ACS polymers Au最新文献

{"title":"Quantifying the Miscibility of Biobased Resins in Binary Polyisoprene Systems","authors":"Johannes Rochau,&nbsp;Jürgen E. K. Schawe,&nbsp;Jorge Lacayo-Pineda","doi":"10.1021/acspolymersau.6c00038","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00038","url":null,"abstract":"<p>The miscibility ofpolymer–resin systems is akey factorfor processing behavior and performance of elastomer compounds, yetit is commonly assessed only indirectly. In this work, a quantitativeapproach for evaluating experimental characterization of the molecularinteraction of amorphous polymer filler composites is introduced basedon glass transition measurements by differential scanning calorimetry(DSC). Binary mixtures of isoprene rubber (IR) with three distinctbiobased resins, a terpene resin, a rosin ester, and a maleic-modifiedrosin ester, were investigated over the entire composition range.The molecular interaction is expressed by an interaction parameterwhich reveals stronger repulsive interactions between IR and the rosinester compared to the other resins of investigation. Mechanical investigationby torque measurements during mixing and transmission electron microscopy(TEM) indicates a correlation between the interaction parameter measuredby DSC and the miscibility of the components of the composites.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1110–1115"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible Cationic Glycopolymer Hydrogels for RNA Delivery in Ticks","authors":"Zoe A. B. Lequeux,&nbsp;Kundu Thapa,&nbsp;Musa Rabiu,&nbsp;Alec N. Simmons,&nbsp;Laila C. W. Peery,&nbsp;John F. Searles,&nbsp;Shahid Karim,&nbsp;Sarah E. Morgan","doi":"10.1021/acspolymersau.6c00064","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00064","url":null,"abstract":"<p>RNA interference (RNAi) offers a promising approach forvectorcontrol in species such as the lone star tick (Amblyomma americanum),but current delivery methods, including microinjection and soaking,are invasive and inefficient for large-scale application. In thiswork, we developed a series of novel physically cross-linked cationicglycopolymer hydrogels for noninvasive double-stranded RNA (dsRNA)delivery and evaluated their rheological properties, release behavior,and in vivo performance. Rheological characterization demonstratedshear-thinning and self-healing behavior conducive to sprayable applications,while release studies revealed tunable cargo delivery dependent onglycomonomer stereochemistry and cationic content. In vivo studiesshowed that cationic terpolymer hydrogels successfully traversed theperitrophic membrane and enabled tissue-specific gene silencing, includingin ovarian tissue. These findings establish a promising platform forsprayable RNAi delivery and provide a framework for the design oftargeted gene delivery systems.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1200–1210"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogels for Skeletal Muscle Regeneration: Design, Fabrication, and Future Applications","authors":"Qinghua Meng,&nbsp;Miaomiao Xiao,&nbsp;Nan Zhang,&nbsp;Zhiyuan Yang,&nbsp;Hongshuai Leng,&nbsp;Xuequan Feng,&nbsp;Luxing Zhou,&nbsp;Chunyu Bao","doi":"10.1021/acspolymersau.6c00055","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00055","url":null,"abstract":"<p>Skeletal muscle playsa crucial role in metabolic homeostasis,but severe injuries such as volumetric muscle loss (VML) compromiseits regenerative capacity. Current clinical strategies have limitations,prompting the exploration of alternative therapies. Hydrogels, withtheir tunable properties, are promising for modulating the regenerativemicroenvironment and supporting muscle regeneration. While existingreviews have addressed hydrogels in muscle regeneration, this comprehensiveReview offers a uniquely integrated and in-depth examination of thefield. We systematically investigate design principles, advanced fabricationstrategies, and critical considerations for translational application,including electroactive, immunomodulatory, and spatiotemporal deliveryfunctionalities, alongside state-of-the-art techniques such as 3Dbioprinting and electrospinning. Furthermore, this Review thoroughlyassesses the multifaceted challenges in clinical translation, meticulouslyaddressing preclinical limitations, scalability, manufacturability,regulatory pathways, and long-term safety, thereby providing a morecomprehensive discourse than often encountered in existing literature.By integrating insights from muscle biology and advanced materialsscience, this review aims to offer a refined perspective on overcomingcurrent barriers, informing the development of next-generation hydrogel-basedtherapies for severe skeletal muscle injuries.