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Academic journal of gastroenterology & hepatology最新文献

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Celiac Disease and Liver Abnormalities: What Relationships? 乳糜泻和肝脏异常:什么关系?
Academic journal of gastroenterology & hepatology Pub Date : 2021-02-22 DOI: 10.33552/AJGH.2020.02.000543
D. Tagzout
{"title":"Celiac Disease and Liver Abnormalities: What Relationships?","authors":"D. Tagzout","doi":"10.33552/AJGH.2020.02.000543","DOIUrl":"https://doi.org/10.33552/AJGH.2020.02.000543","url":null,"abstract":"Celiac disease (CD) may be associated with liver abnormalities (LA) and these abnormalities are often liver blood tests abnormalities corresponding to cryptogenic hypertransaminasemia or celiac hepatitis (CH) which is reversible after strict gluten free diet (GFD). CH may be the only manifestation of unrecognized CD. Other LA may be associated, especially those of dysimmune origin or overload. The mechanisms of these associations are unclear and the role of the GFD is uncertain.","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45884311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severely Elevated Fecal Calprotectin in A Pediatric Patient with Persistent Giardiasis 持续性贾第虫患儿粪钙保护蛋白严重升高
Academic journal of gastroenterology & hepatology Pub Date : 2021-01-28 DOI: 10.33552/AJGH.2020.02.000542
Sona Sehgal
{"title":"Severely Elevated Fecal Calprotectin in A Pediatric Patient with Persistent Giardiasis","authors":"Sona Sehgal","doi":"10.33552/AJGH.2020.02.000542","DOIUrl":"https://doi.org/10.33552/AJGH.2020.02.000542","url":null,"abstract":"Giardia, a protozoan pathogen, is a leading cause of acute gastroenteritis worldwide with higher prevalence in developing countries. It is a treatable diagnosis that should be considered in any patient presenting with clinical symptoms of abdominal pain, bloating, and diarrhea. It is diagnosed with stool microcopy, antigen testing, or immunologic assay. There are few studies on whether Giardia should be considered in the setting of elevated fecal calprotectin (FC), a stool biomarker of intestinal inflammation. We present the case of a patient with markedly elevated FC in the setting of persistent, severe giardiasis.","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47821745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Output Consistency Scale to Standardize Ostomate Output Description in Clinical Practice and Studies. 输出一致性量表在临床实践和研究中规范口腔输出描述。
Academic journal of gastroenterology & hepatology Pub Date : 2021-01-01 DOI: 10.33552/ajgh.2021.03.000554
Lisa A Whisenhunt, Linda H Xu, Fan Yang, Jacques Izard
{"title":"Output Consistency Scale to Standardize Ostomate Output Description in Clinical Practice and Studies.","authors":"Lisa A Whisenhunt,&nbsp;Linda H Xu,&nbsp;Fan Yang,&nbsp;Jacques Izard","doi":"10.33552/ajgh.2021.03.000554","DOIUrl":"https://doi.org/10.33552/ajgh.2021.03.000554","url":null,"abstract":"<p><p>Stool descriptors have become popular due to the large diffusion of the Bristol Stool Form Scale (BSFS) via clinical studies, clinical trials, and social media. The applications have been numerous and centered around standardization of terminology that can be used by health care professionals and patients alike, as well as individuals interested in their wellness and the associated partners in the wellness industry. For a portion of the population, the digestive content is rerouted to an external manufactured pouch or bag, making the use of the BSFS visual descriptors of stool difficult. From day one post-resection surgery, ostomates are challenged with output management. The lack of standardized descriptors may hinder proper communication between the individual and the support team, as well as providing proper characterization in clinical studies and clinical trials. We propose the Lincoln Ostomy Output Consistency Scale for jejunostomy, ileostomy and colostomy (LOOCS) to overcome the limitations of the BSFS for qualifying ostomy outputs. The design was based on the need to describe perceived consistency from the ostomate point of view. We anticipate that the LOOCS scale can be effective in pediatric and adult clinical research settings, as well as self-monitoring to manage the quality of life.</p>","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744382/pdf/nihms-1840019.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10356751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Type 2 Autoimmune Hepatitis Due to Acute Epstein Barr Virus Infection or is it the Other Way Around? 2型自身免疫性肝炎是由急性eb病毒感染引起的，还是相反?
