American journal of preventive cardiology最新文献

{"title":"Precision cardiovascular-kidney-metabolic care – ready for prime time? A fellow’s voice","authors":"Frank Qian","doi":"10.1016/j.ajpc.2026.101669","DOIUrl":"10.1016/j.ajpc.2026.101669","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101669"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial commentary: From prevalence to practice – implementing familial hypercholesterolemia screening in high-risk clinics using an implementation science framework","authors":"Khalid Al-Rasadi , Anurag Mehta","doi":"10.1016/j.ajpc.2026.101469","DOIUrl":"10.1016/j.ajpc.2026.101469","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101469"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental prognostic value of coronary artery calcium progression within a large community-benefit calcium score registry","authors":"Michael D. Glidden ,&nbsp;Santosh K. Sirasapalli ,&nbsp;Mark Yoder ,&nbsp;Jean-Eudes Dazard ,&nbsp;Zhuo Chen ,&nbsp;Sai Rahul Ponnana ,&nbsp;Kanimozhi Sivanantham ,&nbsp;Neda Shafiabadi Hassani ,&nbsp;Tong Zhang ,&nbsp;Gokul Parameswaran ,&nbsp;Robert A. Okyere ,&nbsp;Joseph K. Amoah ,&nbsp;Salil V. Deo ,&nbsp;Ian J. Neeland ,&nbsp;Robert Gilkeson ,&nbsp;Imran Rashid ,&nbsp;Sadeer Al-Kindi ,&nbsp;Daniel I. Simon ,&nbsp;Sanjay Rajagopalan","doi":"10.1016/j.ajpc.2026.101553","DOIUrl":"10.1016/j.ajpc.2026.101553","url":null,"abstract":"<div><h3>Background</h3><div>Coronary artery calcium (CAC) scoring is a robust cardiovascular risk marker, yet the prognostic value of serial assessment and the relative importance of incident calcium versus progression from elevated baseline CAC remains incompletely defined.</div></div><div><h3>Methods</h3><div>We analyzed 4166 CLARIFY registry participants (NCT04075162) who underwent ≥2 CAC scans ≥11 months apart (mean interval 4.5 years). Defining CAC progression (ΔCAC&gt;10 Agatston units, AU) identified 1982 progressors and 2184 non-progressors. Annualized absolute, square-root, and log-transformed progression were evaluated for association with major adverse cardiovascular events (MACE: myocardial infarction, stroke, mortality, revascularization, and heart failure). Incremental prognostic value was assessed by adding annualized progression to the base MESA-CAC model incorporating baseline CAC, demographics, and traditional risk factors.</div></div><div><h3>Results</h3><div>Over a median 5.9 year follow-up, progressors had higher MACE incidence, though risk gradients differed by baseline CAC. Incident CAC from a baseline zero score was not associated with increased MACE (all <em>p</em> &gt; 0.60). However, progression of established CAC was associated with nearly double 5-point MACE (HR 1.96 [1.38–2.80]; <em>p</em> &lt; 0.001) which persisted across baseline CAC strata of 1–100, 101–200, and &gt;200 AU (HR 1.74–2.65; all <em>p</em> &lt; 0.01). Annualized progression independently predicted events, most strongly using log-transformed metrics (overall cohort HR 1.27 [1.15–1.41]; <em>p</em> &lt; 0.0001). Associations persisted across smokers, diabetics and statin-users. Adding annualized progression to the base MESA-CAC model improved net risk reclassification (NRI ∼0.10).</div></div><div><h3>Conclusions</h3><div>Serial CAC imaging may provide incremental prognostic value in individuals with pre-existing atherosclerosis. While incident CAC after a baseline zero score may confer limited short-term risk, it may present a window for preventive intervention.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101553"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of the predicting risk of cardiovascular disease events versus pooled cohort equations risk scores for statin eligibility in an Iranian population","authors":"Samaneh Asgari ,&nbsp;Amirhossein Hasanpour ,&nbsp;Davood Khalili ,&nbsp;Fereidoun Azizi ,&nbsp;Farzad Hadaegh","doi":"10.1016/j.ajpc.2026.101635","DOIUrl":"10.1016/j.ajpc.2026.101635","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101635"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in cardiovascular diseases and risk factors among adults aged 45-64 years in the US, 2011-2023","authors":"Lili Huang ,&nbsp;Ying Zhou ,&nbsp;Shengshuai Shan ,&nbsp;Liping Hu ,&nbsp;Liqing Wei ,&nbsp;Zhilei Shan ,&nbsp;Tangmeng Guo","doi":"10.1016/j.ajpc.2026.101632","DOIUrl":"10.1016/j.ajpc.2026.101632","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101632"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential