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Recent Trends in Surface-Enhanced Raman Scattering-Based In Vitro Diagnostics for Translational Biomedical Research. 基于表面增强拉曼散射的体外诊断在转化生物医学研究中的最新趋势。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-04 DOI: 10.1146/annurev-anchem-070524-093950
Younju Joung, Sohyun Park, Sang-Woo Joo, Jaebum Choo
{"title":"Recent Trends in Surface-Enhanced Raman Scattering-Based In Vitro Diagnostics for Translational Biomedical Research.","authors":"Younju Joung, Sohyun Park, Sang-Woo Joo, Jaebum Choo","doi":"10.1146/annurev-anchem-070524-093950","DOIUrl":"10.1146/annurev-anchem-070524-093950","url":null,"abstract":"<p><p>Surface-enhanced Raman scattering (SERS) spectroscopy has gained prominence in in vitro diagnostics due to its high sensitivity and multiplex detection capabilities. This review highlights recent advances in translational biomedical research using SERS techniques, with a focus on the rapid and accurate diagnosis of intractable diseases such as cancer and infectious diseases such as COVID-19. The review examines SERS-based assays for liquid biopsy biomarkers such as exosomes, circulating tumor cells, and circulating tumor DNAs that have emerged as promising tools in cancer diagnostics and are currently under active investigation in clinical research. Additionally, it explores SERS-based diagnostic techniques developed to overcome the limitations of existing COVID-19 diagnostic methods, including real-time polymerase chain reaction and lateral flow assay immunodiagnostics. Finally, the review addresses the challenges of translating SERS techniques from laboratory research to clinical practice.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"335-357"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein Engineering for Spatiotemporally Resolved Cellular Monitoring. 用于时空分辨细胞监测的蛋白质工程。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-25 DOI: 10.1146/annurev-anchem-070124-035857
Guanwei Zhou, Wenjing Wang
{"title":"Protein Engineering for Spatiotemporally Resolved Cellular Monitoring.","authors":"Guanwei Zhou, Wenjing Wang","doi":"10.1146/annurev-anchem-070124-035857","DOIUrl":"10.1146/annurev-anchem-070124-035857","url":null,"abstract":"<p><p>Protein engineering has been extensively applied to the development of genetically encoded reporters for spatiotemporally resolved monitoring of dynamic biochemical activity across cellular compartments in living cells. Genetically encoded reporters facilitate the visualization and recording of cellular processes, including transmission of signaling molecules, protease activity, and protein-protein interactions. In this review, we describe and assess common reporter motifs and protein engineering strategies for designing genetically encoded reporters. We also discuss essential parameters for evaluating genetically encoded reporters, along with future protein engineering opportunities in this field.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"217-240"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft X-Ray Tomography Has Evolved into a Powerful Tool for Revealing Cell Structures. 软x射线断层扫描已经发展成为揭示细胞结构的有力工具。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-03-03 DOI: 10.1146/annurev-anchem-071124-093849
Venera Weinhardt, Carolyn Larabell
{"title":"Soft X-Ray Tomography Has Evolved into a Powerful Tool for Revealing Cell Structures.","authors":"Venera Weinhardt, Carolyn Larabell","doi":"10.1146/annurev-anchem-071124-093849","DOIUrl":"10.1146/annurev-anchem-071124-093849","url":null,"abstract":"<p><p>Over the past three decades, soft X-ray tomography (SXT) has rapidly evolved from a proof-of-concept microscopy method into a high-throughput quantitative imaging modality. This advancement enables researchers to address central questions in cell biology. Despite its relatively short developmental period compared to light and electron microscopy, SXT has emerged as a powerful imaging technology. It enables measuring chemical changes in cellular organelles, analyzing three-dimensional structures of whole cells and creating digital cellular models to study cell motility. We discuss the unique nature of SXT to visualize cells without fixation or labeling, enabling quantitative analyses of organelle chemical composition. We explore SXT microscopes available worldwide, SXT segmentation software, and the diverse cell types studied using this technique. We conclude with emerging directions in SXT imaging, including a brief discussion of recent discoveries that are highly influential and likely to become integral to cell biology textbooks.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"427-446"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring Skin Volatile Emissions Using Wearable Sensors. 使用可穿戴传感器监测皮肤挥发性排放物。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 DOI: 10.1146/annurev-anchem-071024-020707
R Angioi, N Thamatam, M Agah, A Morrin
