Gian Huamán-Benancio, Carlos Peralta-Ponce, Daniella Vinelli-Arzubiaga, Cesar Esquivel-León, Isabel Pinedo Padilla
{"title":"[Outcomes of percutaneous balloon pulmonary valvuloplasty in pulmonary valve stenosis in the pediatric population in a single center, Lima - Peru].","authors":"Gian Huamán-Benancio, Carlos Peralta-Ponce, Daniella Vinelli-Arzubiaga, Cesar Esquivel-León, Isabel Pinedo Padilla","doi":"10.47487/apcyccv.v3i2.208","DOIUrl":"https://doi.org/10.47487/apcyccv.v3i2.208","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of the procedure and outcomes during follow-up.</p><p><strong>Methods: </strong>80 patients with pulmonary valvular stenosis who underwent percutaneous balloon valvuloplasty between January 2014 and December 2019 are described. Demographic, echocardiographic, and hemodynamic characteristics of the procedure were evaluated. Follow-up included clinical, echocardiographic parameters, pulmonary regurgitation severity, and residual pulmonary gradient at each cutoff point.</p><p><strong>Results: </strong>The age range was 2 years (interquartile range: 10.5 months - 6 years), and the predominant sex was male with 56.2%. The transvalvular pulmonary gradient decreased from 61.7 mmHg +- 21.2 to 17 mmHg (interquartile range: 11-26 mmHg). The immediate success rate was 90%. Follow-up time showed a median of 21 months (interquartile range: 5-47.5 months). All patients at follow-up showed some degree of pulmonary insufficiency at each cutoff point; 17% of the cases at the end of their follow-up were found to have severe insufficiency. Three cases of long-term restenosis were found (3.8%), and 6 (7.5%) were admitted for valvuloplasty surgery or pulmonary valve replacement. The complications reported reached 10% of cases, two patients were admitted to surgery during the procedure for major complications. A significant association was found with severe pulmonary insufficiency at the end of follow-up and ring/balloon ratio.</p><p><strong>Conclusions: </strong>Percutaneous transluminal valvuloplasty with balloon is an effective technique in the treatment of pulmonary valvular stenosis, with reported complications but with good results during follow-up.</p>","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 2","pages":"60-68"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/89/apcyccv-3-60.PMC10284577.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9712337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josías C Ríos-Ortega, Josué Sisniegas-Razón, Roger Conde-Moncada, Yemmy Pérez-Valverde, Julio Morón-Castro
{"title":"Aortic valve replacement through minithoracotomy. Results from the Peruvian experience.","authors":"Josías C Ríos-Ortega, Josué Sisniegas-Razón, Roger Conde-Moncada, Yemmy Pérez-Valverde, Julio Morón-Castro","doi":"10.47487/apcyccv.v3i2.219","DOIUrl":"https://doi.org/10.47487/apcyccv.v3i2.219","url":null,"abstract":"<p><strong>Objectives: </strong>To assess mortality, major valve-related events (MAVRE), and other complications in the perioperative period and follow up in patients with aortic valve replacement (AVR) through mini-thoracotomy (MT).</p><p><strong>Methods: </strong>We retrospectively analyzed patients aged <80 who underwent AVR through MT between January 2017 and December 2021 in a national reference center in Lima, Peru. Patients undergoing other surgical approaches (mini-sternotomy, etc.), other concomitant cardiac procedures, redo, and emergency surgeries were excluded. We measured the variables (MAVRE, mortality, and other clinical variables) at 30 days and a mean follow-up of 12 months.</p><p><strong>Results: </strong>Fifty-four patients were studied, the median age was 69.5 years, and 65% were women. Aortic valve (AV) stenosis was the main indication for surgery (65%), and bicuspid AV represented 55.6% of cases. At 30-days, MAVRE occurred in two patients (3.7%), with no in-hospital mortality. One patient had an intraoperative ischemic stroke, and one required a permanent pacemaker. No patient underwent reoperation due to prosthesis dysfunction or endocarditis. In a mean follow-up of one year, MAVRE occurrence did not show variations with the perioperative period, most patients remained in NYHA I (90.7%) or II (7.4%) compared to the preoperative period (p<0.001).</p><p><strong>Conclusions: </strong>AV replacement through MT is a safe procedure in our center for patients under 80 years.</p>","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 2","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/90/apcyccv-3-69.PMC10241336.