Acta Facultatis Medicae Naissensis最新文献_第2页

The risk of falls in patients with cerebrovascular disease 脑血管疾病患者跌倒的危险

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-41745

Aleksandar Nenadović, Olivera Đurović, Snezana Stanković, Biljana Georgievski-Brkić, Milica Milivojević, Marjana Vukičević, Svetlana Radević, Snežana Radovanović

{"title":"The risk of falls in patients with cerebrovascular disease","authors":"Aleksandar Nenadović, Olivera Đurović, Snezana Stanković, Biljana Georgievski-Brkić, Milica Milivojević, Marjana Vukičević, Svetlana Radević, Snežana Radovanović","doi":"10.5937/afmnai40-41745","DOIUrl":"https://doi.org/10.5937/afmnai40-41745","url":null,"abstract":"Introduction/Aim. Patient falls in hospital conditions are among the most common serious adverse events following a cerebrovascular insult at all stages of the disease. The aim of this study was to investigate the risk of falls in patients with cerebrovascular disease. Methods. A clinical case-control observational study was conducted in this investigation. The sample consisted of patients who suffered from cerebrovascular diseases and were admitted to the Special Hospital for Cerebrovascular Diseases \"Sveti Sava\" in Belgrade, in the period from February 3, 2018, to June 28, 2019. The Morse questionnaire was used to assess a fall risk. All statistical calculations were performed using the standard commercial software package SPSS, version 21.0. Results. Most of the subjects with a cerebrovascular insult (505 (90.0%)) had a high risk of falls, i.e. they had the Morse score values ≥ 45. The mean Morse score of the subjects in the study was 67.07 ± 21.08. The risk of falling, according to the Morse score, is the highest among subjects diagnosed with bleeding (95.7%: 96.7%) and left-sided neurological deficit (91.7%:90.8%) in both examined groups. Conclusion. It is of great importance to organizing training programs for patients, healthcare providers, and medical staff to prevent falls in hospital conditions.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135612329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA: Potential biomarkers in chronic kidney disease MicroRNA:慢性肾脏疾病的潜在生物标志物

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-39805

Vladana Stojiljković, Nikola Stefanović, Marija Vukelić-Nikolić, Branka Đorđević, Jelena Bašić, Gordana Kocić, Tatjana Cvetković

{"title":"MicroRNA: Potential biomarkers in chronic kidney disease","authors":"Vladana Stojiljković, Nikola Stefanović, Marija Vukelić-Nikolić, Branka Đorđević, Jelena Bašić, Gordana Kocić, Tatjana Cvetković","doi":"10.5937/afmnai40-39805","DOIUrl":"https://doi.org/10.5937/afmnai40-39805","url":null,"abstract":"Introduction. Standard biomarkers for the diagnosis and follow-up of chronic kidney disease patients are appropriate neither in early diagnostics, adequate follow-up and progression assessment nor in complication development risk assessment. For that reason, a search for new, more suitable biomarkers continues. Various studies suggested microRNAs as a potential solution, as they are involved in the pathogenesis of diabetic nephropathy, kidney cancer and kidney function impairment in general. Methods. Internet search engines were used to find and select relevant literature data and electronic databases. Results. Research published so far, in oncology especially, have reported various single microRNAs and panels of microRNAs as candidates for routine diagnostic implementation. Chronic kidney disease is, however, quite complex in terms of etiology of the disease occurrence, since there are many causes that can lead to kidney tissue damage and impairment of its function and finally full development of the chronic kidney disease. MicroRNAs are stable in bodily fluids, and hemodialysis procedure does not affect their levels. Also, high RNase activity in chronic kidney disease patients does not accelerate microRNA degradation in their samples. Conclusions. Literature data suggest that microRNAs are appropriate candidates for diagnostic use in chronic kidney disease. However, there are challenges that are yet to be overcome in order to use microRNAs routinely.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135610800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the disease duration and administered therapy with metabolic syndrome in patients with systemic lupus erythematosus 系统性红斑狼疮患者代谢综合征的疾病持续时间和给药治疗的相关性

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-40813

Jovana Cvetković, Sonja Stojanović, Ivan Tasić, Bojana Stamenković, Jovan Nedović, Sanja Stojanović

