Annual review of analytical chemistry (Palo Alto, Calif.)最新文献

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Toward Unrivaled Chromatographic Resolving Power in Proteomics: Design and Development of Comprehensive Spatial Three-Dimensional Liquid-Phase Separation Technology. 迈向蛋白质组学中无与伦比的色谱分辨能力:综合空间三维液相分离技术的设计与开发》。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI: 10.1146/annurev-anchem-061522-044510
Sebastiaan Eeltink, Jelle De Vos, Gert Desmet
{"title":"Toward Unrivaled Chromatographic Resolving Power in Proteomics: Design and Development of Comprehensive Spatial Three-Dimensional Liquid-Phase Separation Technology.","authors":"Sebastiaan Eeltink, Jelle De Vos, Gert Desmet","doi":"10.1146/annurev-anchem-061522-044510","DOIUrl":"10.1146/annurev-anchem-061522-044510","url":null,"abstract":"<p><p>Spatial comprehensive three-dimensional chromatography (3D-LC) offers an innovative approach to achieve unprecedented resolving power in terms of peak capacity and sample throughput. This advanced technique separates components within a 3D separation space, where orthogonal retention mechanisms are incorporated. The parallel development of the second- and third-dimension stages effectively overcomes the inherent limitation of conventional multidimensional approaches, where sampled fractions are analyzed sequentially. This review focuses on the design aspects of the microchip for spatial 3D-LC and the selection of orthogonal separation modes to enable the analysis of intact proteins. The design considerations for the flow distributor and channel layout are discussed, along with various approaches to confine the flow during the subsequent development stages. Additionally, the integration of stationary phases into the microchip is addressed, and interfacing to mass spectrometry detection is discussed. According to Pareto optimality, the integration of isoelectric focusing, size-exclusion chromatography, and reversed-phase chromatography in a spatial 3D-LC approach is predicted to achieve an exceptional peak capacity of over 30,000 within a 1-h analysis, setting a new benchmark in chromatographic performance.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Future of Nanotechnology-Driven Electrochemical and Electrical Point-of-Care Devices and Diagnostic Tests. 纳米技术驱动的电化学和电气护理点设备与诊断测试的未来。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2024-07-01 DOI: 10.1146/annurev-anchem-061622-012029
Rabah Boukherroub, Sabine Szunerits
{"title":"The Future of Nanotechnology-Driven Electrochemical and Electrical Point-of-Care Devices and Diagnostic Tests.","authors":"Rabah Boukherroub, Sabine Szunerits","doi":"10.1146/annurev-anchem-061622-012029","DOIUrl":"10.1146/annurev-anchem-061622-012029","url":null,"abstract":"<p><p>Point-of-care (POC) devices have become rising stars in the biosensing field, aiming at prognosis and diagnosis of diseases with a positive impact on the patient but also on healthcare and social care systems. Putting the patient at the center of interest requires the implementation of noninvasive technologies for collecting biofluids and the development of wearable platforms with integrated artificial intelligence-based tools for improved analytical accuracy and wireless readout technologies. Many electrical and electrochemical transducer technologies have been proposed for POC-based sensing, but several necessitate further development before being widely deployable. This review focuses on recent innovations in electrochemical and electrical biosensors and their growth opportunities for nanotechnology-driven multidisciplinary approaches. With a focus on analytical aspects to pave the way for future electrical/electrochemical diagnostics tests, current limitations and drawbacks as well as directions for future developments are highlighted.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonlinear Electrokinetic Methods of Particles and Cells. 粒子和细胞的非线性电动力学方法。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI: 10.1146/annurev-anchem-061622-040810
Blanca H Lapizco-Encinas
{"title":"Nonlinear Electrokinetic Methods of Particles and Cells.","authors":"Blanca H Lapizco-Encinas","doi":"10.1146/annurev-anchem-061622-040810","DOIUrl":"10.1146/annurev-anchem-061622-040810","url":null,"abstract":"<p><p>Nonlinear electrokinetic phenomena offer label-free, portable, and robust approaches for particle and cell assessment, including selective enrichment, separation, sorting, and characterization. The field of electrokinetics has evolved substantially since the first separation reports by Arne Tiselius in the 1930s. The last century witnessed major advances in the understanding of the weak-field theory, which supported developments in the use of linear electrophoresis and its adoption as a routine analytical technique. More recently, an improved understanding of the strong-field theory enabled the development of nonlinear electrokinetic techniques such as electrorotation, dielectrophoresis, and nonlinear electrophoresis. This review discusses the operating principles and recent applications of these three nonlinear electrokinetic phenomena for the analysis and manipulation of particles and cells and provides an overview of some of the latest developments in the field of nonlinear electrokinetics.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Label-Free Optical Technologies to Enhance Noninvasive Endoscopic Imaging of Early-Stage Cancers. 增强早期癌症无创内窥镜成像的无标签光学技术。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI: 10.1146/annurev-anchem-061622-014208
