Annales de parasitologie humaine et comparee最新文献_第2页

Plasmodium berghei: the use of discontinuous urografin density gradients for the separation of exoerythrocytic malaria parasites. 柏氏疟原虫:使用不连续尿涂素密度梯度分离红细胞外疟原虫。

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01 DOI: 10.1051/parasite/1993685220

G François, I Desombere, M Wéry

引用次数: 2

[In vitro study of leishmanicidal agents with drug carriers]. [药物载体利什曼尼杀灭剂体外研究]。

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01 DOI: 10.1051/parasite/199368134

M Deniau, R Durand, C Bories, M Paul, A Astier, P Couvreur, R Houin

{"title":"[In vitro study of leishmanicidal agents with drug carriers].","authors":"M Deniau, R Durand, C Bories, M Paul, A Astier, P Couvreur, R Houin","doi":"10.1051/parasite/199368134","DOIUrl":"https://doi.org/10.1051/parasite/199368134","url":null,"abstract":"Antileishmanial chemotherapy is hampered by the location of parasites within lysosomal vacuoles of the macrophages which restricts the bioavailability of many potential antileishmanial compounds. In this study, the effectiveness of pentamidine targeted to the infected cells by a linkage to a colloidal drug carrier, methacrylate polymer nanoparticles was explored. In the same way, polyisoalkylcyanoacrylate nanospheres which have, in vitro, trypanolytic properties were also tested. The study was performed in an in vitro model using Leishmania major amastigote stages within the U 937 human monohistiocytic cell line. The antileishmanial activities of unloaded or pentamidine-loaded nanoparticles were compared to those of the free drugs. The 50% effective concentration of targeted pentamidine was 0.10 microgram/ml, while it was up to 2.7 micrograms/ml with the free drug after a 24-hour incubation time. The pentamidine-bound nanoparticles proved to be 25 times more active than the free drug. Unloaded polyisoalkylcyanoacrylate nanoparticles destroyed intracellular amastigote stages (50% EC = 15 micrograms/ml) but at a level close to the cytotoxic concentration.","PeriodicalId":72205,"journal":{"name":"Annales de parasitologie humaine et comparee","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1051/parasite/199368134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19475101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Phylogenetic taxonomy of New World Leishmania. 新世界利什曼原虫的系统发育分类。

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01

V Thomaz-Soccol, G Lanotte, J A Rioux, F Pratlong, A Martini-Dumas, E Serres

引用次数: 0

Phylogenetic taxonomy of New World Leishmania. 新世界利什曼原虫的系统发育分类。

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01 DOI: 10.1051/parasite/1993682104

V. Thomaz-Soccol, G. Lanotte, J. Rioux, Francine Pratlong, A. Martini-Dumas, E. Serres

引用次数: 53

Monophyletic origin of the genus Leishmania Ross, 1903. 利什曼原虫属的单系起源，罗斯，1903。

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01

V Thomaz-Soccol, G Lanotte, J A Rioux, F Pratlong, A Martini-Dumas, E Serres

引用次数: 0

Ultrastructural study of Eimeria gastrosauris a coccidium from the stomach epithelium of Australian Geckoes 澳洲壁虎胃上皮胃龙球虫超微结构研究

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01 DOI: 10.1051/PARASITE/199368270

I. Paperna

引用次数: 6

Laboratory and field studies on Herpetosoma Trypanosomes from Portugal 葡萄牙锥虫的实验室和野外研究

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01 DOI: 10.1051/PARASITE/1993684163

G. Santos-Gomes, P. Abranches, S. Maraghi, M. Dirie, M. C. Silva-Pereira, D. Valverde, D. Molyneux

引用次数: 4

Improved rearing conditions of sandflies (Phlebotomus argentipes), as required for studies on transmission dynamics of leishmaniasis 根据利什曼病传播动力学研究的需要，改善白蛉(阿根廷白蛉)的饲养条件

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01 DOI: 10.1051/PARASITE/1993685244

