Advances in cancer biology - metastasis最新文献

{"title":"Anti-angiogenic potential of novel 31kDa protein of Zanthoxylum rhesta is mediated by inhibition of HIF-1α nuclear translocation in vivo","authors":"Priyanka Dattaraj Naik Parrikar ,&nbsp;K.S. Balaji ,&nbsp;K.K. Dharmappa ,&nbsp;A.D. Sathisha ,&nbsp;Shankar Jayarama","doi":"10.1016/j.adcanc.2022.100063","DOIUrl":"https://doi.org/10.1016/j.adcanc.2022.100063","url":null,"abstract":"<div><p>A novel anticancer protein was isolated and purified from the pericarp of <em>Zanthoxylum rhesta</em>, a plant of culinary and ethnomedicinal importance from the Asian subcontinent. The partial purification process was followed by the fast protein liquid chromatography, gel permeation chromatography. This purified protein was obtained as a single band in the SDS-PAGE with molecular mass of 31 kDa and was named as <em>ZRP</em>. It showed anti-angiogenic activity <em>in vivo</em> in Swiss albino mice inoculated with EAC cells indicated by the reduced peritoneal angiogenesis. <em>In ovo</em> CAM assay also showed reduced neoangiogenesis. <em>ZRP</em> accompanied in VEGF reduction due to hindered nuclear translocation of HIF-1α which is a clear evidence of anti-angiogenic potential of the <em>ZRP</em> protein.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100063"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000375/pdfft?md5=603107d116c74c0ae4c8e77d2f064907&pid=1-s2.0-S2667394022000375-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137356557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational screening of benzophenone integrated derivatives (BIDs) targeting the NACHT domain of the potential target NLRP3 inflammasome","authors":"Shashank M. Patil ,&nbsp;Manu G. ,&nbsp;Jagadeep Chandra Shivachandra ,&nbsp;Anil Kumar K.M. ,&nbsp;Jaanaky Vigneswaran ,&nbsp;Ramith Ramu ,&nbsp;Prithvi S. Shirahatti ,&nbsp;Lakshmi Ranganatha V.","doi":"10.1016/j.adcanc.2022.100056","DOIUrl":"10.1016/j.adcanc.2022.100056","url":null,"abstract":"<div><p>The NLRP3 inflammasome is a crucial component in the innate immune response, which regulates the caspase-1 activation for the production of proinflammatory cytokines IL-1 and IL-18. Hence, NLRP3/caspase-1/IL-β1 signaling pathway becomes responsible for the elevation of pathogenesis of several inflammatory disorders like Alzheimer's, cancer, and diabetes mellitus. Multiple molecular and cellular processes, including ionic flux, mitochondrial malfunction, reactive oxygen species generation, and lysosomal damage, have been shown to activate the NLRP3 inflammasome. We report benzophenone integrated derivative-3 (BID-3) as an effective inhibitor of NACHT domain of NLRP3 inflammasome through <em>in silico</em> studies, which involved molecular docking simulations, molecular dynamics simulations, binding free energy calculations as well as druglikeliness and pharmacokinetic analyses. Out of all the BIDs screened, BID-3 was predicted with higher binding efficiency, stability, and druglikeliness potential, in comparison with the MCC950 reference drug used. With the current scenario depicting no complete cure for NLRP3 inactivation, this investigation proves to be an initial breakthrough in the field of pharmacotherapy and drug-discovery. Results obtained from this study could be used as a prominent input for the <em>in vitro</em> and <em>in vivo</em> investigation of pharmacotherapeutic potential of BIDs against the above-mentioned health maladies targeting NLRP3 inflammasome.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000302/pdfft?md5=422c0363075a6d649f572b7fbfe3a0cb&pid=1-s2.0-S2667394022000302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42368743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell free DNA; diagnostic and prognostic approaches to oncology","authors":"Sjawal Arshad ,&nbsp;Muhammad Babar Khawar ,&nbsp;Ali Hassan ,&nbsp;Ali Afzal ,&nbsp;Abdullah Muhammad Sohail ,&nbsp;Maryam Mukhtar ,&nbsp;Muddasir Hassan Abbasi ,&nbsp;Nadeem Sheikh ,&nbsp;Arwa Azam ,&nbsp;Sara Shahzaman ,&nbsp;Syeda Eisha Hamid","doi":"10.1016/j.adcanc.2022.100052","DOIUrl":"10.1016/j.adcanc.2022.100052","url":null,"abstract":"<div><p>Cell-free DNA (cfDNA) are un-encapsulated DNA fragments present in biological fluids ranging in an average size of up to 200 base pairs. The novel use of cfDNA is a prime candidate in the diagnostic and prognostic approach to unveiling many inflammatory diseases, especially cancer. Moreover, their potential as biomarkers is due to their ubiquitous presence in the body, non-invasive nature, and aiding in a different autopsy method. This review will focus on the diagnostic and prognostic potential of cfDNA as non-invasive biomarkers in oncology.