Advances in neurotoxicology最新文献

Role of glial cells in neurotoxicological effects of alcohol. 神经胶质细胞在酒精神经毒理学作用中的作用。

Advances in neurotoxicology Pub Date : 2025-01-01 Epub Date: 2025-04-11 DOI: 10.1016/bs.ant.2025.03.001

Yousef Tizabi, Bruk Getachew, Michael Aschner, Michael A Collins

引用次数: 0

Utility of zebrafish-based models in understanding molecular mechanisms of neurotoxicity mediated by the gut-brain axis. 基于斑马鱼的模型在了解肠脑轴介导的神经毒性分子机制方面的实用性。

Advances in neurotoxicology Pub Date : 2024-05-01 Epub Date: 2024-02-17 DOI: 10.1016/bs.ant.2024.02.003

Isaac A Adedara, Khadija A Mohammed, Julia Canzian, Babajide O Ajayi, Ebenezer O Farombi, Tatiana Emanuelli, Denis B Rosemberg, Michael Aschner

{"title":"Utility of zebrafish-based models in understanding molecular mechanisms of neurotoxicity mediated by the gut-brain axis.","authors":"Isaac A Adedara, Khadija A Mohammed, Julia Canzian, Babajide O Ajayi, Ebenezer O Farombi, Tatiana Emanuelli, Denis B Rosemberg, Michael Aschner","doi":"10.1016/bs.ant.2024.02.003","DOIUrl":"10.1016/bs.ant.2024.02.003","url":null,"abstract":"The gut microbes perform several beneficial functions which impact the periphery and central nervous systems of the host. Gut microbiota dysbiosis is acknowledged as a major contributor to the development of several neuropsychiatric and neurological disorders including bipolar disorder, depression, anxiety, Parkinson's disease, Alzheimer's disease, attention deficit hyperactivity disorder, and autism spectrum disorder. Thus, elucidation of how the gut microbiota-brain axis plays a role in health and disease conditions is a potential novel approach to prevent and treat brain disorders. The zebrafish (Danio rerio) is an invaluable vertebrate model that possesses conserved brain and intestinal features with those of humans, thus making zebrafish a valued model to investigate the interplay between the gut microbiota and host health. This chapter describes current findings on the utility of zebrafish in understanding molecular mechanisms of neurotoxicity mediated via the gut microbiota-brain axis. Specifically, it highlights the utility of zebrafish as a model organism for understanding how anthropogenic chemicals, pharmaceuticals and bacteria exposure affect animals and human health via the gut-brain axis.","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":"11 ","pages":"177-208"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140917437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron toxicity, ferroptosis and microbiota in Parkinson's disease: Implications for novel targets. 帕金森病的铁毒性、铁变态反应和微生物群：新靶点的意义。

Advances in neurotoxicology Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.1016/bs.ant.2024.02.001

Fernanda Vidal Carvalho, Harold E Landis, Bruk Getachew, Victor Diogenes Amaral Silva, Paulo R Ribeiro, Michael Aschner, Yousef Tizabi

{"title":"Iron toxicity, ferroptosis and microbiota in Parkinson's disease: Implications for novel targets.","authors":"Fernanda Vidal Carvalho, Harold E Landis, Bruk Getachew, Victor Diogenes Amaral Silva, Paulo R Ribeiro, Michael Aschner, Yousef Tizabi","doi":"10.1016/bs.ant.2024.02.001","DOIUrl":"10.1016/bs.ant.2024.02.001","url":null,"abstract":"Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized by loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). Iron (Fe)-dependent programmed cell death known as ferroptosis, plays a crucial role in the etiology and progression of PD. Since SNpc is particularly vulnerable to Fe toxicity, a central role for ferroptosis in the etiology and progression of PD is envisioned. Ferroptosis, characterized by reactive oxygen species (ROS)-dependent accumulation of lipid peroxides, is tightly regulated by a variety of intracellular metabolic processes. Moreover, the recently characterized bi-directional interactions between ferroptosis and the gut microbiota, not only provides another window into the mechanistic underpinnings of PD but could also suggest novel interventions in this devastating disease. Here, following a brief discussion of PD, we focus on how our expanding knowledge of Fe-induced ferroptosis and its interaction with the gut microbiota may contribute to the pathophysiology of PD and how this knowledge may be exploited to provide novel interventions in PD.","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":"11 ","pages":"105-132"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity. 用益生菌调节肠道微生物群，作为抵御内源性和外源性神经毒性的一种策略。

Advances in neurotoxicology Pub Date : 2024-01-01 Epub Date: 2024-03-21 DOI: 10.1016/bs.ant.2024.02.002

Anatoly V Skalny, Michael Aschner, Viktor A Gritsenko, Airton C Martins, Yousef Tizabi, Tatiana V Korobeinikova, Monica M B Paoliello, Alexey A Tinkov

