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Rare complication after common obstetric procedure: rectus sheath hematoma after amniocentesis treated with embolization case report 常见产科手术后罕见并发症:羊膜穿刺术后直肌鞘血肿栓塞治疗一例报告
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-08-05 DOI: 10.1016/j.xagr.2025.100551
Anna R. Ilivicky MD , Shreya S. Katwala BA , Julie A. Vircks DO, MBA , Teresa A. Orth MD, PhD
{"title":"Rare complication after common obstetric procedure: rectus sheath hematoma after amniocentesis treated with embolization case report","authors":"Anna R. Ilivicky MD ,&nbsp;Shreya S. Katwala BA ,&nbsp;Julie A. Vircks DO, MBA ,&nbsp;Teresa A. Orth MD, PhD","doi":"10.1016/j.xagr.2025.100551","DOIUrl":"10.1016/j.xagr.2025.100551","url":null,"abstract":"<div><div>Rectus sheath hematomas are becoming more commonly diagnosed but are typically associated with high-risk patients, such as older adult patients, patients on anticoagulation, or patients with recent trauma. This case describes a woman who underwent genetic amniocentesis at 20 1/7 weeks of gestation with a resultant rectus sheath hematoma that began expanding after an exacerbation of the patient’s chronic obstructive pulmonary disease approximately 2 weeks after the patient’s amniocentesis procedure. Ultimately, embolization and coiling of the right inferior epigastric artery were required due to the expanding hematoma and worsening pain. Antibiotics were administered due to concern for a late complication of amniocentesis and a prolonged recovery with a large hematoma.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"5 4","pages":"Article 100551"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postnatal experiences of women with cardiac conditions: a systematic review and meta-synthesis 妇女产后经历与心脏病:一个系统的回顾和综合
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-09-01 DOI: 10.1016/j.xagr.2025.100564
Jasmine X. Kiley BS , Annabelle Corlett BA , Emma Mitchell-Sparke MPhil , Brittany Jasper MD , Tabitha Wishlade MSc , Catriona Bhagra MD , Sara Wetzler MD , Catherine E. Aiken MBBChir, PhD
{"title":"Postnatal experiences of women with cardiac conditions: a systematic review and meta-synthesis","authors":"Jasmine X. Kiley BS ,&nbsp;Annabelle Corlett BA ,&nbsp;Emma Mitchell-Sparke MPhil ,&nbsp;Brittany Jasper MD ,&nbsp;Tabitha Wishlade MSc ,&nbsp;Catriona Bhagra MD ,&nbsp;Sara Wetzler MD ,&nbsp;Catherine E. Aiken MBBChir, PhD","doi":"10.1016/j.xagr.2025.100564","DOIUrl":"10.1016/j.xagr.2025.100564","url":null,"abstract":"<div><h3>Objective</h3><div>The leading cause of maternal mortality in high-income countries is cardiovascular conditions. The highest risk period for women with cardiac conditions is usually the early postnatal phase; however, postnatal care is often under-resourced. We aim to inform supportive care pathways that address the medical and emotional needs of women with cardiac disease during the postnatal period.</div></div><div><h3>Data Sources</h3><div>To identify studies, Medline via Ovid, Embase via Ovid, CINAHL via EBSCO, PsycINFO via EBSCO, Scopus, Web of Science Core Collection, and ASSIA via ProQuest were searched (database inception—June 2025).</div></div><div><h3>Study Eligibility Criteria</h3><div>Studies reporting qualitative data about the postnatal experiences of women with any cardiac condition globally were included. The postnatal period was defined as the events occurring between delivery and 1 year postpartum.</div></div><div><h3>Study Appraisal and Synthesis Methods</h3><div>The Critical Appraisal Skills Programme checklist for qualitative research was used to perform quality assessment and reduce risk of bias. Inductive coding and thematic analysis were performed using NVivo v.15.