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000260/pdfft?md5=1eaa71b4ad940cc52c414d1c6b2664ae&pid=1-s2.0-S2667394022000260-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44688033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of metastatic potentials of three different cancer stem cell models","authors":"Hager Mansour Ph.D. ,&nbsp;Said M. Afify Ph.D. ,&nbsp;Ghmkin Hassan Ph.D. ,&nbsp;Hagar A. Abu Quora Ph.D. ,&nbsp;Hend M. Nawara Ph.D. ,&nbsp;Maram H. Zahra Ph.D. ,&nbsp;Juan Du Ph.D. ,&nbsp;Sadia Monzur Ph.D. ,&nbsp;Toshiaki Ohara M.D., Ph.D. ,&nbsp;Akimasa Seno PhD ,&nbsp;Masaharu Seno Ph.D.","doi":"10.1016/j.adcanc.2022.100062","DOIUrl":"10.1016/j.adcanc.2022.100062","url":null,"abstract":"<div><p>Metastasis is one of the major causes of cancer deaths. However, the mechanisms of cancer cells acquiring aggressiveness and metastatic potential are still under investigation. Although cancer stem cells (CSCs) have been suggested as tumor initiating cells responsible for cancer metastasis, no sufficiently practical models have been found because of less availability of CSCs. We have developed novel CSC models derived from mouse induced pluripotent stem cells (miPSCs) in the presence of conditioned media (CM) from different cancer cell lines. Here, we tried to establish the models of metastasis using three different CSC models, miPS-LLCev, miPS-BT549cm and miPS-Huh7cm cells. The metastatic abilities of these CSC models were evaluated by intraperitoneal injections into mice. The developed metastases were histologically analyzed and the differences in gene expression between parental and metastasized cells were assessed. The expression of CSC and stemness markers was maintained in the cells isolated from metastasis. The three types of CSCs were further analyzed by RNA-sequencing to identify the enriched cytoplasmic signaling pathways. As a result, the three CSC models exhibited different patterns of metastases while the metastasis of miPS-LLCev cells appeared the most aggressive demonstrating hepatocellular carcinoma, which developed from the inside of the liver, as well as pulmonary metastasis. Metastasis related “HIF-1 pathway” was nominated as the candidate of enriched pathway in miPS-LLCev and miPS-Huh7cm cells implying that these CSC models possessed distinguished metastatic potential. Therefore, we concluded that the CSC models developed in this study would provide good models of metastasis linked with the aggressiveness.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000363/pdfft?md5=1ef2b6d9cee3a1e4df2d28553fc75722&pid=1-s2.0-S2667394022000363-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43238492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The multifaceted role of IL-12 in cancer","authors":"Um e Habiba ,&nbsp;Mussarat Rafiq ,&nbsp;Muhammad Babar Khawar ,&nbsp;Bismillah Nazir ,&nbsp;Gulfam Haider ,&nbsp;Nadia Nazir","doi":"10.1016/j.adcanc.2022.100053","DOIUrl":"10.1016/j.adcanc.2022.100053","url":null,"abstract":"<div><p>Interleukin-12 is a heterodimeric cytokine having many family members IL-23, IL-27, IL-35, and recently discovered IL-39, produced by macrophages and dendritic cells. IL-12 is an effector cytokine and engages in anti-tumor and many immunotherapies as IL-12 DNA expression, Th1 helper cells, and natural killer cells. IL-12 stimulates interferon γ (INF-γ) synthesis by the activation of STAT4 which then differentiates the Th1 helper cells with the T-bet transcription, playing an important role in cancer treatment. This review focuses on the role of IL-12 family as an antitumor agent as understanding the biology and molecular mechanism of IL-12 family members is crucial for designing new therapeutic strategies against different cancers.