impact on cholesterol goal achievement and predicted cardiovascular risk by the addition of ezetimibe and bempedoic acid on top of statins: a simulation from the SANTORINI study","authors":"Kausik K. Ray ,&nbsp;Carlos Aguiar ,&nbsp;Marcello Arca ,&nbsp;Derek L. Connolly ,&nbsp;Mats Eriksson ,&nbsp;Jean Ferrières ,&nbsp;Ulrich Laufs ,&nbsp;Jose M. Mostaza ,&nbsp;David Nanchen ,&nbsp;Charles Boachie ,&nbsp;Ben Lee ,&nbsp;Jarkko Soronen ,&nbsp;Christian Becker ,&nbsp;Ernst Rietzschel ,&nbsp;Timo Strandberg ,&nbsp;Hermann Toplak ,&nbsp;Frank L.J. Visseren ,&nbsp;Alberico L. Catapano ,&nbsp;on behalf of the SANTORINI study investigators","doi":"10.1016/j.ajpc.2026.101577","DOIUrl":"10.1016/j.ajpc.2026.101577","url":null,"abstract":"<div><h3>Background</h3><div>In SANTORINI, one-third of patients achieved low-density lipoprotein cholesterol (LDL-C) goals at 1-year follow-up, with oral combination therapies used in approximately 38 %. We simulated the potential impact of adding oral lipid-lowering therapies (LLTs) on goal attainment and predicted residual cardiovascular (CV) risk.</div></div><div><h3>Methods</h3><div>Using observed LLT use and LDL-C levels as a baseline, a Monte Carlo simulation was applied. The predicted improvements in LDL-C through the sequential addition of ezetimibe (if not already received) and bempedoic acid (if not at goal with ezetimibe) was evaluated in patients not at goal (LDL-C simulation set; <em>N</em> = 6866), nor receiving background bempedoic acid or proprotein convertase subtilisin/kexin type 9 inhibitor therapies (treatment optimisation set; <em>N</em> = 4467). Predicted 10-year CV risk reduction from expected LDL-C changes were also assessed (CV risk simulation set; <em>N</em> = 4327).</div></div><div><h3>Results</h3><div>Adding ezetimibe and ezetimibe plus bempedoic acid increased the predicted number of patients at goal from 28.4 % to 43.8 % and 63.1 %, respectively. The predicted relative risk reductions of a major CV event was 7.6 % and 13.4 % after each treatment optimisation step. Relative to the predicted residual 10-year risk of 25.1 % at the end of SANTORINI, further LLT optimisation was predicted to lower absolute CV risk by 2.0 % and 3.4 % with each additional LLT optimisation step.</div></div><div><h3>Conclusions</h3><div>Approximately two-thirds of patients could reach their LDL-C targets after the stepwise addition of ezetimibe and bempedoic acid in patients not at goal with statins and/or ezetimibe, with likely meaningful CV risk reductions over 10 years.</div></div><div><h3>Funding</h3><div>This study was funded by Daiichi Sankyo Europe GmbH, Munich, Germany.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov identifier: NCT04271280</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101577"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of the PREVENT equations: The science and art of risk communication","authors":"Alexander C. Razavi ,&nbsp;Roger S. Blumenthal","doi":"10.1016/j.ajpc.2026.101503","DOIUrl":"10.1016/j.ajpc.2026.101503","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101503"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial adipose tissue signatures in Asian coronary artery disease: Insights from cardiac CT","authors":"Xiaomeng Wang ,&nbsp;Liang Zhong ,&nbsp;Swee Yaw Tan ,&nbsp;Lynette Li San Teo ,&nbsp;Weimin Huang ,&nbsp;Hwee Kuan Lee ,&nbsp;Shuang Leng ,&nbsp;Yan Ting Loong ,&nbsp;Nur Amirah Syahindah Raffiee ,&nbsp;Sock Hwee Tan ,&nbsp;Thon Hon Yong ,&nbsp;Min Sen Yew ,&nbsp;Ching Hui Sia ,&nbsp;Mayank Dalakoti ,&nbsp;Leslee J Shaw ,&nbsp;Eugene Yang ,&nbsp;Mark Yan Yee Chan ,&nbsp;Derek J Hausenloy ,&nbsp;Lohendran Baskaran","doi":"10.1016/j.ajpc.2026.101453","DOIUrl":"10.1016/j.ajpc.2026.101453","url":null,"abstract":"<div><h3>Objectives</h3><div>We aim to compare cardiac CT characteristics of epicardial adipose tissue (EAT), coronary plaque, and perivascular adipose tissue (PVAT) among East, South and Southeast Asian coronary artery disease (CAD) patients.</div></div><div><h3>Methods</h3><div>This retrospective, cross-sectional study analyzed data from 2702 stable CAD patients, including 2078 East (56.4 ± 11.2 years, 59.5% male), 310 South (53.2 ± 10.4 years, 62.4% male), and 314 Southeast Asian (52.9 ± 11.2 years, 60.6% male) patients. From this clinical cohort, available imaging subsets were analyzed: 1090 patients with analyzable non-contrast computed tomography for EAT assessment and 751 patients with coronary computed tomography angiography for plaque and PVAT characterization.