Advanced research in gastroenterology & hepatology最新文献

{"title":"Shadows and Ghosts of the Hair Matrix: Pilomatrixoma","authors":"A. Bajaji","doi":"10.19080/ARGH.2018.11.555823","DOIUrl":"https://doi.org/10.19080/ARGH.2018.11.555823","url":null,"abstract":"The neoplasm, established as the “Calcifying Epithelioma of Malherbe”, were scripted as the lesions commencing from the sebaceous glands in the late 19th century (1880) by Malherbe and associates [1]. The histology comprises of the islands of epithelial cells and shadow cells, illustrated in the early 20th century (1922) [2]. “Pilomatrixoma” as a terminology was popularized in the late 20th century (1961) [3] and designated the neoplasm as a derivative of the hair matrix, thus circumventing the term “epithelioma”, which may connote a malignancy. The enzyme histochemistry and ultra-structural analysis of the lesion was also computed in the late 20th century (1966) [4], confirming that it originated from the primitive basal cells of the epidermis which differentiate towards the hair matrix.","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48778036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoprotective Effect of Thymoquinone Against Cadmium Induced Liver Toxicity in Wistar Rat by Inhibiting Reactive Oxygen Species","authors":"M. F. Alam","doi":"10.19080/argh.2018.11.555822","DOIUrl":"https://doi.org/10.19080/argh.2018.11.555822","url":null,"abstract":"The present study was designed to find out the hepatoprotective effect of Thymoquinone against cadmium induced liver toxicity in rat. Four different groups of rats were used for this study. In details Group-I was nornal rat; Group-II was toxic Cd (2 mg/kg/day) has given to rats subcutaneously for 7 days. Group-III was pre-treated with Thymoquinone and followed by Cd (2 mg/kg/day) for 7 days. Group-IV was given Thymoquinone (20 mg/kg/day) as a positive control for 7 days. At the end of experiment blood was taken for biochemical study (AST, ALT, ALP and Total Bilirubin) and thereafter animal was killed, and liver was dissected out to analyze oxidative stress (LPO, and GSH). The biochemical study indicated that the level of enzymes (AST, ALT, ALP and Total Bilirubin) was significantly (P≤0.01) elevated in the serum of Group-II and TBARS contents were also increased significantly in Group-II while the concentration of glutathione was significantly reduced in Cd induced (Group-II) as compared to normal control. When the rat was treated with Thymoquinone, TBARS content reduced significantly in Group-III and biochemical enzyme were also restored in Group-III while the glutathione (GSH) content increased as compared to Group-II. When alone Thymoquinone was given in Group-IV there was no any kind of biochemical enzyme elevation were found or neither no significant oxidative stress observed. In this way study indicated that Thymoquinone is effective for the treatment of liver diseases against heavy metal.","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49017204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helicobacter Pylori Strains Isolated from Iraqi Subjects with Gastritis, Peptic Ulcer, and Carcinoma of Stomach Genetic Sequences: A New Variants","authors":"Abdulghani Mohamed Alsamarai","doi":"10.19080/ARGH.2018.11.555821","DOIUrl":"https://doi.org/10.19080/ARGH.2018.11.555821","url":null,"abstract":"","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68370819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Children Developing Gastro Intestinal Symptoms after Oral Polio Vaccination - Beware of CMPA","authors":"B. Acharyya","doi":"10.19080/ARGH.2018.11.555819","DOIUrl":"https://doi.org/10.19080/ARGH.2018.11.555819","url":null,"abstract":"Child hood immunization to prevent infectious diseases was one of the most successful health care steps in the last century. Presently allergy is increasing all over the world. Cow’s Milk Protein Allergy is the commonest food protein allergy in infancy, at the highest vaccine receiving age of life. Few children with CMPA showed Gastrointestinal symptoms like diarrhoea, vomiting and screaming episodes following Oral Polio Vaccination. This initiated the following retrospective observational study to see the present relation and pattern of reactions after polio vaccination in children with CMPA and whether this type of reactions can give a hint towards diagnosis of CMPA in undiagnosed or missed CMPA cases.","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43362475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Elevated Body Mass Index is Associated with Lower Serum Adalimumab Levels without Clinical Significance","authors":"Nilesh Lodhia","doi":"10.19080/ARGH.2018.11.555818","DOIUrl":"https://doi.org/10.19080/ARGH.2018.11.555818","url":null,"abstract":"Background: Biologics, specifically anti-TNF agents, have been an integral part of our treatment paradigm for IBD for several years. However, therapeutic drug monitoring (TDM) enhances our ability to optimize dosing regimens. Studies have shown that trough levels<4.9ug/ mL are associated with loss of response to adalimumab (ADA). An increased body weight may change the pharmacokinetics of adalimumab in IBD. The primary aim of this study was to evaluate the impact of body mass index (BMI) on adalimumab drug levels in IBD patients, as well as its potential clinical implications. Methods: A database was compiled via retrospective chart review of 507 IBD patients