Academic Emergency Medicine最新文献

{"title":"Enhancing geriatric trauma mortality prediction: Modifying and assessing the Geriatric Trauma Outcome Score with net benefit and decision curve analysis.","authors":"Pawan Acharya, Tabitha Garwe, Sara K Vesely, Amanda Janitz, Jennifer D Peck, Alisa M Cross","doi":"10.1111/acem.15103","DOIUrl":"https://doi.org/10.1111/acem.15103","url":null,"abstract":"<p><strong>Objective: </strong>Calibration and discrimination indicators alone are insufficient for evaluating the clinical usefulness of prediction models, as they do not account for the cost of misclassification errors. This study aimed to modify the Geriatric Trauma Outcome Score (GTOS) and assess the clinical utility of the modified model using net benefit (NB) and decision curve analysis (DCA) for predicting in-hospital mortality.</p><p><strong>Methods: </strong>The Trauma Quality Improvement Program (TQIP) 2017 was used to identify geriatric trauma patients (≥ 65 years) treated at Level I trauma centers. The outcome of interest was in-hospital mortality. The GTOS was modified to include additional patient, injury, and treatment characteristics identified through machine learning methods, focusing on early risk stratification. Calibration and discrimination indicators, along with NB and DCA, were utilized for evaluation.</p><p><strong>Results: </strong>Of the 67,222 admitted geriatric trauma patients, 5.6% died in the hospital. The modified GTOS score included the following variables with associated weights: initial airway intervention (5), Glasgow Coma Scale ≤13 (5), packed red blood cell transfusion within 24 h (3), penetrating injury (2), age ≥ 75 years (2), preexisting comorbidity (1), and torso injury (1), with a total range from 0 to 19. The modified GTOS demonstrated a significantly higher area under the curve (0.92 vs. 0.84, p < 0.0001), lower misclassification error (4.9% vs. 5.2%), and lower Brier score (0.036 vs. 0.042) compared to the original GTOS. DCA showed that using the modified GTOS for predicting in-hospital mortality resulted in higher NB than treating all, treating none, and treating based on the original GTOS across a wide range of clinician preferences.</p><p><strong>Conclusions: </strong>The modified GTOS model exhibited superior predictive ability and clinical utility compared to the original GTOS. NB and DCA offer valuable complementary methods to calibration and discrimination indicators, comprehensively evaluating the clinical usefulness of prediction models and decision strategies.</p>","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broken gods.","authors":"Sophia Görgens","doi":"10.1111/acem.15119","DOIUrl":"https://doi.org/10.1111/acem.15119","url":null,"abstract":"","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which grading system better predicts 28-day mortality in nontraumatic subarachnoid hemorrhage: Traditional clinical scores or combined grading systems?","authors":"Adem Az, Ozgur Sogut, Ertugrul Altinbilek, Irem Yildirim Oral, Mustafa Calik, Merve Metiner, Abuzer Coskun, Burak Demirci, Ramazan Guven, Ertugrul Altug, Burcu Durmus, Nihat Mujdat Hokenek, Eymen Tekedereli","doi":"10.1111/acem.15121","DOIUrl":"https://doi.org/10.1111/acem.15121","url":null,"abstract":"<p><strong>Background: </strong>The objective was to investigate the predictive ability of traditional clinical, radiological scores, and combined grading systems for 28-day mortality in patients with nontraumatic subarachnoid hemorrhage (SAH).</p><p><strong>Methods: </strong>This multicenter cohort study enrolled 451 adults who presented to the emergency departments of six major tertiary care hospitals in Istanbul with nontraumatic aneurysmal SAH. Demographic data; clinical characteristics; and traditional clinical grading scores were recorded, including the Glasgow Coma Scale (GCS), Hunt and Hess scale (HHS), World Federation of Neurological Surgeons (WFNS) scale, modified Fisher scale (mFS), and two combined grading systems, the VASOGRADE and Ogilvy-Carter scales. These data were compared between survivors and nonsurvivors.</p><p><strong>Results: </strong>A total of 451 patients were included, comprising 242 males (53.7%) and 209 females (46.3%), with a mean ± SD age of 54.8 ± 14.1 years. The overall mortality rate was 28.2% (n = 127). Nonsurvivors had significantly lower mean GCS scores and higher HHS, WFNS, mFS, and Ogilvy-Carter scores compared to survivors (all p < 0.001). A significantly higher proportion of nonsurvivors were categorized in the red group based on VASOGRADE (p < 0.001). Multivariable logistic regression analysis identified age, sex, HHS, mFS, WFNS, and VASOGRADE as independent predictors of mortality. The WFNS scale emerged as the most reliable predictor of mortality with an area under the curve of 0.878.