal rendezvous via IVUS catheter in a superficial femoral artery chronic total occlusion.","authors":"Kazunori Omote, Daisuke Sunaga, Ryosuke Ito, Naohiro Funayama","doi":"10.4244/AIJ-D-25-00079","DOIUrl":"10.4244/AIJ-D-25-00079","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 2","pages":"e160-e161"},"PeriodicalIF":0.0,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13440518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double-kissing single-string culotte bifurcation stenting guided by optical coherence tomography.","authors":"Bernard Wong, Eugene Brian Wu","doi":"10.4244/AIJ-D-25-00038","DOIUrl":"10.4244/AIJ-D-25-00038","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 1","pages":"60-61"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flipping the focus - treating post-capillary pulmonary hypertension with pulmonary artery denervation.","authors":"Joseph P Hart, Mark G Davies","doi":"10.4244/AIJ-D-26-00006","DOIUrl":"10.4244/AIJ-D-26-00006","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 1","pages":"14-16"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiographic and functional assessment after paclitaxel or sirolimus drug-coated balloons for de novo coronary artery disease in small vessels: PICCOLETO VI study.","authors":"Simone Fezzi, Mauro Gitto, Aurora Trevisanello, Faisal Sharif, Gabriele Venturi, Jacek Bezubka, Sylwia Iwanczyk, Wojciech Wanha, Michał Hawranek, Maksymilian Mielczarek, Piotr Wańczura, Monica Verdoia, Pietro Pieri, Antonio Mugnolo, Bharat Khialani, Ilya Litovchik, Antoinette Monayer, Tuomas T Rissanen, Flavio Ribichini, Antonio Colombo, Bernardo Cortese","doi":"10.4244/AIJ-D-25-00057","DOIUrl":"10.4244/AIJ-D-25-00057","url":null,"abstract":"<p><strong>Background: </strong>Paclitaxel-coated balloons (PCB) have strong supporting evidence for use in small coronary vessels, while sirolimus-coated balloons (SCB) have shown variable angiographic results, raising questions about their overall effectiveness.</p><p><strong>Aims: </strong>The PICCOLETO VI study aimed to compare the angiographic and physiological outcomes of various PCB and SCB technologies in treating <i>de novo</i> coronary artery disease.</p><p><strong>Methods: </strong>This international, multicentre study included patients who underwent percutaneous coronary intervention and had elective angiographic follow-up 5-9 months later. Angiographic and physiological assessments were performed by a core laboratory, including Murray law-based quantitative flow ratio (μFR).</p><p><strong>Results: </strong>Based on a cohort of 293 patients, 227 lesions treated either with a PCB (n=148) or an SCB (n=79) were included. No differences in terms of baseline clinical or angiographic characteristics were reported between the two cohorts. PCB showed lower late lumen loss (-0.05±0.56 mm vs +0.10±0.59 mm; p=0.05) and a higher prevalence of late lumen enlargement (58.1% vs 40.5%; p=0.01). The primary endpoint of late functional loss was not statistically different, with a trend in favour of PCB (-0.01±0.15 vs +0.03±0.13; p=0.09). There was no difference in terms of target lesion failure, with a higher rate of ischaemia-inducing vessels at follow-up in the SCB group (14.9% vs 26.6%; p=0.03). A μFR <=0.86 following drug-coated balloon (DCB) treatment emerged as a reliable cutoff for predicting follow-up ischaemia, with an accuracy of 80%, whereas no significant interaction was observed for a post-DCB angiographic degree of stenosis >=30%.</p><p><strong>Conclusions: </strong>In this direct comparison between two classes of DCB, late functional loss was comparable between PCB and SCB, with PCB confirming superior angiographic performance.</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 1","pages":"28-40"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the hidden: a surprising discovery in a patient with LAD in-stent restenosis.","authors":"Atul Kaushik, Avinash Mani, Vijay Kumar, Vishal Rastogi, Ashok Seth","doi":"10.4244/AIJ-D-25-00030","DOIUrl":"10.4244/AIJ-D-25-00030","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 1","pages":"62-63"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excimer laser coronary atherectomy-assisted percutaneous coronary intervention in complex coronary artery lesions: an early Indian experience.","authors":"Kirti Punamiya, A V Ganesh Kumar","doi":"10.4244/AIJ-D-25-00033","DOIUrl":"10.4244/AIJ-D-25-00033","url":null,"abstract":"<p><strong>Background: </strong>Excimer laser coronary atherectomy (ELCA) to modify or debulk atherosclerotic plaque during percutaneous coronary intervention (PCI) has been in clinical use for the past four decades. Primarily, ELCA was introduced to mitigate the challenges posed by routine PCI for complex lesions and in crossing resistant lesions.</p><p><strong>Aims: </strong>The aim of the present study was to evaluate the efficacy and safety of ELCA in complex coronary lesions.</p><p><strong>Methods: </strong>This study included 71 consecutive patients who underwent treatment with ELCA-assisted PCI for complex coronary lesions. The data were analysed for the incidence of procedural success and related complications with major adverse cardiovascular outcomes at baseline, post-procedure, 1-month and 6-month follow-up.