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9582614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Rheumatic mitral aggression. Usefulness of 3d transesophageal echocardiography].","authors":"Kelly Cupe-Chacalcaje, Lindsay Benites-Yshpilco, Angela Cachicatari-Beltrán, Dante Urdanivia-Ruiz, Eliana Rafael-Horna, Paol Rojas, Gerald Lévano-Pachas, Roberto Baltodano-Arellano","doi":"10.47487/apcyccv.v3i2.211","DOIUrl":"https://doi.org/10.47487/apcyccv.v3i2.211","url":null,"abstract":"<p><p>Rheumatic heart disease is the leading cause of cardiovascular disease in children under 25 years of age worldwide, with the highest prevalence in low-income countries. The usual and distinctive finding of rheumatic aggression is mitral stenosis, which leads to serious cardiovascular consequences. International guidelines establish transthoracic echocardiography (TTE) as the diagnostic test for rheumatic heart disease; however, it has limitations in the measurement of planimetry and those inherent to Doppler. Transesophageal 3D echocardiography (TTE-3D) is a new modality that shows realistic images of the mitral valve and has the added value of accurately locating the plane of maximum stenosis and better determining commissural involvement.</p>","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 2","pages":"98-111"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/37/apcyccv-3-98.PMC10241339.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cynthia Paredes-Paucar, Leonardo Villa Medina, Diego Araiza-Garaygordobil, Rodrigo Gopar-Nieto, Pablo Martínez-Amezcua, Alejandro Cabello-Lopez, Daniel Sierra-Lara, José Luis Briseño De La Cruz, Hector Gonzáles Pacheco, Alexandra Arias Mendoza
{"title":"[Prognostic value of the absolute decrease of the N-terminal portion of B-type natriuretic propeptide in decompensated heart failure: secondary analysis of the CLUSTER-HF study].","authors":"Cynthia Paredes-Paucar, Leonardo Villa Medina, Diego Araiza-Garaygordobil, Rodrigo Gopar-Nieto, Pablo Martínez-Amezcua, Alejandro Cabello-Lopez, Daniel Sierra-Lara, José Luis Briseño De La Cruz, Hector Gonzáles Pacheco, Alexandra Arias Mendoza","doi":"10.47487/apcyccv.v3i1.198","DOIUrl":"10.47487/apcyccv.v3i1.198","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to determine the prognostic value of the absolute decrease in the N-terminal portion of pro-B-type natriuretic peptide (NT-proBNP) to prevent fewer clinical events, in the population of CLUSTER-HF (efficacy of ultrasound lung to guide therapy and prevent readmissions in heart failure).</p><p><strong>Materials and methods: </strong>This study was conducted in a subgroup of ninety-four patients with available NT-proBNP information at hospital discharge and prior to randomization in the CLUSTER-HF study. The primary objective of the study was to determine the prognostic value of absolute NT-proBNP decline below which fewer events of all-cause death, emergency room visits, and rehospitalization for heart failure at 180 days.</p><p><strong>Results: </strong>The absolute decrease in NT-proBNP below 3,350 pg/mL has a moderate discriminative capacity with AUC= 0.602, with a prognostic value in the combined event at 180 days (log-rank test, p=0.01). Also, according to the multivariable analysis, it is an independent marker of clinical events at 180 days OR 0.319 (0.102-0.995, p=0.04) above other clinical variables.</p><p><strong>Conclusions: </strong>An absolute decrease to 3,350 pg/mL of NT-proBNP or less at discharge from the hospitalization due to heart failure, was associated with fewer clinical events at 180 days.</p>","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 1","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/86/apcyccv-3-08.PMC10318989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9859361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Germán Valenzuela-Rodríguez, Miguel Lescano-Alva, Mayte Bryce-Alberti, Arianna Portmann-Baracco, Walter Prudencio-León
{"title":"[Acute cardiovascular complications in a Peruvian population of oncology patients].","authors":"Germán Valenzuela-Rodríguez, Miguel Lescano-Alva, Mayte Bryce-Alberti, Arianna Portmann-Baracco, Walter Prudencio-León","doi":"10.47487/apcyccv.v3i1.192","DOIUrl":"10.47487/apcyccv.v3i1.192","url":null,"abstract":"<p><strong>Objective: </strong>To know the most frequent acute cardiovascular complications in a Peruvian population of oncologic patients.</p><p><strong>Materials and methods: </strong>Retrospective, descriptive study of oncologic patients treated at Clinica Delgado between January 2014 and December 2019, from which the subgroup with the seven most prevalent cancers at the national level was selected according to information from Globocan 2018. Additionally, we evaluated the epidemiology of patients with cardiovascular complications that conditioned their hospitalization or were detected during this, calculating their cardiovascular risk according to Hermann and SCORE risk scales.