K. Ghosh, A. Ghosh, S. Basak, S. Adhya, A. Bhattacharya

引用次数: 1

Human bilharzial ureters. II. Cellular dynamic against deposited eggs. 人类双侧输尿管。2细胞动力学对抗卵的沉积。

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01 DOI: 10.1051/parasite/1993683121

S M el-Shoura

{"title":"Human bilharzial ureters. II. Cellular dynamic against deposited eggs.","authors":"S M el-Shoura","doi":"10.1051/parasite/1993683121","DOIUrl":"https://doi.org/10.1051/parasite/1993683121","url":null,"abstract":"The cellular dynamic against deposited Schistosoma haematobium eggs was studied in the submucosa and muscularis of the lower ureteral segments of Saudi patients with chronic urinary schistosomiasis. This dynamic activity was greatly affected by the damaged phase of the egg embryo. Freshly deposited eggs with \"healthy\" embryos were entirely surrounded by long cytoplasmic extensions of fibroblasts. Eggs with partially damaged embryos were surrounded by plasma cells which were focally adhered to spines of egg-shells and releasing their granular contents over their surface. Eggs with \"dead\" embryos, or empty egg-shells, were surrounded by actively mobile macrophages possessing numerous lysosomes, phagocytic vacuoles, and convoluted surface projections. After \"peeling\" off the outer and intermediate shell layers, macrophages invaded into eggs and fused together forming multinucleate giant macrophages. This study showed that the fibroblastic extensions acted as barriers between the parasite eggs or their products, and the host tissue; the plasma cell secretion over the egg surface may be involved in the migration of macrophages towards deposited eggs; and macrophages were the only dynamic cells responsible for the egg-shell invasion possibly for elimination.","PeriodicalId":72205,"journal":{"name":"Annales de parasitologie humaine et comparee","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1051/parasite/1993683121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19205195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effect of ivermectin on two filaria-vector pairs. Brugia malayi-Aedes aegypti; Litomosoides sigmodontis-Bdellonyssus bacoti. 伊维菌素对两对丝虫病媒的影响。马来西亚-埃及伊蚊;双歧杆菌。

Annales de parasitologie humaine et comparee Pub Date : 1993-01-01 DOI: 10.1051/parasite/1993683144

F Chandre, G Petit, M Diagne, P Maréchal, O Bain

{"title":"Effect of ivermectin on two filaria-vector pairs. Brugia malayi-Aedes aegypti; Litomosoides sigmodontis-Bdellonyssus bacoti.","authors":"F Chandre, G Petit, M Diagne, P Maréchal, O Bain","doi":"10.1051/parasite/1993683144","DOIUrl":"https://doi.org/10.1051/parasite/1993683144","url":null,"abstract":"The effect of ivermectin was studied on two filaria-vector pairs, Brugia malayi-Aedes aegypti and Litomosoides sigmodontis-Bdellonyssus bacoti. The rodent hosts, respectively Mastomys coucha and Meriones unguiculatus, were treated with ivermectin doses of 0.05 mg/kg, or 0.2 mg/kg or 2 mg/kg. Batches of vectors were fed on rodents, infected or not, treated or not, from H7 to D43 post-ivermectin. Vector survival was observed and dissections were performed to study the filarial development. It appears that ivermectin has no systemic effect on vectors, or very little. The drug acts on transmission because it affects the microfilariae. Transmission of L. sigmodontis is blocked because microfilariae are eliminated from the blood. Transmission of B. malayi is blocked although microfilaremia remains present at a low level. Two particular features are observed: microfilariae are hyper-ingested, but they do not cross the stomach wall (in contrast, they cross at a high rate in the control batch of Aedes, due to the \"stomach wall limitation\"). These events might be explained by a muscular passivity of the microfilariae treated with ivermectin. Transmission of the two filarioid species is restored normally about D25-40 post ivermectin because a new population of microfilariae has appeared. These ivermectin experiments emphasize the diversity and complexity of two important phases of the filarial cycle in the vector: the ingestion of microfilariae and the passage through the stomach wall.","PeriodicalId":72205,"journal":{"name":"Annales de parasitologie humaine et comparee","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1051/parasite/1993683144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19205196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2