Acta reumatologica portuguesa最新文献_第7页

Coronavirus Disease 19 (COVID-19) complicated with post-viral arthritis. 冠状病毒病19 (COVID-19)并发病毒后关节炎。

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-10-01

Isabel Fragata, Ana Filipa Mourão

引用次数: 0

The role of endothelium-derived hyperpolarizing factor in children with familial mediterranean fever. 内皮源性超极化因子在家族性地中海热患儿中的作用。

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-10-01

Yelda Turkmenoglu, Elif Guney, Ahmet Irdem, Hasan Dursun

{"title":"The role of endothelium-derived hyperpolarizing factor in children with familial mediterranean fever.","authors":"Yelda Turkmenoglu, Elif Guney, Ahmet Irdem, Hasan Dursun","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Familial Mediterranean Fever is an autoinflammatory disease characterized by inflammatory attacks in serous tissues often accompanied by endothelial dysfunction. This study aimed to evaluate the effect of endothelium-derived hyperpolarizing factor, which is an indicator of endothelial dysfunction in children with familial Mediterranean fever.Methods: This study include 57 children with familial Mediterranean fever and 31 children as healthy controls. Blood samples were collected from all participants to measure their endothelium-derived hyperpolarizing factor, complete blood count and C-reactive protein. In addition, inflammatory markers, mutation analyses, and microalbuminuria were examined only in the patient group.Results: The mean age of the patient group was 9.8 ± 4.0 (2.5-18) years, while the mean age of control group was 9.5 ± 3.9 (2.5-16) years (p=0.808). Study group had significantly higher C-reactive protein levels and systolic and diastolic blood pressures and lower endothelium-derived hyperpolarizing factor values than the control group (p=0.0001, p=0.002, p=0.035 and p=0.009, respectively).Conclusion: Low levels of endothelium-derived hyperpolarizing factor, high levels C-reactive protein and high blood pressure in patients with familial Mediterranean fever can be attributed to the changes in the endothelium resulting from subacute inflammation.","PeriodicalId":7229,"journal":{"name":"Acta reumatologica portuguesa","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38799347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chikungunya arthritis - should we expect it to become more common in Portuguese rheumatology? 基孔肯雅关节炎——我们应该期待它在葡萄牙风湿病学中变得更常见吗?

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-10-01

Diogo Esperança Almeida, Emanuel Costa, Ana Sofia Pinto, Joana Leite Silva, Joana Sousa Neves, Ana Roxo Ribeiro, Marcos Cerqueira

引用次数: 0

Subacute cutaneous lupus erythematosus in a patient with Sjögren's syndrome taking terbinafine for onychomycosis. 服用特比萘芬治疗甲癣的Sjögren综合征患者的亚急性皮肤红斑狼疮。

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-10-01

Nathalie Madeira, Cândida Silva, Luís Cunha-Miranda

引用次数: 0

Septic arthritis: a 5-year review of admissions to the Orthopedic Department. 脓毒性关节炎:骨科5年入院回顾

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-10-01

Joana Ramos Rodrigues, Cristina Varino Sousa, Joana Silva, Soraia Azevedo, Francisca Guimarães, Diogo Esperança Almeida, Hugo Parente, Daniela Santos Faria, José Tavares Costa

{"title":"Septic arthritis: a 5-year review of admissions to the Orthopedic Department.","authors":"Joana Ramos Rodrigues, Cristina Varino Sousa, Joana Silva, Soraia Azevedo, Francisca Guimarães, Diogo Esperança Almeida, Hugo Parente, Daniela Santos Faria, José Tavares Costa","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: Characterization of sociodemographic and clinical aspects of patients admitted to the Orthopedic Department (OD) after observation in the Emergency Room (ER) with the diagnosis of septic arthritis (SA).Material and methods: A retrospective, monocentric, cross-sectional study was conducted. Sociodemographic and clinical data on patients admitted to the OD with suspected SA between April 2014 and September 2019 were collected.Results: One-hundred and ten patients were included. In the overall sample, most patients were male (n=61; 55.5%) with a median age of 70 (IQR=20) years old. Thirty-six patients (32.7%) had a previous history of hyperuricemia or gout, or had this diagnosis established at the time of their hospital admission. Monoarthritis was the most common form of presentation (n=106; 96.4%), with the knee being the most frequently involved joint (n=60; 54.5%). S. aureus was the most representative microorganism in synovial fluid (SF) cultures (n=33; 30.6%). SF cultures did not allow the identification of a causative microorganism in 53 cases submitted to arthrotomy (50.5%). Serum C-reactive protein (CRP) was a predictive factor for microorganism identification in SF cultures, with values ≥ 17.6 mg/dl presenting a sensibility and specificity of 60.8% and 77.4%, respectively [CI 95% (0.52 - 0.80)]. Patients with a diagnosis of hyperuricemia or gout presented a higher risk for a negative SF culture result (OR = 4.7 [CI 95% =1.9 - 11.5]).Conclusions: Elderly subjects with multiple comorbidities, namely cardiovascular risk factors, seem more prone to SA. Serum CRP appears to be a predictive factor for the identification of a causative microorganism. The higher risk of a negative SF culture in patients with hyperuricemia or gout should alert us for the possibility of misdiagnosis of SA in patients with an acute gout attack.","PeriodicalId":7229,"journal":{"name":"Acta reumatologica portuguesa","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38799756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuberculosis under anti-TNF therapy: case series of a center (reporting the experience from the period 2006-2019). 抗肿瘤坏死因子治疗下的结核病:某中心病例系列(报告2006-2019年期间的经验)。

