Recent Trends in Surface-Enhanced Raman Scattering-Based In Vitro Diagnostics for Translational Biomedical Research.

IF 7.5

Annual review of analytical chemistry (Palo Alto, Calif.) Pub Date : 2025-05-01 Epub Date: 2025-02-04 DOI:10.1146/annurev-anchem-070524-093950

Younju Joung, Sohyun Park, Sang-Woo Joo, Jaebum Choo

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Abstract

Surface-enhanced Raman scattering (SERS) spectroscopy has gained prominence in in vitro diagnostics due to its high sensitivity and multiplex detection capabilities. This review highlights recent advances in translational biomedical research using SERS techniques, with a focus on the rapid and accurate diagnosis of intractable diseases such as cancer and infectious diseases such as COVID-19. The review examines SERS-based assays for liquid biopsy biomarkers such as exosomes, circulating tumor cells, and circulating tumor DNAs that have emerged as promising tools in cancer diagnostics and are currently under active investigation in clinical research. Additionally, it explores SERS-based diagnostic techniques developed to overcome the limitations of existing COVID-19 diagnostic methods, including real-time polymerase chain reaction and lateral flow assay immunodiagnostics. Finally, the review addresses the challenges of translating SERS techniques from laboratory research to clinical practice.

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基于表面增强拉曼散射的体外诊断在转化生物医学研究中的最新趋势。

由于其高灵敏度和多重检测能力，表面增强拉曼散射（SERS）光谱在体外诊断中获得了突出地位。本文综述了利用SERS技术进行转化生物医学研究的最新进展，重点介绍了癌症等难治性疾病和COVID-19等传染病的快速准确诊断。本文综述了基于sers的液体活检生物标志物检测方法，如外泌体、循环肿瘤细胞和循环肿瘤dna，这些生物标志物已成为癌症诊断的有前途的工具，目前正在临床研究中积极研究。此外，它还探索了基于sers的诊断技术，以克服现有COVID-19诊断方法的局限性，包括实时聚合酶链反应和侧流分析免疫诊断。最后，回顾了将SERS技术从实验室研究转化为临床实践的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annual review of analytical chemistry (Palo Alto, Calif.)

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