</div></div><div><h3>Results</h3><div>Compared to East Asian patients, South Asian patients exhibited higher EAT attenuation and high-density EAT volume ratio but lower EAT volume (difference: +1.45HU, 95% CI [0.05, 2.84], <em>p</em> = 0.042; +2.79% [0.76, 4.83], <em>p</em> = 0.007; -33.54cm³ [-41.79, -25.29], <em>p</em> &lt; 0.001). No significant differences were found in plaque volumes or compositions and PVAT mean attenuation across the three groups (<em>p</em> &gt; 0.05). Despite higher diabetes prevalence and family history of CAD in South Asian patients, these factors were not independently associated with EAT differences.</div></div><div><h3>Conclusions</h3><div>In a multi-ethnic Asian cohort of stable CAD patients, South Asians showed a distinct pro-inflammatory EAT profile, including higher EAT attenuation and high-density volume ratio, independent of traditional risk factors, despite having similar coronary plaque burden, composition, and PVAT characteristics as other Asian groups. This finding suggests that ethnic-specific cardiovascular pathophysiology may operate through mechanisms beyond traditional cardiovascular risk factors.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101453"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a role for measuring coronary artery calcium progression in 2026?","authors":"Omar Dzaye ,&nbsp;Michael J. Blaha ,&nbsp;Alexander C. Razavi","doi":"10.1016/j.ajpc.2026.101557","DOIUrl":"10.1016/j.ajpc.2026.101557","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101557"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary niacin intake with cardiovascular-kidney-metabolic syndrome risk and mortality","authors":"Xuecui Zhang ,&nbsp;Debin Chen ,&nbsp;Liangwei Wu ,&nbsp;Yizhou Zhuang ,&nbsp;Jiakang Yang ,&nbsp;Yaojie Wang ,&nbsp;Yining Li ,&nbsp;Qijun Zhang ,&nbsp;Jianhui Zhao","doi":"10.1016/j.ajpc.2026.101470","DOIUrl":"10.1016/j.ajpc.2026.101470","url":null,"abstract":"<div><h3>Background</h3><div>Dietary niacin, an essential nutrient, protects against metabolic diseases; however, its association with Cardiovascular-Kidney-Metabolic (CKM) syndrome and related mortality remains poorly understood.</div></div><div><h3>Methods</h3><div>We examined the associations between dietary niacin intake and the prevalence of advanced CKM syndrome using logistic regression models, as well as the associations between dietary niacin intake and mortality (all-cause, cardiovascular, and cancer) across CKM stages using Cox proportional hazards models, based on data from the National Health and Nutrition Examination Survey. Non-linear relationships were examined using restricted cubic spline (RCS) analyses.</div></div><div><h3>Results</h3><div>Among the 14,282 participants, 14.3% (2,042/14,282) were identified as having advanced-stage CKM syndrome. Higher dietary niacin intake was inversely associated with the prevalence of advanced-stage CKM syndrome (odds ratio [OR] = 0.72, 95% CI: 0.62-0.85). Stronger inverse associations were observed among participants aged over 40 years, those with higher physical activity levels, and those without hyperlipidemia. In patients with CKM stages 0-2, higher niacin intake was inversely associated with the risks of all-cause mortality (hazard ratio [HR] 0.75, 95% CI: 0.61-0.91), cardiovascular mortality (HR 0.53, 95% CI: 0.29-0.94), and cancer mortality (HR 0.70, 95% CI: 0.49-0.93). In patients with CKM stages 3-4, higher niacin intake was negatively associated with the risks of all-cause mortality (HR 0.82, 95% CI: 0.67-0.97) and cancer mortality (HR 0.53, 95% CI: 0.29-0.95). RCS analysis revealed a negative linear relationship of dietary niacin with advanced CKM syndrome and non-linear associations with all-cause, cardiovascular, and cancer mortality among patients in CKM stages 3-4.</div></div><div><h3>Conclusion</h3><div>Dietary niacin intake may be associated with a lower prevalence of advanced-stage CKM syndrome and reduced mortality across all CKM stages, suggesting its potential role in dietary interventions for CKM prevention and management.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101470"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}