流行病学期刊(英文)最新文献

{"title":"Antiretroviral Therapy Discontinuation among Adults Receiving HIV Care in Kadoma City in 2015-2019","authors":"Godwell Nhidza, D. Chirundu, T. Juru, Emmanuel Govha, N. Gombe, A. Chadambuka, M. Tshimanga","doi":"10.4236/ojepi.2022.122012","DOIUrl":"https://doi.org/10.4236/ojepi.2022.122012","url":null,"abstract":"Background: Discontinuation remains a legitimate threat to the long-term success of antiretroviral therapy (ART) scale-up in Zimbabwe. Furthermore, the characteristics associated with ART discontinuation and trends are poorly understood in developing countries like Zimbabwe. We analysed the HIV/AIDS data to describe the characteristics associated with ART discontinuation and the trends from 2015 to 2019. Methods: We conducted an analytical cross-sectional study using secondary data from Electronic Patient Management System (ePMS) in Kadoma City. We interviewed eighteen health care workers to find the reasons for ART discontinuation. Data were analysed using Microsoft Office Excel 2016 and Epi info 7 version 7.2.2.6. Microsoft office excel was used to generate linear graphs to demonstrate the trends in ART discontinuation in Kadoma City in 2015-2019. Epi info 7 was used to generate fre-quencies, means, prevalence odds ratios p-values, and 95% confidence intervals (CI) and significance testing. Backward stepwise logistic regression analysis was done to determine the independent factors associated with discontinuation. Results: A total number of 2833 patients were enrolled on ART from 2015 to 2019. One hundred and seventy-three 173/2833 attended school (adjusted pOR = 3.9, [95% CI: 2.5 - 6.0], p = 0.003) and having immunological failure (adjusted pOR = 6.2, [95% CI: 4.5 - 8.6], p = 0.0001). The reasons mentioned by the health care workers which cause people living with HIV (PLHIV) to discontinue ART were health state not improving 13/18 (72.2%), participating in artisanal mining activities 11/18 (61.1%), change in marital status 9/18 (50.0%), medical side effects of ART 8/18 (44.4%), living far from health facilities 5/18 (27.8%) and relocating to neighbouring countries 3/18 (16.7%). Conclusion: We concluded that the characteristics associated with ART discontinuation were having never attended school, being less than forty years of age and having immunological failure. The reasons why patients discontinue ART were health state not improving, participating in artisanal mining activities, change in marital status, medical side effects of ART, living far from health facilities, and relocating to neighbouring countries. We recommended continuous provision of health education, enhanced adherence counselling sessions to those with unsup-pressed viral loads and investigating the cause of virologic failure.","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70634566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Grades and Management of Prostate Cancer among Men Attending Oncology Unit at Bugando Medical Centre Mwanza, Tanzania","authors":"Deogratias Katabalo, Joyce Josephat, Winfrida Minja, Stanley Mwita, K. Marwa, P. Rambau","doi":"10.4236/ojepi.2022.12213","DOIUrl":"https://doi.org/10.4236/ojepi.2022.12213","url":null,"abstract":"","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70634700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Data Analysis of Tuberculosis Deaths in Bulawayo Province, Zimbabwe, 2016-2019","authors":"T. Moyo, E. Sibanda, N. Gombe, T. Juru, Emmanuel Govha, Maurice Omondi, A. Chadambuka, M. Tshimanga","doi":"10.4236/ojepi.2022.121005","DOIUrl":"https://doi.org/10.4236/ojepi.2022.121005","url":null,"abstract":"Background: Tuberculosis is a leading cause of death globally, and the third leading cause of death in Zimbabwe. Death from any cause following a diagnosis of tuberculosis is classified as a tuberculosis death. Bulawayo Province reported high tuberculosis death rates from 15.3% in 2016 to 14.2% in 2019 against a threshold of 5%. We analyzed tuberculosis deaths for Bulawayo Province to characterize patients dying and to make recommendations for improving treatment outcomes for susceptible tuberculosis cases. Methods: A descriptive cross-sectional study was conducted. We analyzed all (N = 469) records of tuberculosis deaths from 19/19 Bulawayo tuberculosis diagnosing centers from 01 January 2016 to 31 December 2019. Microsoft ® Excel 2007 was used to generate graphs and Stata ® version 17 was used to conduct chi-square tests for trends. Results: Males accounted for 278/469 (59.3%) of the deaths. The median age of death was 40 years (Q 1 = 33: Q 3 = 51). The proportion of TB deaths increased from 63/114 (55%) in 2016 to 57/90 (63%) in 2019 for males (p < 0.01). The majority of deaths 