Academic journal of gastroenterology & hepatology Pub Date : 2020-12-09 DOI: 10.33552/AJGH.2020.02.000541
K. Busari
{"title":"Type 2 Autoimmune Hepatitis Due to Acute Epstein Barr Virus Infection or is it the Other Way Around?","authors":"K. Busari","doi":"10.33552/AJGH.2020.02.000541","DOIUrl":"https://doi.org/10.33552/AJGH.2020.02.000541","url":null,"abstract":"We present a case of a 19-year-old female who presented with abdominal pain and severe pruritus. Viral studies including complete hepatitis panel were negative for acute infection, however acute infectious mononucleosis heterophiles antibodies were positive along with liver kidney microsome (LKM-1) antibody. Patient’s liver on MRCP was markedly heterogenous and nodular with areas of confluent hepatic fibrosis consistent with cirrhosis. Subsequent liver biopsy confirmed findings of acute hepatitis with extensive parenchymal extinction and necrosis with moderate to severe mixed inflammation. The patient was initiated on cholestyramine 4 gm pack daily, prednisone and transferred to a tertiary center for liver transplant evaluation.","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44442559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Severe Ischemic Colitis in A Patient with Melas Syndrome 梅拉斯综合征患者的严重缺血性结肠炎
Academic journal of gastroenterology & hepatology Pub Date : 2020-10-29 DOI: 10.33552/AJGH.2020.02.000540
E. Lázaro
{"title":"Severe Ischemic Colitis in A Patient with Melas Syndrome","authors":"E. Lázaro","doi":"10.33552/AJGH.2020.02.000540","DOIUrl":"https://doi.org/10.33552/AJGH.2020.02.000540","url":null,"abstract":"MELAS syndrome is a genetic mitochondrial myopathy affecting less than 0.05% of people, which occurs with encephalomyopathy, lactic acidosis and cerebral ischemia [1]. Although it has a variable phenotypic expression, the predominant digestive manifestations [2,3] are constipation and pseudo-obstruction which are infrequent and occasionally serious. We present a patient with MELAS syndrome and the digestive disorder chronic ischemic colitis following intestinal obstruction due to fecaloma.","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46717669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary and Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis and Ascites 肝硬化腹水患者继发性和自发性细菌性腹膜炎
Academic journal of gastroenterology & hepatology Pub Date : 2020-10-02 DOI: 10.33552/AJGH.2020.02.000538
Kiprin G
{"title":"Secondary and Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis and Ascites","authors":"Kiprin G","doi":"10.33552/AJGH.2020.02.000538","DOIUrl":"https://doi.org/10.33552/AJGH.2020.02.000538","url":null,"abstract":"in class B. Peritonitis in Child-Pugh class A cirrhosis is probably secondary. IAC (International Ascites Club) recommends the SBP diagnosis to be taken in polymorphonuclear leucocytes (PMNs) in ascitic fluid >250/mm3 regardless of the result of bacterial cultures. Leucocytes /and ascitic fluid total protein (AFTP)/ increase in ascitic fluid after diuretic treatment, but not the PMNs. In patients with AFTP<10g/L the risk of SBP increases tenfold /decreased opsonic activity of ascitic fluid/. The ascitic bacterial cultures in SBP are rarely positive. At present, half of the episodes of SBP are caused by gram-positive bacteria. Blood cultures should be performed in all patients with suspected SBP. Bacterioscites (5%) does not need treatment, but monitoring, if there are no clinical symptoms and signs of systemic inflammation or infection. SecBP should be suspected in patients who have localized abdominal symptoms or signs, presence of multiple microorganisms (aerobes and anaerobes) in ascitic culture, very high ascitic neutrophil count and high ascitic total protein concentration. A SecBP should be suspected when at least two of the following features are present in ascitic fluid: glucose levels <50mg/dL, protein concentration >10g/L, lactic dehydrogenase concentration > normal serum levels. Due to the low sensitivity and specificity of these criteria for SecBP, examination of alkaline phosphatase (>225U/L) and carcinoembryonic antigen (>5ng/ml) in ascites are recommended /Runyon’s criteria/. Patients with suspected SecBP should undergo CT. Conclusion: The medical and surgical treatment of peritonitis in liver cirrhosis may be almost equally dangerous in wrong diagnosis.","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41939265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex Innovative Design for NASH Clinical Trials NASH临床试验的复杂创新设计