</div></div><div><h3>Results</h3><div>Eleven qualitative studies were included in the meta-synthesis. We identified a chronological framework to describe the postnatal experiences of women with cardiac conditions. We identified key themes of (1) initial fragmentation of attention, (2) physical and psychosocial transitions, and (3) planning for the future. Women described a fragmentation of attention after delivery of their infant, as their own mindset frequently shifted toward motherhood, while their care team focused more on the infant and maternal cardiac recovery. Their experience of motherhood often differed from their expectations, adding to feelings of stress around their postnatal experience. Emotional recovery from complex pregnancies was influenced by desire for future pregnancies and by the degree of support available from family and wider community.</div></div><div><h3>Conclusion</h3><div>Cardiac conditions profoundly influence postnatal emotional and psychosocial well-being. During the early postnatal phase, care must balance the needs of mother, infant, and maternal cardiac condition. Postnatal cardio-obstetric care should include debriefing appointments with providers, with thorough, sensitive discussion of the risks of potential future pregnancies. Supporting women’s transition into motherhood is critical to help them process experiences and engage with care to improve their long-term cardiac prognosis.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"5 4","pages":"Article 100564"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hospital waterbirth for low-risk birthing people: findings of a randomized controlled trial 低风险分娩人群的医院水分娩:一项随机对照试验的结果
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-08-14 DOI: 10.1016/j.xagr.2025.100558
Emily Malloy PhD, CNM , Jessica J.F. Kram MPH , James O. Adefisoye PhD , Marie Forgie DO , Diana Kleber RN , MaryAnne Scherer CNM , Anna Anklam CNM , Natasha Hernandez MD , Lisa Hanson PhD, CNM
{"title":"Hospital waterbirth for low-risk birthing people: findings of a randomized controlled trial","authors":"Emily Malloy PhD, CNM ,&nbsp;Jessica J.F. Kram MPH ,&nbsp;James O. Adefisoye PhD ,&nbsp;Marie Forgie DO ,&nbsp;Diana Kleber RN ,&nbsp;MaryAnne Scherer CNM ,&nbsp;Anna Anklam CNM ,&nbsp;Natasha Hernandez MD ,&nbsp;Lisa Hanson PhD, CNM","doi":"10.1016/j.xagr.2025.100558","DOIUrl":"10.1016/j.xagr.2025.100558","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Waterbirth is the act of giving birth submerged in a tub of warm water, with the baby born underwater. Support for widespread adoption of waterbirth in the United States (US) has been limited by predominantly retrospective study designs, the underutilization of interdisciplinary citations, and disagreement between professional organizations. No randomized controlled trials of waterbirth have been conducted in the US.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;The purpose of this randomized controlled trial was to compare pain management, maternal and neonatal outcomes, and maternal satisfaction between low-risk water and land group study participants.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Study Design&lt;/h3&gt;&lt;div&gt;Low-risk pregnant adults were offered study participation between 25 to 34 weeks of gestation during routine prenatal care. Participants who met the inclusion criteria were consented, enrolled, and randomly assigned to waterbirth or land birth in a 2:1 unblinded fashion, to achieve a sample size of n=120 (80 waterbirth: 40 land birth). The sample size was adjusted for attrition and increased to n=186 (124 waterbirth: 62 land birth) based on an interim analysis. Participants in both arms were excluded if they developed intrapartum risk factors prior to delivery using a modified intention-to-treat model. Study participants received routine intrapartum care, including all available pain relief options. Only those assigned to the waterbirth group were given the option of giving birth in water. Prior to discharge, participants completed &lt;em&gt;The US Birth Satisfaction Scale Revised&lt;/em&gt;. The primary study outcome was the use of any intravenous narcotics and/or epidural anesthesia. Secondary outcomes included predetermined composite maternal and neonatal outcomes and overall birth satisfaction. Using a modified intention-to-treat approach, outcomes were analyzed using Chi-square, Fisher’s Exact, or Wilcoxon-Mann-Whitney test as appropriate. Relative risks (RR) were computed where applicable.