{"title":"Association of the disease duration and administered therapy with metabolic syndrome in patients with systemic lupus erythematosus","authors":"Jovana Cvetković, Sonja Stojanović, Ivan Tasić, Bojana Stamenković, Jovan Nedović, Sanja Stojanović","doi":"10.5937/afmnai40-40813","DOIUrl":"https://doi.org/10.5937/afmnai40-40813","url":null,"abstract":"Aim. The aim of the paper was to examine the impact of disease duration and administered therapy on the development of metabolic syndrome (MetS) in patients with systemic lupus erythematosus (SLE). Material and methods. This study involved 55 patients (50 females and 5 males) with the diagnosis and 49 healthy controls of similar age. MetS was defined according to modified NCEP-ATP III diagnostic criteria, and obesity was defined by body mass index BMI > 30. Results. In the group of SLE patients with MetS, there were 23 individuals (41.82%). In the control group, there were 10 (20.4%) patients with MetS. There were significantly more SLE patients with MetS in comparison to the controls (p = 0.04). Duration of the disease in the group with MetS was longer in comparison to those without MetS, but it was not statistically significant (15.35 ± 10.26 vs 10.44 ± 7.88, p = 0.073). The study confirmed that there is a moderate association (CC = 0.355) between disease duration and number of MetS parameters, however, this dependency was not statistically significant (p = 0.439). In the group without MetS, there were statistically more patients treated with antimalarial drugs monotherapy (p = 0.023). It has been found that the patients with MetS were treated with corticosteroid therapy longer than those without MetS, but it was not statistically significant (153.57 ± 103.34 vs 114.75 ± 83.32, p = 0.129). Conclusion. Patients with longer SLE duration have more often MetS. It has been shown that, statistically, more patients without MetS were treated with antimalarial drugs monotherapy, and that long-term CS use, in our study, was not associated with higher incidence of MetS.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of ELOVL3 as a novel prognostic marker for liver cancer ELOVL3作为新的肝癌预后标志物的鉴定

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-40853

Yiyang Chen, Wanbang Zhou, Yiju Gon, Xi Ou

{"title":"Identification of ELOVL3 as a novel prognostic marker for liver cancer","authors":"Yiyang Chen, Wanbang Zhou, Yiju Gon, Xi Ou","doi":"10.5937/afmnai40-40853","DOIUrl":"https://doi.org/10.5937/afmnai40-40853","url":null,"abstract":"Introduction. The incidence of liver cancer is increasing globally. Fatty acids in lipid metabolism are associated with cancer risk by maintaining cancer cell membrane structure and transducing cancer signaling, and their increased synthesis promotes tumor growth, angiogenesis, and tumor metastasis. Methods. After identification of the ELOVL3 gene involved in fatty acid metabolism, which is related to the prognosis of liver cancer, its expression level was extracted from The Cancer Genome Atlas (TCGA) database, and differential analysis, survival analysis, clinical correlation analysis and nomogram were used to predict the survival rate. A comprehensive meta-analysis was performed to further evaluate the prognostic value of ELOVL3. Finally, enrichment analysis and immune analysis were performed on the high and low expression groups of ELOVL3 gene to explore the value of ELOVL3 in predicting the prognosis and immunotherapy of liver cancer patients. Results. Patients with high ELOVL3 expression had poor overall survival and progression-free survival. The nomogram and the area under the ROC curve also indicated that the expression of ELOVL3 gene had high accuracy in predicting the survival time of liver cancer patients. The expression of ELOVL3 was significantly different in the early stage of tumor grade, tumor stage and T stage. Enrichment analysis and immunological analysis revealed a variety of information. The immunotherapy analysis also showed that low ELOVL3 was more effective than high ELOVL3 when receiving immunotherapy. Conclusion. The expression of ELOVL3 gene is significantly elevated in HCC and is associated with cancer development and poor prognosis.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Necrotizing fascitis: A case report 坏死性筋膜炎1例

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-39840

Mladen Kasalović, Gojko Igrutinović, Zlatan Elek, Aleksandar Jakovljević, Nikola Miljković, Milica Milentijević

引用次数: 0

Right ventricular metastasis of uterine cervical cancer: A case report 子宫颈癌右心室转移1例

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-39597

Milovan Stojanović, Bojan Ilić, Dragan Marinković, Sandra Šarić, Dejan Hristov, Marina Deljanin-Ilić

{"title":"Right ventricular metastasis of uterine cervical cancer: A case report","authors":"Milovan Stojanović, Bojan Ilić, Dragan Marinković, Sandra Šarić, Dejan Hristov, Marina Deljanin-Ilić","doi":"10.5937/afmnai40-39597","DOIUrl":"https://doi.org/10.5937/afmnai40-39597","url":null,"abstract":"Introduction. Cardiac metastasis of uterine cervical cancer diagnosed prior to mortality (antemortem) is extremely rare. Case report. A female patient 49 years old was brought to the Emergency Department of the Institute for Treatment and Rehabilitation Niška Banja in cardiac arrest, without a pulse and blood pressure. An electrocardiogram revealed sustained ventricular tachycardia, which was terminated by two DC shocks (100J + 150J). Anamnesis and medical history revealed that she had had her squamous cell carcinoma of the uterine cervix removed and had subsequently received seven out of ten planned cycles of chemotherapy and twenty-eight cycles of radiotherapy. The patient was then transferred to the Coronary Unit, where cardiac ultrasound was performed. A homogenous mass measuring 31 x 50 mm was found in the right ventricle. In view of this, cardiac magnetic resonance imaging was performed. This confirmed the presence of the tumor mass in the right ventricle. Unfortunately, only a month after being discharged from our Institute, the patient was admitted to the Clinic of Neurology due to a loss of consciousness. Computer tomography of endocranium was performed revealing metastatic brain lesions. The patient succumbed to the disease just a couple of months later. Conclusion. We presented a rare case of antemortem diagnosed right ventricle metastases in a patient with uterine cervical cancer. Setting the diagnosis in these patients is a challenge in everyday clinical practice since metastases can produce the clinical picture that masks the real etymology of uterine cervical cancer.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135612319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aesthetic appearance assessment in adolescents with idiopathic scoliosis 青少年特发性脊柱侧凸的美学外观评价

