AJOG global reports最新文献

{"title":"Sexual knowledge as a predictor of intention in sexual activity in university women","authors":"Janett V. Chávez-Sosa MPH, Luis M. Ticahuanca Tacora BMSc, Criss M. Flores Burga BMSc, Jerusalen A. Garnique Fernandez BMSc, Salomon Huancahuire-Vega PhD","doi":"10.1016/j.xagr.2026.100677","DOIUrl":"10.1016/j.xagr.2026.100677","url":null,"abstract":"<div><h3>BACKGROUND</h3><div>Sexual health knowledge is a key determinant of adolescents’ and young adults’ sexual and reproductive behaviors. However, limited evidence exists on how sexual knowledge influences behavioral intentions among university women who have not yet initiated sexual activity. Understanding these relationships is essential for designing evidence-based educational and public health strategies that promote safer sexual decision-making and reproductive autonomy.</div></div><div><h3>OBJECTIVE</h3><div>To evaluate whether the level of sexual health knowledge predicts intentions regarding sexual activity, sexual protection, and sexual risk among university women with no history of sexual intercourse.</div></div><div><h3>STUDY DESIGN</h3><div>A cross-sectional, analytical study was conducted among female university students aged 18–35 years enrolled in a private university in East Lima during the 2025-I academic semester. A total of 493 participants met eligibility criteria, which included absence of prior sexual intercourse and capacity to complete questionnaires independently. Sexual health knowledge was measured using the validated knowledge dimension of the CAPSEX questionnaire, and sexual intentions were assessed with the female version of the Intention Scale in Sexual Activity. Descriptive statistics, Spearman correlation analyses, and multiple linear regression models were used to examine associations between knowledge scores and intentions. Multivariate models were adjusted for age, relationship status, place of origin, school of enrollment, year of study, family income, and employment status. Significance was set at <em>P</em><.05.</div></div><div><h3>RESULTS</h3><div>Overall, 51.3% of participants demonstrated adequate sexual knowledge. Knowledge was not significantly correlated with intention of sexual activity (ρ=–0.063; <em>P</em>=.165). In multivariate analyses, higher sexual knowledge predicted lower intention of sexual risk (B=−0.302; 95% CI: −0.462 to −0.141; <em>P</em><.001) and higher intention of sexual protection (B=0.127; 95% CI: 0.019 to 0.235; <em>P</em>=.021). Age was positively associated with sexual risk intention (B=0.181; 95% CI: 0.018 to 0.344; <em>P</em>=.029). Low family income was associated with higher intention of sexual protection (B=0.572; 95% CI: 0.145 to 0.999; <em>P</em>=.009) and reduced intention of sexual risk (B=−0.744; 95% CI: −1.382 to −0.105; <em>P</em>=.023). Not working showed lower scores with sexual protection intention (B=−0.513; 95% CI: −0.988 to −0.039; <em>P</em>=.034).</div></div><div><h3>CONCLUSION</h3><div>Sexual health knowledge independently predicts both decreased sexual risk intention and increased protective intention among university women without prior sexual activity. Socioeconomic disadvantage remains an important modifying factor. Strengthening comprehensive sexuality education within higher education institutions may enhance reproductive autonomy and reduce ","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 3","pages":"Article 100677"},"PeriodicalIF":2.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital and AI-assisted approaches across the preeclampsia care pathway: a scoping review","authors":"Ova Emilia PhD,&nbsp;Susaldi Susaldi M. Biomed,&nbsp;Yova Agustini M. Keb,&nbsp;Meita Dhamayanti PhD,&nbsp;Fanni Hanifa M. Keb,&nbsp;Hardinsyah Hardinsyah PhD,&nbsp;Triagung Yuliyana PhD,&nbsp;Salma Widya Azhari BSc","doi":"10.1016/j.xagr.2026.100683","DOIUrl":"10.1016/j.xagr.2026.100683","url":null,"abstract":"<div><h3>OBJECTIVE</h3><div>To map peer-reviewed evidence across four linked functions of digital and AI-assisted preeclampsia care—risk prediction, patient education, remote blood pressure monitoring, and clinician-directed escalation—and determine whether these functions have been evaluated together as an integrated clinical service.</div></div><div><h3>DATA SOURCES</h3><div>PubMed, Scopus, and ScienceDirect were searched for records published from January 2010 to May 11, 2026.