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Role of Click Chemistry in development of Biomedicines 点击化学在生物医学发展中的作用
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/apj.2021.6.2.2
Shailee V. Tiwari, Mohammad Zishan Ibrahim
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引用次数: 0
Potential antimalarial activity of artemether-lumefantrine-doxycycline: A study in mice infected with Plasmodium berghei 蒿甲醚-甲苯胺-强力霉素潜在的抗疟活性:对感染伯氏疟原虫小鼠的研究
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/APJ.2021.6.1.4
Udeme O. Georgewill, Elias Adikwu
{"title":"Potential antimalarial activity of artemether-lumefantrine-doxycycline: A study in mice infected with Plasmodium berghei","authors":"Udeme O. Georgewill, Elias Adikwu","doi":"10.31024/APJ.2021.6.1.4","DOIUrl":"https://doi.org/10.31024/APJ.2021.6.1.4","url":null,"abstract":"Antimalarial drug resistance is one of the greatest challenges towards eradicating malaria. Exploring new combination therapies can overcome resistance challenges. The present study examined the antiplasmodial effect of artemether/lumefantrine/doxycycline (A/L/D) on a mouse model infected with Plasmodium berghei . Adult Swiss albino mice (22-30g) intraperitoneally infected with blood containing 1x10 7 Plasmodium berghei were randomly grouped and orally treated daily with D (2.2 mg/kg), A/L (1.71/13.7 mg/kg) and A/L/D. The negative control was treated daily with normal saline (0.2ml) whereas the positive control was treated daily with chloroquine (CQ) (10mg/kg). After treatment, blood samples were assessed for percentage parasitemia and biochemical parameters. Mice were observed for mean survival time (MST). D, A/L and A/L/D produced significant decreases in percentage parasitemia levels at p<0.05; p<0.01 and p<0.001, respectively when compared to negative control. In the curative test, D, A/L and A/L/D produced 60.4%, 70.3%, and 90.0% parasitemia inhibitions, respectively whereas CQ produced 76.0% parasitemia inhibition. D, A/L, A/L/D and CQ produced 63.2 %, 80.1%, 92.3% and 83.6% parasitemia inhibitions, respectively in the suppressive test. D, A/L, and A/L/D prevented Plasmodium berghei-induced alterations in biochemical parameters by increasing packed cell volume, red blood cells, hemoglobin, and high-density lipoprotein and decreasing white blood cells, total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels significantly at p<0.05 and p<0.01 and p<0.001, respectively when compared to the negative control. A/L/D produced significant antiplasmodial activity therefore, it may be used clinically for the treatment of malaria.","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82899976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacovigilance study of anti-tubercular drugs in a community healthcare hospital 某社区卫生医院抗结核药物的药物警戒研究
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/apj.2021.6.4.2
B. Sharma, N. Lodhi, R. Goswami, Abhishek Banke
{"title":"Pharmacovigilance study of anti-tubercular drugs in a community healthcare hospital","authors":"B. Sharma, N. Lodhi, R. Goswami, Abhishek Banke","doi":"10.31024/apj.2021.6.4.2","DOIUrl":"https://doi.org/10.31024/apj.2021.6.4.2","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86001674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medicinal plants as antibacterial agents: A special reference to Emblica officinalis, Ocimum sanctum, Aloe vera and Aegle marmelos 药用植物抗菌剂:特别提到了恩布利亚、圣木、芦荟和蜜瓜
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/apj.2021.6.5.1
R. Sawhney, Prerana Hazarika, Archit Sawhney
{"title":"Medicinal plants as antibacterial agents: A special reference to Emblica officinalis, Ocimum sanctum, Aloe vera and Aegle marmelos","authors":"R. Sawhney, Prerana Hazarika, Archit Sawhney","doi":"10.31024/apj.2021.6.5.1","DOIUrl":"https://doi.org/10.31024/apj.2021.6.5.1","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88499277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Characteristics, transmission and pathogenesis of human Polyomavirus: A Review 人多瘤病毒的特点、传播和发病机制综述