{"title":"Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity.","authors":"Anatoly V Skalny, Michael Aschner, Viktor A Gritsenko, Airton C Martins, Yousef Tizabi, Tatiana V Korobeinikova, Monica M B Paoliello, Alexey A Tinkov","doi":"10.1016/bs.ant.2024.02.002","DOIUrl":"10.1016/bs.ant.2024.02.002","url":null,"abstract":"The existing data demonstrate that probiotic supplementation affords protective effects against neurotoxicity of exogenous (e.g., metals, ethanol, propionic acid, aflatoxin B1, organic pollutants) and endogenous (e.g., LPS, glucose, Aβ, phospho-tau, α-synuclein) agents. Although the protective mechanisms of probiotic treatments differ between various neurotoxic agents, several key mechanisms at both the intestinal and brain levels seem inherent to all of them. Specifically, probiotic-induced improvement in gut microbiota diversity and taxonomic characteristics results in modulation of gut-derived metabolite production with increased secretion of SFCA. Moreover, modulation of gut microbiota results in inhibition of intestinal absorption of neurotoxic agents and their deposition in brain. Probiotics also maintain gut wall integrity and inhibit intestinal inflammation, thus reducing systemic levels of LPS. Centrally, probiotics ameliorate neurotoxin-induced neuroinflammation by decreasing LPS-induced TLR4/MyD88/NF-κB signaling and prevention of microglia activation. Neuroprotective mechanisms of probiotics also include inhibition of apoptosis and oxidative stress, at least partially by up-regulation of SIRT1 signaling. Moreover, probiotics reduce inhibitory effect of neurotoxic agents on BDNF expression, on neurogenesis, and on synaptic function. They can also reverse altered neurotransmitter metabolism and exert an antiamyloidogenic effect. The latter may be due to up-regulation of ADAM10 activity and down-regulation of presenilin 1 expression. Therefore, in view of the multiple mechanisms invoked for the neuroprotective effect of probiotics, as well as their high tolerance and safety, the use of probiotics should be considered as a therapeutic strategy for ameliorating adverse brain effects of various endogenous and exogenous agents.","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":"11 ","pages":"133-176"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140917432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotoxicology of metals and metallic nanoparticles in Caenorhabditis elegans. 秀丽隐杆线虫中金属和金属纳米颗粒的神经毒理学研究。

Advances in neurotoxicology Pub Date : 2023-01-01 DOI: 10.1016/bs.ant.2023.03.001

Danielle Araujo Agarrayua, Aline Castro Silva, Nariani Rocha Saraiva, Ana Thalita Soares, Michael Aschner, Daiana Silva Avila

引用次数: 1

Genetic factors in methylmercury-induced neurotoxicity: What have we learned from Caenorhabditis elegans models? 甲基汞诱导神经毒性的遗传因素:我们从秀丽隐杆线虫模型中学到了什么?

Advances in neurotoxicology Pub Date : 2023-01-01 DOI: 10.1016/bs.ant.2023.01.006

Tao Ke, Fernando Barbosa Junior, Abel Santamaria, Aaron B Bowman, Michael Aschner

引用次数: 0

Nauphoeta cinerea as an emerging model in neurotoxicology. 作为一种新兴的神经毒理学模型。

Advances in neurotoxicology Pub Date : 2023-01-01 DOI: 10.1016/bs.ant.2023.01.004

Isaac A Adedara, Khadija A Mohammed, Julia Canzian, Denis B Rosemberg, Michael Aschner, Ebenezer O Farombi, Joao Batista Rocha

引用次数: 2

Perspective on halogenated organic compounds. 卤代有机化合物透视。

Advances in neurotoxicology Pub Date : 2023-01-01 Epub Date: 2023-08-02 DOI: 10.1016/bs.ant.2023.06.001

Prasada Rao S Kodavanti, Lucio G Costa, Michael Aschner

{"title":"Perspective on halogenated organic compounds.","authors":"Prasada Rao S Kodavanti, Lucio G Costa, Michael Aschner","doi":"10.1016/bs.ant.2023.06.001","DOIUrl":"10.1016/bs.ant.2023.06.001","url":null,"abstract":"During the past century, a vast number of organic chemicals have been manufactured and used in industrial, agricultural, public health, consumer products, and other applications. The widespread use in bulk quantities of halogenated organic chemicals (HOCs; also called Organohalogens), including chlorinated, brominated, and fluorinated compounds, and their persistent nature have resulted in global environmental contamination. Increasing levels of HOCs in environmental media (i.e., air, water, soil, sediment) and in human tissues including adipose tissue, breast milk, and placenta continue to be a cause of ecological and human health concern. Human exposure can occur through multiple pathways including direct skin contact, inhalation, drinking water, and mainly through food consumption. HOCs exposure has been implicated in a myriad of health effects including reproductive, neurological, immunological, endocrine, behavioral, and carcinogenic effects in both wildlife and humans. In addition, recent studies indicate that exposure to HOCs contributes to obesity and type 2 diabetes. Because of these adverse health effects, several regulatory agencies either banned or placed severe restrictions on their production and usage. In turn, many industries withdrew from production and usage of HOCs. This action resulted in decline of older HOCs such as polychlorinated biphenyls (PCBs), but more recent HOCs such as polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl substances (PFAS) show a steady increase/stable with time in the global environment. Based on their use pattern and their persistent chemical properties, human exposure to HOCs will likely continue. Hence, understanding human health effects and taking preventive measures for such exposures are necessary.","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":"10 ","pages":"1-25"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive impact of exposure to airborne particles captured by brain imaging. 脑成像捕捉到暴露在空气中粒子对认知的影响。

Advances in neurotoxicology Pub Date : 2022-01-01 DOI: 10.1016/bs.ant.2022.05.002

Somaiyeh Azmoun, Yenny Fariñas Diaz, Cheuk Y Tang, Megan Horton, Sean A P Clouston, Ben J Luft, Evelyn J Bromet, Sam Gandy, Donatella Placidi, Claudia Ambrosi, Lorella Mascaro, Carlo Rodella, Barbara Paghera, Roberto Gasparotti, Jeremy W Chambers, Kim Tieu, Daniele Corbo, Roberto G Lucchini

引用次数: 0

Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies. 铝神经毒性的分子机制:不良反应和治疗策略的最新进展。

Advances in neurotoxicology Pub Date : 2021-01-01 Epub Date: 2021-02-11 DOI: 10.1016/bs.ant.2020.12.001

Anatoly V Skalny, Michael Aschner, Yueming Jiang, Yordanka G Gluhcheva, Yousef Tizabi, Ryszard Lobinski, Alexey A Tinkov

引用次数: 35