Acta Oncologica最新文献

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Psychological distress and tumor cell β2-adrenergic receptor levels in patients with surgically resected non-small cell lung cancer. 非小细胞肺癌手术切除患者的心理困扰和肿瘤细胞β2-肾上腺素能受体水平。
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-05-04 DOI: 10.2340/ao.v65.45317
Hronn Hardardottir, Thor Aspelund, Bryndis Valdimarsdottir, Jurate Asmundsson, Vigdis Petursdottir, Katja Fall, Erika Broström, Heiddis Valdimarsdottir, Fang Fang, Magnus K Magnusson, Thorarinn Gudjonsson, Tomas Gudbjartsson, Erica K Sloan, Susan K Lutgendorf, Christer Jansson, Unnur A Valdimarsdottir
{"title":"Psychological distress and tumor cell β2-adrenergic receptor levels in patients with surgically resected non-small cell lung cancer.","authors":"Hronn Hardardottir, Thor Aspelund, Bryndis Valdimarsdottir, Jurate Asmundsson, Vigdis Petursdottir, Katja Fall, Erika Broström, Heiddis Valdimarsdottir, Fang Fang, Magnus K Magnusson, Thorarinn Gudjonsson, Tomas Gudbjartsson, Erica K Sloan, Susan K Lutgendorf, Christer Jansson, Unnur A Valdimarsdottir","doi":"10.2340/ao.v65.45317","DOIUrl":"10.2340/ao.v65.45317","url":null,"abstract":"","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"370-374"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenocarcinoma of the small intestine cohort: prospectively collecting real-world data to improve care and quality of life for patients with a rare cancer. 小肠腺癌队列:前瞻性地收集真实世界数据,以改善罕见癌症患者的护理和生活质量。
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-04-28 DOI: 10.2340/ao.v65.45471
Pascale J M Schafrat, Tim R De Back, Felice N Van Erning, Frederieke H Van der Baan, Geraldine R Vink, Miriam Koopman, Ruben S A Goedegebuure, Louis Vermeulen, Ignace H J T De Hingh, Dirkje W Sommeijer
{"title":"Adenocarcinoma of the small intestine cohort: prospectively collecting real-world data to improve care and quality of life for patients with a rare cancer.","authors":"Pascale J M Schafrat, Tim R De Back, Felice N Van Erning, Frederieke H Van der Baan, Geraldine R Vink, Miriam Koopman, Ruben S A Goedegebuure, Louis Vermeulen, Ignace H J T De Hingh, Dirkje W Sommeijer","doi":"10.2340/ao.v65.45471","DOIUrl":"10.2340/ao.v65.45471","url":null,"abstract":"<p><strong>Background and purpose: </strong>Small intestinal adenocarcinoma (SIA) is a rare cancer with a poor prognosis. Optimal treatment strategies are unclear as biological understanding of the disease is limited and randomized controlled trials are lacking. Current management is based on protocols for other gastrointestinal cancers. Therefore, the AdenoCarcinoma of the Small Intestine (ACSI) cohort was initiated, a subcohort of the nationwide Prospective Dutch ColoRectal Cancer cohort (PLCRC) study. The ACSI cohort aims to provide a large-scale, prospective SIA cohort, where clinical and molecular data will be combined to improve knowledge on tumor biology, treatment responsiveness, disease outcome and patient reported outcomes (PROs). Patient/material and methods: All adult SIA patients in the Netherlands are eligible for inclusion. Nationwide inclusion is facilitated by 68 hospitals. Clinical data are collected, as well as optional PROs, pathology- and blood samples.</p><p><strong>Results: </strong>Until June 2025, 143 patients have been enrolled. Data of the first 105 patients show a median age of 65 years (interquartile range 58-73) at diagnosis with a slight male predominance (60%). Most tumors are located in the duodenum (57%) and 27% of patients present with stage IV disease, with a majority having single-site metastases (64%). Primary tumor resection is performed in 80%, while systemic treatment is administered in 42%. Four patients did not receive any anti-tumor treatment (14%). Mismatch repair deficiency is detected in 28% of patients.</p><p><strong>Interpretation: </strong>The ACSI cohort enables structured national collection of clinical data, tumor samples and PROs of SIA patients. These data provide a valuable source for further research and improvement of care for this patient group.</p>","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"363-369"},"PeriodicalIF":2.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiotherapy and diagnostic capacity in relation to the changing cancer burden in the Baltic States. 与波罗的海国家不断变化的癌症负担有关的放射治疗和诊断能力。