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1029–1046"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Synthesis and Ring-Opening Metathesis Polymerization of Energetic Norbornene Materials","authors":"Valerie A. Sterling,&nbsp;Jack V. Davis,&nbsp;Jeremy T. Tisdale,&nbsp;David E. Chavez","doi":"10.1021/acspolymersau.6c00025","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00025","url":null,"abstract":"<p>Energetic norbornenes are promising candidates towardthe developmentof new energetic polymers due to the synthetic versatility of norbornenering-opening metathesis polymerizations used in commercial applications.We report the synthesis of two energetic norbornene materials thatcan be made in two steps with modest yields, containing either trinitroethanolor fluorodinitroethanol substituents. The norbornene monomers werethen polymerized, and the polymers were characterized by Fourier transforminfrared spectroscopy (FT-IR), differential scanning calorimetry (DSC),contact angle measurements, and proton and carbon nuclear magneticresonance spectroscopies (¹H and ¹³C{¹H} NMR). Additionally, small-scale safety data consisting of electrostaticdischarge (ESD), friction (FS), and impact (IS) sensitivities weremeasured for the norbornene monomers and their resulting polymers.These analyses revealed that energetic norbornene materials are relativelyinsensitive and have densities comparable to that of TNT (1.47–1.81g·cm^–3).</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1088–1095"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rigid Biobased Vinylogous Urethane Vitrimers from d-isosorbide/Furfural-Derived Monomers","authors":"Ondrej Kopilec,&nbsp;Jiri Hodan,&nbsp;Ondrej Sedlacek,&nbsp;Hynek Beneš","doi":"10.1021/acspolymersau.6c00063","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00063","url":null,"abstract":"<p>Biobased covalentadaptable networks (CANs, vitrimers)that combinehigh glass transition temperatures, mechanical robustness, and reprocessabilityremain scarce, particularly in vinylogous urethane vitrimer chemistry.Herein, we report the synthesis of rigid vinylogous urethane CANsderived from biobased <span>d</span>-isosorbide bis-acetoacetate and thefurfural-based diamine propane-2,2-di(2-furylmethylamine) (PDFA).The materials were prepared by a solvent-free bulk curing strategyusing mixtures of di- and trifunctional amines, enabling direct formationof cross-linked networks without additional processing solvents. Theuse of PDFA significantly increased the renewable carbon content whilemaintaining the rigidity required for glassy high-performance materials.The resulting networks exhibited tunable thermomechanical propertiesdepending on amine structure and composition, with glass transitiontemperatures up to 125 °C and thermal stability up to 290 °C.Stress-relaxation experiments confirmed fast catalyst-free bond exchangein the rubbery state, with relaxation occurring on the scale of tensto hundreds of seconds and activation energies dependent on the diaminestructure. Selected materials displayed efficient reprocessabilityby compression molding while largely preserving their thermal andtensile properties after recycling. These results demonstrate thatcombining <span>d</span>-isosorbide with a rigid furfural-derived diamineis an effective strategy toward biobased, glassy vinylogous urethanevitrimers that unite high renewable carbon content, elevated servicetemperature, and recyclability.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1147–1156"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermodynamics of Interfacial Water Confinement Reveal Altered Mechanical Properties in Polysaccharides Films","authors":"Hojin Seo,&nbsp;Xiaoqing Yu,&nbsp;Tequila A. L. Harris","doi":"10.1021/acspolymersau.6c00003","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00003","url":null,"abstract":"<p>In this work, we introduce a water-driven thermodynamicmechanism,herein referred to as hydro-softening, rendering polysaccharide filmssoft and stretchable during thin-film processing. Distinct from conventionalwater-mediated plasticization or swelling, we show that substrateeffects during processing can reorganize hydration clusters on thepolymer chain, generating disjoining pressure and penalizing configurationalentropy, with mechanical softening thereby arising as a consequence.Chemical, thermal, and