</div></div><div><h3>STUDY ELIGIBILITY CRITERIA</h3><div>Peer-reviewed original empirical and technical studies of artificial intelligence, machine learning, clinical decision support, telemedicine, mobile health, remote monitoring, digital education, or care escalation for preeclampsia or hypertensive disorders of pregnancy were eligible. Reviews, protocols, conference abstracts without a full report, editorials, and opinion articles were excluded.</div></div><div><h3>STUDY APPRAISAL AND SYNTHESIS METHODS</h3><div>The review followed PRISMA-ScR and Joanna Briggs Institute guidance. Two reviewers independently screened records. One reviewer charted data and a second independently verified them. Findings were organized by the four predefined functions and synthesized thematically. Formal critical appraisal was not performed; the synthesis therefore describes the evidence map rather than certainty or implementation readiness.</div></div><div><h3>RESULTS</h3><div>The searches identified 1396 records. After 313 duplicates were removed, 1083 records were screened, and 320 full-text articles were assessed; 286 full-text articles were excluded, and 34 studies conducted in diverse single- and multicountry settings were included. Prediction models reported favorable discrimination estimates, but calibration, independent validation, and equity assessment were inconsistent. Remote monitoring findings were mixed: BUMP 1 did not show earlier clinic-recorded detection of hypertension, whereas some replacement-care models reduced visits or admissions without an observed increase in adverse outcomes. Education studies mainly examined hypothetical responses or communication gaps rather than measured behavior change. Adoption surveys and qualitative implementation studies did not establish clinical effectiveness. No study prospectively evaluated all four functions as a coordinated service; this was treated as a descriptive observation, not evidence of effectiveness or novelty.</div></div><div><h3>CONCLUSION</h3><div>Component evidence supports staged study, not routine implementation of an integrated pathway. Searching three electronic information sources, excluding gray literature, and not performing formal appraisal may have omitted relevant implementation evidence. Future codesigned prospective studies should evaluate calibration, safety, workload, equity, and maternal and perinatal outcomes.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 3","pages":"Article 100683"},"PeriodicalIF":2.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nifedipine-associated maternal oxygen desaturation in an IVF twin pregnancy complicated by preterm premature rupture of membranes: a case report","authors":"Yu-Ting Cheng MD,&nbsp;Chih-Jung Liu MD,&nbsp;Te-Fu Chan MD, PhD,&nbsp;Wei-Yun Hsu MD","doi":"10.1016/j.xagr.2026.100681","DOIUrl":"10.1016/j.xagr.2026.100681","url":null,"abstract":"<div><h3>OBJECTIVE</h3><div>To report a case of nifedipine-associated maternal oxygen desaturation in an IVF-conceived twin pregnancy complicated by PPROM with complete clinical documentation, and to provide denominator context from a retrospective review of institutional experience prompted by this case.</div></div><div><h3>STUDY DESIGN</h3><div>Case report at a single tertiary center. Following the Index Case, we conducted a retrospective review of all 103 patients who received nifedipine tocolysis at our institution over the preceding 2 years (January 2024–January 2026). Among these, 10 (9.7%) had IVF-conceived multiple gestations complicated by PPROM—the clinical profile shared with the Index Case; 3 of these 10 (30%) had developed oxygen desaturation. Only the Index Case had complete clinical workup and is reported in detail.</div></div><div><h3>RESULTS</h3><div>Among 103 nifedipine tocolysis patients, 10 (9.7%) had IVF-conceived multiple gestations complicated by PPROM; 3 of these 10 (30%) developed oxygen desaturation. Two additional cases lacked complete workup and could not be attributed to nifedipine. The Index Case: a 36-year-old with IVF-conceived DCDA twins at 23+3 weeks developed SpO₂ 88% to 90% within hours of nifedipine. Echocardiography: preserved LVEF; BNP 626 pg/mL; troponin <em>I</em>&lt;0.01 ng/mL; chest radiography: no alveolar pulmonary edema. Magnesium sulfate was never concurrent with nifedipine; it was given once for fetal neuroprotection after Episode 1, before either rechallenge. SpO₂ normalized without diuretics after each nifedipine discontinuation. Two deliberate rechallenges (Episodes 2 and 3, both without MgSO₄) both reproduced desaturation; Episode 2 required intensive care unit admission. Atosiban was initiated without recurrence.