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;From January 2022 to December 2023, 186 participants were enrolled (n=124 waterbirth, n=62 land birth). Following enrollment, 106 participants (n=74 waterbirth, and n=32 land birth) remained eligible for the study. Attrition was 39%. Compared to the land birth group, waterbirth participants were significantly less likely to use intravenous narcotics [RR: 0.36 (95% confidence interval [CI], 0.17−0.75), &lt;em&gt;P&lt;&lt;/em&gt;.01] and epidural analgesia [RR: 0.38 (95% CI, 0.24−0.58), &lt;em&gt;P&lt;&lt;/em&gt;.01] and had shorter average first stage labor duration [median difference -2.00 hours (95% CI, -3.00 to 1.00), &lt;em&gt;P&lt;/em&gt;=.43]. One cord avulsion occurred in the waterbirth group. Additional maternal and neonatal outcomes were not significantly different between groups. Waterbirth participants experienced higher overall birth satisfaction [median difference 3.50 (95% CI, 1.00-5.00), &lt;em&gt;P&lt;/em&gt;=.01].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"5 4","pages":"Article 100558"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sacral Tarlov cysts and spontaneous persistent genital arousal: 2 unrecognized and underappreciated health conditions with an uncertain relationship 骶骨塔洛夫囊肿与自发性持续性生殖器兴奋:两种未被认识和低估的健康状况与不确定的关系
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-08-22 DOI: 10.1016/j.xagr.2025.100563
Randa Yosef MD , Gaylene Pron PhD , Nucelio Lemos MD , Kieran Murphy MD
{"title":"Sacral Tarlov cysts and spontaneous persistent genital arousal: 2 unrecognized and underappreciated health conditions with an uncertain relationship","authors":"Randa Yosef MD ,&nbsp;Gaylene Pron PhD ,&nbsp;Nucelio Lemos MD ,&nbsp;Kieran Murphy MD","doi":"10.1016/j.xagr.2025.100563","DOIUrl":"10.1016/j.xagr.2025.100563","url":null,"abstract":"<div><div>Tarlov cysts commonly occur in women but are often thought to be asymptomatic findings. However, recent studies have suggested that Tarlov cysts can be a contributing factor to various pain and neurologic dysfunctions with a significant effect on health-related quality of life. Tarlov cysts and various intrapelvic pathologies can result in compression or impairment of peripheral and spinal nerve roots and can potentially affect women’s sexual function, particularly by causing persistent genital arousal disorder. Persistent genital arousal disorder is characterized by spontaneous and often unrelenting sensations of genital arousal in the absence of sexual desire or stimulation and, by definition, is intrusive, unwanted, and distressing. This review details the prevalence, characteristics, and treatments of persistent genital arousal disorder and Tarlov cysts and evaluates potential relationships between these conditions.</div><div>The prevalence of persistent genital arousal disorder ranges from 1.6% to 11.1% in community-based surveys, and 33% of women who are referred to a sexual health clinic report at least 1 persistent genital arousal disorder screening question. The prevalence of Tarlov cysts ranges from 1.5% to 13.2% and is higher among women referred to pain centers, ranging from 16% to 39%. Despite the already high prevalence, these numbers for both conditions are likely underestimated as sexual dysfunction. Therefore, persistent genital arousal disorder is not readily disclosed, and optimal sacral magnetic resonance imaging is infrequently performed to detect Tarlov cysts. Persistent genital arousal disorder is a symptom complex for which psychological, vascular, central, and peripheral neurologic factors have been proposed as possible causes.</div><div>When peripheral nerve entrapments are believed to be the cause of persistent genital arousal disorder, mechanical release of the nerve or nerve root is the generally accepted treatment. Several surgical and minimally invasive percutaneous procedures are effective treatments when Tarlov cysts are symptomatic, although evidence for their effectiveness for persistent genital arousal disorder is limited. For surgical/interventional failures to decompress nerves and decrease symptoms in patients with Tarlov cysts or persistent genital arousal disorder, neuromodulation is increasingly being performed as a rescue therapy.