Acta physiologica Hungarica最新文献_第8页

Effects of hypoxia and hypercapnia on human HRV and respiratory sinus arrhythmia. 低氧和高碳酸血症对人HRV和呼吸性窦性心律失常的影响。

Acta physiologica Hungarica Pub Date : 2014-09-01 DOI: 10.1556/APhysiol.101.2014.3.1

Stephen J Brown, M J Barnes, T Mündel

{"title":"Effects of hypoxia and hypercapnia on human HRV and respiratory sinus arrhythmia.","authors":"Stephen J Brown, M J Barnes, T Mündel","doi":"10.1556/APhysiol.101.2014.3.1","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.3.1","url":null,"abstract":"Purpose: Hypercapnia increases minute ventilation (V’E) with little effect on heart rate (HR), whereas hypoxia may increase HR without affecting V’E. However, the effects of hypercapnia and hypoxia on both heart rate variability(HRV) and the clustering of heart beats during spontaneous breathing (respiratory sinus arrhythmia – RSA), are not clear.Methods: In this study, 10 human volunteers breathed room air (RA), hypercapnic (5% CO2) or hypoxic (10%O2) gas mixtures, each for 6 min, while resting supine. ECG, mean arterial pressure (MAP), ventilatory flow, inhaled and exhaled fractions of CO2 and O2, were recorded throughout.Results: Both V’E and MAP increased with 5%CO2, with no change in HR. Hypoxia did not change ventilation but increased HR. High frequency components of HRV, and the relative proportion of heart beats occurring during inhalation increased with 5% CO2, but neither changed with 10% O2.Conclusion: Increased RSA concomitant with increased MAP suggests RSA – vagal dissociation with hypercapnia. Elevated heart rate with acute hypoxia with no change in either frequency components of HRV or the distribution of heart beats during ventilation, suggested that clustering of heart beats may not be a mechanism to improve ventilation-perfusion matching during hypoxia.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.3.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32636312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Genetic effects on refraction and correlation with hemodynamic variables: a twin study. 遗传对折射的影响及其与血流动力学变量的相关性:一项双胞胎研究。

Acta physiologica Hungarica Pub Date : 2014-09-01 DOI: 10.1556/APhysiol.101.2014.3.6

G Zs Toth, Adam Domonkos Tarnoki, D L Tarnoki, A Racz, Z Szekelyhidi, L Littvay, K Karlinger, A Lannert, A A Molnar, Zs Garami, V Berczi, I Suveges, J Nemeth

{"title":"Genetic effects on refraction and correlation with hemodynamic variables: a twin study.","authors":"G Zs Toth, Adam Domonkos Tarnoki, D L Tarnoki, A Racz, Z Szekelyhidi, L Littvay, K Karlinger, A Lannert, A A Molnar, Zs Garami, V Berczi, I Suveges, J Nemeth","doi":"10.1556/APhysiol.101.2014.3.6","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.3.6","url":null,"abstract":"Spherical equivalent (SE) has not been linked to increased cardiovascular morbidity. Methods: 132 Hungarian twins(age 43.3±16.9 years) underwent refraction measurements (Huvitz MRK-3100 Premium AutoRefractokeratometer)and oscillometry (TensioMed Arteriograph). Results: Heritability analysis indicated major role for genetic components in the presence of right and left SE (82.7%, 95%CI, 62.9 to 93.7%, and 89.3%, 95%CI, 72.8 to 96.6%),while unshared environmental effects accounted for 17% (95%CI, 6.3% to 37%), and 11% (95%CI, 3.4% to 26.7%)of variations adjusted for age and sex. Bilateral SE showed weak age-dependent correlations with augmentation index (AIx), aortic pulse wave velocity (r ranging between 0.218 and 0.389, all p < 0.01), aortic systolic blood pressure and pulse pressure (r between 0.188 and 0.289, p < 0.05). Conclusions: These findings support heritability of spherical equivalent, which does not coexist with altered hemodynamics (e.g. accelerated arterial aging).Accordingly, SE and the investigated hemodynamic parameters seem neither phenotypically nor genetically associated.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.3.6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32636226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of N-methyl-D-aspartic acid on activity of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione level in selected organs of the mouse. n -甲基- d -天冬氨酸对小鼠各脏器超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶活性及还原型谷胱甘肽水平的影响。

Acta physiologica Hungarica Pub Date : 2014-09-01 DOI: 10.1556/APhysiol.101.2014.003

