{"title":"Ventral Displacement of Spinal Cord in Spontaneous Intracranial Hypotension: A Sign Easily Be Overlooked.","authors":"Mao-Hsun Lin, Yung-Chu Hsu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Spontaneous intracranial hypotension (SIH) is suspected in patients presenting orthostatic headache and needs excluding structural or iatrogenic causes. Image studies are required to confirm the diagnosis and define exact locations of cerebrospinal fluid leakage, but currently there is no single study sensitive enough to make identifications among patients with various symptoms.</p><p><strong>Case report: </strong>We present a 24-year-old young woman having acute orthostatic headache. She denied having previous headache, head trauma, or neuraxial procedures like lumbar punctures. Brain magnetic resonance image (MRI) with gadolinium enhancement reported normal findings on arrival. She received conservative treatment including analgesics and aggressive intravenous hydration, but her headache improved little. Whole spine MRI with gadolinium enhancement revealed no obvious leakage of cerebrospinal fluid but typical dilated epidural veins with ventral displacement of her thoracic spinal cord. After autologous epidural blood patches therapy, her headache relieved completely.</p><p><strong>Conclusion: </strong>We review the typical and uncommon findings of spinal MRI in SIH, which is more sensitive than brain MRI in acute stages. Spinal MRI offers the diagnostic value in SIH especially when cranial images do not respond in time.</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"29(2) ","pages":"59-63"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37959038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick M Chen, Michael M Chen, Chia-Chun Chiang, Scott Olson, Divya S Bolar, Kunal Agrawal
{"title":"Moyamoya Presenting after Whole Body Cryotherapy.","authors":"Patrick M Chen, Michael M Chen, Chia-Chun Chiang, Scott Olson, Divya S Bolar, Kunal Agrawal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background purpose: </strong>Moyamoya syndrome is the progressive stenosis of intracranial carotids with secondary collateralization. Whole body cryotherapy (WBC) involves external cooling and is used in holistic and sports medicine, its neurologic effects are unknown.</p><p><strong>Case report: </strong>We report a first case of symptoms of moyamoya syndrome presenting following WBC and diagnosed with classic MRI ( \"Brush Sign\", \"Ivy sign\") and digital subtracted angiography.</p><p><strong>Conclusion: </strong>WBC may provoke symptoms of moyamoya syndrome possibly through hyperventilation or vasoconstriction. Practitioners should be aware of possible consequences of WBC in patients with poor cerebrovascular reserve.</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"29(2) ","pages":"64-66"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37959039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concomitant Guillain-Barré Syndrome and Acute Transverse Myelitis in an Older Adult-A Case Report.","authors":"Ching-I Wu, Chia-Lun Wu, Kuo-Hsuan Chang, Wen-Yi Huang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Guillain-Barré syndrome concomitant with spinal cord involvement, which is defined as Guillain-Barré syndrome and acute transverse myelitis overlap syndrome, is rarely seen in the elders. Here we present a 68-year-old female patient who developed Guillain-Barré syndrome, as well as acute transverse myelitis at the same episode.</p><p><strong>Case report: </strong>This patient developed acute weakness of lower limbs, which then rapidly became tetraplegia and hyporeflexia within 5 days. She also had impaired pinprick and vibration sensations below T4, as well as urinary and defecation incontinence. The nerve conduction studies revealed a motorsensory axonal neuropathy. Cerebrospinal fluid analysis showed albuminocytological dissociation and elevated IgG index. The spinal magnetic resonance imaging study revealed heterogeneously contrastenhanced, long-segmental intramedullary lesion from C2 to T3. Other laboratory findings, including blood anti-aquaporin 4 antibody, were not remarkable. The patient's tetraplegia was gradually improved by plasmapheresis and methylprednisolone pulse therapy.</p><p><strong>Conclusion: </strong>Although Guillain-Barré syndrome and acute transverse myelitis overlap syndrome is occasionally seen in young adults, it could still occur in the elderly patients. Plasmapheresis and steroid pulse therapy could be beneficial to improve functional outcome of patients with this immunemediated neurological disease.</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"29(1) ","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37829744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum Iron and Zinc Levels in Lebanese Multiple Sclerosis Patients.","authors":"Alaa Matar, Shada Jennani, Hassan Abdallah, Nabil Mohsen, Jamilah Borjac","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that attacks mainly the myelin sheath covering the axons of neurons. Various studies have reported a potential role of zinc and iron in MS disease. The aim of this study is to estimate the serum level of iron and zinc in Lebanese MS patients.