</div><div>Because of the weak evidence base, the relationship between Tarlov cysts and persistent genital arousal disorder remains uncertain, and healthcare professionals are encouraged to inquire more broadly about the symptoms related to these conditions, conduct neurologic examinations, and order relevant sacral imaging to clarify the relationship further.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"5 4","pages":"Article 100563"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prophylactic resuscitative endovascular balloon occlusion in the management of placenta percreta: a case report 预防性复苏血管内球囊闭塞治疗先天性胎盘1例报告
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-10-01 DOI: 10.1016/j.xagr.2025.100576
Monica Rodriguez DO, MPH , Nicole Tenzel MD , Rachel Russo MD, MAS , Robert Cohen MD
{"title":"Prophylactic resuscitative endovascular balloon occlusion in the management of placenta percreta: a case report","authors":"Monica Rodriguez DO, MPH ,&nbsp;Nicole Tenzel MD ,&nbsp;Rachel Russo MD, MAS ,&nbsp;Robert Cohen MD","doi":"10.1016/j.xagr.2025.100576","DOIUrl":"10.1016/j.xagr.2025.100576","url":null,"abstract":"<div><h3>Introduction</h3><div>Few reports exist on the prophylactic use of a resuscitative endovascular balloon occlusion of the aorta (REBOA) catheter and its application for prolonged occlusion times exceeding 60 minutes during cesarean hysterectomy in placenta accreta spectrum disorders.</div></div><div><h3>Case</h3><div>In the case of suspected placenta percreta, the prophylactic placement of a REBOA catheter before cesarean hysterectomy provided prompt life-saving post-arrest resuscitation and 166 minutes of occlusion time without any REBOA-related complications.</div></div><div><h3>Conclusion</h3><div>Prophylactic REBOA catheter placement is a groundbreaking approach with the potential to revolutionize the management of obstetric hemorrhage. This case underscores the efficacy of prolonged endovascular occlusion, using both partial and complete aortic occlusion techniques and core aortic blood pressure monitoring to assess hemodynamic status.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"5 4","pages":"Article 100576"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pHyph, a novel antibiotic-free treatment for bacterial vaginosis, promotes Lactobacillus growth and reduces the abundance of pathogens in the vagina pHyph,一种新型的无抗生素治疗细菌性阴道病,促进乳酸菌的生长,减少阴道内病原体的丰度
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-09-14 DOI: 10.1016/j.xagr.2025.100566
Emilia Lahtinen MS , Luisa W. Hugerth PhD , Gabriella Edfeldt PhD , Annette Säfholm PhD , Sten Kornfält MS , Lars Engstrand PhD, MD , Helena Strevens PhD, MD , Ina Schuppe-Koistinen PhD
{"title":"pHyph, a novel antibiotic-free treatment for bacterial vaginosis, promotes Lactobacillus growth and reduces the abundance of pathogens in the vagina","authors":"Emilia Lahtinen MS ,&nbsp;Luisa W. Hugerth PhD ,&nbsp;Gabriella Edfeldt PhD ,&nbsp;Annette Säfholm PhD ,&nbsp;Sten Kornfält MS ,&nbsp;Lars Engstrand PhD, MD ,&nbsp;Helena Strevens PhD, MD ,&nbsp;Ina Schuppe-Koistinen PhD","doi":"10.1016/j.xagr.2025.100566","DOIUrl":"10.1016/j.xagr.2025.100566","url":null,"abstract":"<div><h3>Background</h3><div>Bacterial vaginosis (BV) is the most common vaginal infection among women of reproductive age worldwide, caused by dysbiosis of the vaginal microbiome. Despite its prevalence, the underlying molecular mechanisms remain poorly understood, making diagnosis and treatment challenging. Although antibiotics are the standard therapy, recurrence rates are high, up to 50% within 1 year, and repeated treatments contribute to the rise of antimicrobial resistance. There is an urgent need for alternative, sustainable, and microbiome-friendly treatment options.