Annual review of analytical chemistry (Palo Alto, Calif.)最新文献_第3页

Capillary Electrophoresis-Mass Spectrometry for Top-Down Proteomics. 毛细管电泳-质谱法用于自上而下的蛋白质组学。

IF 7.5

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-01-23 DOI: 10.1146/annurev-anchem-071124-092242

Qianjie Wang, Qianyi Wang, Guijie Zhu, Liangliang Sun

引用次数: 0

Strategies for Electrochemical Point-of-Care Biosensors. 电化学即时生物传感器的策略。

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1146/annurev-anchem-071124-103739

Dagwin Wachholz Junior, Patricia Batista Deroco, Bruna M Hryniewicz, Lauro Tatsuo Kubota

{"title":"Strategies for Electrochemical Point-of-Care Biosensors.","authors":"Dagwin Wachholz Junior, Patricia Batista Deroco, Bruna M Hryniewicz, Lauro Tatsuo Kubota","doi":"10.1146/annurev-anchem-071124-103739","DOIUrl":"10.1146/annurev-anchem-071124-103739","url":null,"abstract":"Electrochemical biosensors have emerged as pivotal tools in point-of-care (POC) sensing, offering rapid, sensitive, and cost-effective detection platforms. Different strategies for advancing electrochemical POC biosensors have been explored recently, including fabrication methodologies and advances in biorecognition elements. This review comprehensively explores the miniaturization and integration of portable and wireless devices into fully integrated systems, highlighting recent advancements and challenges in fabrication techniques. We also discuss different enhancement strategies for biorecognition in POC testing, including immunosensors, aptasensors, genosensors, and CRISPR-based biosensors, evaluating their respective strengths and applications. Furthermore, this review addresses the complexity of multiplexing within electrochemical biosensing platforms. Finally, we outline some critical considerations for field deployment and commercialization of electrochemical POC biosensors. We aim to provide a comprehensive overview of advancing electrochemical biosensors toward robust and scalable POC solutions by synthesizing advancements across this emerging field.","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"307-333"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in Signal Amplification and Microstructure Manufacturing for Photoelectrochemical Sensing. 光电化学传感信号放大与微结构制造研究进展。

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 DOI: 10.1146/annurev-anchem-070524-093940

Xu Liu, Di Yang, Bingqian Liu, Dianping Tang

引用次数: 0

Analytic Approaches to Physicochemical Properties of Materials for Biomedical Applications Across Nanoscopic and Macroscopic Length Scales. 跨纳米和宏观长度尺度的生物医学应用材料物理化学特性分析方法。

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-14 DOI: 10.1146/annurev-anchem-061622-015821

Farnaz Fazelpour, Lindsey C Hill, Matthew R Markovetz, David B Hill

{"title":"Analytic Approaches to Physicochemical Properties of Materials for Biomedical Applications Across Nanoscopic and Macroscopic Length Scales.","authors":"Farnaz Fazelpour, Lindsey C Hill, Matthew R Markovetz, David B Hill","doi":"10.1146/annurev-anchem-061622-015821","DOIUrl":"10.1146/annurev-anchem-061622-015821","url":null,"abstract":"The design and implementation of biomedical devices for both diagnostic and direct medical applications have revolutionized patient care, paving the way for improved patient outcomes. Understanding the characteristics of materials used in the design of new devices is essential for their advancement. In this review, our goal is to assist biomedical researchers in appreciating the importance of these properties and the role of selecting the proper measurement. We discuss how the nanoscopic molecular composition, arrangement, and interactions generate the properties of liquids, solids, viscoelastic materials, and colloids and discuss the measurement techniques that can be used to assess these properties from the nanoscale to the macroscale. We explore the linear and nonlinear mechanical responses of materials, elucidate their behaviors under varying conditions, and discuss corresponding measurement techniques. Finally, we highlight the importance of tailoring measurements to the underlying biological processes and applications being investigated.","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"473-495"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding Extracellular Protein Glycosylation in Human Health and Disease. 解码人类健康和疾病中的细胞外蛋白糖基化。

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-01-15 DOI: 10.1146/annurev-anchem-071024-124203

Alexandra D Steigmeyer, Sarah C Lowery, Valentina Rangel-Angarita, Stacy A Malaker

{"title":"Decoding Extracellular Protein Glycosylation in Human Health and Disease.","authors":"Alexandra D Steigmeyer, Sarah C Lowery, Valentina Rangel-Angarita, Stacy A Malaker","doi":"10.1146/annurev-anchem-071024-124203","DOIUrl":"10.1146/annurev-anchem-071024-124203","url":null,"abstract":"Protein glycosylation, the covalent attachment of carbohydrate, or glycan, structures onto the protein backbone, is one of the most complex and heterogeneous post-translational modifications (PTMs). Extracellular protein glycosylation, in particular N- and mucin-type O-glycosylation, plays pivotal roles in a number of biophysical and biochemical processes, such as protein folding and stability, cell adhesion, signaling, and protection. As such, aberrant glycosylation is implicated in a variety of diseases, including cancer. However, the nontemplated nature and structural heterogeneity of protein glycosylation hinder glycoprotein characterization with traditional methods. Recent advances in analytical techniques have improved capabilities for decoding glycan complexity, a promising step toward understanding the role of glycosylation in human health and disease. In this review, we highlight key and emerging techniques to study protein glycosylation, and we emphasize how these techniques have improved our understanding of glycosylation in a biologically relevant context.","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"241-264"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forensic Analytical Chemistry for Minimizing Injustice: Advances and Challenges. 减少不公正的法医分析化学：进展和挑战。