</p><p><strong>Conclusions: </strong>Although the GCS and Ogilvy-Carter scales effectively distinguished survivors from nonsurvivors, they were not independent predictors of mortality. The WFNS scale was identified as the most reliable predictor of mortality in aneurysmal SAH patients, followed by the mFS and HHS.</p>","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepant documentation: What happens when two clinicians document on the same patient?","authors":"Charlotte W Croteau, Justin Margolin, Ali S Raja, James Kimo Takayesu, Joshua J Baugh","doi":"10.1111/acem.15105","DOIUrl":"https://doi.org/10.1111/acem.15105","url":null,"abstract":"","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalize or discharge the emergency department patient with syncope? A systematic review and meta-analysis of direct evidence for SAEM GRACE.","authors":"Robert Allen, Ian S deSouza, Abel Wakai, Rebekah Richards, Amelie Ardilouze, Eric Dunne, Isidora Rovic, Roshanak Benabbas, Shariar Zehtabchi, Richard Sinert","doi":"10.1111/acem.15111","DOIUrl":"https://doi.org/10.1111/acem.15111","url":null,"abstract":"<p><strong>Background: </strong>Syncope is a frequent reason for hospitalization from the emergency department (ED), but the benefit of hospitalization is unclear. This systematic review and meta-analysis (SRMA) aims to cohere and synthesize the best current evidence regarding the potential benefit of hospitalization for ED syncope patients for developing an evidence-based ED syncope management guideline.</p><p><strong>Methods: </strong>We conducted a SRMA according to the patient-intervention-control-outcome (PICO) framework: In patients 16 years of age or older who present to the ED with syncope (population), does hospitalization (intervention) or direct ED discharge (comparison) improve short-term outcomes (outcome)? The primary outcome was a composite of all adverse events as defined by individual studies, up to 30 days. Two reviewers independently assessed articles for inclusion and methodological quality. We measured heterogeneity among included studies with I-squared statistic and used GRADE criteria to assess the quality of evidence.</p><p><strong>Results: </strong>Our search strategy identified 2140 publications and included 18 publications (510,545 participants) in the analysis. All studies reported higher rates of adverse events in hospitalized patients (0.7%-43.8%) compared to discharged patients (0%-3.7%). Our meta-analysis detected considerable statistical heterogeneity. The GRADE assessment for all adverse events and all-cause mortality revealed risk ratios of >5 favoring ED discharge for both outcomes at a median follow-up of 30 days. However, point estimates are limited by serious risk of bias, inconsistency, imprecision, indirectness, and publication bias.</p><p><strong>Conclusions: </strong>Due to the uncertainty of the available evidence, this SRMA's findings do not support a recommendation for or against hospitalizing patients presenting to ED with syncope. However, discharging low-risk patients with syncope from the ED is associated with a low risk of short-term adverse events.</p>","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach to measuring emergency physician efficiency.","authors":"Kiersten Diercks, Samuel A McDonald, Jeffery C Metzger, Carl Piel, Bhaskar Thakur, A J Kirk, Deborah B Diercks","doi":"10.1111/acem.15114","DOIUrl":"https://doi.org/10.1111/acem.15114","url":null,"abstract":"","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-based clinical decision support in the emergency department: A scoping review.","authors":"Hashim Kareemi, Krishan Yadav, Courtney Price, Niklas Bobrovitz, Andrew Meehan, Henry Li, Gautam Goel, Sameer Masood, Lars Grant, Maxim Ben-Yakov, Wojtek Michalowski, Christian Vaillancourt","doi":"10.1111/acem.15099","DOIUrl":"https://doi.org/10.1111/acem.15099","url":null,"abstract":"<p><strong>Objective: </strong>Artificial intelligence (AI)-based clinical decision support (CDS) has the potential to augment high-stakes clinical decisions in the emergency department (ED). However, its current usage and translation to implementation remains poorly understood. We asked: (1) What is the current landscape of AI-CDS for individual patient care in the ED? and (2) What phases of development have AI-CDS tools achieved?