Angewandte Chemie (Weinheim an der Bergstrasse, Germany)最新文献

Synthese von α-Arylacrylamiden via Lewis Base vermitteltem Aryl/Wasserstoff-Austausch. 通过路易斯碱介导的芳基/氢交换合成 α-芳基丙烯酰胺。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2022-10-04 Epub Date: 2022-08-29 DOI: 10.1002/ange.202207475

Miran Lemmerer, Haoqi Zhang, Anthony J Fernandes, Tobias Fischer, Marianne Mießkes, Yi Xiao, Nuno Maulide

引用次数: 0

Transmembrane Shuttling of Photosynthetically Produced Electrons to Propel Extracellular Biocatalytic Redox Reactions in a Modular Fashion. 光合作用产生的电子跨膜穿梭，以模块化方式推动细胞外生物催化氧化还原反应。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2022-10-04 Epub Date: 2022-08-29 DOI: 10.1002/ange.202207971

Valentina Jurkaš, Florian Weissensteiner, Piera De Santis, Stephan Vrabl, Frieda A Sorgenfrei, Sarah Bierbaumer, Selin Kara, Robert Kourist, Pramod P Wangikar, Christoph K Winkler, Wolfgang Kroutil

{"title":"Transmembrane Shuttling of Photosynthetically Produced Electrons to Propel Extracellular Biocatalytic Redox Reactions in a Modular Fashion.","authors":"Valentina Jurkaš, Florian Weissensteiner, Piera De Santis, Stephan Vrabl, Frieda A Sorgenfrei, Sarah Bierbaumer, Selin Kara, Robert Kourist, Pramod P Wangikar, Christoph K Winkler, Wolfgang Kroutil","doi":"10.1002/ange.202207971","DOIUrl":"10.1002/ange.202207971","url":null,"abstract":"Many biocatalytic redox reactions depend on the cofactor NAD(P)H, which may be provided by dedicated recycling systems. Exploiting light and water for NADPH-regeneration as it is performed, e.g. by cyanobacteria, is conceptually very appealing due to its high atom economy. However, the current use of cyanobacteria is limited, e.g. by challenging and time-consuming heterologous enzyme expression in cyanobacteria as well as limitations of substrate or product transport through the cell wall. Here we establish a transmembrane electron shuttling system propelled by the cyanobacterial photosynthesis to drive extracellular NAD(P)H-dependent redox reactions. The modular photo-electron shuttling (MPS) overcomes the need for cloning and problems associated with enzyme- or substrate-toxicity and substrate uptake. The MPS was demonstrated on four classes of enzymes with 19 enzymes and various types of substrates, reaching conversions of up to 99 % and giving products with >99 % optical purity.","PeriodicalId":72198,"journal":{"name":"Angewandte Chemie (Weinheim an der Bergstrasse, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10946770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass Spectrometry Detection and Imaging of a Non-Covalent Protein-Drug Complex in Tissue from Orally Dosed Rats. 口服大鼠组织中的非共价蛋白质-药物复合物的质谱检测与成像

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2022-09-05 Epub Date: 2022-07-13 DOI: 10.1002/ange.202202075

Eva Illes-Toth, Oliver J Hale, James W Hughes, Nicole Strittmatter, Jonathan Rose, Ben Clayton, Rebecca Sargeant, Stewart Jones, Andreas Dannhorn, Richard J A Goodwin, Helen J Cooper

引用次数: 0

A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis. 一种钌（II）多吡啶络合物能破坏肌动蛋白细胞骨架的组装并阻断细胞分裂。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2022-07-04 Epub Date: 2022-05-09 DOI: 10.1002/ange.202117449

Martin R Gill, Paul J Jarman, Vanessa Hearnden, Simon D Fairbanks, Marcella Bassetto, Hannes Maib, John Palmer, Kathryn R Ayscough, Jim A Thomas, Carl Smythe

引用次数: 0

Stabilisierung von Elektronentransferwegen erlaubt Stabilität von Biohybrid-Photoelektroden über Jahre. 稳定电子传递途径可使生物杂交光电电极长年保持稳定。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2022-06-13 Epub Date: 2022-04-19 DOI: 10.1002/ange.202201148

Vincent M Friebe, Agata J Barszcz, Michael R Jones, Raoul N Frese

引用次数: 0

Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection. 中和Aptamers能阻断S/RBD-ACE2相互作用并防止宿主细胞感染

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2021-04-26 Epub Date: 2021-03-22 DOI: 10.1002/ange.202100345

Xiaohui Liu, Yi-Ling Wang, Jacky Wu, Jianjun Qi, Zihua Zeng, Quanyuan Wan, Zhenghu Chen, Pragya Manandhar, Victoria S Cavener, Nina R Boyle, Xinping Fu, Eric Salazar, Suresh V Kuchipudi, Vivek Kapur, Xiaoliu Zhang, Michihisa Umetani, Mehmet Sen, Richard C Willson, Shu-Hsia Chen, Youli Zu