Shuang Chang, Halina Krzyzanowska, Audrey K Bowden
{"title":"Label-Free Optical Technologies to Enhance Noninvasive Endoscopic Imaging of Early-Stage Cancers.","authors":"Shuang Chang, Halina Krzyzanowska, Audrey K Bowden","doi":"10.1146/annurev-anchem-061622-014208","DOIUrl":"10.1146/annurev-anchem-061622-014208","url":null,"abstract":"<p><p>White light endoscopic imaging allows for the examination of internal human organs and is essential in the detection and treatment of early-stage cancers. To facilitate diagnosis of precancerous changes and early-stage cancers, label-free optical technologies that provide enhanced malignancy-specific contrast and depth information have been extensively researched. The rapid development of technology in the past two decades has enabled integration of these optical technologies into clinical endoscopy. In recent years, the significant advantages of using these adjunct optical devices have been shown, suggesting readiness for clinical translation. In this review, we provide an overview of the working principles and miniaturization considerations and summarize the clinical and preclinical demonstrations of several such techniques for early-stage cancer detection. We also offer an outlook for the integration of multiple technologies and the use of computer-aided diagnosis in clinical endoscopy.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Present and Future Landscapes of Molecular Diagnostics. 分子诊断的现状与未来。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI: 10.1146/annurev-anchem-061622-015112
Justin C Rolando, Arek V Melkonian, David R Walt
{"title":"The Present and Future Landscapes of Molecular Diagnostics.","authors":"Justin C Rolando, Arek V Melkonian, David R Walt","doi":"10.1146/annurev-anchem-061622-015112","DOIUrl":"10.1146/annurev-anchem-061622-015112","url":null,"abstract":"<p><p>Nucleic acid testing is the cornerstone of modern molecular diagnostics. This review describes the current status and future directions of molecular diagnostics, focusing on four major techniques: polymerase chain reaction (PCR), next-generation sequencing (NGS), isothermal amplification methods such as recombinase polymerase amplification (RPA) and loop-mediated isothermal amplification (LAMP), and clustered regularly interspaced short palindromic repeats (CRISPR)-based detection methods. We explore the advantages and limitations of each technique, describe how each overlaps with or complements other techniques, and examine current clinical offerings. This review provides a broad perspective into the landscape of molecular diagnostics and highlights potential future directions in this rapidly evolving field.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Areas in Undergraduate Analytical Chemistry Education: Microfluidics, Microcontrollers, and Chemometrics. 分析化学本科教育的新兴领域:微流控技术、微控制器和化学计量学。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI: 10.1146/annurev-anchem-061622-041922
Amber M Hupp, Michelle L Kovarik, Daniel A McCurry
{"title":"Emerging Areas in Undergraduate Analytical Chemistry Education: Microfluidics, Microcontrollers, and Chemometrics.","authors":"Amber M Hupp, Michelle L Kovarik, Daniel A McCurry","doi":"10.1146/annurev-anchem-061622-041922","DOIUrl":"10.1146/annurev-anchem-061622-041922","url":null,"abstract":"<p><p>Analytical chemistry is a fast-paced field with frequent introduction of new techniques via research labs; however, incorporation of new techniques into academic curricula lags their adoption in research and industry. This review describes the recent educational literature on microfluidics, microcontrollers, and chemometrics in the undergraduate analytical chemistry curriculum. Each section highlights opportunities for nonexpert faculty to get started with these techniques and more advanced implementations suitable for experienced practitioners. While the addition of new topics to any curriculum brings some opportunity costs, student engagement with cutting edge techniques brings many benefits, including enhanced preparation for graduate school and professional careers and development of transferable skills, such as coding. Formal assessment of student outcomes is encouraged to promote broader adoption of these techniques.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Designs and Applications for Biomembrane Biosensors. 生物膜生物传感器的新兴设计与应用。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2024-07-01 DOI: 10.1146/annurev-anchem-061622-042618
Ekaterina Selivanovitch, Alexis Ostwalt, Zhongmou Chao, Susan Daniel