</p><p><strong>Methods: </strong>We performed a scoping review of AI for prognostic, diagnostic, and treatment decisions regarding individual ED patient care. We searched five databases (MEDLINE, EMBASE, Cochrane Central, Scopus, Web of Science) and gray literature sources from January 1, 2010, to December 11, 2023. We adhered to guidelines from the Joanna Briggs Institute and PRISMA Extension for Scoping Reviews. We published our protocol on Open Science Framework (DOI 10.17605/OSF.IO/FDZ3Y).</p><p><strong>Results: </strong>Of 5168 unique records identified, we selected 605 studies for inclusion. The majority (369, 61%) were published in 2021-2023. The studies ranged over a variety of clinical applications, patient populations, and AI model types. Prognostic outcomes were most commonly assessed (270, 44.6%), followed by diagnostic (193, 31.9%) and disposition (115, 19%). Most studies remained in the earliest phase of preclinical development (572, 94.5%) with few advancing to later phases (33, 5.5%).</p><p><strong>Conclusions: </strong>By thoroughly mapping the landscape of AI-CDS in the ED, we demonstrate a rapidly increasing volume of studies covering a breadth of clinical applications, yet few have achieved advanced phases of testing or implementation. A more granular understanding of the barriers and facilitators to implementing AI-CDS in the ED is needed.</p>","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When will we finally listen? A statistical commentary on the inadequate management of missing data in trauma research.","authors":"Melissa O'Neill, Sheldon Cheskes, Ian R Drennan, Charles Keown-Stoneman, Steve Lin, Brodie Nolan","doi":"10.1111/acem.15112","DOIUrl":"https://doi.org/10.1111/acem.15112","url":null,"abstract":"","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and predictors of nonresponse to intranasal midazolam in children undergoing laceration repair.","authors":"Sarah R Martin, Kelly Bauer, Theodore W Heyming, Jenny Zhu, Helen Lee, Zeev N Kain","doi":"10.1111/acem.15106","DOIUrl":"https://doi.org/10.1111/acem.15106","url":null,"abstract":"<p><strong>Background/objective: </strong>Pediatric laceration repairs are common in the emergency department (ED) and often associated with significant procedural anxiety. Despite the increased use of intranasal midazolam (INM) prior to pediatric ED procedures, there is limited, real-world data on the effects of INM on anxiety. This study aimed to describe the proportion of children who were nonresponsive to INM (i.e., exhibited extreme anxiety) and identify factors associated with INM nonresponse.</p><p><strong>Methods: </strong>This cross-sectional study included a sample of 102 children (ages 2-10 years) who received 0.2 mg/kg INM prior to laceration repair in the ED. Procedural anxiety was assessed using the modified Yale Preoperative Anxiety Scale (mYPAS). Children exhibiting extreme procedural anxiety (mYPAS score ≥72.91) when procedure started were labeled as INM nonresponders. Bivariate and multivariable logistic regression analyses explored associations between child age, temperament, laceration location, time from INM administration, and likelihood of INM nonresponse.</p><p><strong>Results: </strong>In this sample, 45.1% of the children were classified as INM nonresponders, exhibiting extreme procedural anxiety. Bivariate analyses indicated that nonresponders were younger, had lower sociability temperament, longer delay between INM administration and the procedure, and were more likely to have extremity lacerations. In the logistic regression, younger age (odds ratio [OR] 0.79, p = 0.034), lower sociability temperament (OR 0.28, p = 0.002), and extremity lacerations (OR 8.04, p = 0.009) were significantly associated with likelihood of INM nonresponse.</p><p><strong>Conclusions: </strong>Nearly half of the children in our sample exhibited extreme procedural anxiety despite receiving INM. The high incidence of nonresponse to INM has important clinical practice implications and suggests that 0.2 mg/kg INM alone may not be sufficient to manage all pediatric procedural anxiety in the ED. Findings highlight a need for further research examining multimodal strategies to manage procedural anxiety in the pediatric ED, particularly for younger children with low sociability temperament or extremity lacerations.</p>","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of administration sequence of induction agents on first-attempt failure during emergency intubation.","authors":"Elyssia M Bourke, Ned W R Douglas","doi":"10.1111/acem.15065","DOIUrl":"10.1111/acem.15065","url":null,"abstract":"","PeriodicalId":7105,"journal":{"name":"Academic Emergency Medicine","volume":" ","pages":"183-184"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}