</p><p><strong>Methods: </strong>Sixty-nine participants were enrolled in this study, 27 were diagnosed with MS according to McDonald's criteria and 42 were normal control. Subjects were matched in age. Serum iron and zinc levels were measured using colorimetric methods. Descriptive methods and Mann-Whitney U test were used in the statistical analysis.</p><p><strong>Results: </strong>The mean age of MS patients and healthy subjects was 42.8 and 38.3 years respectively. The mean serum iron level in patient and control groups was 84.7 and 83.3 μg/dl respectively. The mean serum zinc level in patient and control groups was 80.6 and 82.0 μg/dl respectively. No significant association was observed between serum iron and zinc levels in both groups. No association was also observed between serum iron and zinc levels in terms of gender.</p><p><strong>Conclusion: </strong>Our results showed no significant difference in serum iron and zinc levels between MS patients and healthy controls.</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"29(1) ","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37829743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progressive Myelopathy in a Patient with Pediatric Onset Neuromyelitis Optica Spectrum Disorder: A Case Report and a Mini Review.","authors":"Abdorreza Naser Moghadasi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Neuromyelitis optica is an autoimmune disease characterized mainly by the involvement of the spinal cord and optic nerve. Clinical studies have identified the disease progression as the most important red flag. Previous researches showed that only 2% of patients with neuromyelitis optica experience a progressive course. On the other hand, neuromyelitis optica is rarely occurred in children. In the present study a case of neuromyelitis optica was reported in a female who suffered from progressive myelopathy in the course of the disease.</p><p><strong>Case report: </strong>The patient was a 30-year-old woman who has been affected to the disease at the age of 10 manifesting the quadriparesis. The patient also manifested optic neuritis twice. The disease became progressive at the age of 27. According to the results of the magnetic resonance imaging on spinal cord, severe atrophy was observed in the cervical and thoracic spine cord. The patient's antiaquaporin 4 antibody was positive.</p><p><strong>Conclusion: </strong>Neuromyelitis optica is an astrocytopathy disease characterized by debilitating attacks. A very small percentage of patients may suffer a progressive course. According to the reported cases, this progressive course may be completely variable symptomatically, including progressive myelopathy, progressive vision impairments, and progressive cognitive impairment.</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"29(1) ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37829742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sepideh Paybast, Ali Emami, Mohsen Koosha, Fatemeh Baghalha
{"title":"Novel Coronavirus Disease (COVID-19) and Central Nervous System Complications: What Neurologist Need to Know.","authors":"Sepideh Paybast, Ali Emami, Mohsen Koosha, Fatemeh Baghalha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The novel coronavirus (Covid-19) is a family of large enveloped non-segmented positive-sense RNA viruses which has been considered as a global health concern as it has a very high transmissibility potential. Regarding to the similarity of the virus to SARS-CoV, it is postulated that the Covid-19 accumulates mainly in the nasal epithelia and lower respiratory airways. However, there is evidence suggesting the Covid-19 neurotropism which might contribute to respiratory failure. Here in we aim to review the central nervous system complications of the Covid-19 CoV since the emergence of the virus. Keywords: Novel Coronavirus, Covid19-Cov, CNS Complication, Nervous System.</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"29(1) ","pages":"24-31"},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37829746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guan-Woei Tseng, Ting-Yu Kuo, Pao-Sheng Yen, Chon-Haw Tsai, Ming-Kuei Lu
{"title":"Sonographic Clue in Non-traumatic Carotid-cavernous Fistula: Report of a Case and Literature Review.","authors":"Guan-Woei Tseng, Ting-Yu Kuo, Pao-Sheng Yen, Chon-Haw Tsai, Ming-Kuei Lu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Failure to recognize a carotid-cavernous fistula (CCF) promptly may lead to worse prognosis due to a setback in providing proper treatment. To promote early diagnosis of non-traumatic CCF, we report a case with classic clinical symptoms and signs that was diagnosed and followed up with carotid Doppler sonography (CDS) and transcranial color-coded duplex (TCD).</p><p><strong>Case report: </strong>A 45-year-old woman developed an intermittent headache, pulsatile tinnitus, and double vision sequentially within ten days. Progressive left retro-orbital pain, continuous ringing in the left ear, sensory impairment of trigeminal nerve and abducens nerve palsy were also noted on examination. Despite insignificant findings on computed tomography (CT) of the brain, TCD revealed an aberrant flow pattern with high velocity and low resistance at the left carotid siphon. Digital subtraction angiography (DSA) later confirmed a left direct type CCF by illustrating a quick opacification of left cavernous sinus via the internal carotid artery.