Academic journal of gastroenterology & hepatology Pub Date : 2020-09-14 DOI: 10.33552/AJGH.2020.02.000537
S. Chow
{"title":"Complex Innovative Design for NASH Clinical Trials","authors":"S. Chow","doi":"10.33552/AJGH.2020.02.000537","DOIUrl":"https://doi.org/10.33552/AJGH.2020.02.000537","url":null,"abstract":"The prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is increasing world-wide. The development of drug product for treating NASH is considered unmet medical need. Due to the increasing prevalence and the health burden, there is a high need to develop therapeutic strategies for patients with NASH. The primary objective of the treatment for NASH is to prevent liver-related morbidity and mortality, which generally takes a long time (e.g., more than 10-20 years) to develop. In practice, it is not feasible to conduct such clinical studies. Thus, regulatory agencies such as United States Food and Drug Administration (FDA) encourage to look at surrogate endpoints for review and approval. Seamless adaptive clinical trial designs in NASH provide an opportunity to shorten the overall path to registration for a new drug and offer continuity for patients enrolled in the study. In this article, Characteristics for applying various seamless adaptive designs to clinical trials in NASH are reviewed. Statistical, clinical, and strategic issues related to drug development of NASH are also discussed.","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43675519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical Characteristics and Surgical Treatment of Presacral Cysts 骶前囊肿的临床特点及外科治疗
Academic journal of gastroenterology & hepatology Pub Date : 2020-06-18 DOI: 10.33552/ajgh.2020.02.000534
B. Niu
{"title":"Clinical Characteristics and Surgical Treatment of Presacral Cysts","authors":"B. Niu","doi":"10.33552/ajgh.2020.02.000534","DOIUrl":"https://doi.org/10.33552/ajgh.2020.02.000534","url":null,"abstract":"Presacral cysts are cystic lesions occurring near the sacrorectal fossa, which can be clearly diagnosed by CT and MRI and anal digital examination before surgery. The characteristics of the tumor itself and the special location are not conducive to surgical resection. The introduction of laparoscopic techniques has brought hope for treatment, but attention should be paid to avoid damage to the rectal and presacral venous plexus. Presacral cysts with insidious onset should be checked regularly and discovered timely. Patients have good prognosis. Multi-disciplinary diagnosis was necessary. This review aims to summarize the clinical characteristics, diagnostic methods, surgical treatment, and prognosis of presacral cysts.","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41488859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Types and Indications of Cholecystectomy in Nigeria: Our Experience in Damaturu, North-Eastern Nigeria 尼日利亚胆囊切除术的类型和适应证：我们在尼日利亚东北部达马图鲁的经验
Academic journal of gastroenterology & hepatology Pub Date : 2020-06-18 DOI: 10.33552/ajgh.2020.02.000535
Ningi Ab
{"title":"The Types and Indications of Cholecystectomy in Nigeria: Our Experience in Damaturu, North-Eastern Nigeria","authors":"Ningi Ab","doi":"10.33552/ajgh.2020.02.000535","DOIUrl":"https://doi.org/10.33552/ajgh.2020.02.000535","url":null,"abstract":"","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42815662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Large Gastroesophageal Junction Mass in an Elderly Caucasian Male 一例老年高加索男性胃食管交界处巨大肿块
Academic journal of gastroenterology & hepatology Pub Date : 2020-06-11 DOI: 10.33552/ajgh.2020.02.000533
N. Parker
{"title":"A Large Gastroesophageal Junction Mass in an Elderly Caucasian Male","authors":"N. Parker","doi":"10.33552/ajgh.2020.02.000533","DOIUrl":"https://doi.org/10.33552/ajgh.2020.02.000533","url":null,"abstract":"","PeriodicalId":72038,"journal":{"name":"Academic journal of gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43332828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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