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-04-27 DOI: 10.2340/ao.v65.45442
Erika Korobeinikova, Kristaps Paļskis, Manjit Dosanjh, Freddie Bray, Eduard Gershkevitsh, Inga Balode, Alvis Bernans, Gaļina Boka, Laimonas Jaruševičius, Zanda Liepa, Māris Mežeckis, Aista Plieskienė, Maija Radziņa, Romas Skomskis, Giedrė Smailytė, Sandra Stepiņa, Jonas Venius
{"title":"Radiotherapy and diagnostic capacity in relation to the changing cancer burden in the Baltic States.","authors":"Erika Korobeinikova, Kristaps Paļskis, Manjit Dosanjh, Freddie Bray, Eduard Gershkevitsh, Inga Balode, Alvis Bernans, Gaļina Boka, Laimonas Jaruševičius, Zanda Liepa, Māris Mežeckis, Aista Plieskienė, Maija Radziņa, Romas Skomskis, Giedrė Smailytė, Sandra Stepiņa, Jonas Venius","doi":"10.2340/ao.v65.45442","DOIUrl":"10.2340/ao.v65.45442","url":null,"abstract":"<p><strong>Background and purpose: </strong>Cancer mortality rates in the Baltic States (Estonia, Latvia, and Lithuania) exceeds the European Union (EU) average, in part due to limited access to radiation therapy (RT). We updated RT capacity and utilization to inform regional planning. Patient/material and methods: We conducted a census of all 11 RT centres (2016-2023) via a standardized questionnaire, cross-validated with national registries and international databases. We compared technology availability, workforce, and utilization with EU countries in relation to the present cancer burden and projections to 2050. This multicentre observational study adhered to STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) guidelines.</p><p><strong>Results: </strong>Only 35-42% of cancer patients received RT, below the 50% recommendation. Linear accelerator availability ranged from 3.8 to 5.1 per million inhabitants, figures that are almost half those seen in EU countries with higher Gross Domestic Product (GDP) per capita. While the use of intensity modulated RT, volumetric modulated arc therapy and stereotactic RT increased, staffing levels has remained static in recent years. Mortality-to-incidence ratio correlated negatively with GDP (r = -0.7) and RT capacity (r = -0.7).</p><p><strong>Interpretation: </strong>Despite technological progress in the Baltic States, major gaps persist in RT access and workforce levels. Baltic States still underperform compared to EU countries with higher GDP per capita in terms of equipment availability, workforce capacity, and overall cancer outcomes. Future-oriented strategic investments, based on regional collaboration and shared infrastructure are urgently needed, including the development of a regional particle therapy centre, to ensure equitable access to state-of-the art advanced cancer care across the Baltic States.</p>","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"355-362"},"PeriodicalIF":2.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of neuropathic pain in cancer survivors: a scoping review of pharmacological, exercise, and psychosocial interventions. 治疗神经性疼痛的癌症幸存者:药理学,运动和心理干预的范围审查。
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-04-24 DOI: 10.2340/ao.v65.45347
Ellen Lund Schaldemose, Bolette Skjødt Rafn, Pernille Envold Bidstrup, Agon Olloni, Katrin Schättiger, Peter Christensen, Cæcilie Borregaard Myrhøj, Maja Johannsen Lindberg, Christoffer Johansen, Sandra Jensen, Ida Hovdenak, Sasja Jul Håkonsen, Lise Ventzel
{"title":"Treatment of neuropathic pain in cancer survivors: a scoping review of pharmacological, exercise, and psychosocial interventions.","authors":"Ellen Lund Schaldemose, Bolette Skjødt Rafn, Pernille Envold Bidstrup, Agon Olloni, Katrin Schättiger, Peter Christensen, Cæcilie Borregaard Myrhøj, Maja Johannsen Lindberg, Christoffer Johansen, Sandra Jensen, Ida Hovdenak, Sasja Jul Håkonsen, Lise Ventzel","doi":"10.2340/ao.v65.45347","DOIUrl":"10.2340/ao.v65.45347","url":null,"abstract":"<p><strong>Background and purpose: </strong>Neuropathic pain is a debilitating late effect among cancer survivors. This scoping review aims to provide an overview of pharmacological, psychological, and