Waldemar Szaroma, K Dziubek, E Kapusta

{"title":"Effect of N-methyl-D-aspartic acid on activity of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione level in selected organs of the mouse.","authors":"Waldemar Szaroma, K Dziubek, E Kapusta","doi":"10.1556/APhysiol.101.2014.003","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.003","url":null,"abstract":"One of the major classes of ionotropic glutamate receptors is the class of N-methyl-D-aspartate receptors (NMDARs). Receptor activation recruits, via calcium signal transduction mechanisms which play important roles in oxidative metabolism, mitochondrial free radical production and occurrence of other mitochondrial factors which potentially contribute to excitotoxicity and neuronal death. In the present study, the effects of stimulation of NMDARs by applying N-methyl-D-aspartic acid (NMDA) in the brain, liver, kidneys and pancreas on change of the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHPx) and in the amount of reduced glutathione (GSH) in blood, brain, liver and kidneys has been investigated. Statistically significant decrease of the activity of SOD, CAT and GSHPx and in the amount of reduced glutathione (GSH) was found in the examined organs after administration of NMDA, an agonist of NMDA receptors, demonstrating that NMDA administration compromises the antioxidant status in the investigated organs of the mouse. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32371875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Ten-year cardiovascular risk assessment in university students. 大学生十年心血管风险评估。

Acta physiologica Hungarica Pub Date : 2014-09-01 DOI: 10.1556/APhysiol.101.2014.3.7

Martina Uvacsek, Zs Kneffel, M Tóth, A W Johnson, P Vehrs, J W Myrer, R Hager

{"title":"Ten-year cardiovascular risk assessment in university students.","authors":"Martina Uvacsek, Zs Kneffel, M Tóth, A W Johnson, P Vehrs, J W Myrer, R Hager","doi":"10.1556/APhysiol.101.2014.3.7","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.3.7","url":null,"abstract":"Cardiovascular disease (CVD) is responsible for more than half of all deaths in the European region. The aim of the study was to compare body composition, blood pressure, total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C), family history, activity behaviors, and the 10-year risk of having a heart attack between 166 university students (21.62 ± 2.59 yrs) from Utah (USA) and 198 students (22.11 ± 2.51 yrs) from Hungary. Ninety-two percent of the Hungarian students and 100% of the Utah students had an estimated 10-year Framingham risk score of 1% or less. The high prevalence of low risk was primarily due to the young age of study participants, healthy body composition and non-smoking behavior. Hungarians who had higher 10-year risk of heart attack had significantly higher waist hip ratio (WHR), TC, diastolic blood pressure (DBP) and were smokers compared to those Hungarians with lower risk. The self-reported physical activity levels between the two groups of students were not different. In conclusion the young men and women who participated in this study were, for the most part healthy; however the smoking habits and the lower physical activity of the Hungarian students likely elevated their risk of CVD. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.3.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32636227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Hemodynamic effects of slow breathing: does the pattern matter beyond the rate? 慢呼吸的血流动力学影响:模式比呼吸速率更重要吗?

Acta physiologica Hungarica Pub Date : 2014-09-01 DOI: 10.1556/APhysiol.101.2014.3.2

D Paprika, Z Gingl, László Rudas, E Zöllei

{"title":"Hemodynamic effects of slow breathing: does the pattern matter beyond the rate?","authors":"D Paprika, Z Gingl, László Rudas, E Zöllei","doi":"10.1556/APhysiol.101.2014.3.2","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.3.2","url":null,"abstract":"Purpose: Patterned breathing allows standardized serial measurements of heart rate variability and baroreflex indices. The slow breathing augments these parameters, and regular exercises, including yoga breathing practices with even respiratory rates have long-term beneficial effects in cardiovascular diseases. The role of temporization of breathing phases, i.e. the ratio of expiration to inspiration, is not known. In order to characterize the hemodynamic and autonomic responses during varying breathing phases 27 volunteers performed three short breathing sessions at 6/minutes frequency with 5:5, 3:7 and 7:3 inspiration expiration ratios.Results: The immediate responses in arterial pressure and heart rate were negligible. The time domain parameters of heart rate variability (SDRR, PNN50,RMSSD) increased significantly with patterned breathing. So did the spontaneous baroreflex gain of increasing sequences (up-BRS, from 12 ± 7 to 17 ± 10 ms/mmHg, p < 0.05), and the cross-spectral low frequency gain, the LFalpha (from 11 ± 7 to 15 ± 7 ms/mmHg, p < 0.05). None of these parameters differed significantly from each other while using any of tested inspiratory-expiratory patterns.Conclusion: The major determinant of autonomic responses induced by slow patterned breathing is the breathing rate itself. From our observations, it follows that slow breathing exercises performed either with diagnostic or therapeutic purpose could be simplified, allowing more extensive investigations.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.3.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32636313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Side effects of the calcineurin inhibitor, such as new-onset diabetes after kidney transplantation. 钙调磷酸酶抑制剂的副作用，如肾移植后新发糖尿病。

Acta physiologica Hungarica Pub Date : 2014-09-01 DOI: 10.1556/APhysiol.101.2014.3.13

