Acute critical care最新文献_第9页

C- Reactive protein Kinetic in the Prognosis of Ventilator-Associated Pneumonia C-反应蛋白动力学与呼吸机相关性肺炎预后的关系

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa2264

S. Pothal, Chandan Kumar Shit, Pravati Dutta, Rekha Manjhi, Aurobindo Behera

引用次数: 1

Quantitative CT based selective Lung-Volume Reduction by prolonged Weaning in COPD GOLD D Patients with massive Emphysema 慢性阻塞性肺病GOLD D伴大量肺气肿患者延长脱机后选择性肺容量减少的定量CT

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa2188

M. Lavae-Mokhtari, Omar Alshintiry, J. Fichter, G. May, V. Vieth, N. Dickgreber

引用次数: 0

Novel pharmacological inhibition of EZH2 attenuates septic shock by altering innate inflammatory responses to sepsis 新型药物抑制EZH2通过改变先天炎症反应来减轻脓毒症休克

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa2271

Lunxian Tang

{"title":"Novel pharmacological inhibition of EZH2 attenuates septic shock by altering innate inflammatory responses to sepsis","authors":"Lunxian Tang","doi":"10.1183/13993003.congress-2019.pa2271","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa2271","url":null,"abstract":"The function of histone methyltransferase enhancer of zeste homolog 2 (EZH2) in sepsis remains unknown. We reported here that the expression of EZH2 and H3K27me3 was significantly upregulated in the circulation of septic patients, whereas patients who survived presented downregulated the expression of EZH2 on CD14+ monocytes/macrophages. We further identified increased expression of EZH2 in the circulation, peritoneal fluid, and septic lungs from CLP mice. 3-DZNeP treated CLP mice improved mortality and protected from organ injury. EZH2 inhibition not only suppressed the activation of inflammatory cells and release of cytokines in the circulation and infectious sites, but also promoted bacteria clearance and replenished the circulating monocyte and neutrophil pool from bone marrow. Blockage of EZH2 also suppressed the progression of lung injury and alleviated inflammation by decreasing the pulmonary cell apoptosis, reducing inflammatory cells infiltration and cytokines release through inhibition of the STAT3 signaling pathway and recovery of PPARγ activation. In addition, EZH2 inhibitor blunted macrophage M1 polarization by SOCS3/STAT1 pathway. Overall, these data suggest that EZH2 could be a potential biomarker predicting clinical outcome and a new target for therapeutic interference in sepsis.","PeriodicalId":7201,"journal":{"name":"Acute critical care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81307916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A new treatment algorithm for acute exacerbation of IPF: a retrospective cohort study IPF急性加重的新治疗算法:一项回顾性队列研究

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4018

A. Vianello, S. Ferrarese, B. Molena, G. Arcaro, F. Braccioni, L. Paladini, F. Gallan

{"title":"A new treatment algorithm for acute exacerbation of IPF: a retrospective cohort study","authors":"A. Vianello, S. Ferrarese, B. Molena, G. Arcaro, F. Braccioni, L. Paladini, F. Gallan","doi":"10.1183/13993003.congress-2019.pa4018","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4018","url":null,"abstract":"Background: Some patients with Idiopathic Pulmonary Fibrosis (IPF) develop acute exacerbation (AE-IPF) leading to severe Acute Respiratory Failure (ARF); despite conventional supportive therapy, the mortality rate remains extremely high. Aims and Objectives: To assess how a treatment algorithm incorporating High Flow Nasal Cannula (HNFC) oxygen therapy and Extracorporeal CO2 Removal (ECCO2R) may affect the short-term mortality of patients with AE-IPF who develop ARF. Methods: Seventeen AE-IPF patients admitted to a Respiratory Intensive Care Unit (RICU) for ARF were managed using a treatment algorithm incorporating HFNC and ECCO2R. Mortality rate during their stay in the RICU and short-term survival rates were recorded. Results: The implementation of the treatment algorithm led to a successful outcome in 9 patients (52.9%). 8 patients (47.1%) died within 39 days of being admitted to the RICU. The survival rate was 70.6% (±0.1 %) at 15 days, 52.9% (±0.1%) at 30 days, 35.3% (±0.1%) at 90 days, and 15.6% (±9.73 %) at 365 days. Four/10 patients who did not respond to conventional oxygen therapy showed a satisfactory response to HFNC. Conclusions: Short-term mortality fell to below 50 per cent when a treatment algorithm incorporating HFNC and ECCO2R was implemented in a group of AE-IPF patients admitted to a RICU for ARF. Subjects not responding to conventional oxygen therapy seemed to benefit from HFNC.","PeriodicalId":7201,"journal":{"name":"Acute critical care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88111640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Free leptin index in critically ill septic patients: a prospective case-control study 危重症脓毒症患者游离瘦素指数:一项前瞻性病例对照研究