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/apj.2021.6.5.3
Mohammad Ameen Mohammad Mahmood, Mohammad Zishan Ibrahim, Shailee V. Tiwari
{"title":"Characteristics, transmission and pathogenesis of human Polyomavirus: A Review","authors":"Mohammad Ameen Mohammad Mahmood, Mohammad Zishan Ibrahim, Shailee V. Tiwari","doi":"10.31024/apj.2021.6.5.3","DOIUrl":"https://doi.org/10.31024/apj.2021.6.5.3","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90836847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiological quality of ready – to- eat soya bean curd (Awara) sold in Wudil town, Kano-Nigeria 尼日利亚卡诺州Wudil镇出售的即食豆腐(Awara)的微生物质量
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/apj.2021.6.5.2
A. Yakubu, A. A. Shehu, A. Umar, I. Farida, S. Umar, U. Y. Yahaya
{"title":"Microbiological quality of ready – to- eat soya bean curd (Awara) sold in Wudil town, Kano-Nigeria","authors":"A. Yakubu, A. A. Shehu, A. Umar, I. Farida, S. Umar, U. Y. Yahaya","doi":"10.31024/apj.2021.6.5.2","DOIUrl":"https://doi.org/10.31024/apj.2021.6.5.2","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83418301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controlled drug release rate and contemporary issues in oral drug delivery formulations 口服给药制剂的药物控释率及当代问题
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/apj.2021.6.2.1
Ritu Jain, R. Tiwari, R. S. Dubey, A. Tiwari, A. Shukla
{"title":"Controlled drug release rate and contemporary issues in oral drug delivery formulations","authors":"Ritu Jain, R. Tiwari, R. S. Dubey, A. Tiwari, A. Shukla","doi":"10.31024/apj.2021.6.2.1","DOIUrl":"https://doi.org/10.31024/apj.2021.6.2.1","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90713352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lupeol: Bioactive triterpenoid act as anti-inflammatory agent 芦皮醇:具有生物活性的三萜，具有抗炎作用
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/apj.2021.6.2.3
R. Tiwari, Ritu Jain, R. S. Dubey, Aarti Tiwari, A. Shukla
{"title":"Lupeol: Bioactive triterpenoid act as anti-inflammatory agent","authors":"R. Tiwari, Ritu Jain, R. S. Dubey, Aarti Tiwari, A. Shukla","doi":"10.31024/apj.2021.6.2.3","DOIUrl":"https://doi.org/10.31024/apj.2021.6.2.3","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"199 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76621011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaceutical and biotechnological applications of microsponges as novel nano technological drug delivery system 微海绵作为新型纳米技术给药系统的制药和生物技术应用
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/apj.2021.6.4.1
Shankar B. Kalbhare, A. Velhal, Mandar J. Bhandwalkar, Rupali V. Jadhav, Akash S. Nalawade
{"title":"Pharmaceutical and biotechnological applications of microsponges as novel nano technological drug delivery system","authors":"Shankar B. Kalbhare, A. Velhal, Mandar J. Bhandwalkar, Rupali V. Jadhav, Akash S. Nalawade","doi":"10.31024/apj.2021.6.4.1","DOIUrl":"https://doi.org/10.31024/apj.2021.6.4.1","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81702619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Heinsia crinata leaves on laxative activity 红海棠叶通便作用的研究
Advance Pharmaceutical Journal Pub Date : 2021-01-01 DOI: 10.31024/apj.2021.6.4.4
J. Okokon, Ndianabasi Polycarp Brown, Godswill J. Udom, H. K. Bankhede
{"title":"Investigation of Heinsia crinata leaves on laxative activity","authors":"J. Okokon, Ndianabasi Polycarp Brown, Godswill J. Udom, H. K. Bankhede","doi":"10.31024/apj.2021.6.4.4","DOIUrl":"https://doi.org/10.31024/apj.2021.6.4.4","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85320342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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