</p><p><strong>Results: </strong>Forty-four patients had complications; 27 (61.4%) were hospitalized due to acute cardiovascular causes. The mean age of this subgroup was 69.88 years (SD 12.77), and 22 (81.5%) were older than 60 years. Fourteen (51.9%) were male. According to the Hermann scale, 33.3% had intermediate-risk and 14.9% had a high or very high risk. According to the SCORE scale, 62.97% had an intermediate-risk and 7.40% high risk. The most common acute cardiovascular complications were deep vein thrombosis and ischemic stroke (66.65%). One patient (3.7%) reported previous cardiovascular disease. Four patients (14.8%) had a fatal outcome during hospitalization. The median length of hospitalization was five days.</p><p><strong>Conclusions: </strong>We present the cases of acute cardiovascular complications in a population of oncologic patients and their vascular risk according to Hermann and SCORE scales. The most common complications were deep vein thrombosis (48.14%), stroke (18.51%), and myocardial infarction (14.81%).</p>","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/f3/apcyccv-3-01.PMC10424505.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10013482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro Rojas, Josué Sisniegas, Romel Zamudio, Josías Ríos
{"title":"[Revascularización quirúrgica utilizando dos arterias torácicas internas en Sudamérica].","authors":"Pedro Rojas, Josué Sisniegas, Romel Zamudio, Josías Ríos","doi":"10.47487/apcyccv.v3i1.199","DOIUrl":"10.47487/apcyccv.v3i1.199","url":null,"abstract":"<p><p>La derivación de la arteria coronaria utilizando la arteria torácica interna bilateral se ha relacionado con beneficios de supervivencia en pacientes con enfermedad arterial coronaria, pero los datos no son concluyentes. En Sudamérica, varios centros reportaron su propia experiencia con buenos resultados en supervivencia, mínimos eventos cardiovasculares postoperatorios y un bajo grado de infección mediastínica, sin embargo, el número de casos es bajo y la ausencia de publicaciones en varios países es preocupante. Revisamos las principales publicaciones sobre el injerto de arteria torácica interna bilateral en nuestra región, evaluando cuánto hemos avanzado en la cirugía coronaria.</p>","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 1","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/e2/apcyccv-3-33.PMC10318995.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9859360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruth N Estupiñán-Paredes, Nelson L Moreno-Ruiz, Jeffrey Castellanos-Parada, Carlos A Arias-Barrera
{"title":"[Advanced heart failure due to coronary aneurysms].","authors":"Ruth N Estupiñán-Paredes, Nelson L Moreno-Ruiz, Jeffrey Castellanos-Parada, Carlos A Arias-Barrera","doi":"10.47487/apcyccv.v3i1.188","DOIUrl":"10.47487/apcyccv.v3i1.188","url":null,"abstract":"<p><p>We present the case of a 61 years old man with hypothyroidism, hypertension, type 2 diabetes mellitus, and ischemic cardiopathy, who was admitted with a diagnosis of non-ST elevation myocardial infarction. The coronary angiography describes coronary ectasia with giant aneurysm and slow flow in the right coronary and aneurysm with slow flow anterior descending coronary. The echocardiogram shows contractility disorders with severely decreased left ventricular ejection fraction (20%) despite optimal medical management. This case presents a patient with ischemic heart disease and advanced heart failure secondary to coronary aneurysm, the proposed optimal treatment was a heart transplant given the disease's progression.</p>","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 1","pages":"41-44"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/f0/apcyccv-3-41.PMC10318986.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9859359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Isquemia recurrente posterior a infarto agudo de miocardio en el adulto mayor. Insólita presentación inicial de arteritis de Takayasu","authors":"Luis Murillo Pérez, Zoila Rodríguez Urteaga","doi":"10.47487/apcyccv.v3i1.190","DOIUrl":"https://doi.org/10.47487/apcyccv.v3i1.190","url":null,"abstract":"RESUMEN Se presenta el caso de un paciente varón de 62 años que cursó con dolor torácico opresivo; fue diagnosticado de infarto agudo de miocardio y recibió tratamiento de reperfusión con angioplastia primaria. En la evolución cursó con un nuevo episodio de infarto de miocardio, por lo que se realizaron estudios complementarios que condujeron al diagnóstico de arteritis de Takayasu. Desafortunadamente, presentó una evolución tórpida a pesar del manejo instaurado. Es infrecuente la presentación clínica en pacientes mayores de 60 años, por ello es importante considerarlo dentro del diagnóstico diferencial en pacientes con enfermedad coronaria difusa e isquemia miocárdica recurrente, debido a la rápida progresión y elevada morbimortalidad, incluso a pesar de estrategias de revascularización exitosas.","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 1","pages":"45 - 52"},"PeriodicalIF":0.0,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49386448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Espinoza Alva, Milagros Yanina Mallma Gómez, Juan Manuel Muñoz Moreno