</div></div><div><h3>CONCLUSION</h3><div>This case, strengthened by two positive rechallenges occurring without concurrent magnesium sulfate, provides compelling temporal evidence for nifedipine-associated respiratory compromise in an IVF twin pregnancy with PPROM. The pattern of desaturation without radiographic alveolar pulmonary edema, elevated BNP, and resolution without diuresis suggests subclinical hemodynamic perturbation as the underlying mechanism. Clinicians should maintain heightened vigilance for unexplained oxygen desaturation during nifedipine tocolysis in this patient population.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 3","pages":"Article 100681"},"PeriodicalIF":2.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors for long-term survivors in advanced-stage epithelial ovarian cancer","authors":"Tarinee Manchana MD,&nbsp;Nicha Assavapokee MD","doi":"10.1016/j.xagr.2026.100675","DOIUrl":"10.1016/j.xagr.2026.100675","url":null,"abstract":"<div><h3>BACKGROUND</h3><div>Most women with epithelial ovarian cancer present with advanced-stage disease and have poor survival outcomes. However, the factor associated with long-term survival and the prognostic impact of histologic subtype in this population remain incompletely characterized.</div></div><div><h3>OBJECTIVE</h3><div>To identify factors associated with long-term survival and to compare survival outcomes across histologic subtypes in advanced-stage epithelial ovarian cancer.</div></div><div><h3>STUDY DESIGN</h3><div>We conducted a retrospective cohort study of 359 women with stage III to IV epithelial ovarian cancer. Multivariable logistic regression analysis was used to identify independent predictors of long-term survival, defined as overall survival of 5 years or longer. Cox proportional hazards models were applied to evaluate survival outcomes.</div></div><div><h3>RESULTS</h3><div>Among patients with advanced-stage epithelial ovarian cancer, 109 patients (30.4%) achieved long-term survival. Median follow-up was 111.8 months. <em>BRCA</em> mutation status was independently associated with improved long-term survival (adjusted OR 8.11, 95% CI 2.46–26.67; <em>P</em>&lt;.001). Optimal surgical cytoreduction and good performance status were also independently associated with long-term survival. In contrast, clear cell carcinoma was a negative predictor of long-term survival and associated with inferior oncologic outcomes, including a 5-year overall survival of 13.1% and an approximately twofold increased risk of mortality compared with high-grade serous carcinoma (adjusted HR 2.01, 95% CI 1.37–2.95; <em>P</em>&lt;.001). A landmark analysis among 5-year survivors showed that the <em>BRCA</em> survival advantage did not persist beyond 5 years (<em>P</em>=.661).</div></div><div><h3>CONCLUSION</h3><div>Long-term survival in advanced-stage epithelial ovarian cancer is independently associated with <em>BRCA</em> mutation status, optimal surgical cytoreduction, favorable performance status, and histologic subtype. Clear cell carcinoma is linked to significantly worse outcomes. These findings highlight the importance of universal genetic testing and maximal surgical cytoreduction.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 3","pages":"Article 100675"},"PeriodicalIF":2.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy in a patient with glycogen storage disease type Ia (von Gierke disease): case report and management strategy","authors":"Camila Andrea Camargo Rodríguez MD,&nbsp;Cristian Rolando Avellaneda-Garnica MD,&nbsp;Rafael Leonardo Aragón-Mendoza MD,&nbsp;Yaisa Maritza Castaño Toro MD,&nbsp;David Rodriguez Buritica MD","doi":"10.1016/j.xagr.2026.100672","DOIUrl":"10.1016/j.xagr.2026.100672","url":null,"abstract":"<div><div>Glycogen storage disease type I (GSDI) is caused by biallelic pathogenic variants in the gene encoding the glucose-6-phosphatase complex. Deficiency of this enzyme in the liver, kidneys, and intestines leads to glycogen accumulation in these organs and, consequently, to inadequate glucose production due to impaired glycogenolysis and gluconeogenesis. The condition is rare, and only a limited number of cases have been reported