</p><p><strong>Results: </strong>The study included 71 real-world patients with highly complex lesion subsets, comprising uncrossable chronic total occlusions (CTOs; 26 [33.77%]), moderately to heavily calcified lesions (33 [42.86%]), long diffused in-stent restenosis (ISR) lesions (30 [38.96%]), and ST-segment elevation myocardial infarction with a large thrombus burden (27 [35.06%]). The study population was predominantly male (87.32%), including 71 individuals with a mean age of 63.51±13.57 years. The mean left ventricular ejection fraction (LVEF) was 45.1±11.6%; however, 15 patients (21.13%) had an LVEF of <30%. A total of 31 (43.66%) patients had a SYNTAX score of >22. The direct use of maximum energy as a default setting was used in 52 patients (85.3%) and was not associated with any procedural or patient complications. No major adverse cardiac events (MACE) were reported during hospitalisation. The cumulative procedural success rate was 100%, and the device success rate was 96.10%. The 6-month incidence of MACE was significantly low at 2 (2.82%) and was attributed to target vessel revascularisations only.</p><p><strong>Conclusions: </strong>In this study, ELCA was observed to be an effective and safe device, making it a suitable alternative strategy for complex PCI in patients with difficult-to-cross lesions such as CTO, ISR, heavily thrombotic lesions, and calcified lesions. In difficult-to-cross lesions, even when the ELCA device failed to advance across, the delivered ELCA energy modified the lesion sufficiently to render it crossable. There were no safety concerns despite the direct use of maximum energy as a default strategy in this study population.</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 1","pages":"50-57"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: The AHEAD score in acute myocardial infarction: a call for more rigorous validation.","authors":"Mike Saji","doi":"10.4244/AIJ-D-25-00097","DOIUrl":"10.4244/AIJ-D-25-00097","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 1","pages":"70-71"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head-to-head comparison of limus- versus paclitaxel-coated balloons in the treatment of in-stent restenosis: a meta-analysis.","authors":"Marios Sagris, Stergios Soulaidopoulos, Nikolaos Ktenopoulos, Angelos Papanikolaou, Kyriakos Dimitriadis, Nikolaos Patsourakos, Dimitris Tousoulis, Bruno Scheller, Antonio Colombo, Konstantinos Tsioufis","doi":"10.4244/AIJ-D-25-00029","DOIUrl":"10.4244/AIJ-D-25-00029","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of robust comparative data between limus drug-coated balloons (DCBs) versus paclitaxel-coated balloons (PCBs) on their efficacy and safety in treating in-stent restenosis (ISR).</p><p><strong>Aims: </strong>The objective of this systematic review and meta-analysis was to compare the efficacy and safety of limus DCBs versus PCBs in terms of clinical and angiographic outcomes during a 12-month follow-up.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we systematically explored PubMed, Scopus, and Cochrane databases up to 20 February 2025 for studies comparing limus DCBs versus PCBs in terms of safety, efficacy, and angiographic outcomes in treating ISR. The primary outcomes were the incidence of clinically driven target lesion revascularisation (TLR) and failure (TLF). Secondary endpoints were major adverse cardiovascular events (MACE) and angiographic findings during follow-up.</p><p><strong>Results: </strong>Data from six randomised controlled trials (RCTs), including a total of 639 patients treated with limus DCBs and 569 with PCBs for ISR, were analysed with a mean follow-up of 12 months. In this analysis, all six RCTs reported on TLR (limus DCB 14% vs PCB 11.4%) and TLF (limus DCB 15% vs PCB 14%) incidence, showing no significant difference between the limus DCB and PCB groups. No significant differences were observed in MACE (16.4% vs 13.5%), all-cause mortality (1.8% vs 1.4%), cardiac death (1.4% vs 1.0%) or target vessel myocardial infarction (0.9% vs 1.0%), for limus DCBs versus PCBs, respectively. Angiographic outcomes showed no significant differences in post-intervention minimal lumen diameter (standardised mean difference [SMD] +0.06, 95% confidence interval [CI]: -0.07 to 0.18; I²=0%) or binary restenosis (limus DCB 19.5% vs PCB 12.9%) at follow-up between the groups. The risk of late lumen loss was also comparable between limus DCBs and PCBs for both in-segment (SMD +0.02, 95% CI: -0.18 to 0.23; I²=32%) and in-lesion (SMD -0.03, 95% CI: -0.31 to 0.24; I²=27%) analyses. Low heterogeneity was observed across the studies.</p><p><strong>Conclusions: </strong>Our findings suggest that limus DCBs are equally as effective and safe as PCBs for treating ISR, demonstrating non-inferiority in both clinical and angiographic outcomes at 12 months post-intervention.</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"12 1","pages":"17-27"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}