278/469 (59.3%) occurred in the intensive phase of treatment and anemia was a co-morbid condition in only 44/469 (9.4%) of the tuberculosis deaths. Testing for anemia was not routinely done. Conclusion: High death rates particularly in the intensive phase, could be attributed to sub-optimal clinical care. Tuberculosis programs should work towards adopting differentiated care models for tuberculosis patients and developing algorithms for patients at high risk of death.","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70634752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Delays During the Pandemic Months on Survival of Lung Cancer Patients in Canada in 2020.","authors":"Luv Khandelwal, Housneara Begum, P. Nippak","doi":"10.21203/rs.3.rs-862115/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-862115/v1","url":null,"abstract":"\u0000 Objective\u0000\u0000Most cancer deaths in the world are due to lung cancer and delays in diagnosis and treatment sharply reduce survival in lung cancer patients. This study examined the impact of delays during the early months of the pandemic on the survival of newly identified lung cancer patients in Canada in 2020.\u0000Methods\u0000\u0000The incidence of lung cancer, using population statistics from Statistics Canada and incidence rates from the Canadian Cancer Statistics in 2020, was estimated. Stage-wise incidences for each sex were calculated for each age group for each month of 2020. Using delay impact on each stage the final results were calculated.\u0000Results\u0000\u0000A total of 5,004 life years would have been lost due to 448 deaths in the long term (40 months) attributed to the delays caused during March, April, May and June in Canada. The estimated incidence for all stages of lung cancer for these months was 9,801 although the observed incidence was expected to be 6,571 due to reduced screenings. Hence, it was within the missing 3,231 cases that delays would occur. Over the short term (10 months) there are expected to be 151 early deaths and 273 deaths in the intermediate-term (20 months).\u0000Conclusion\u0000\u0000The COVID pandemic is estimated to result in increased mortality and fewer diagnosis’ of lung cancer patients in Canada in 2020.","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46526723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Effect of Sunlight on COVID-19 among Countries with and without Lock-Downs","authors":"J. Sagripanti","doi":"10.4236/ojepi.2021.113027","DOIUrl":"https://doi.org/10.4236/ojepi.2021.113027","url":null,"abstract":"Objective: The main aim of the study was to determine whether COVID-19 epidemiological data reported by countries in different hemispheres correlated with the seasons of the year. Since stay-at-home orders could be a main factor affecting the time individuals spent outdoors, the progression of COVID-19 in countries that mandated the most stringent lock-downs and stay-at-home orders was compared to countries in the same hemisphere that did not order their citizens to remain at home. Methods: Infections attributed to COVID-19 per million inhabitants, deaths per infections × 100, and deaths per million inhabitants from different countries were analyzed utilizing national reports registered in the Johns’ Hopkins database together with the most recent world population data. The null hypothesis (no difference between countries with and without lock-downs) was tested (two tailed test, p Results: The shift of highest infection rates from countries in the northern-towards countries in the southern-hemisphere during early 2020 and the reverse in December of the same year correlates with the seasonal variation in the flux of germicidal sunlight. Mortality rate for the same virus among different countries did not show a seasonal component. COVID-19 infection mortality rate was considerably lower in developing countries of South America (11 of the largest countries) than in several (at least 8) developed European countries. Discussion: COVID-19 resulted in higher infections during winter than in summer. The finding of a seasonal component, correlating the progression of the pandemic with local solar flux, demonstrates that infectious virus in the environment plays a role in the pandemic since direct person-to-person transmission would afford little time for solar inactivation. Similar epidemiological data amongst “locked” and “unlocked” countries demonstrates that lock-downs and similar confining measures had no effect on the chances of healthy individuals becoming infected with SARS-CoV-2 or dying of COVID-19.","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45526380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposed Libyan