</div></div><div><h3>Objective</h3><div>To evaluate whether <em>p</em>Hyph, a novel antibiotic-free treatment, promotes a shift in the vaginal microbiome toward a health-associated composition in women with clinically diagnosed BV.</div></div><div><h3>Study design</h3><div>In a randomized, double-blind, placebo-controlled trial, vaginal swabs were collected from 152 women diagnosed with BV. Microbiome composition was assessed before and after a 6-day treatment with <em>p</em>Hyph or a placebo-like comparator, using qPCR targeting 25 bacterial, 2 viral, and 8 eukaryotic species.</div></div><div><h3>Results</h3><div><em>p</em>Hyph significantly increased the abundance of <em>Lactobacillus iners, Lactobacillus gasseri</em> and <em>Lactobacillus jensenii</em> after treatment, while decreasing the abundance of BV-associated species, such as <em>Gardnerella vaginalis</em>, BVAB2, and <em>Fannyhessea vaginae</em> (Wilcoxon signed rank test, <em>P&lt;.</em>05). The growth-promoting effect on <em>Lactobacillus</em> was more pronounced in women who had detectable levels at baseline. Notably, a substantial number of participants in the <em>p</em>Hyph group (n=33) transitioned to a <em>Lactobacillus</em>-dominated community state type (CST), compared to none in the comparator group.</div></div><div><h3>Conclusions</h3><div><em>p</em>Hyph supports BV resolution by promoting a <em>Lactobacillus</em>-dominated vaginal microbiome and reducing BV-associated species, offering a promising antibiotic-free alternative.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"5 4","pages":"Article 100566"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic pelvic pain secondary to venous congestion of longitudinal vaginal septum: a case report 阴道纵隔静脉充血继发慢性盆腔疼痛1例
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-03-14 DOI: 10.1016/j.xagr.2025.100480
Megan A. Stevenson MD , Koah R. Vierkoetter MD , Jennifer W.H. Wong MD
{"title":"Chronic pelvic pain secondary to venous congestion of longitudinal vaginal septum: a case report","authors":"Megan A. Stevenson MD ,&nbsp;Koah R. Vierkoetter MD ,&nbsp;Jennifer W.H. Wong MD","doi":"10.1016/j.xagr.2025.100480","DOIUrl":"10.1016/j.xagr.2025.100480","url":null,"abstract":"<div><div>We describe the first written description of chronic pelvic pain secondary to venous congestion isolated to a longitudinal vaginal septum. A 29-year-old nulliparous female with chronic pelvic pain was diagnosed with a complete longitudinal vaginal septum and complete septate uterus. The patient desired surgical management, and the vaginal septum was excised without complications. Vascular congestion of the septal tissue was noted on pathology, and postoperatively, the patient's pelvic pain improved significantly. Typically, patients with a longitudinal vaginal septum present with pain isolated to vaginal penetration. For atypical presentations like chronic pelvic pain, surgical resection is reasonable to consider with shared patient decision-making.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"5 4","pages":"Article 100480"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantifying maternal vaccination opportunities across gestational age windows: a real-world multi-country, longitudinal study 通过胎龄窗口量化孕产妇接种疫苗的机会:一项真实世界的多国纵向研究
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-10-19 DOI: 10.1016/j.xagr.2025.100579
Rachel Ford MPH , Oluwatosin Nkereuwem MPH , Ugochukwu Madubueze MPH , Urudinachi Agbo FWACP , Suraj Bhattarai MSc , Rabin Thami MBBS , Dan Kajungu PhD , Victoria Nambasa MSc , Agnes Msoka PhD , Mir Mobarak Hossain MPH , Edward P.K. Parker PhD , Beate Kampmann PhD