</p><p><strong>Conclusion: </strong>In addition to invasive DSA, non-invasive CDS and TCD may serve as useful apparatus during the initial evaluation and subsequent follow-ups. The positive sonographic clues, including abnormal turbulent and hemodynamic parameters, are quite exhibitive in the existence of CCFs.</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"29(1) ","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37829745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential Mechanism and Pathways in Cerebral Ischemia- Reperfusion Injury: Therapeutic GLANCE.","authors":"Fatemeh Amini, Zeinab Deris Zayeri, Khojasteh Hoseiny Nejad","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Abtract Cerebral ischemia-reperfusion injury is a progressive disease that results in the lack of oxygen and nutrients needed for cellular metabolism in neurons due to blood flow disorders. The pathogenesis of this disease is different; however, it has been shown that the onset of inflammation interacts with I/R through the production of active oxygen species and increases the apoptosis of the neural cells. Therefore, different signaling pathways interfere with the induction of inflammation and the production of active oxygen species. Therefore, the common point of these pathways leads to the appearance of apotosisinducing molecules and inhibit the expression of anti-apoptosis molecules such as BCL-2. In the other hand, due to the dual role of some of these pathways in apoptosis and angiogenesis, it can be said that further studies can be useful in finding suitable therapeutic strategies based on the pathogenesis of Cerebral ischemia-reperfusion injury inducing angiogenesis in order to repair damaged veins and prevent disease progression. Keywords: Reperfusion; Nitric Oxide; Reactive Oxygen Species; Therapeutics.</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"28(4) ","pages":"88-94"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37616763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giacomo Rebella, Luca Basso, Margherita Federici, Antonio Castaldi
{"title":"Recurrent Epistaxis of Unknown Origin: the Role of Imaging.","authors":"Giacomo Rebella, Luca Basso, Margherita Federici, Antonio Castaldi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report two cases of patients who presented to the Emergency Room (ER) with a history of recurrent epistaxis. Conservative treatment was provided to both patients and the most common causes of bleeding were excluded. Patients underwent radiological examinations that revealed the presence of an Intracavernous Carotid Artery Aneurysm (ICAA) extending into the sphenoid sinus through the erosion of postero-lateral bony wall. Aneurysms rupture caused massive nasal bleeding. The purpose of our case report is to illustrate as a very common symptom like epistaxis, in a small number of cases can be underestimated: rare and severe causes of nasal bleeding, as ICAA, should therefore always be considered in the differential diagnosis.</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"28(4) ","pages":"126-130"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37616765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low Persistence of Antithrombotic Agents is Associated with Poor Outcomes after First-ever Acute Ischemic Stroke.","authors":"Shih-Hsuan Chen, Hsuei-Chen Lee, Ku-Chou Chang, Jen-Wen Hung, Hsiu-Min Chen, Ching-Yi Wu, Chung-Lin Yang, Yu-Ching Huang, Hui-Hsuan Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the time-trend persistence with antithrombotic agents (AT) and assessed the impact of AT persistence on outcome events and adverse events (AE) within two years after first-ever acute ischemic stroke (IS).</p><p><strong>Methods: </strong>Using Taiwan's National Health Insurance claims dataset, 7,341 IS subjects hospitalized between 2001 and 2005 with AT prescribed at discharge and survived at least 3 months were followed up for 2 years. Time-trends of AT usage were analyzed. Medication persistence was assessed as the proportion of days covered (PDC) for filled prescription, and categorized into low, intermediate and high persistence. Multivariate logistic regression analysis and multivariate Cox proportional hazard regression models were performed to identify factors associated with AT persistence and its impact on vascular outcomes.</p><p><strong>Results: </strong>AT persistence rates declined sharply from 81% to 52% during the first 6 months. In addition to patient and facility-level characteristics, occurrence of AE (e.g., GI bleeding/ulceration, fractures/ major trauma, and iatrogenic/unspecific illness) was inversely related to AT persistence. Compared with patients with low persistence, the composite risk of recurrent stroke, cardiovascular disease, or death from any cause was significantly lower in patients with intermediate (Hazard Ratio [HR] 0.64, 0.57-0.71) or high AT persistence (0.74, 0.66-0.83).</p>","PeriodicalId":7102,"journal":{"name":"Acta neurologica Taiwanica","volume":"28(4) ","pages":"95-118"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37616764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}