exercise interventions for neuropathic pain among cancer survivors and to identify further relevant research areas. Patient/material and methods: PubMed, PsychInfo, and EMBASE were systematically searched for studies published from January 2004 to January 2026 and abstract and full text screening was carried out. The target population was cancer survivors who had completed primary treatment and have no active disease. Neuropathic pain was defined as a) a mean pain intensity the last week/month of ≥ 3 at a numerical rating scale (0 = no pain, 10 = worst pain), and b) symptoms of neuropathy, or c) neuropathic pain diagnosed by an experienced neurologist.</p><p><strong>Results: </strong>Of the 956 systematic reviews/guidelines and 604 original studies identified, 11 pharmacological, two psychological and three studies on exercise were eligible. Most of the studies included patients with breast cancer. Duloxetine was effective in reducing neuropathic pain from painful chemotherapy-induced neuropathy and gabapentin + concomitant morphine compared to morphine alone reduced neuropathic pain in cancer survivors with neuropathic pain due to radiation therapy, and surgery. Mindfulness-based cognitive behavioral therapy showed no effect after correction for multiple comparisons. Exercise interventions were useful in both reducing neuropathic pain as well as neuropathic symptoms.</p><p><strong>Interpretation: </strong>This scoping review found evidence for pharmacological treatment of neuropathic pain in cancer survivors, could not make any conclusion on psychological treatment, and exercise interventions show promising effects. Further research on interdisciplinary treatment of neuropathic pain among cancer survivors is needed.</p>","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"333-343"},"PeriodicalIF":2.7,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of radiotherapy in patients with advanced melanoma failing targeted therapy. 放疗在靶向治疗失败的晚期黑色素瘤患者中的作用。
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-04-24 DOI: 10.2340/ao.v65.45437
Ellen Heurlin, Lina Grödeberg, Hildur Helgadottir
{"title":"The role of radiotherapy in patients with advanced melanoma failing targeted therapy.","authors":"Ellen Heurlin, Lina Grödeberg, Hildur Helgadottir","doi":"10.2340/ao.v65.45437","DOIUrl":"10.2340/ao.v65.45437","url":null,"abstract":"<p><strong>Background and purpose: </strong>Approximately 50% of patients with metastatic melanoma harbor mutations in the BRAF gene, making them eligible for targeted therapy (TT). However, treatment options become limited once resistance develops. The role of radiotherapy (RT) in this context remains uncertain, and concerns exist regarding toxicity when RT is delivered concurrently with TT. Patient/material and methods: This retrospective study included metastatic melanoma patients treated with RT after experiencing disease progressing on TT between 2015 and 2023. Patients were grouped by subsequent systemic therapy: RT-STOP (discontinued TT), RT-TT (continued TT), and RT-ICI (switched to immune checkpoint inhibitors (ICI)). Study endpoints were progression-free survival (PFS), overall survival (OS), efficacy, and toxicity.</p><p><strong>Results: </strong>Sixty-three patients were analyzed. Median PFS and OS were 1.9 and 3.1 months. The median OS in RT-STOP, RT-TT, and RT-ICI was 1.7, 4.7, and 3.0 months, while the 1-year OS rate was 4.9, 7.6, and 33.4%, respectively (p = 0.001). RT was well tolerated, with no grade ≥3 adverse events observed and 50.9% of patients derived a local benefit.</p><p><strong>Interpretation: </strong>In advanced melanoma patients with disease progression on TT, RT was safe and provided a local effect. Although survival outcomes remained suboptimal, continuation of TT beyond progression or transition to ICI following RT was associated with improved OS compared with discontinuation of TT. These results support the role of RT as a safe bridging modality, suggest benefit from treatment beyond progression with TT, and warrant confirmation in prospective trials.</p>","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"344-354"},"PeriodicalIF":2.7,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of self-reported pain in patients 5 years after rectal cancer treatment: results from the prospective QoLiRECT cohort study. 直肠癌治疗5年后患者自我报告疼痛的患病率:来自前瞻性QoLiRECT队列研究的结果