Bernadett Borda, Cs Lengyel, T Várkonyi, E Kemény, A Ottlakán, A Kubik, Cs Keresztes, Gy Lázár

{"title":"Side effects of the calcineurin inhibitor, such as new-onset diabetes after kidney transplantation.","authors":"Bernadett Borda, Cs Lengyel, T Várkonyi, E Kemény, A Ottlakán, A Kubik, Cs Keresztes, Gy Lázár","doi":"10.1556/APhysiol.101.2014.3.13","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.3.13","url":null,"abstract":"New-onset diabetes after transplantation (NODAT) is one of the frequent complications following kidney transplantation. Patients were randomized to receive cyclosporine A- or tacrolimus-based immunosuppression. Fasting and oral glucose tolerance tests were performed, and the patients were assigned to one of the following three groups based on the results: normal, impaired fasting glucose/impaired glucose tolerance (IFG/IGT), or NODAT. NODAT developed in 14% of patients receiving cyclosporine A-based immunosuppression and in 26% of patients taking tacrolimus (p = 0.0002). Albumin levels were similar, but uric acid level (p = 0.002) and the age of the recipient (p = 0.003) were significantly different comparing the diabetic and the normal groups. Evaluation of tissue samples revealed that acute cellular rejection (ACR) and interstitial fibrosis/tubular atrophy (IF/TA) were significantly different in the NODAT group. The pathological effect of new-onset diabetes after kidney transplantation can be detected in the morphology of the renal allograft earlier, before the development of any sign of functional impairment. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.3.13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32636232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Physiological response is similar in overweight and normoweight boys during cycling: a longitudinal study. 生理反应在超重和正常体重的男孩骑自行车时是相似的:一项纵向研究。

Acta physiologica Hungarica Pub Date : 2014-06-01 DOI: 10.1556/APhysiol.101.2014.2.12

M Maciejczyk, J Szymura, J Gradek, J Cempla, M Więcek

{"title":"Physiological response is similar in overweight and normoweight boys during cycling: a longitudinal study.","authors":"M Maciejczyk, J Szymura, J Gradek, J Cempla, M Więcek","doi":"10.1556/APhysiol.101.2014.2.12","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.2.12","url":null,"abstract":"The purpose of this study was to determine whether metabolic cost is similar in overweight and normoweight children when workload during exercise on a cycle-ergometer is adjusted relative to an objectively determined second ventilatory threshold (VT2) or the maximal workload (Pmax). The tests were conducted every 2 years: first at the age of 10 years and the third test at around the age of 14 years. The levels of maximal oxygen consumption (VO(2)max), Pmax, and the VT2 were determined by means of graded tests on a cycle ergometer. The main test consisted of two 6-minute exercises of submaximal constant intensity (below and above VT2) performed on a cycle ergometer, with a 4-minute recovery between efforts. The workload during cycling was adjusted individually for each participant and adjusted to the values determined in the graded test: workload at VT2 and Pmax. Physiological response (absolute and relative to free-fat mass oxygen uptake, heart rate, pulmonary ventilation, tidal volume, and breathing frequency) is similar in overweight and normoweight boys when workload on a cycle ergometer is adjusted to VT2. The only significant intergroup difference was seen in relative to body mass oxygen intake.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.2.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32399536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A comparative study on dyslipidaemia inducing diets in various rat strains. 不同品系大鼠血脂异常诱导饮食的比较研究。

Acta physiologica Hungarica Pub Date : 2014-06-01 DOI: 10.1556/APhysiol.101.2014.2.13

J T Padra, I Seres, A Oláh, F Fenyvesi, G Paragh, G Paragh, László Csernoch, G Fóris, P Kertai

{"title":"A comparative study on dyslipidaemia inducing diets in various rat strains.","authors":"J T Padra, I Seres, A Oláh, F Fenyvesi, G Paragh, G Paragh, László Csernoch, G Fóris, P Kertai","doi":"10.1556/APhysiol.101.2014.2.13","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.2.13","url":null,"abstract":"In our experiments we compared the serum lipoprotein lipid composition of Fischer 344 (F344) and Long-Evans (LE) inbred rats as well as of their hybrid FLF(1) from both sexes after feeding them for 2, 4 and 8 weeks with different diets. The following diets were used: 1) standard diet marked as CRLT/N; 2) diet reach in butter marked as BR; 3) diet containing cholesterol, sodium cholate and methylthiouracil marked as CR; 4) diet marked as BRC, which is the Hartroft-Sós diet modified by our research group consisting of the diets BR and CR. The latter diet was the most effective, because within two weeks the level of serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglyceride in the F344 female rats increased 8, 30, 4 and 8 times, respectively. The male rats of the Long-Evans strain showed moderately increased values while the FLF(1) female hybrids derived from the hybridization of LE males and F344 females had values closer to those of the mother strain. Despite the fact that during this time the LDL/HDL ratio increased from 0.06 to 2.97 and the PON-1 activity decreased to one-third, a significant lipid deposition could not be shown in the wall of the abdominal aorta even two months later. Our experimental model is suitable for the chemoprevention of dyslipidaemia or rapid testing of molecules chosen for its treatment.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.2.13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32399537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Oscillation in O2 uptake in impulse exercise. 冲动运动中氧摄取的振荡。

