内皮源性超极化因子在家族性地中海热患儿中的作用。

IF 1 4区 医学 Q4 RHEUMATOLOGY
Acta reumatologica portuguesa Pub Date : 2020-10-01
Yelda Turkmenoglu, Elif Guney, Ahmet Irdem, Hasan Dursun
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引用次数: 0

摘要

目的:家族性地中海热是一种以浆液组织炎症发作为特征的自身炎症性疾病,常伴有内皮功能障碍。本研究旨在评估内皮源性超极化因子对家族性地中海热患儿内皮功能障碍的影响。方法:以57例家族性地中海热患儿为研究对象,以31例患儿为健康对照。收集所有参与者的血液样本,测量他们的内皮源性超极化因子、全血细胞计数和c反应蛋白。此外,仅在患者组中检查炎症标志物、突变分析和微量白蛋白尿。结果:患者组平均年龄为9.8±4.0(2.5 ~ 18)岁,对照组平均年龄为9.5±3.9(2.5 ~ 16)岁(p=0.808)。研究组的c反应蛋白水平、收缩压和舒张压明显高于对照组,内皮源性超极化因子值明显低于对照组(p=0.0001, p=0.002, p=0.035和p=0.009)。结论:亚急性炎症引起的内皮细胞改变可能是家族性地中海热患者内皮源性超极化因子水平低、c反应蛋白水平高、血压升高的主要原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of endothelium-derived hyperpolarizing factor in children with familial mediterranean fever.

Objective: Familial Mediterranean Fever is an autoinflammatory disease characterized by inflammatory attacks in serous tissues often accompanied by endothelial dysfunction. This study aimed to evaluate the effect of endothelium-derived hyperpolarizing factor, which is an indicator of endothelial dysfunction in children with familial Mediterranean fever.

Methods: This study include 57 children with familial Mediterranean fever and 31 children as healthy controls. Blood samples were collected from all participants to measure their endothelium-derived hyperpolarizing factor, complete blood count and C-reactive protein. In addition, inflammatory markers, mutation analyses, and microalbuminuria were examined only in the patient group.

Results: The mean age of the patient group was 9.8 ± 4.0 (2.5-18) years, while the mean age of control group was 9.5 ± 3.9 (2.5-16) years (p=0.808). Study group had significantly higher C-reactive protein levels and systolic and diastolic blood pressures and lower endothelium-derived hyperpolarizing factor values than the control group (p=0.0001, p=0.002, p=0.035 and p=0.009, respectively).

Conclusion: Low levels of endothelium-derived hyperpolarizing factor, high levels C-reactive protein and high blood pressure in patients with familial Mediterranean fever can be attributed to the changes in the endothelium resulting from subacute inflammation.

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来源期刊
Acta reumatologica portuguesa
Acta reumatologica portuguesa 医学-风湿病学
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Acta Reumatólogica Portuguesa is a scientific peer reviewed journal covering all aspects of rheumatic diseases and related to Rheumatology. The journal publishes original articles, reviews, clinical cases, images in rheumatology, letters to the editor and clinical teaching (e.g. guidelines and clinical protocols). Published since 1973, Acta Reumatológica Portuguesa is the official scientific publication of the Portuguese Society of Rheumatology, a non-profit organization that promotes the knowledge and investigation of rheumatic diseases and the development of Rheumatology.
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