in pregnant women with favorable maternal and perinatal outcomes. This is partly because GSDI has been associated with significant morbidity, including maternal metabolic disturbances, renal and/or hepatic disease, preeclampsia, and fetal growth restriction, among other complications. We present the case of a 23-year-old woman with a diagnosis of GSDI who was evaluated at 19 weeks of pregnancy and managed according to a multidisciplinary protocol, resulting in a favorable perinatal outcome. This case highlights the need for clinical management protocols with specific strategies during the preconception period, pregnancy, delivery, and postpartum, aimed at preventing complications and improving maternal and perinatal outcomes.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 3","pages":"Article 100672"},"PeriodicalIF":2.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148642984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon monoxide poisoning, gas embolism and fluid overload during resectoscopic myomectomy","authors":"Xue Li MD,&nbsp;Lei Zhang MD,&nbsp;Ying Liang MD,&nbsp;Zhen-Zhen Xu MD,&nbsp;Xian Su MD,&nbsp;Yu-Ting Li MD,&nbsp;Ye Lu MD,&nbsp;Ting Ding MD","doi":"10.1016/j.xagr.2026.100644","DOIUrl":"10.1016/j.xagr.2026.100644","url":null,"abstract":"<div><div>Resectoscopic myomectomy (RM) is a standard minimally invasive procedure but carries risks of distinct complications. We report a rare case of a 36-year-old woman who simultaneously developed a triad of life-threatening complications during HM: carbon monoxide poisoning, gas embolism, and fluid overload. The patient presented with precipitous drops in end-tidal carbon dioxide and bispectral index silence. Arterial blood gas analysis revealed severe metabolic acidosis, electrolyte disturbances, and a carboxyhemoglobin level of 27.1%. Definitive diagnosis via arterial blood gas analysis and subsequent multimodal management, bolstered by the patient’s excellent physiological reserve, led to a full recovery. This case highlights the critical need for strict fluid management during RM and CO-oximetry’s indispensable role in detecting concurrent carbon monoxide toxicity.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 3","pages":"Article 100644"},"PeriodicalIF":2.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of lower-dose vs higher-dose aspirin for preeclampsia prevention: a systematic review and meta-analysis of randomized controlled trials","authors":"Aamina M. Ahmed BS,&nbsp;Ravi Goyal MD, PhD","doi":"10.1016/j.xagr.2026.100673","DOIUrl":"10.1016/j.xagr.2026.100673","url":null,"abstract":"<div><h3>OBJECTIVE</h3><div>To determine whether higher-dose aspirin (150–162 mg/d) reduces preeclampsia risk compared with lower-dose aspirin (75–81 mg/d) in pregnant women at elevated risk, using pooled evidence from all available head-to-head randomized controlled trials.</div></div><div><h3>DATA SOURCES</h3><div>PubMed/MEDLINE, Cochrane CENTRAL, Embase, Scopus, and ClinicalTrials.gov were searched from inception through April 27, 2026.</div></div><div><h3>STUDY ELIGIBILITY CRITERIA</h3><div>Parallel-group randomized controlled trials comparing at least two aspirin dose arms (head-to-head dose comparison) in pregnant women at elevated risk for preeclampsia, with a binary preeclampsia outcome reported. Aspirin-vs-placebo trials were excluded.</div></div><div><h3>STUDY APPRAISAL AND SYNTHESIS METHODS</h3><div>Log odds ratios were pooled using restricted maximum likelihood (REML) estimation with the Hartung–Knapp–Sidik–Jonkman (HKSJ) correction. Risk of bias was assessed using the Cochrane RoB 2 tool; evidence certainty was graded using GRADE. Egger’s test, Duval–Tweedie trim-and-fill, and univariate meta-regression (geography, dose ratio, gestational age at initiation) were performed.</div></div><div><h3>RESULTS</h3><div>Six randomized controlled trials enrolling 1099 participants across five countries were included. REML+HKSJ pooled OR 1.93 (95% CI 0.84–4.42, <em>P</em>=.096; <em>I</em>²=64.9%), representing approximately 48% lower odds of preeclampsia with higher-dose aspirin, a clinically substantial effect size that did not reach conventional statistical significance, primarily due to limited sample size (<em>N</em>=1099) and substantial between-study heterogeneity. Egger’s test was significant (<em>P</em>=.010); trim-and-fill estimated three missing studies (adjusted OR 1.92, 95% CI 1.47–2.50). No significant dose advantage was seen in North American trials (OR 1.25, 95% CI 0.67–2.34). A safety signal for placental abruption was identified with higher-dose aspirin in one large trial (8 vs 0 events). GRADE certainty: Very Low.