Guidelines for the Management of Inpatient Hyperglycemia with Corona Virus-19 (COVID-19) Infection","authors":"Adela H. Elamami","doi":"10.4236/ojepi.2021.113020","DOIUrl":"https://doi.org/10.4236/ojepi.2021.113020","url":null,"abstract":"Serious hyperglycemia is one of the manifestations of COVID-19 infection which increase patient morbidity and mortality especially in patient requiring hospitalization. Consequently, many protocols and algorithms for hospitalized patients with COVID-19 induced hyperglycemia based mainly on recent studies and previous evidence on non-COVID-19 patients were published. Of note nearly all guidelines released by the different COVID-19 committees in Libya don’t include a clear focus on management of in-patient hyperglycemia and maybe this plays a pivotal role in increase our COVID-19 in-hospital mortality. I proposed a simplified approach depending on the released international guidelines to be easily implemented by Libyan health care staff caring about COVID-19 patients and hoping to be accepted by our National Diabetes Committee.","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41917500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diarrhea Disease among Children under 5 Years of Age: A Global Systematic Review","authors":"Winfred Mbinya Manetu, Stephen M’masi, C. Recha","doi":"10.4236/ojepi.2021.113018","DOIUrl":"https://doi.org/10.4236/ojepi.2021.113018","url":null,"abstract":"Diarrhea diseases remain the second leading cause of death among children under five years globally. Nearly one in every five child deaths, about 1.6 million each year, are due to diarrhea. Further, diarrhea kills more young children than malaria, measles and Acquired Immunodeficiency Syndrome (AIDS) combined. As a result, better understanding of childhood diarrhea occurrence can perhaps help reduce associated morbidity and mortality rates. Therefore, this study conducted a global systematic review on occurrence of childhood diarrhea. The broad objective of this study was to review present and past researches on childhood diarrhea and most importantly for children under 5 years of age. The review focused on understanding the burden of diarrhea, causes of childhood diarrhea and solutions to the disease. A systematic literature review was conducted using the databases of PubMed, CINAHL, Web of Science and Google Scholar. Search key terms used were childhood diarrhea, risk factors and intervention practices. Journal articles and related reports were filtered and limited from 2005 to 2020. Sixty-one reports and articles that met inclusion criteria were used in this review. Review found that, childhood diarrhea imposes economic costs on the health system and families. Also, repeated bouts of diarrhea can lead to malnutrition, stunting and delayed brain growth later in life and can lead to stress and tension to the affected households. The dependence on open water sources which are often contaminated with fecal materials was found as the major cause of the rising prevalence of childhood diarrhea. Other important factors were poor hygienic practices and lack of sanitation facilities contribute to the spread of diarrhea diseases. Improvements in the quality of drinking water, sanitation facilities and hygiene practices especially in low and middle income countries have been suggested by many studies as an intervention to reduce childhood diarrhea.","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42757748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrostatic Mopping of Viruses with Medicinal Synthetic Aluminum-Magnesium Silicate {Al4(SiO4)3 + 3Mg2SiO4 → 2Al2Mg3(SiO4)3}, for Quick Cure of COVID-19: A Better Control Measure","authors":"M. Ezeibe, F. Onyeachonam, M. Sanda, I. J. Ogbonna, E. Kalu, N. Njoku, M. Udobi","doi":"10.4236/ojepi.2021.113024","DOIUrl":"https://doi.org/10.4236/ojepi.2021.113024","url":null,"abstract":"COVID-19 virus has positive electrical charges. So, particles that are negatively charged would, by opposite charges-electrostatic attraction, inhibit its replication’s first stage (attachment to cells) and mop its extra-cellular particles. Positively charged particles would similarly mop/destroy cells it infects because unlike healthy cells which are neutral, infected/tumor cells have negative electrical charges. Nanoparticles (0.96 nm) of Aluminum-magnesium silicate (AMS), WHO-approved medicine/adjuvant have both negative and positive charged ends. As adjuvant it improves antimicrobials’ efficacies (clearing secondary infections) while as silicate it enhances immunity. By inhibiting viral replication; mopping extra-cellular viruses/abnormal cells; clearing secondary infections; enhancing immunity, AMS terminates