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-10-01

Ana Valido, Joana Silva Dinis, Maria João Saavedra, João Eurico Fonseca

引用次数: 0

[Integrated care process for systemic lupus erythematosus: towards quality in healthcare]. 系统性红斑狼疮的综合护理流程:迈向医疗质量。

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-10-01

Sofia Carvalho Barreira, Patrícia Martins, Inês Cordeiro, João Eurico Fonseca, Carla Macieira

引用次数: 0

Unmet needs in primary Sjögren's syndrome and the never-ending quest for the perfect biomarker. 原发性Sjögren综合征的未满足需求和对完美生物标志物的永无止境的追求。

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-07-31

A Alunno, F Carubbi

引用次数: 0

Matrix metalloproteinase 7 is a candidate biomarker in systemic sclerosis-associated interstitial lung disease. 基质金属蛋白酶7是系统性硬化症相关间质性肺疾病的候选生物标志物。

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-07-01

Zhixiao Xu, Wenwen Chen, Chengshui Chen

{"title":"Matrix metalloproteinase 7 is a candidate biomarker in systemic sclerosis-associated interstitial lung disease.","authors":"Zhixiao Xu, Wenwen Chen, Chengshui Chen","doi":"","DOIUrl":"","url":null,"abstract":"Background: Pulmonary complications, including pulmonary fibrosis, are the leading causes of death in systemic sclerosis(SSc). However, the aetiology and pathophysiologic mechanisms of the disease have not been comprehensively investigated, and drugs for treating systemic sclerosis-associated interstitial lung disease (SSc-ILD) are limited. The objective of this study was to identify key novel genes and pathways linked to SSc-ILD and decipher the molecular mechanisms involved in the disease.Methods: We compared three microarray datasets in the GEO database including 42 SSc-ILD samples and 18 normal samples to obtain differentially expressed genes (DEGs). Gene Ontology (GO) analysis and the Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway analysis were performed, and a protein-protein interaction network was constructed. After validation, gene set enrichment analysis (GSEA) was applied to obtain further insights into the function of the selected hub genes.Results: A total of 25 DEGs were filtered. The GO analysis revealed genes that were mainly enriched in immune response, chemokine activity, and extracellular regions. KEGG pathway analysis of the DEGs revealed that SSc-ILD was associated with the tumour necrosis factor (TNF) signalling pathway and cytokine-cytokine receptor interaction. Matrix metallopeptidase 7 (MMP7) expression was consistently increased in all the three datasets, and results of the GSEA indicated that MMP7 might play a role in the regulation of the G-protein coupled amine receptor activity.Conclusions: In summary, the novel DEGs, especially MMP7 and the SSc-ILD pathway genes identified in this study might provide further insights into potential molecular mechanism of the disease.","PeriodicalId":7229,"journal":{"name":"Acta reumatologica portuguesa","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38654649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and clinical manifestations of Erasmus syndrome in systemic sclerosis: a cross-sectional study. 系统性硬化症中伊拉斯谟综合征的患病率和临床表现:一项横断面研究。

IF 1 4区医学

Acta reumatologica portuguesa Pub Date : 2020-07-01

Soraia Azevedo, Joana Sousa-Neves, Daniela Santos-Faria, Joana Leite Silva, Joana Ramos Rodrigues, Daniela Peixoto, José Tavares-Costa, Sérgio Alcino, Carmo Afonso, Filipa Teixeira

{"title":"Prevalence and clinical manifestations of Erasmus syndrome in systemic sclerosis: a cross-sectional study.","authors":"Soraia Azevedo, Joana Sousa-Neves, Daniela Santos-Faria, Joana Leite Silva, Joana Ramos Rodrigues, Daniela Peixoto, José Tavares-Costa, Sérgio Alcino, Carmo Afonso, Filipa Teixeira","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Erasmus syndrome (ErS) is a rare entity in which Systemic Sclerosis (SSc) develops following exposure to silica, with or without associated silicosis. The objectives of this study were: 1) to evaluate the prevalence of ErS in our SSc cohort; 2) to characterize the cases; 3) to evaluate the clinical and laboratory characteristics of SSc in patients with (Ers) or without silica exposure.Methods: Cross-sectional and analytical study. Sociodemographic, clinical and laboratory data were collected from all patients with SSc diagnosed in our department according to ACR / EULAR criteria. Data on professional activity and possible exposure to silica were obtained by phone interview.Results: Among 48 patients with SSc, the prevalence of ErS was 16.7% (8/48). All cases identified were male, corresponding to 72.7% of men with SSc followed at our department. There was a statistically significant association between ErS and male gender (p.","PeriodicalId":7229,"journal":{"name":"Acta reumatologica portuguesa","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38654656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0