</div></div><div><h3>CONCLUSION</h3><div>Applying conservative statistical methods (REML+HKSJ), higher-dose aspirin (150–162 mg/d) was associated with approximately 48% lower odds of preeclampsia vs lower-dose aspirin (75–81 mg/d; OR 1.93), a clinically meaningful effect that did not reach conventional statistical significance (95% CI 0.84–4.42, <em>P</em>=.096) due to limited sample size and heterogeneity. Clinical significance and statistical significance must be considered independently; the magnitude of this effect warrants serious attention in guideline discussions. A placental abruption safety signal warrants further investigation. Larger, harmonized head-to-head trials with preterm preeclampsia as the primary endpoint are needed.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 3","pages":"Article 100673"},"PeriodicalIF":2.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eclampsia risk prediction across diverse U.S. populations using CDC data: machine learning versus ACOG checklists","authors":"Anne F. Minsart MD, PhD, MPH ,&nbsp;Marwa Alhaj Ahmad MSc ,&nbsp;Lisbeth Waagstein MSc, MPH ,&nbsp;Rivalin Aho Glele MSc, MPH ,&nbsp;Nadirah Ghenimi MD, PhD, MPH","doi":"10.1016/j.xagr.2026.100646","DOIUrl":"10.1016/j.xagr.2026.100646","url":null,"abstract":"<div><h3>Background</h3><div>Various tools are employed in clinical practice to predict (pre)eclampsia. Artificial intelligence offers a promising approach for identifying people at risk. More data is needed on models trained for diverse populations.</div></div><div><h3>Objective</h3><div>This study aimed to develop machine learning prediction models for eclampsia utilizing CDC data from 3.6 million births in 2022, compare them to the American College of Obstetrics and Gynecology (ACOG) checklist, and assess their applicability to various population subgroups.</div></div><div><h3>Study design</h3><div>Machine learning models were trained on predictors outlined by the ACOG, and available pregnancy characteristics in vital statistics. The best model was then applied on 6 subsets—American Indian or Alaska, Hawaiian Native or Other Pacific Islander, Asian, Black/African American, mixed heritage, lower income, and being born abroad.</div></div><div><h3>Results</h3><div>The ACOG checklist applied on this cohort had a true-positive rate of 81.4% for predicting eclampsia and a false-positive rate of 68.9%. Logistic regression, Random Forest, LightGBM and XGBoost achieved an Area-under-the-receiver-operating-characteristic-curve of 0.64, recall rates around 50% and false-positive rates around 25%. The Area-under-the-receiver-operating-characteristic-curve was lower among individuals identifying as Black/African American, American Indian or Alaska Native and Native Hawaiian or Other Pacific Islander, and those born abroad or with lower income.</div></div><div><h3>Conclusion</h3><div>The ACOG checklist had a very high false-positive rate but achieved a high detection rate, while requiring less computational resources than the machine learning models. Demographic biases and variability in machine learning model performance highlight the need for external validation tailored to specific populations.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 2","pages":"Article 100646"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guideline adherence to aspirin prophylaxis use for preeclampsia among healthcare providers in Northwest Ethiopia: an explanatory sequential mixed-methods study","authors":"Samuel Berihun Dagnew MSc ,&nbsp;Desalegn Addis Mussie MSc ,&nbsp;Tilaye Arega Moges MSc ,&nbsp;Samuel Agegnew Wondm MSc ,&nbsp;Woretaw Sisay Zewdu MSc ,&nbsp;Abel Temeche Kassaw MSc ,&nbsp;Tigabu Eskeziya Zerihun MSc ,&nbsp;Getachew Yitayew Tarekegn MSc ,&nbsp;Fasil Bayafers Tamene MSc ,&nbsp;Abaynesh Fentahun Bekalu MSc","doi":"10.1016/j.xagr.2026.100649","DOIUrl":"10.1016/j.xagr.2026.100649","url":null,"abstract":"<div><h3>BACKGROUND</h3><div>Preeclampsia is a significant cause of illness and mortality among mothers and newborns, especially in countries with limited resources. Preeclampsia is less common when low-dose aspirin (LDA) is used early in high-risk pregnancies.