viral-infections/abnormal cells’ metastases. Natural AMS has impurities and its deposits are not found in Nigeria. So, Aluminum silicate and Magnesium silicate (WHO-approved medicines) were used for Medicinal synthetic AMS {MSAMS: Al4 (SiO4)3 + 3Mg2SiO4 → 2Al2Mg3 (SiO4)3}. Since AMS is un-absorbable, dextrose monohydrate is incorporated in MSAMS-formulations to convey its Nanoparticles into blood for circulation to all organs/tissues (active-transportation). The MSAMS achieved quick cure (within 3 days) of all four COVID-19 patients used for its first-phase trial (one in Nigeria, two in Cameroon, one in Tanzania).","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45522665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of Hepatitis B Virus Infection and Risk Factors among Adolescents and Youth in Secondary School in 2018, Commune of Covè, Benin","authors":"B. G. Damien, B. Aguèmon, C. Degbey, Styline Agbazahou, Sètondji G R Padonou, Marius-Edgard Ouendo","doi":"10.4236/ojepi.2021.113028","DOIUrl":"https://doi.org/10.4236/ojepi.2021.113028","url":null,"abstract":"Background: Hepatitis B is a vaccine-preventable liver infection caused by the hepatitis B virus. The study aimed to determine the prevalence and associated factors of hepatitis B infection in adolescents and youth attending secondary school in Cove, urban area in Benin. Methods: From 4th to 10th February 2018, a cross-sectional survey was conducted among adolescents and youth aged 15 to 24 years old. Subjects were randomly selected. Hepatitis B surface antigenaemia (HBsAg) was assayed in blood using rapid enzyme-linked immunosorbent assay kits. Univariate and multivariate analyses were performed. Results: Two hundred adolescents and youth were recruited. The seroprevalence of hepatitis B virus infection was 18.50%. According to the multivariate logistic regression model, being infected by hepatitis B was 4.32 times higher in the age group of 15 - 19 years old than in 20 - 24 years age group (PR = 4.32 95% CI [1.51 - 12.34], p = 0.0063). Similarly, students who had not been aware of hepatitis B were more infected than those who were sensitized (PR = 14.60 [95% CI 4.98 - 4.27], p = 0.0001). With regard to lifestyle, individuals with tattoos or piercings were 8.60 times more likely to have been infected by HBV than those without tattoos or piercings, (PR = 8.60; 95% CI [3.41 - 21.70], p < 0.0001). Conclusion: The seroprevalence of hepatitis B among adolescents and youth attending secondary school was high. Regular screening of HVB infection status should be included in school health services in Benin. Awareness campaigns and health education on HVB transmission and prevention should be promoted and strengthened.","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43701798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hypertension during Pregnancy in Benin: Results from STEPS Survey in 2015","authors":"Y. C. Houehanou, S. Amidou, D. Sonou, M. Agonnoudé, G. Gbaguidi, Maria-Conchéta Tchibozo, D. Houinato","doi":"10.4236/ojepi.2021.113025","DOIUrl":"https://doi.org/10.4236/ojepi.2021.113025","url":null,"abstract":"Introduction: Hypertension disorders of pregnancy are one of the leading causes of maternal and fetal deaths. We aimed to estimate the prevalence of hypertension among pregnant women having participated in the STEPS survey in Benin in 2015. Methods: This was a database analysis. STEPS survey included consenting adults aged 18 to 69 years, living in Benin for at least 6 months prior to the survey. The participants were selected in households by a three-stage random sampling technique. The World Health Organization (WHO) STEPS instrument was used for data collection. After an individual interview with the participant at home, blood pressure was measured according to WHO recommendations. Pregnant women database was extracted for analysis. A multivariable logistic regression was done for associated factors identification. Results: A total of 2800 women (out of 5127 people) participated in the STEPS study of which 240 declared to be pregnant. The mean age was 28.9 ± 6.8 years. The prevalence of hypertension was 13.3%. Severe hypertension represented 2.9%. Hypertension during pregnancy was associated with primary school education level (compared to none, adjusted OR = 0.3, 95% CI [0.1 - 0.9], p = 0.042). No significant association was found with behavioral factors. Conclusion: The prevalence of hypertension during pregnancy is high in Benin. In-depth studies and targeted interventions for prevention should be implemented.","PeriodicalId":71174,"journal":{"name":"流行病学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46435492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}