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-04-22 DOI: 10.2340/ao.v65.45198
Tekla Kjellberg Nätterdal, Rode Grönkvist, Eva Haglind, Jacob Rosenberg, Elisabeth González, Dan Asplund, Sofie Walming, Eva Angenete
{"title":"Prevalence of self-reported pain in patients 5 years after rectal cancer treatment: results from the prospective QoLiRECT cohort study.","authors":"Tekla Kjellberg Nätterdal, Rode Grönkvist, Eva Haglind, Jacob Rosenberg, Elisabeth González, Dan Asplund, Sofie Walming, Eva Angenete","doi":"10.2340/ao.v65.45198","DOIUrl":"10.2340/ao.v65.45198","url":null,"abstract":"<p><strong>Background and purpose: </strong>Pain as a long-term outcome following rectal cancer treatment has received limited attention in previous studies. This prospective cohort study examined pain prevalence up to 5 years post-surgery in patients treated with curative intent. Secondary aims included evaluating pain intensity and its interference with daily life, and comparing pain experiences with a reference population. In addition, potential risk factors for pain were explored. Patient/material and methods: The study is based on the multicenter prospective cohort study QoLiRECT including patients from 16 surgical departments in Denmark and Sweden (2012-2015). Questionnaires regarding Quality of Life were administered at diagnosis and at 1, 2 and 5 years after treatment. Information about self-assessed pain was primarily derived from the 'Brief Pain Inventory - Short Form'. Comparisons were made with an age- and sex- matched reference population.</p><p><strong>Results: </strong>Five years post-treatment, 37% of rectal cancer survivors reported pain exceeding common types of pain, with an average pain level of 3.8 and interference score of 3.1 (range 0-10). Pain was mainly located to the lower extremities, back and pelvis. Surprisingly, pain prevalence was higher in the reference population (53%), a difference consistent at all time points. No significant difference was found between groups regarding average pain or interference. Higher pain levels were associated with female sex, severe baseline pain, and elevated Body Mass Index (BMI).</p><p><strong>Interpretation: </strong>Pain was more common in the reference population, while intensity and interference were similar between groups. This suggests that the experience of pain may differ after surviving cancer, and such differences might be considered when studying pain in cancer survivors.</p>","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"306-315"},"PeriodicalIF":2.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility of patient-reported outcomes collection in clinical routine at a radiotherapy department. 放疗科临床常规收集患者报告结果的可行性。
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-04-22 DOI: 10.2340/ao.v65.45546
Ingrid Fagerström Kristensen, Anton Linnér, Martin Nilsson, Viktor Rogowski, Per Munck Af Rosenschöld, Mats Jerkeman
{"title":"Feasibility of patient-reported outcomes collection in clinical routine at a radiotherapy department.","authors":"Ingrid Fagerström Kristensen, Anton Linnér, Martin Nilsson, Viktor Rogowski, Per Munck Af Rosenschöld, Mats Jerkeman","doi":"10.2340/ao.v65.45546","DOIUrl":"10.2340/ao.v65.45546","url":null,"abstract":"<p><strong>Background and purpose: </strong>Routine collection of patient-reported outcome measures (PROMs) may provide valuable real-world data on quality of life (QoL) and treatment tolerability, complementing clinical outcomes. This study evaluated the feasibility of launching a semi-automated, department-wide PROM collection program at a large tertiary radiotherapy centre.</p><p><strong>Patients and methods: </strong>Patients ≥ 18 years referred for radiotherapy were invited to participate. Exclusion criteria were inability to provide informed consent, severe cognitive conditions, or language barriers. PROMs were collected using a web-based application (\"Blå Appen\") at baseline, end-of-treatment, and follow-up intervals, using the EORTC QLQ-C30 questionnaire (Version 3).