{"title":"Monitoring Skin Volatile Emissions Using Wearable Sensors.","authors":"R Angioi, N Thamatam, M Agah, A Morrin","doi":"10.1146/annurev-anchem-071024-020707","DOIUrl":"https://doi.org/10.1146/annurev-anchem-071024-020707","url":null,"abstract":"<p><p>Human skin emits a continuous flux of volatile compounds reflecting various metabolic processes in the body, microbial activity, and environmental factors. Harnessing this emission for diagnostics is of great interest given the noninvasive, passive, and accessible nature of the emission, and there is much research underway to understand the value of this skin-emitted volatile organic compound (VOC) matrix. In parallel to this, wearable skin VOC sensors are emerging and garnering attention due to their potential to provide noninvasive, real-time information for monitoring human health, overcoming many of the design challenges related to biofluid monitoring via wearables. The projected opportunities for skin VOCs are fueling innovations in wearable VOC monitoring. This review discusses the most recent developments, from fully integrated wearable skin VOC sensors that exploit existing semiconductor technology to the design and preparation of advanced new sensing materials and devices to deliver new modalities for wearable skin VOC sensors. We articulate the challenges, limitations, and opportunities for technological advances to provide a perspective on promising directions for future developments.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":"18 1","pages":"285-305"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Assays Enabled by Engineered Nanoparticles. 通过工程纳米颗粒实现诊断分析。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-04 DOI: 10.1146/annurev-anchem-052124-085604
Boxi Lu, Yanwei Cai, Dou Wang, Xingyu Jiang
{"title":"Diagnostic Assays Enabled by Engineered Nanoparticles.","authors":"Boxi Lu, Yanwei Cai, Dou Wang, Xingyu Jiang","doi":"10.1146/annurev-anchem-052124-085604","DOIUrl":"10.1146/annurev-anchem-052124-085604","url":null,"abstract":"<p><p>Nanoparticles have broad applications in medical diagnosis, bioengineering, and various other domains. Engineered nanoparticles are pivotal in enhancing in vitro detection performance. Utilizing signal readouts such as bioluminescence, fluorescence, and others, nanoparticles enable precise, real-time monitoring of a wide range of analytes. Furthermore, nanoparticles are ingeniously designed to improve the efficiency of in vivo imaging. Nanoparticles are integral to both deep-body imaging, which utilizes advanced techniques such as magnetic resonance imaging or computed tomography (CT), and high-resolution, real-time optical imaging, which are essential for applications such as fluorescence-guided surgery. Here, we highlight these impactful diagnostic assays enabled by engineered nanoparticles, comparing their advantages and disadvantages extensively. For the introduction of each method, we compare the most classic and latest research as much as possible to provide a comprehensive perspective. Finally, we summarize the current limitations and challenges of nanoparticles for diagnostic analysis while also exploring future trends and prospects.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"265-284"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental Exposures and Health Risks: A Metabolomics Perspective on Exposomics Research. 环境暴露与健康风险：暴露组学研究的代谢组学视角。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-10 DOI: 10.1146/annurev-anchem-071524-125307
Ana Ruxandra Stanciu, Claire Gillespie, Philip Britz-McKibbin
{"title":"Environmental Exposures and Health Risks: A Metabolomics Perspective on Exposomics Research.","authors":"Ana Ruxandra Stanciu, Claire Gillespie, Philip Britz-McKibbin","doi":"10.1146/annurev-anchem-071524-125307","DOIUrl":"10.1146/annurev-anchem-071524-125307","url":null,"abstract":"<p><p>Exposomics refers to the comprehensive analysis of environmental exposures over the lifespan and assessment of their biological effects on human health. This new frontier in environmental research promises new insights for assessment of the hazards of complex chemical exposures as compared to targeted biomonitoring of a limited panel of known toxicant(s). Metabolomics plays a pivotal role in expanding exposomic initiatives that require orthogonal separation methods coupled to high-resolution mass spectrometry while using minimally invasive specimens from prospective cohort studies that can capture early life exposures. However, several grand analytical challenges remain, including high-throughput metabolomic data workflows that are scalable to large populations, the identification of unknown contaminants and their contact sources, and elucidating the impact of multiple co-exposures at critical stages of development. In this review, we outline new advances in metabolomic technologies for exposomics research over the past five years that are urgently needed to guide regulatory policies via better exposure mitigation and strategies to improve metabolic resilience.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"47-71"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Microbiome Analysis by Mass Spectrometry-Based Metaproteomics. 基于质谱的临床微生物组分析
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-01-15 DOI: 10.1146/annurev-anchem-071124-113819
Xu Zhang, Zhibin Ning, Janice Mayne, Daniel Figeys
