Angewandte Chemie (Weinheim an der Bergstrasse, Germany)最新文献_第2页

Probing the Lipid Annular Belt by Gas-Phase Dissociation of Membrane Proteins in Nanodiscs. 纳米圆盘膜蛋白气相解离探测脂质环状带。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2016-01-11 Epub Date: 2015-11-23 DOI: 10.1002/ange.201508289

Michael T Marty, Kin Kuan Hoi, Joseph Gault, Carol V Robinson

引用次数: 7

Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis. 盐霉素生物合成中吡喃环A形成的酶学研究。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2015-11-09 Epub Date: 2015-09-17 DOI: 10.1002/ange.201507090

Hanna Luhavaya, Marcio V B Dias, Simon R Williams, Hui Hong, Luciana G de Oliveira, Peter F Leadlay

引用次数: 4

Ribosome Subunit Stapling for Orthogonal Translation in E. coli. 大肠杆菌正交翻译的核糖体亚基钉接。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2015-10-19 Epub Date: 2015-08-26 DOI: 10.1002/ange.201506311

Stephen D Fried, Wolfgang H Schmied, Chayasith Uttamapinant, Jason W Chin

引用次数: 45

Formation of Ruthenium Carbenes by gem-Hydrogen Transfer to Internal Alkynes: Implications for Alkyne trans-Hydrogenation. 通过向内部炔烃转移gem-Hydrogen形成钌羰基：对炔烃反式氢化的影响。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2015-10-12 Epub Date: 2015-08-31 DOI: 10.1002/ange.201506075

Markus Leutzsch, Larry M Wolf, Puneet Gupta, Michael Fuchs, Walter Thiel, Christophe Farès, Alois Fürstner

{"title":"Formation of Ruthenium Carbenes by gem-Hydrogen Transfer to Internal Alkynes: Implications for Alkyne trans-Hydrogenation.","authors":"Markus Leutzsch, Larry M Wolf, Puneet Gupta, Michael Fuchs, Walter Thiel, Christophe Farès, Alois Fürstner","doi":"10.1002/ange.201506075","DOIUrl":"10.1002/ange.201506075","url":null,"abstract":"Insights into the mechanism of the unusual trans-hydrogenation of internal alkynes catalyzed by {Cp*Ru} complexes were gained by para-hydrogen (p-H2) induced polarization (PHIP) transfer NMR spectroscopy. It was found that the productive trans-reduction competes with a pathway in which both H atoms of H2 are delivered to a single alkyne C atom of the substrate while the second alkyne C atom is converted into a metal carbene. This \"geminal hydrogenation\" mode seems unprecedented; it was independently confirmed by the isolation and structural characterization of a ruthenium carbene complex stabilized by secondary inter-ligand interactions. A detailed DFT study shows that the trans alkene and the carbene complex originate from a common metallacyclopropene intermediate. Furthermore, the computational analysis and the PHIP NMR data concur in that the metal carbene is the major gateway to olefin isomerization and over-reduction, which frequently interfere with regular alkyne trans-hydrogenation.","PeriodicalId":72198,"journal":{"name":"Angewandte Chemie (Weinheim an der Bergstrasse, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34331129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. LP99:首个选择性BRD7/9溴域抑制剂的发现和合成。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2015-05-18 Epub Date: 2015-04-13 DOI: 10.1002/ange.201501394

Peter G K Clark, Lucas C C Vieira, Cynthia Tallant, Oleg Fedorov, Dean C Singleton, Catherine M Rogers, Octovia P Monteiro, James M Bennett, Roberta Baronio, Susanne Müller, Danette L Daniels, Jacqui Méndez, Stefan Knapp, Paul E Brennan, Darren J Dixon

{"title":"LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.","authors":"Peter G K Clark, Lucas C C Vieira, Cynthia Tallant, Oleg Fedorov, Dean C Singleton, Catherine M Rogers, Octovia P Monteiro, James M Bennett, Roberta Baronio, Susanne Müller, Danette L Daniels, Jacqui Méndez, Stefan Knapp, Paul E Brennan, Darren J Dixon","doi":"10.1002/ange.201501394","DOIUrl":"https://doi.org/10.1002/ange.201501394","url":null,"abstract":"The bromodomain-containing proteins BRD9 and BRD7 are part of the human SWI/SNF chromatin-remodeling complexes BAF and PBAF. To date, no selective inhibitor for BRD7/9 has been reported despite its potential value as a biological tool or as a lead for future therapeutics. The quinolone-fused lactam LP99 is now reported as the first potent and selective inhibitor of the BRD7 and BRD9 bromodomains. Development of LP99 from a fragment hit was expedited through balancing structure-based inhibitor design and biophysical characterization against tractable chemical synthesis: Complexity-building nitro-Mannich/lactamization cascade processes allowed for early structure-activity relationship studies whereas an enantioselective organocatalytic nitro-Mannich reaction enabled the synthesis of the lead scaffold in enantioenriched form and on scale. This epigenetic probe was shown to inhibit the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. Moreover, LP99 was used to demonstrate that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion.","PeriodicalId":72198,"journal":{"name":"Angewandte Chemie (Weinheim an der Bergstrasse, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ange.201501394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34504120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 148

Caterpillar Track Complexes in Template-Directed Synthesis and Correlated Molecular Motion. 模板指导合成和相关分子运动中的毛毛虫轨道复合物。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2015-04-27 Epub Date: 2015-02-12 DOI: 10.1002/ange.201412293

Shiqi Liu, Dmitry V Kondratuk, Sophie A L Rousseaux, Guzmán Gil-Ramírez, Melanie C O'Sullivan, Jonathan Cremers, Tim D W Claridge, Harry L Anderson

{"title":"Caterpillar Track Complexes in Template-Directed Synthesis and Correlated Molecular Motion.","authors":"Shiqi Liu, Dmitry V Kondratuk, Sophie A L Rousseaux, Guzmán Gil-Ramírez, Melanie C O'Sullivan, Jonathan Cremers, Tim D W Claridge, Harry L Anderson","doi":"10.1002/ange.201412293","DOIUrl":"10.1002/ange.201412293","url":null,"abstract":"Small alterations to the structure of a star-shaped template totally change its mode of operation. The hexapyridyl template directs the conversion of a porphyrin dimer to the cyclic hexamer, but deleting one pyridine site changes the product to the cyclic decamer, while deleting two binding sites changes the product to the cyclic octamer. This surprising switch in selectivity is explained by the formation of 2:1 caterpillar track complexes, in which two template wheels bind inside the nanoring. Caterpillar track complexes can also be prepared by binding the hexapyridyl template inside the 8- and 10-porphyrin nanorings. NMR exchange spectroscopy (EXSY) experiments show that these complexes exhibit correlated motion, in which the conrotatory rotation of the two template wheels is coupled to rotation of the nanoring track. In the case of the 10-porphyrin system, the correlated motion can be locked by binding palladium(II) dichloride between the two templates.","PeriodicalId":72198,"journal":{"name":"Angewandte Chemie (Weinheim an der Bergstrasse, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34681776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biology and biochemistry of reproduction and contraception. 生殖和避孕的生物学和生物化学。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 1962-10-01

W JOCHLE

引用次数: 0