</p><p><strong>Results: </strong>During the study period (January 2022 to April 2025), 12,472 patients underwent treatment in the department. A total of 4,764 provided informed consent for study participation, where 3,699 (77.6%) remained after exclusion due to data loss or data inconsistency. Among these, 3,056 patients (82.6%) provided at least one usable PROM questionnaire at baseline. Participants were younger (median age 69 years vs. 71 years). Overall, global health status was relatively high at baseline and remained stable or slightly improved at one-year follow-up. To further investigate clinically significant changes in QoL over time, we evaluated the proportion of patients in each diagnostic category who experienced a change of > 10 points in selected QLQ-C30 scales between baseline and follow-up. Breast cancer patients had the highest rates of meaningful improvement and the lowest rates of major deterioration. In contrast, prostate cancer patients were more prone to significant declines in QoL scales over time.</p><p><strong>Interpretation: </strong>This prospective study demonstrates that department-wide collection of PROM is feasible. Using a digital platform, we achieved a high initial response rate and successfully engaged patients across a broad range of cancers. The routine PROM collection provided valuable insights into patients' quality of life and symptom burden during and after treatment.</p>","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"326-332"},"PeriodicalIF":2.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing survival disparity between children, adolescents, and young adults with osteosarcoma or Ewing sarcoma of bone from 1990 to 2024: a population-based cohort study. 从1990年到2024年,患有骨肉瘤或尤文氏肉瘤的儿童、青少年和年轻人的生存差距越来越大:一项基于人群的队列研究
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-04-22 DOI: 10.2340/ao.v65.45405
Daniel Thor Halberg Dybdal, Klaus Rostgaard, Henrik Hjalgrim, Ninna Aggerholm-Pedersen, Niels Junker, Thomas Baad-Hansen, Pernille Wendtland Edslev, Eva Kristine Ruud Kjær, Akmal Safwat, Michael Mørk Petersen, Lisa Lyngsie Hjalgrim
{"title":"Increasing survival disparity between children, adolescents, and young adults with osteosarcoma or Ewing sarcoma of bone from 1990 to 2024: a population-based cohort study.","authors":"Daniel Thor Halberg Dybdal, Klaus Rostgaard, Henrik Hjalgrim, Ninna Aggerholm-Pedersen, Niels Junker, Thomas Baad-Hansen, Pernille Wendtland Edslev, Eva Kristine Ruud Kjær, Akmal Safwat, Michael Mørk Petersen, Lisa Lyngsie Hjalgrim","doi":"10.2340/ao.v65.45405","DOIUrl":"10.2340/ao.v65.45405","url":null,"abstract":"<p><strong>Background and purpose: </strong>Bone sarcomas are important contributors to early-life cancer mortality and morbidity. Optimisation of treatment regimens has improved survival, but the survival disparity between children, adolescents and young adults has widened. Population-based studies are needed to understand and address these disparities. This is the first comprehensive study of early-life bone sarcomas in Denmark. Patient/material and methods: We combined population-wide data from national registers from 1990 to 2024 with clinical data from patient records. We calculated age-standardised incidence rates, 5-year relative survival rates stratified by several clinical factors, and Aalen-Johansen estimators for relapse/progression and death within 5 years.</p><p><strong>Results: </strong>A total of 578 patients under 40 years of age were diagnosed with either osteosarcoma (n = 336) or Ewing sarcoma of bone (n = 242) in Denmark between 1990 and 2024. Five-year relative survival improved for patients aged 0-24 years but stagnated for those aged 25-39 years. We observed age-dependent differences in the distribution of tumours and in relative survival across anatomical sites, tumour sizes, and treatment regimens. Metastatic disease or a tumour diameter of > 8 cm reduced relative survival by 19 to 45 percentage points.</p><p><strong>Interpretation: </strong>Survival disparities between children, adolescents, and young adults with bone sarcomas are likely multifactorial. Age-dependent differences in the distribution of tumours across anatomical sites and in tumour size appear to play a role. The incidence of and survival from relapse/progression also appear to favour younger patients. Including patients in international, joint paediatric-adult treatment protocols remains a high priority.</p>","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"316-325"},"PeriodicalIF":2.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for distant recurrence in patients with rectal cancer supporting selection for total neoadjuvant therapy. 直肠癌患者远处复发的危险因素支持选择全新辅助治疗。