{"title":"Clinical Microbiome Analysis by Mass Spectrometry-Based Metaproteomics.","authors":"Xu Zhang, Zhibin Ning, Janice Mayne, Daniel Figeys","doi":"10.1146/annurev-anchem-071124-113819","DOIUrl":"10.1146/annurev-anchem-071124-113819","url":null,"abstract":"<p><p>Mass spectrometry-based proteomics and metaproteomics have long been used in the study of human microbiomes, with the potential of metaproteomics only recently being fully harnessed. This progress is due to the advancements of high-performance mass spectrometers, innovative proteomics strategies, and the development of dedicated bioinformatics tools. In this review, we critically examine the recent technological developments that enhance the application of metaproteomics in clinical microbiome analysis. We also summarize significant advancements in the application of metaproteomics to study human microbiomes across various body sites under disease conditions. Despite these, the potential of metaproteomics remains underutilized due to typically small sample sizes and insufficient data mining. We thereby highlight some key aspects that could facilitate the broader and more effective application of mass spectrometry-based metaproteomics in clinical microbiome analysis, including the development of microbiome assays for translational research and application.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"149-172"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Capillary Electrophoresis-Mass Spectrometry for Top-Down Proteomics. 毛细管电泳-质谱法用于自上而下的蛋白质组学。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-01-23 DOI: 10.1146/annurev-anchem-071124-092242
Qianjie Wang, Qianyi Wang, Guijie Zhu, Liangliang Sun
{"title":"Capillary Electrophoresis-Mass Spectrometry for Top-Down Proteomics.","authors":"Qianjie Wang, Qianyi Wang, Guijie Zhu, Liangliang Sun","doi":"10.1146/annurev-anchem-071124-092242","DOIUrl":"10.1146/annurev-anchem-071124-092242","url":null,"abstract":"<p><p>Mass spectrometry (MS)-based top-down proteomics (TDP) characterizes proteoforms in cells, tissues, and biological fluids (e.g., human plasma) to better our understanding of protein function and to discover new protein biomarkers for disease diagnosis and therapeutic development. Separations of proteoforms with high peak capacity are needed due to the high complexity of biological samples. Capillary electrophoresis (CE)-MS has been recognized as a powerful analytical tool for protein analysis since the 1980s owing to its high separation efficiency and sensitivity of CE-MS for proteoforms. Here, we review benefits of CE-MS for advancing TDP, challenges and solutions of the method, and the main research areas in which CE-MS-based TDP can make significant contributions. We provide a brief perspective of CE-MS-based TDP moving forward.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"125-147"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Online Comprehensive Two-Dimensional Liquid Chromatography Method Development. 在线综合二维液相色谱法研究进展
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1146/annurev-anchem-071524-090321
Eugene H J Nell, Magriet Muller, André de Villiers
{"title":"Advances in Online Comprehensive Two-Dimensional Liquid Chromatography Method Development.","authors":"Eugene H J Nell, Magriet Muller, André de Villiers","doi":"10.1146/annurev-anchem-071524-090321","DOIUrl":"10.1146/annurev-anchem-071524-090321","url":null,"abstract":"<p><p>Comprehensive two-dimensional liquid chromatography (LC×LC) is increasingly being used to provide new information on the composition of complex samples. More widespread use of the technique is, however, hampered by the complexity of method development, which involves the selection and optimization of a very large number of experimental variables while considering their interdependence and relationship with conflicting analysis goals. This contribution summarizes the progress made in online LC×LC method development to date. Recent trends in advanced method optimization are highlighted to demonstrate how progress in the field enables the development of highly efficient LC×LC methods.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":" ","pages":"359-381"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roots of Innovation in Analytical Chemistry. 分析化学创新的根源。
Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 DOI: 10.1146/annurev-anchem-061622-035620
Edgar A Arriaga, Jani C Ingram, Charles A Lucy, Leyte Winfield
{"title":"Roots of Innovation in Analytical Chemistry.","authors":"Edgar A Arriaga, Jani C Ingram, Charles A Lucy, Leyte Winfield","doi":"10.1146/annurev-anchem-061622-035620","DOIUrl":"https://doi.org/10.1146/annurev-anchem-061622-035620","url":null,"abstract":"<p><p>The article profiles 11 academic analytical chemists and explores the impact of their unique backgrounds and identities on their creativity and contributions to the field. The narratives provide inspiration and a reminder of the humanity of those contributing to innovation in analytical chemistry. Arranged alphabetically by last name, these innovators are Abraham Badu-Tawiah, Karl Booksh, Luis A. Colón, Purnendu (Sandy) Dasgupta, Jani C. Ingram, Lisa M. Jones, Matthew Lockett, Shelley Minteer, Renã A.S. Robinson, Joaquín Rodríguez-López, and Isiah M. Warner.</p>","PeriodicalId":72239,"journal":{"name":"Annual review of analytical chemistry (Palo Alto, Calif.)","volume":"18 1","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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