Acta physiologica Hungarica Pub Date : 2014-06-01 DOI: 10.1556/APhysiol.101.2014.2.2

T Yano, R Afroundeh, R Yamanaka, T Arimitsu, C S Lian, K Shirakawa, T Yunoki

{"title":"Oscillation in O2 uptake in impulse exercise.","authors":"T Yano, R Afroundeh, R Yamanaka, T Arimitsu, C S Lian, K Shirakawa, T Yunoki","doi":"10.1556/APhysiol.101.2014.2.2","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.2.2","url":null,"abstract":"The purpose of the present study was to examine 1) whether O(2) uptake (VO(2)) oscillates during light exercise and 2) whether the oscillation is enhanced after impulse exercise. After resting for 1 min on a bicycle seat, subjects performed 5-min pre-exercise with 25 watts work load, 10-s impulse exercise with 200 watts work load and 15-min post exercise with 25 watts work load at 80 rpm. VO(2) during pre-exercise significantly increased during impulse exercise and suddenly decreased and re-increased until 23 s after impulse exercise. In the cross correlation between heart rate (HR) and VO(2) after impulse exercise, VO(2) strongly correlated to HR with a time delay of -4 s. Peak of power spectral density (PSD) in HR appeared at 0.0039 Hz and peak of PSD in VO(2) appeared at 0.019 Hz. The peak of the cross power spectrum between VO(2) and HR appeared at 0.0078 Hz. The results suggested that there is an oscillation in O(2) uptake during light exercise that is associated with the oscillation in O(2) consumption in active muscle. The oscillation is enhanced not only by change in O(2) consumption but also by O(2) content transported from active muscle to the lungs.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32401528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Metabolic and ventilatory effects of oral glucose load at rest and during incremental aerobic muscular work in young healthy adults. 年轻健康成人静息和增量有氧肌肉运动时口服葡萄糖负荷的代谢和通气作用

Acta physiologica Hungarica Pub Date : 2014-06-01 DOI: 10.1556/APhysiol.101.2014.2.8

A Rubini, A Parmagnani, A Paoli

{"title":"Metabolic and ventilatory effects of oral glucose load at rest and during incremental aerobic muscular work in young healthy adults.","authors":"A Rubini, A Parmagnani, A Paoli","doi":"10.1556/APhysiol.101.2014.2.8","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.2.8","url":null,"abstract":"We measured respiratory ratio (RR), pulmonary ventilation (VE) and end-tidal carbon dioxide partial pressure (ETPCO2) at rest and during cycling aerobic workloads (20%, 40%, 60% of estimated maximal oxygen uptake). Measurements were taken after overnight fasting and after an oral glucose load. RR, VE and ETPCO2 increased with workload. Glucose load caused RR and VE increments at rest (0.75 ± 0.01 vs. 0.86 ± 0.02, p < 0.01, and 10.8 ± 0.43 vs. 12.1 ± 0.49 l/min, p < 0.01, respectively) and for each workload (20% estimated maximal oxygen uptake: 0.77 ± 0.01 vs. 0.855 ± 0.02, p < 0.01, and 16.2 ± 0.73 vs. 17.7 ± 0.8 l/min, p < 0.01; 40% estimated maximal oxygen uptake: 0.76 ± 0.02 vs. 0.82 ± 0.01, p < 0.01, and 25.9 ± 1.1 vs. 28.3 ± 1.3 l/min, p < 0.05; 60% estimated maximal oxygen uptake: 0.85 ± 0.02 vs. 0.91 ± 0.02, p < 0.01, and 37.4 ± 1.7 vs. 40.9 ± 1.9 l/min, p < 0.05) but ETPCO2 did not change. The differences in RR before and after glucose load became smaller as the workload increased. Linear regression analysis of VE and carbon dioxide output yielded virtually identical results for both fasting and glucose load conditions. We have concluded that: a) for the metabolic carbon dioxide load increment due to glucose-induced RR increment, the physiological response is an increase of VE at all workloads. This response modulates constant ETPCO2 values; b) on workload increment, skeletal muscle increasingly utilises more and more glycogen stores, regardless of the blood glucose availability. This reduces the usefulness of dietary manipulations decreasing carbon dioxide metabolic load during muscular work in respiratory failure; c) the absolute value of metabolic carbon dioxide load exerts a role in ventilation regulation at rest and during aerobic exercise. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32401533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1