{"title":"Quantifying maternal vaccination opportunities across gestational age windows: a real-world multi-country, longitudinal study","authors":"Rachel Ford MPH ,&nbsp;Oluwatosin Nkereuwem MPH ,&nbsp;Ugochukwu Madubueze MPH ,&nbsp;Urudinachi Agbo FWACP ,&nbsp;Suraj Bhattarai MSc ,&nbsp;Rabin Thami MBBS ,&nbsp;Dan Kajungu PhD ,&nbsp;Victoria Nambasa MSc ,&nbsp;Agnes Msoka PhD ,&nbsp;Mir Mobarak Hossain MPH ,&nbsp;Edward P.K. Parker PhD ,&nbsp;Beate Kampmann PhD","doi":"10.1016/j.xagr.2025.100579","DOIUrl":"10.1016/j.xagr.2025.100579","url":null,"abstract":"<div><h3>Background</h3><div>Maternal vaccination is a recognized strategy for reducing maternal and neonatal morbidity and mortality, including in low- and middle-income countries (LMICs). As new vaccines such as those for respiratory syncytial virus (RSV) and group B streptococcus (GBS) will be administered according to gestational age (GA), understanding real-world patterns of contact of pregnant women with antenatal care services (ANC) across pregnancy is essential to inform the most effective delivery strategies.</div></div><div><h3>Methods</h3><div>We conducted a retrospective longitudinal, multisite analysis using anonymized data extracted from maternal health registers at ANC and delivery clinics in 6 LMICs: Bangladesh, The Gambia, Nepal, Nigeria, Tanzania, and Uganda. Eligible clinics contributed data from ANC and delivery services and access to routine data from January 2019 to December 2022. Retrospective, individual-level ANC attendance data from a total of 123,867 individuals were included in the study. These included the total number of ANC attendances per woman and GA at first and last ANC contact. The GA determination practices of each clinic were also recorded.</div></div><div><h3>Results</h3><div>Across all sites, women had a median of 4 ANC contacts per pregnancy (IQR 2–5). An estimated 79·2% of women had at least one ANC contact during the 24–36-week GA window, falling to 66·6% in a 28−36 week GA window, and 46·5% at 32−36 weeks. When stratified by ANC contact frequency, the proportion with at least one contact in 24−36 weeks increased to 94·1% among women with ≥4 ANC contacts, indicating significantly greater vaccine delivery potential among those with more frequent ANC contacts.</div></div><div><h3>Conclusion</h3><div>In these LMIC settings, the 24–36-week GA window presents opportunity for delivering maternal vaccination at high coverage. These findings underscore the need to align maternal vaccine delivery strategies with real-world ANC patterns to ensure equitable and timely vaccine access in LMICs.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"5 4","pages":"Article 100579"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monkeypox virus infection in a 23-year-old woman with a genital rash and global skin lesions: evidence for spouse-to-spouse transmission 出现生殖器皮疹和全身皮肤病变的23岁妇女猴痘病毒感染:配偶间传播的证据
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-08-14 DOI: 10.1016/j.xagr.2025.100550
Wen-Shuang Li MSc , Rong-Jing Dong PhD , Shui-Tao Yi MSc , Ru-Qin Zhang BSc , Rui-Xia Chen MSc , Yan-Jie Ning MSc , Dian-Jiang Xiao BSc
{"title":"Monkeypox virus infection in a 23-year-old woman with a genital rash and global skin lesions: evidence for spouse-to-spouse transmission","authors":"Wen-Shuang Li MSc ,&nbsp;Rong-Jing Dong PhD ,&nbsp;Shui-Tao Yi MSc ,&nbsp;Ru-Qin Zhang BSc ,&nbsp;Rui-Xia Chen MSc ,&nbsp;Yan-Jie Ning MSc ,&nbsp;Dian-Jiang Xiao BSc","doi":"10.1016/j.xagr.2025.100550","DOIUrl":"10.1016/j.xagr.2025.100550","url":null,"abstract":"<div><div>We report one case in China of a couple simultaneously infected with the monkeypox. Both spouses developed genital skin lesions successively and the female partner had widespread skin lesions all over her body, while the male partner is HIV-positive, had a history of homosexual behavior before the onset of symptoms.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"5 4","pages":"Article 100550"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-theatre demonstration of laparoscopic retroperitoneal anatomy as an educational tool for final-year MBBS students: a novel quasi randomized experiment 在手术室演示腹腔镜腹膜后解剖作为最后一年MBBS学生的教育工具:一个新颖的准随机实验
AJOG global reports Pub Date : 2025-11-01 Epub Date: 2025-10-09 DOI: 10.1016/j.xagr.2025.100572
Rumi Bhattacharjee MD , Sangita Pandey MD , Manisha Jana MBBS , Jaishree Ganjiwale MSc , Nitin Raithatha MD , Somashekhar Nimbalkar MD
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