</div></div><div><h3>OBJECTIVE</h3><div>The purpose of this study was to evaluate aspirin prophylaxis guideline adherence among Northwest Ethiopian healthcare providers (HCPs).</div></div><div><h3>STUDY DESIGN</h3><div>A sequential mixed-methods explanatory research was carried out in three tertiary hospitals between March and May of 2025. Using a standardized questionnaire based on WHO, ACOG, and NICE standards, quantitative data was gathered from 304 HCPs who were chosen at random. Logistic regression was used to examine adherence-related characteristics. Qualitative perspectives were investigated through in-depth interviews with providers who were specifically chosen.</div></div><div><h3>RESULTS</h3><div>Among 304 participants (mean age 29.8 ± 4.7 years; 56.6% male), nurses (38.2%) and midwives (32.6%) predominated. Only 41.4% had adequate knowledge, 54.3% held a positive attitude, and 34.9% exhibited good adherence to guidelines. Poor knowledge (AOR = 3.42), negative/uncertain attitude (AOR = 2.67), and &lt;5 years of experience (AOR = 1.89) were independently associated with poor adherence. Qualitative findings identified four themes: knowledge gaps, safety concerns, system-level barriers (absence of national guideline, drug stock-outs, high workload), and limited experience/mentorship.</div></div><div><h3>CONCLUSION</h3><div>Adherence to aspirin prophylaxis guidelines is not optimal. To improve maternal outcomes, specific training, mentorship, supportive supervision, and the creation of national guidelines must address knowledge gaps, attitudes, clinical experience, and systemic barriers.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 2","pages":"Article 100649"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns and associated factors of complementary and alternative therapy use for dysmenorrhea among undergraduate students in North India","authors":"Rakhi Mishra MSc ,&nbsp;Aradhna Kumari BSc ,&nbsp;Arushi Sumal BSc ,&nbsp;Ashu Bhardwaj BSc ,&nbsp;Ayushi Sharma BSc ,&nbsp;Bhawna BSc ,&nbsp;Chhabi Simran BSc ,&nbsp;Deep Mala BSc ,&nbsp;Deepa BSc ,&nbsp;Deepika BSc ,&nbsp;Savita Kumari MSc","doi":"10.1016/j.xagr.2026.100633","DOIUrl":"10.1016/j.xagr.2026.100633","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Dysmenorrhea is common among young women and adversely affects daily activities and academic performance. Concerns regarding long-term use of analgesics have increased reliance on complementary and alternative therapies (CAT). This study aimed to assess the use of CAT and its association with the severity of dysmenorrhea among undergraduate students.</div></div><div><h3>Methods</h3><div>A quantitative descriptive study was conducted among undergraduate nursing students at a tertiary care institute in Uttarakhand, North India. A total enumerative sampling approach was adopted, enrolling 293 students who reported experiencing dysmenorrhea within the preceding 6 months. Data were collected using a validated, self-administered questionnaire that covered socio-demographic and menstrual characteristics, dysmenorrhea severity assessed using the WaLIDD scale, and CAT utilization measured through a structured Likert scale. Data analysis included descriptive statistics, Chi-square tests, binary logistic regression, and effect size estimation using Cramer’s <em>V</em>.</div></div><div><h3>Results</h3><div>The mean age of participants was 21.2±1.5 years. Overall, 51.9% reported moderate dysmenorrhea and 14.0% severe dysmenorrhea. Supportive CATs such as chocolates, music therapy, local heat application, and hot drinks were most commonly used. Increasing dysmenorrhea severity was significantly associated with higher CAT utilization across all domains, with the strongest association observed for supportive methods (<em>P</em>&lt;.001; Cramer’s <em>V</em>=0.23). Higher academic year and sharp intermittent pain were significantly associated with moderate–severe dysmenorrhea.</div></div><div><h3>Conclusion</h3><div>Dysmenorrhea is highly prevalent among undergraduate students, and greater severity is associated with increased CAT use. Integrating evidence-based nonpharmacological interventions into campus health services may improve menstrual health outcomes.</div></div>","PeriodicalId":72141,"journal":{"name":"AJOG global reports","volume":"6 2","pages":"Article 100633"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148167668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}