{"title":"Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection.","authors":"Xiaohui Liu, Yi-Ling Wang, Jacky Wu, Jianjun Qi, Zihua Zeng, Quanyuan Wan, Zhenghu Chen, Pragya Manandhar, Victoria S Cavener, Nina R Boyle, Xinping Fu, Eric Salazar, Suresh V Kuchipudi, Vivek Kapur, Xiaoliu Zhang, Michihisa Umetani, Mehmet Sen, Richard C Willson, Shu-Hsia Chen, Youli Zu","doi":"10.1002/ange.202100345","DOIUrl":"10.1002/ange.202100345","url":null,"abstract":"The receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 spike (S) protein plays a central role in mediating the first step of virus infection to cause disease: virus binding to angiotensin-converting enzyme 2 (ACE2) receptors on human host cells. Therefore, S/RBD is an ideal target for blocking and neutralization therapies to prevent and treat coronavirus disease 2019 (COVID-19). Using a target-based selection approach, we developed oligonucleotide aptamers containing a conserved sequence motif that specifically targets S/RBD. Synthetic aptamers had high binding affinity for S/RBD-coated virus mimics (K D≈7 nM) and also blocked interaction of S/RBD with ACE2 receptors (IC50≈5 nM). Importantly, aptamers were able to neutralize S protein-expressing viral particles and prevent host cell infection, suggesting a promising COVID-19 therapy strategy.","PeriodicalId":72198,"journal":{"name":"Angewandte Chemie (Weinheim an der Bergstrasse, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250357/pdf/ANGE-133-10361.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39159253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism. SARS-CoV-2刺突结合DNA适体通过rbd独立机制抑制假病毒感染

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2021-04-26 Epub Date: 2021-03-25 DOI: 10.1002/ange.202100316

Anton Schmitz, Anna Weber, Mehtap Bayin, Stefan Breuers, Volkmar Fieberg, Michael Famulok, Günter Mayer

引用次数: 5

[A facile method for producing selenocysteine-containing proteins]. [生产含硒半胱氨酸蛋白质的简便方法]。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2018-06-11 Epub Date: 2018-04-06

Takahito Mukai, Anastasia Sevostyanova, Tateki Suzuki, Xian Fu, Dieter Söll

引用次数: 0

X-ray Excited Optical Fluorescence and Diffraction Imaging of Reactivity and Crystallinity in a Zeolite Crystal: Crystallography and Molecular Spectroscopy in One. 沸石晶体反应性和结晶性的x射线激发光学荧光和衍射成像:晶体学和分子光谱学于一体。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2016-06-20 Epub Date: 2016-05-04 DOI: 10.1002/ange.201601796

Zoran Ristanović, Jan P Hofmann, Marie-Ingrid Richard, Tao Jiang, Gilbert A Chahine, Tobias U Schülli, Florian Meirer, Bert M Weckhuysen

{"title":"X-ray Excited Optical Fluorescence and Diffraction Imaging of Reactivity and Crystallinity in a Zeolite Crystal: Crystallography and Molecular Spectroscopy in One.","authors":"Zoran Ristanović, Jan P Hofmann, Marie-Ingrid Richard, Tao Jiang, Gilbert A Chahine, Tobias U Schülli, Florian Meirer, Bert M Weckhuysen","doi":"10.1002/ange.201601796","DOIUrl":"https://doi.org/10.1002/ange.201601796","url":null,"abstract":"Structure-activity relationships in heterogeneous catalysis are challenging to be measured on a single-particle level. For the first time, one X-ray beam is used to determine the crystallographic structure and reactivity of a single zeolite crystal. The method generates μm-resolved X-ray diffraction (μ-XRD) and X-ray excited optical fluorescence (μ-XEOF) maps of the crystallinity and Brønsted reactivity of a zeolite crystal previously reacted with a styrene probe molecule. The local gradients in chemical reactivity (derived from μ-XEOF) were correlated with local crystallinity and framework Al content, determined by μ-XRD. Two distinctly different types of fluorescent species formed selectively, depending on the local zeolite crystallinity. The results illustrate the potential of this approach to resolve the crystallographic structure of a porous material and its reactivity in one experiment via X-ray induced fluorescence of organic molecules formed at the reactive centers.","PeriodicalId":72198,"journal":{"name":"Angewandte Chemie (Weinheim an der Bergstrasse, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ange.201601796","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34721082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics. 1,2,3-三唑肽模拟物的酶促大环化。

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) Pub Date : 2016-05-04 Epub Date: 2016-04-05 DOI: 10.1002/ange.201601564

Emilia Oueis, Marcel Jaspars, Nicholas J Westwood, James H Naismith

引用次数: 0