seen at our Digestive Disease Center (DDC) between July 2013 and March 2016. Variables in the database include patient’s weight, medications, serum adalimumab levels, dates of medication administration, endoscopic findings, fecal calprotectin, erythrocyte sedimentation rate, and C-reactive protein. Results: Using ANOVA to compare the two groups, there was a significant association with lower ADA levels in patient with BMI >30kg/ m2 when compared to those with BMI <30kg/m2 (p = 0.009). Average adalimumab levels in these two groups were 11.8ug/mL and 8.8ug/mL, respectively. Within these groups, there was no statistically significant difference in severity of endoscopic findings. Furthermore, there was no statistically significant difference in serum inflammatory markers between groups. Conclusion: In a cohort of patients with inflammatory bowel disease, despite a downward trend in serum adalimumab levels as weight increased, there did not seem to be any apparent clinical significance to these findings. They neither correlated to severity of endoscopic findings, or to elevations in serum inflammatory markers. 57% of the total sample size was either overweight or obese, which we feel accurately reflects the phenotypic breakdown of the overall IBD population, as well as that of the general population. More studies are needed to follow the long-term progression of these lower adalimumab levels to determine if this leads to increased antidrug antibody formation and/or loss of response over time.","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44935426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Recognition Technology and Detection of Over Sexuality in Private Organizations Combined with Shelter House. Baseline Integrated Behavioural and Biological Assessment among Most at‐Risk Low Standards Hope Less Institutions in Pune, India","authors":"R. Hajare","doi":"10.19080/ARGH.2018.11.555816","DOIUrl":"https://doi.org/10.19080/ARGH.2018.11.555816","url":null,"abstract":"The Human face has an astonishing variety of feature which not only helps us recogniseothers, but it can predictor toward correct result of real one and unintentional signals. It has one the unique functions separated form machines. This technology can controlled women’s violation and detection of aggression of sex in working places. It can identified people of doubt in teaching institutions located in slums. This technology has new kind of power. It allows to identify bad habits uses in working place, and it can identify anybody touch the students for bad intensions. Researcher has shown that face can point sexuality.The technology has power to tract unrealistic movement can follow around and characterise based on face recognitions. It can potentially check the over sexuality toward the sex additions which physiologically ill too. It will even be guess sexuality through facial feature and attraction towards the students. It has force to face feature.","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42263263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concept of Agni in Ayurveda","authors":"Dnyaneshwar. K. Jadhav","doi":"10.19080/ARGH.2018.11.555815","DOIUrl":"https://doi.org/10.19080/ARGH.2018.11.555815","url":null,"abstract":"","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41996143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Anal Fistula: Fistulotomy or Fistulectomy?","authors":"E. Weledji","doi":"10.19080/ARGH.2018.11.555817","DOIUrl":"https://doi.org/10.19080/ARGH.2018.11.555817","url":null,"abstract":"A fistula has a primary tract and may have secondary extensions. Complete eradication of both may lead to cure. Layopen (fistulotomy) is the most certain treatment where it is possible and when the risks have been properly explained and accepted. Anterior fistulas in women are dangerous and should only rarely be laid open. The technique of fistulectomy, which excises rather than incises the fistula track, has been criticised on the basis of the greater tissue loss leading to delayed healing. However, fistulectomy by a core-out technique rather than excision of the track have several advocates. The paper discussed the natural history of the idiopathic anal fistula and the pros and cons of these two common modes of treatment.","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45304176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Men are Missing from Fertility Debates","authors":"R. Hajare, Ommega Internationals","doi":"10.15436/2471-0601.18.1974","DOIUrl":"https://doi.org/10.15436/2471-0601.18.1974","url":null,"abstract":"","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46535157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A “Double Route” to Duodenum: The Unusual Case of Healing’s Bleeding Ulcer","authors":"V. D’Ovidio","doi":"10.19080/argh.2018.11.555812","DOIUrl":"https://doi.org/10.19080/argh.2018.11.555812","url":null,"abstract":"A 79-year-old woman was admitted to the emergency room of our hospital for hematemesis and syncope(Hb was 9.9 g/dl). She referred chronic use of NSAID (Non-Steroidal Anti-Inflammatory Drugs) for arthralgia without any concomitant proton pump inhibitors (PPIs). An EGDS (Esophagogastroduodenoscopy) was promptly performed and a 25 mm, actively bleeding pre-pyloric antral ulcer was diagnosed (Forrest 1b).","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47756101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}