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000272/pdfft?md5=60cd40f6bfc1a6dbd36839ba467edff9&pid=1-s2.0-S2667394022000272-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42708078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P4HA2: A link between tumor-intrinsic hypoxia, partial EMT and collective migration","authors":"Vaishali Aggarwal ,&nbsp;Sarthak Sahoo ,&nbsp;Vera S. Donnenberg ,&nbsp;Priyanka Chakraborty ,&nbsp;Mohit Kumar Jolly ,&nbsp;Shilpa Sant","doi":"10.1016/j.adcanc.2022.100057","DOIUrl":"10.1016/j.adcanc.2022.100057","url":null,"abstract":"<div><p>Epithelial-to-mesenchymal transition (EMT), a well-established phenomenon studied across pan-cancer types, has long been known to be a major player in driving tumor invasion and metastasis. Recent studies have highlighted the importance of partial EMT phenotypes in metastasis. Initially thought as a transitional state between epithelial and mesenchymal phenotypic states, partial EMT state is now widely recognized as a key driver of intra-tumoral heterogeneity and phenotypic plasticity, further accelerating tumor metastasis and therapeutic resistance. However, how tumor microenvironment regulates partial EMT phenotypes remains unclear. We have developed unique size-controlled three-dimensional microtumor models that recapitulate tumor-intrinsic hypoxia and the emergence of collectively migrating cells. In this study, we further interrogate these microtumor models to understand how tumor-intrinsic hypoxia regulates partial EMT and collective migration in hypoxic large microtumors fabricated from T47D breast cancer cells. We compared global gene expression profiles of hypoxic, migratory microtumors to that of non-hypoxic, non-migratory microtumors at early and late time-points. Using our microtumor models, we identified unique gene signatures for tumor-intrinsic hypoxia (early <em>versus</em> late), partial EMT and migration (pre-migratory <em>versus</em> migratory phenotype). Through differential gene expression analysis between the microtumor models with an overlap of hypoxia, partial EMT and migration signatures, we identified prolyl 4-hydroxylase subunit 2 (P4HA2), a hypoxia responsive gene, as a central regulator common to hypoxia, partial EMT and collective migration. Further, the inhibition of P4HA2 significantly blocked collective migration in hypoxic microtumors. Thus, using the integrated computational-experimental analysis, we identify the key role of P4HA2 in tumor-intrinsic hypoxia-driven partial EMT and collective migration.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/77/nihms-1836629.PMC9517480.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells","authors":"Meng-Wei Ko ,&nbsp;Barbara Breznik ,&nbsp;Emanuela Senjor ,&nbsp;Anahid Jewett","doi":"10.1016/j.adcanc.2022.100043","DOIUrl":"10.1016/j.adcanc.2022.100043","url":null,"abstract":"<div><p>We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and induces cell death of oral and pancreatic tumor cells, and the effect is much more pronounced on stem-like/poorly differentiated OSCSCs and MP2 cells when compared to well-differentiated OSCCs, and PL-12 tumor cells. In addition, WIN 55,212-2 decreases cell surface expression of CD44, CD54, MHC class I and PD-L1 on oral and pancreatic tumor cells with the exception of PD-L1 expression on well-differentiated PL-12 pancreatic tumor cells which exhibits an increase in the expression rather than a decrease. Overall, we demonstrate that WIN 55,212-2 has an increased targeting activity against cancer stem cells/poorly differentiated oral and pancreatic tumor cells when compared to well-differentiated tumor cells, and furthermore, such differences in function do not correlate with the levels of CB1 and CB2 receptor expression on tumor cells, suggesting it's function either through post-receptor mediated activation and/or yet-to-be identified novel receptors. Intraperitoneal (IP) delivery of WIN 55-212-2 in humanized BLT mice is found to impart an activating potential for NK cells demonstrating increased NK cell mediated cytotoxicity and secretion of IFN-γ in our preliminary experiments. These results not only suggest a direct targeting of CSCs/poorly differentiated tumors by WIN 55-212-2 but also by indirect targeting of such tumors through the activation and increased functions of NK cells.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266739402200017X/pdfft?md5=10e396cf5272a210b1edee74f91026cd&pid=1-s2.0-S266739402200017X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45243472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers","authors":"Rahul Bhattacharjee ,&nbsp;Priya Mitra ,&nbsp;Nitin Gupta ,&nbsp;Sony Sharma ,&nbsp;Vipendra Kumar Singh ,&nbsp;Nobendu Mukerjee ,&nbsp;Archna Dhasmana ,&nbsp;Rohit Gundamaraju","doi":"10.1016/j.adcanc.2022.100050","DOIUrl":"10.1016/j.adcanc.2022.100050","url":null,"abstract":"<div><p>Exosomes are cargos facilitating the transport of miRNAs across cancer cells. Exosomal miRNA has been an area of interest in recent times due to their triple role in cancer proliferation. The current review discusses the triple role of exosomal miRNAs and proposes its application in diagnosis as a prognostic