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1146/annurev-anchem-072624-030546

Raychelle Burks, Georgina Sauzier, Brooke W Kammrath, Max M Houck

引用次数: 0

Machine Learning in Small-Molecule Mass Spectrometry. 小分子质谱中的机器学习。

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1146/annurev-anchem-071224-082157

Yuhui Hong, Yuzhen Ye, Haixu Tang

{"title":"Machine Learning in Small-Molecule Mass Spectrometry.","authors":"Yuhui Hong, Yuzhen Ye, Haixu Tang","doi":"10.1146/annurev-anchem-071224-082157","DOIUrl":"10.1146/annurev-anchem-071224-082157","url":null,"abstract":"Tandem mass spectrometry (MS/MS) is crucial for small-molecule analysis; however, traditional computational methods are limited by incomplete reference libraries and complex data processing. Machine learning (ML) is transforming small-molecule mass spectrometry in three key directions: (a) predicting MS/MS spectra and related physicochemical properties to expand reference libraries, (b) improving spectral matching through automated pattern extraction, and (c) predicting molecular structures of compounds directly from their MS/MS spectra. We review ML approaches for molecular representations [descriptors, simplified molecular-input line-entry (SMILE) strings, and graphs] and MS/MS spectra representations (using binned vectors and peak lists) along with recent advances in spectra prediction, retention time, collision cross sections, and spectral matching. Finally, we discuss ML-integrated workflows for chemical formula identification. By addressing the limitations of current methods for compound identification, these ML approaches can greatly enhance the understanding of biological processes and the development of diagnostic and therapeutic tools.","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"193-215"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidics with Machine Learning for Biophysical Characterization of Cells. 微流体与机器学习在细胞生物物理表征中的应用。

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-25 DOI: 10.1146/annurev-anchem-061622-025021

Hyungkook Jeon, Jongyoon Han

引用次数: 0

Bioelectronic Large-Area Transistors for High-Performance Sensing. 用于高性能传感的生物电子大面积晶体管。

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-26 DOI: 10.1146/annurev-anchem-061522-034729

Eleonora Macchia, Paolo Bollella, Luisa Torsi

{"title":"Bioelectronic Large-Area Transistors for High-Performance Sensing.","authors":"Eleonora Macchia, Paolo Bollella, Luisa Torsi","doi":"10.1146/annurev-anchem-061522-034729","DOIUrl":"10.1146/annurev-anchem-061522-034729","url":null,"abstract":"Bioelectronics, originating from Galvani's eighteenth-century experiments, blends biology, medicine, and electronics to create devices that can be closely connected to biological systems. This review focuses on bioelectronic large-area field-effect transistor (FET) sensing devices, emphasizing their sensitivity, specificity, and reliability. The role of analytical chemistry in optimizing performance-level control is pivotal, and the review discusses key performance metrics, including limit of identification (LOI), reliability and selectivity. The assessment of the LOI level is addressed using examples of FET-based bioelectronic sensors capable of detecting concentrations at least in the picomolar range. Examples of sensors capable of detecting concentrations in the tens of zeptomolar range are also provided, demonstrating that a single molecule in 0.1 mL can be reliably detected. Working at the LOI also minimizes random errors, which can be as low as 1%. The review also explores the use of molecularly imprinted polymers for highly selective FET bioelectronic detections, noting their sustainability and robustness in comparison to natural antibodies.","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"407-425"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative Sample Preparation Strategies for Emerging Pollutants in Environmental Samples. 环境样品中新兴污染物的创新样品制备策略。

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 DOI: 10.1146/annurev-anchem-071224-093709

Héctor Martínez-Pérez-Cejuela, Emanuela Gionfriddo

{"title":"Innovative Sample Preparation Strategies for Emerging Pollutants in Environmental Samples.","authors":"Héctor Martínez-Pérez-Cejuela, Emanuela Gionfriddo","doi":"10.1146/annurev-anchem-071224-093709","DOIUrl":"https://doi.org/10.1146/annurev-anchem-071224-093709","url":null,"abstract":"Sample treatment plays a crucial role in ensuring accurate analysis of contaminants in aqueous, gaseous, and solid matrices. Emerging contaminants such as microplastics and poly- and perfluoroalkyl substances pose challenges due to their ubiquity and potential adverse effects on the environment and human health. By setting stringent guidelines, environmental protection agencies drive research and innovation in analytical methodologies. However, current reference methods are based on traditional techniques with a high use of chemicals and considerable waste generation. This review highlights the importance of advanced techniques, including solid-phase extraction and microextraction methods, enhanced by novel materials, for preparing environmental samples. Additionally, it discusses innovative formats and devices, such as drone-based systems and three-dimensional-printed devices, which are expanding the scope of environmental monitoring. This review aims to provide a comprehensive overview of trends and advances in sample preparation for environmental analysis over the past five years, offering insights into progress made and future directions.","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":"18 1","pages":"73-95"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0