mechanical characterization corroborates thepresence of confined water molecules as the primary driver of hydro-softening.Notably, we observed distinct cold crystallization of confined waterunder hydro-softened conditions. We also found greater mass loss attemperatures above 100 °C─the boiling point of unboundwater─coupled with pronounced decreases in both elastic modulusand hardness under hydro-softened conditions. Furthermore, a physicallyinformed simulation is introduced to structurally model the emergentconfined water, qualitatively revealing how steric confinement altersthe hydration landscape, leading to anisotropic hydration clustering.Although water-induced softening has long been observed in polymers,the absence of mechanistic insight has constrained the developmentof functional materials. The thermodynamic framework established hereaddresses this limitation, enabling a more deliberate and extensibleapplication of these systems.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1062–1071"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biobased Carbohydrate-Based Linear Aliphatic Polyesters Containing Acetyl-Protected Sorbitol, Mannitol, and Xylitol: Synthesis and Their Thermal, Tensile Properties","authors":"Ayana Inoue,&nbsp;Mohamed Mehawed Abdellatif,&nbsp;Seiji Higashi,&nbsp;Kousaku Tao,&nbsp;Hiroshi Hirano,&nbsp;Koichi Takada,&nbsp;Makawun Sonkasettrin,&nbsp;Panuwat Padungros,&nbsp;Kotohiro Nomura","doi":"10.1021/acspolymersau.6c00068","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00068","url":null,"abstract":"<p>Development of functionalpolymers from biorenewable resourceshas been considered as an important subject in terms of circular economy.High molecular weight biobased aliphatic polyesters (<em>M</em>_n = 53900–65600 g/mol) consisting of bis(undec-10-enoate)of acetyl-protected <em>D</em>-sorbitol, <em>D</em>-mannitol, and of <em>D</em>-xylitol have been prepared byacyclic diene metathesis (ADMET) polymerization using molybdenum–alkylidenecatalyst in toluene; subsequent olefin hydrogenation gave the saturatedpolyesters without significant decreases in the <em>M</em>_n values (<em>M</em>_n = 55300–64900g/mol). The resultant saturated polyesters containing sorbitol andxylitol were semicrystalline materials possessing melting temperatureat 17.1 and 14.3 °C, respectively, whereas the polyester containingmannitol was amorphous. The mechanical properties (tensile stressand elongation at break) of the resultant polymer film containingsorbitol displayed a unique contrast to that containing the reportedisosorbide-based polyester and showed unique elongation at break (1580%).The mechanical properties in the polymer films containing mannitoland xylitol were improved by preparing the composite materials witha small amount of cellulose nanofiber (1.0 wt %).</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1192–1199"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoarchitectonics Approach for Hydrogel Surface Functionalization via Self-Assembly of Terminally Modified Cello-oligosaccharides","authors":"Daniel Muara Sentosa,&nbsp;Hiroto Maruyama,&nbsp;Yuuki Hata,&nbsp;Kai Sugiura,&nbsp;Yu-Cheng Chiu,&nbsp;Takeshi Serizawa","doi":"10.1021/acspolymersau.6c00076","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00076","url":null,"abstract":"<p>Advances in hydrogel research have enabled the designof bulk networkswith diverse functionalities; however, precise control of interfacialproperties remains a key challenge to expanding their applications,particularly in biointerfaces. Here, we report a simple and versatilesurface functionalization strategy based on the self-assembly of terminallymodified cello-oligosaccharides. When azido-functionalized cello-oligosaccharidesdissolved in 85% phosphoric acid are applied to hydrogel surfaces,mixing with the intrinsic water within the hydrogels induces rapidself-assembly, forming nanostructured granular coatings at the interface.This method is applicable to both chemically and physically cross-linkedhydrogels. The resulting azido-functionalized surfaces enable postfunctionalizationvia click chemistry, allowing biomolecule immobilization. As a proofof concept, antigen-conjugated hydrogels were used for the detectionof specific immunoglobulin G, exhibiting selective responses evenin serum-containing environments due to the antibiofouling propertiesof the assemblies. These findings establish terminally modified cello-oligosaccharidesas a new class of interfacial modifiers for hydrogels, providing afacile route to biofunctional and antifouling interfaces for sensingand diagnostic applications.