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-04-17 DOI: 10.2340/ao.v65.45169
Anna Baech Slipsager, Rana Bahij, Heidi Søgaard Christensen, Laura Vittrup Diness, Birgitte Mayland Havelund, Anne Ramlov, Signe Korsgaard Skriver, Joanna Eliza Szpejewska, Olga Tcacenco, Christian Thomsen, Laurids Østergaard Poulsen
{"title":"Risk factors for distant recurrence in patients with rectal cancer supporting selection for total neoadjuvant therapy.","authors":"Anna Baech Slipsager, Rana Bahij, Heidi Søgaard Christensen, Laura Vittrup Diness, Birgitte Mayland Havelund, Anne Ramlov, Signe Korsgaard Skriver, Joanna Eliza Szpejewska, Olga Tcacenco, Christian Thomsen, Laurids Østergaard Poulsen","doi":"10.2340/ao.v65.45169","DOIUrl":"10.2340/ao.v65.45169","url":null,"abstract":"<p><strong>Background and purpose: </strong>In locally advanced rectal cancer, distant recurrence remains a major challenge. Total neoadjuvant therapy (TNT) has been implemented to reduce this risk. Identification of risk factors for distant recurrence to support selection of TNT is crucial to avoid excessive treatment. This study aimed to identify magnetic resonance imaging (MRI) features predictive of distant recurrence in patients with rectal cancer.</p><p><strong>Material and methods: </strong>In this national retrospective cohort study, all patients were diagnosed with non-metastatic rectal cancer between 2016 and 2020 and received neoadjuvant radiotherapy followed by surgery. MRI features from the diagnostic report, including cT-stage, cN-stage, clinical extramural vascular invasion (cEMVI), distance to the mesorectal fascia (MRF), and tumor deposit, were registered. The primary endpoint was distant recurrence.</p><p><strong>Results: </strong>A total of 648 patients were included in the study. In multivariate analysis using multiple imputation, risk factors significantly associated with distant recurrence were cT3c/cT3d/cT4-stage (hazard ratio [HR]: 1.8), cEMVI positive tumors (HR: 2.05), and cT3-stage tumors with a distance to MRF of ≤ 2 mm (HR: 1.51) compared with patients with cT1/cT2/cT3/cT3a/cT3b-stage, cEMVI negative tumors, and cT3-stage tumors with a distance to MRF > 2 mm, respectively. The cN-stage was not significantly associated with distant recurrence. Due to 67% missing data on tumor deposit status, the results regarding this feature cannot be considered conclusive.</p><p><strong>Interpretation: </strong>In this study, cT-stage, cEMVI status, and distance to MRF are prognostic features for risk stratification for patients receiving neoadjuvant radiotherapy. These results may be used for selecting patients for future treatment strategies such as TNT.</p>","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"289-296"},"PeriodicalIF":2.7,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multidisciplinary team meetings for lung cancer in the Nordic countries: results from a Nordic survey. 北欧国家肺癌多学科小组会议:北欧调查结果。
IF 2.7 3区 医学
Acta Oncologica Pub Date : 2026-04-17 DOI: 10.2340/ao.v65.45213
Anja Gouliaev, Janna Berg, Johan Isaksson, Heidi Andersén, Torben Riis Rasmussen
{"title":"Multidisciplinary team meetings for lung cancer in the Nordic countries: results from a Nordic survey.","authors":"Anja Gouliaev, Janna Berg, Johan Isaksson, Heidi Andersén, Torben Riis Rasmussen","doi":"10.2340/ao.v65.45213","DOIUrl":"10.2340/ao.v65.45213","url":null,"abstract":"","PeriodicalId":7110,"journal":{"name":"Acta Oncologica","volume":"65 ","pages":"301-305"},"PeriodicalIF":2.7,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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