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa2259

I. Karampela, Evangelia Kandri, E. Chrysanthopoulou, G. Skyllas, G. Christodoulatos, G. Antonakos, E. Vogiatzakis, A. Armaganidis, M. Dalamaga

引用次数: 1

High Flow Nasal Oxygen Therapy Usage in the Adult Intensive Care Units in Turkey: Multi-center, Prospective Study 高流量鼻氧治疗在土耳其成人重症监护病房的使用:多中心前瞻性研究

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4020

F. Yıldırım, S. Ocal, Ebru Ortaç, Ömer Zühtü Yöndem, B. Yüksel, T. Akbaş, O. Balbay, E. Aydın, F. Aydın, Nilgün Mendil, S. Turan, H. Dal, Y. Dikmen, E. Erdoğan, Serdar Akpınar, G. Aygencel, M. Turkoglu, Nur Karaaslan, S. Izdes, H. Demir, N. Şenoğlu, Burcu Sayan, C. Kıraklı, R. Kayali, Pervin Korkmaz, F. Bacakoğlu, F. Koşar

{"title":"High Flow Nasal Oxygen Therapy Usage in the Adult Intensive Care Units in Turkey: Multi-center, Prospective Study","authors":"F. Yıldırım, S. Ocal, Ebru Ortaç, Ömer Zühtü Yöndem, B. Yüksel, T. Akbaş, O. Balbay, E. Aydın, F. Aydın, Nilgün Mendil, S. Turan, H. Dal, Y. Dikmen, E. Erdoğan, Serdar Akpınar, G. Aygencel, M. Turkoglu, Nur Karaaslan, S. Izdes, H. Demir, N. Şenoğlu, Burcu Sayan, C. Kıraklı, R. Kayali, Pervin Korkmaz, F. Bacakoğlu, F. Koşar","doi":"10.1183/13993003.congress-2019.pa4020","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4020","url":null,"abstract":"Aim: High flow nasal oxygen (HFNO) is widely used all over the world as oxygen support therapy. In our study, we aimed to evaluate the clinical characteristics of the patients treated with HFNO therapy, indications and results of HFNO therapy in adult ICUs of Turkey. Method: This multicenter, prospective, observational was conducted between 15 January 2018 and 15 January 2019 and included 14 centers. Results: The study included 298 patients with a mean age of 65.8±17.1 years, 172 (57.7%) of the patients were male. APACHE II and SOFA scores were 22.5±7.8 and 5.8±3.4 respectively. The mean respiratory rate of the patients at the onset of HFNO was 26.2±7.6 breaths/min, SpO2 89.3±8.2% and median Dyspnea score was 7. Most common indication for the use of HFNO was respiratory failure in 220 (73.8%) patients. Other indications were the risk of post-operative respiratory failure in 57 (29.8%) patients, palliative purposes in 17 (5.7%) patients. Type 1 hypoxemic respiratory failure was most common reason for respiratory failure (70.8%). Median HFNO administration time 4 [1-21] days, median initial flow rate was 54 L/min, and median initiation FiO2 was 60%. Initial respiratory rate (p","PeriodicalId":7201,"journal":{"name":"Acute critical care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79205381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The outcome of patients with acute stroke requiring intensive care unit admission 急性脑卒中患者需要重症监护病房入院的结果

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa2283

B. Khassawneh, Ali M Ibnian, Ahmed Yassin, Abdel-Hameed W. Al-Mistarehi, Islam E’Leimat, Musaab K. Ali, Ahmad Shannaq, K. El-Salem

引用次数: 2

Macrolides resitance to streptococcus pneumonia 大环内酯类药物对肺炎链球菌的耐药性

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa2267

Erum Umer, Z. Ahmed, Syed Ali Arsalan

引用次数: 0

Hand Grip Strength Predicts In-hospital Clinical Outcomes in Mechanically Ventilated Patients 手部握力预测机械通气患者的住院临床结果

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4016

Chatkarin Tepwimonpetkun, N. Saiphoklang

引用次数: 0

Serum kinetics of total leptin and soluble leptin receptor as prognostic tools in sepsis 总瘦素和可溶性瘦素受体的血清动力学作为脓毒症的预后工具

Acute critical care Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa2260

I. Karampela, Evangelia Kandri, G. Skyllas, E. Chrysanthopoulou, G. Christodoulatos, G. Antonakos, E. Vogiatzakis, A. Armaganidis, M. Dalamaga

引用次数: 0