marker. Exosomal miRNAs are miRNAs found inside the exosomal structure of 30–150 nm of an extracellular vesicle. The synthesis and biogenesis of these exosomal miRNA involve an endosomal sorting complex required for transport which releases miRNAs and relevant proteins to cause tumor heterogeneity, drug resistance, and cancer metastasis. Herein, we have highlighted the role of exosomal miRNAs in both drug resistance and cancer metastasis. Additionally, we have elucidated the impact of exosomal miRNAs upon host immunity, which will provide us with the idea of host immune rejection. Furthermore, we have elaborated the clinical importance of exosomal miRNAs as a prognostic marker.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000247/pdfft?md5=9af9d4ecb2f30ec5c2c8acee6130fc00&pid=1-s2.0-S2667394022000247-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42829582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention on lactate in cancer: A promising approach for the development of cancer therapeutics","authors":"Dolly Sharma ,&nbsp;Mamta Singh ,&nbsp;Rajat Gupta ,&nbsp;Vivek Kumar ,&nbsp;Vinit Kumar ,&nbsp;Reshma Rani","doi":"10.1016/j.adcanc.2022.100058","DOIUrl":"10.1016/j.adcanc.2022.100058","url":null,"abstract":"<div><p>Lactate, the main product of tumor glycolysis is considered one of the most crucial metabolites in the tumor microenvironment. The reprogrammed cancer cell metabolism is closely associated with the enhanced rate of tumor glycolysis leading to excess lactate production concomitant with increased extracellular acidification. This decline in pH in the vicinity of cancer cells is largely attributed to reprogrammed tumor glycolysis (Warburg effect). Substantial literature data to date suggest that lactate is not merely a waste product of tumor glycolysis, albeit serves as the main fuel to meet the anabolic requirements of cancer cells. Lactate plays a critical role in tumor growth, migration and invasion, tumor metastasis, tumor microenvironment and immune modulation. This review summarizes the current knowledge about the role of lactate in tumor glycolysis, its fate and transporters, lactate shuttle, and metabolic symbiosis. It also condenses the role of lactate in the tumor microenvironment and immune invasion and the development of therapeutic strategies.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100058"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000326/pdfft?md5=2d212fc091322286f662f766c42e3532&pid=1-s2.0-S2667394022000326-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44690690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of inflammations and EMT in carcinogenesis","authors":"Md Shariful Islam ,&nbsp;Md Reaz Morshed ,&nbsp;Golap Babu ,&nbsp;Md Asaduzzaman Khan","doi":"10.1016/j.adcanc.2022.100055","DOIUrl":"10.1016/j.adcanc.2022.100055","url":null,"abstract":"<div><p>Cancer is one of the major health burdens in modern world, and its mechanism is very complex, which is one of the main reasons for difficulties in cancer drug development. The development of cancer is associated with chronic inflammation, although inflammation is an essential biological process. The epithelial-mesenchymal transition (EMT) is a crucial step in development process of human tissue and involve in the regulatory pathways. On the contrary, the uncontrolled EMT is responsible for the initiation of cancer, its metastasis, immunosuppression, and resistance to antitumor treatment. Interestingly, there is an interrelationship between inflammation and EMT process. Usually, proinflammatory cytokines activate EMT inducing transcription factors (EMT-TFs), causing epithelial cells to change into cancerous mesenchymal cell by activating the mesenchymal cells markers, such as N- Cadherin, Fibronectin, Vimentin etc., and inhibiting the epithelial cells markers such as E− Cadherin, Claudin 1, Occludin, and β-catenin. Consequently, epithelial cells are dissociated, invasive, motile, resistant to therapy, resistant to apoptosis, and undergo mesenchymal cells angiogenesis. Some natural products and short RNAs have been identified to interfere with inflammation-EMT axis to inhibit cancer progression and metastasis. We have described these relationships in this review article and also described the therapeutic perspectives for cancer.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000296/pdfft?md5=b3b225e324ee3ca5be1e6c5ec9cec112&pid=1-s2.0-S2667394022000296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42209959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}