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1223–1233"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Puncture Behavior, Tear Behavior, and Essential Work of Fracture of iPP Film with Continuous and Ordered β-Transcrystallinity","authors":"Guixue Liang,&nbsp;Qipeng Guo,&nbsp;Deliang Wang,&nbsp;Jianlong Lei,&nbsp;Huili Li,&nbsp;Jiang Li,&nbsp;Shaoyun Guo","doi":"10.1021/acspolymersau.6c00075","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00075","url":null,"abstract":"<p>This study investigates the puncture and tear fracturebehaviorof isotactic polypropylene (iPP) films with an ultrahigh fractionof continuous and ordered β-transcrystallinity (β-TC),in comparison with α-spherocrystal, α-transcrystallinity,and β-spherocrystal films. In puncture tests, where the loadingis applied perpendicular to the film surface, the β-TC filmwithstood a displacement exceeding 10 mm without rupture, absorbingsubstantially more energy than the other films. In tear tests, wherethe loading is applied parallel to the film surface, the β-TCfilm displayed pronounced ductile tearing characteristics, includingsignificant yielding and strain-hardening, indicative of superiorin-plane tear resistance. Quantitative evaluation using the EssentialWork of Fracture (EWF) method further revealed that the specific essentialwork of fracture (w_e)─a measure of intrinsic fracturetoughness─reached 38.229 kJ/m² for the β-TCfilm, representing an 81.39% enhancement over the β-spherocrystalfilm. These findings systematically establish a clear correlationbetween the ordered β-transcrystalline morphology and the multidimensionalfracture resistance of iPP films, highlighting a promising strategyfor the design of high-performance polymer films.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1211–1222"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Assembly of Shaped ABC Coil-Bottlebrush Block Terpolymers","authors":"Camila Perales Rodriguez,&nbsp;Mahesh K. Mahanthappa,&nbsp;Timothy P. Lodge","doi":"10.1021/acspolymersau.6c00057","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00057","url":null,"abstract":"<p>A series of 100 “shaped” ABC coil–brushtriblockterpolymers were prepared by sequential living ring-opening metathesispolymerization (ROMP) of 5-norbornene-2,3-<em>exo</em>,<em>exo</em>-dicarboxylic acid dimethyl ester (<strong>M</strong>) andnorbornenyl diester macromonomers <strong>P</strong>_{<em><strong>a</strong></em>} and <strong>P</strong>_{<em><strong>b</strong></em>}, each bearing two identical side chains that areprecise oligomers of poly(ethylene-<em>alt</em>-propylene)containing <em>a</em>,<em>b</em> = 1, 2, 4, or 9 repeatunits. These <strong>MP</strong>_{<em><strong>a</strong></em>}<strong>P</strong>_{<em><strong>b</strong></em>} block terpolymerswere designed such that the more polar coil <strong>M</strong> block meltmicrophase separates from the mutually miscible <strong>P</strong>_<em>a</em> and <strong>P</strong>_<em>b</em> segments (<em>a</em> ≠ <em>b</em>),which form a digitally shaped bottlebrush segment, in order to assesshow bottlebrush shape affects block copolymer network phase stability.Thus, samples with total <em>M</em>_n = 7–30kg/mol, dispersities 1.02 ≤ <em>Đ</em> ≤1.04, and volumetric compositions 0.26 ≤ <em>f</em>_M ≤ 0.58 were chosen to target the region wherenetwork phases such as the double gyroid (GYR) might be expected.Small-angle X-ray scattering (SAXS) analyses revealed that all ofthese polymers were well-segregated based on SAXS measurements at100 °C, with no evidence of proximity to an order–disordertransition. Most samples formed hexagonal (HEX) or lamellar (LAM)phases, with some persistent HEX/LAM coexistence, with a critical <em>f</em>_M-value at the HEX/LAM order-to-order transitionthat depends on the length and sequence of P blocks. However, theformation of GYR was systematically suppressed by the shaped brusharchitecture, especially when the longer <strong>P</strong> block was <strong>P</strong>₉; this is surprising, given that previously reported <strong>MP</strong>_{<em><strong>a</strong></em>} diblocks exhibitedsignificant GYR phase windows. Furthermore, despite the low glasstransition temperatures of the blocks (<em>T</em>_g,M = 69 °C, <em>T</em>_g,Pa ≤ –42°C), there was no evidence of structural refinement over a timescale of hours, indicating very slow ordering kinetics.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1124–1133"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}