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-36944

V. Živković, L. Dimitrijević, H. Čolović, D. Zlatanovic, M. Spalević, N. Savić

{"title":"Aesthetic appearance assessment in adolescents with idiopathic scoliosis","authors":"V. Živković, L. Dimitrijević, H. Čolović, D. Zlatanovic, M. Spalević, N. Savić","doi":"10.5937/afmnai40-36944","DOIUrl":"https://doi.org/10.5937/afmnai40-36944","url":null,"abstract":"Introduction. Aesthetic appearance is one of the major concerns in adolescent idiopathic scoliosis (AIS) patients and its improvement is one of the main treatment's goals. Poor trunk appearance is associated with reduced quality of life in adolescents with idiopathic scoliosis. Aim. To review instruments that have been created to evaluate poor trunk appearance in these children. Material and methods. PubMed database and the Consortium of Libraries of Serbia for Unified Acquisition - KoBSON were searched using the keywords \"adolescent scoliosis\", \"aesthetic appearance\", \"evaluation\" and \"questionnaires\". Results. In order to evaluate the aesthetic impairment in these patients, various instruments have been created. They can roughly be classed as instruments that assess subjective perception or objective aesthetic appearance. The first group consists primarily of self-administered quality of life questionnaires that include an aesthetic component, such as the Scoliosis Research Society 22 (SRS-22) questionnaire and the Italian Spinal Youth Quality of Life (ISYQoL) questionnaire, as well as visual scales based on patient-completed trunk drawings, such as the Walter Reed Assessment Scale, the Spinal Appearance Questionnaire, and the Trunk Appearance Perception Scale. Trunk asymmetry scales that use pictures, such as the TRACE (Trunk Aestethic Clinical Evaluation), the POTSI (Posterior Trunk Symmetry Index) and the ATSI (Anterior Trunk Symmetry Index), 2-dimensional digital photography, and surface topography can all be used to assess the aesthetic profile of subjects, allowing for objective evaluation. Conclusion. Each clinical examination should include a specific assessment of trunk asymmetry. Various instruments were developed with the goal of decreasing x-ray radiation exposure in these patients.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can continuous glucose monitoring be used as a new tool for diagnosing white coat hyperglycaemia and possibly some other entities? 连续血糖监测能否作为诊断白大褂高血糖和其他疾病的新工具?

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-37498

M. Stojanović, Milica Pešić, S. Ilić, M. Deljanin-Ilić, V. Ćirić

{"title":"Can continuous glucose monitoring be used as a new tool for diagnosing white coat hyperglycaemia and possibly some other entities?","authors":"M. Stojanović, Milica Pešić, S. Ilić, M. Deljanin-Ilić, V. Ćirić","doi":"10.5937/afmnai40-37498","DOIUrl":"https://doi.org/10.5937/afmnai40-37498","url":null,"abstract":"Introduction. Since 1999 continuous glucose monitoring (CGM) has been used to measure the amount of glucose in the interstitial fluid. CGM is crucial when it comes to developing the ambulatory glucose profile and giving information on time spent in range (TIR), percentage of time spent above and below range, as well as variability. Discussion. It was in 1992 that Campbell et al. first described white coat hyperglycaemia, who explained it as patients having elevated blood glucose levels in a clinician's office or laboratory and normal glucose levels obtained by self-monitoring. Prior to the introduction of CGM, white coat hyperglycaemia was described as the discrepancy in the levels of office glucose and self-monitoring blood glucose (SMBG). Nowadays, it may be said that a patient has white coat hyperglycaemia when they have elevated office levels and normal SMBG levels or TIR above 70% on CGM. Recognising white coat hyperglycaemia is of crucial importance for treatment as its intensification based on office glycaemia alone can lead to episodes of hypoglycaemia and a potentially lethal outcome. Should comparison be made with arterial hypertension and ambulatory blood pressure monitoring (ABPM), CGM may provide several other options: 1) masked hyperglycaemia; 2) isolated nocturnal hyperglycaemia. Conclusion. It seems logical that CGM can be used for diagnosing white coat hyperglycaemia and possibly some (new) entities. Nonetheless, the clinical significance of all these entities can only be discussed after conducting adequately designed randomised clinical trials, which we would strongly encourage.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moxifloxacin-induced mental status change 莫西沙星诱导的精神状态改变

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-36485

S. Güler, D. Kocaşaban

引用次数: 0

Implications of anesthetic techniques on cardiocirculatory stability in laparoscopic cholecystectomy 腹腔镜胆囊切除术中麻醉技术对心肺循环稳定性的影响

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI: 10.5937/afmnai40-38044

B. Stosic, M. Stosic, Jelena D Zivadinovic, I. Veselinović

引用次数: 0