{"title":"Emerging Designs and Applications for Biomembrane Biosensors.","authors":"Ekaterina Selivanovitch, Alexis Ostwalt, Zhongmou Chao, Susan Daniel","doi":"10.1146/annurev-anchem-061622-042618","DOIUrl":"10.1146/annurev-anchem-061622-042618","url":null,"abstract":"<p><p>Nature has inspired the development of biomimetic membrane sensors in which the functionalities of biological molecules, such as proteins and lipids, are harnessed for sensing applications. This review provides an overview of the recent developments for biomembrane sensors compatible with either bulk or planar sensing applications, namely using lipid vesicles or supported lipid bilayers, respectively. We first describe the individual components required for these sensing platforms and the design principles that are considered when constructing them, and we segue into recent applications being implemented across multiple fields. Our goal for this review is to illustrate the versatility of nature's biomembrane toolbox and simultaneously highlight how biosensor platforms can be enhanced by harnessing it.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maximizing Analytical Performance in Biomolecular Discovery with LC-MS: Focus on Psychiatric Disorders. 利用 LC-MS 最大限度提高生物分子发现的分析性能:聚焦精神疾病。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI: 10.1146/annurev-anchem-061522-041154
Bradley J Smith, Paul C Guest, Daniel Martins-de-Souza
{"title":"Maximizing Analytical Performance in Biomolecular Discovery with LC-MS: Focus on Psychiatric Disorders.","authors":"Bradley J Smith, Paul C Guest, Daniel Martins-de-Souza","doi":"10.1146/annurev-anchem-061522-041154","DOIUrl":"10.1146/annurev-anchem-061522-041154","url":null,"abstract":"<p><p>In this review, we discuss the cutting-edge developments in mass spectrometry proteomics and metabolomics that have brought improvements for the identification of new disease-based biomarkers. A special focus is placed on psychiatric disorders, for example, schizophrenia, because they are considered to be not a single disease entity but rather a spectrum of disorders with many overlapping symptoms. This review includes descriptions of various types of commonly used mass spectrometry platforms for biomarker research, as well as complementary techniques to maximize data coverage, reduce sample heterogeneity, and work around potentially confounding factors. Finally, we summarize the different statistical methods that can be used for improving data quality to aid in reliability and interpretation of proteomics findings, as well as to enhance their translatability into clinical use and generalizability to new data sets.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteriophage-Based Bioanalysis. 基于噬菌体的生物分析。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2024-07-01 DOI: 10.1146/annurev-anchem-071323-084224
David R Parker, Sam R Nugen
{"title":"Bacteriophage-Based Bioanalysis.","authors":"David R Parker, Sam R Nugen","doi":"10.1146/annurev-anchem-071323-084224","DOIUrl":"10.1146/annurev-anchem-071323-084224","url":null,"abstract":"<p><p>Bacteriophages, which are viral predators of bacteria, have evolved to efficiently recognize, bind, infect, and lyse their host, resulting in the release of tens to hundreds of propagated viruses. These abilities have attracted biosensor developers who have developed new methods to detect bacteria. Recently, several comprehensive reviews have covered many of the advances made regarding the performance of phage-based biosensors. Therefore, in this review, we first describe the landscape of phage-based biosensors and then cover advances in other aspects of phage biology and engineering that can be used to make high-impact contributions to biosensor development. Many of these advances are in fields adjacent to analytical chemistry such as synthetic biology, machine learning, and genetic engineering and will allow those looking to develop phage-based biosensors to start taking alternative approaches, such as a bottom-up design and synthesis of custom phages with the singular task of detecting their host.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gels in Microscale Electrophoresis. 凝胶在微型电泳。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2023-06-14 DOI: 10.1146/annurev-anchem-091522-080207
Lisa A Holland, Laura D Casto-Boggess
{"title":"Gels in Microscale Electrophoresis.","authors":"Lisa A Holland,&nbsp;Laura D Casto-Boggess","doi":"10.1146/annurev-anchem-091522-080207","DOIUrl":"10.1146/annurev-anchem-091522-080207","url":null,"abstract":"<p><p>Gel matrices are fundamental to electrophoresis analyses of biopolymers in microscale channels. Both capillary gel and microchannel gel electrophoresis systems have produced fundamental advances in the scientific community. These analytical techniques remain as foundational tools in bioanalytical chemistry and are indispensable in the field of biotherapeutics. This review summarizes the current state of gels in microscale channels and provides a brief description of electrophoretic transport in gels. In addition to the discussion of traditional polymers, several nontraditional gels are introduced. Advances in gel matrices highlighted include selective polymers modified to contain added functionality as well as thermally responsive gels formed through self-assembly. This review discusses cutting-edge applications to challenging areas of discovery in DNA, RNA, protein, and glycan analyses. Finally, emerging techniques that result in multifunctional assays for real-time biochemical processing in capillary and three-dimensional channels are identified.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9634476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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