{"title":"[Mechanical complications after myocardial infarction in a National Reference Hospital].","authors":"Daniel Espinoza Alva, Milagros Yanina Mallma Gómez, Juan Manuel Muñoz Moreno","doi":"10.47487/apcyccv.v3i1.200","DOIUrl":"https://doi.org/10.47487/apcyccv.v3i1.200","url":null,"abstract":"<p><strong>Objective: </strong>To determine the clinical characteristics, therapeutic and in-hospital mortality of patients with mechanical complications post myocardial infarction.</p><p><strong>Materials and methods: </strong>Observational, descriptive and retrospective study. We included patients >18 years old with a diagnosis of mechanical complication post myocardial infarction hospitalized at the Instituto Nacional Cardiovascular- INCOR in Lima -Peru, from January 1, 2017 to December 31, 2021. Variables like clinical characteristics, treatments, complications, and in-hospital mortality were studied.</p><p><strong>Results: </strong>We found 37 cases, with a predominance of males (73.0%) and a median age of 73 years old. The location of the myocardial infarction was 51.4% in the anterior wall and 43.2% in the inferior wall. The patients received reperfusion therapy with fibrinolysis in 5 cases (13.5%), coronary angioplasty in 5 (13.5%), and 73% received only medical management prior to the diagnosis of mechanical complications. Of the 37 patients, 13 (35.1%) presented isolated ventricular free wall rupture, 12 (32.4%) isolated interventricular septum rupture, 10 (27.0%) the combination of ventricular free wall rupture and interventricular septum, and 2 (5.4%) papillary muscle rupture. In-hospital mortality was 51.4%.</p><p><strong>Conclusions: </strong>The ventricular free wall rupture was the most frequent complication, patients with mechanical complications after myocardial infarction still maintain high intra-hospital mortality rates, mainly in those who did not have adequate surgical treatment.</p>","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/b1/apcyccv-3-25.PMC10318997.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9804973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Compliance with the cardiology residency training program during the COVID-19 pandemic, Lima-Peru].","authors":"Adriel Olortegui Yzu, Rosalía Fernández Coronado, Luis Murillo Pérez, Patty Fernández Rodríguez","doi":"10.47487/apcyccv.v3i1.196","DOIUrl":"https://doi.org/10.47487/apcyccv.v3i1.196","url":null,"abstract":"<p><strong>Objective: </strong>To characterize compliance with the annual curricular program of second and third-year cardiology residents in hospital of Lima-Peru during the COVID-19 pandemic.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted, through a questionnaire applied to seventy-eight cardiology residents from the second and third year of specialty. We evaluated the compliance with rotations in clinical fields, individual compliance with the annual program, and the achievement of minimum training standards.</p><p><strong>Results: </strong>Compliance with rotations in clinical fields was highly variable (from 7.9% in Cardiac Rehabilitation for the second year to 90.9% for imaging in cardiology). Regarding individual compliance, 98.7% did not manage to comply with the annual program. Finally, only the standard of evaluation by radionuclides of myocardial function and perfusion was achieved by all residents, concerning the scope of the other achievements, variations are reported from 4.4% for performing stress tests to 75.8% in the to participate in interventional cardiology procedures. Associations were found between compliance with rotations with the type of health organization and type of university.</p><p><strong>Conclusions: </strong>The COVID-19 pandemic has considerably affected the training of cardiology residents, mainly due to non-compliance with the annual curriculum.</p>","PeriodicalId":72295,"journal":{"name":"Archivos Peruanos de cardiologia y cirugia cardiovascular","volume":"3 1","pages":"16-24"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/09/apcyccv-3-16.PMC10318988.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9859363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}