Molecular Diversity最新文献

Design, synthesis and antitumor activity of thiadiazole derivatives as novel ALK kinase inhibitors. 新型ALK激酶抑制剂噻二唑衍生物的设计、合成及抗肿瘤活性研究。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-22 DOI: 10.1007/s11030-025-11259-7

Yiwen Huo, Qinjiang Zhou, Cheng Zhang, Yanna Lv, Rongfei Liu, Mingyue Hou, Xiaoxuan Duan, Yue Liu, Jinxing Hu

{"title":"Design, synthesis and antitumor activity of thiadiazole derivatives as novel ALK kinase inhibitors.","authors":"Yiwen Huo, Qinjiang Zhou, Cheng Zhang, Yanna Lv, Rongfei Liu, Mingyue Hou, Xiaoxuan Duan, Yue Liu, Jinxing Hu","doi":"10.1007/s11030-025-11259-7","DOIUrl":"https://doi.org/10.1007/s11030-025-11259-7","url":null,"abstract":"In recent years, the number of patients with ALK-positive NSCLC has increased, along with the emergence of various resistance mutations. To address the resistance issues caused by ALK mutations, this study used Crizotinib as the lead compound and modified its side chain to design and synthesize a series of compounds containing thiadiazole structures. The compounds were evaluated through tyrosine kinase inhibition assays and cellular experiments. The results show that compound B11 exhibits strong cytotoxic activity against the NSCLC NCI-H2228 cell line. Moreover, B11 demonstrates a dose-dependent effect, inhibiting NCI-H2228 cell viability, inducing G0/G1-phase cell cycle arrest, and promoting cell death. More importantly, compound B11 overcomes the resistance caused by the ALKG1202R mutation. Ultimately, compound B11, which contains a thiadiazole structure, shows promising activity (ALKL1196M IC50 = 5.57 nM; ALKwt IC50 = 9.19 nM; ALKG1202R IC50 = 15.6 nM).","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-modifiable trapezoidal cage and selective recognition of SO₄^2- from HPO₄^2--containing environments. 后修改梯形笼和选择性识别SO42-从含有HPO42-的环境。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-22 DOI: 10.1007/s11030-025-11269-5

Yuchen Feng, Xuehua Ma, Feiying Ruan, Caihong Mao, Xiaobo Hu

{"title":"Post-modifiable trapezoidal cage and selective recognition of SO42- from HPO42--containing environments.","authors":"Yuchen Feng, Xuehua Ma, Feiying Ruan, Caihong Mao, Xiaobo Hu","doi":"10.1007/s11030-025-11269-5","DOIUrl":"https://doi.org/10.1007/s11030-025-11269-5","url":null,"abstract":"Selective recognition of SO42- from HPO42--containing environments is highly challenging, as SO42- and HPO42- not only share similar structures and sizes, but also exhibit similarities in many characteristics such as charge density, acidity, and hydration energy. In this contribution, a post-modifiable trapezoidal cage (1a) was developed to address the selective recognition of SO42- from HPO42-, as well as to cope with the difficulties of trapezoidal cages in post-modification and property variation. Coupled with the newly explored [4 + 4] cyclization strategy, the synthesis efficiency of producing trapezoidal cages has also been greatly improved. Afterward, by taking advantage of the tetrahedrally deployed binding sites of the trapezoidal cage 1a, selective recognition of SO42- from HPO42- can be realized even in complex environments containing many other anions. Through NMR, fluorescence, nonlinear fitting analysis, and HRMS experiments, the binding affinity and binding stoichiometry of 1a + anion were extensively studied. The results demonstrate that 1a + SO42- follows a 1:1 host-guest binding mode and exhibits a much higher binding affinity (K ~ 1.7 × 108 M-1) than HPO42- (K = 2.6 × 106 M-1) or any other anions (K = 104-105 M-1) in 5% methanol/chloroform. The selective recognition of SO42- in complex environments including HPO42- can provide valuable considerations for the precise design of receptors that can distinguish subtle structural differences in substrates, while the post-modification strategy may also help improve the synthesis and extendibility of other covalent cages.","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational mechanistic insight of fungal metabolites for novel acetylcholinesterase inhibitors. 新型乙酰胆碱酯酶抑制剂真菌代谢物的计算机制研究。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-21 DOI: 10.1007/s11030-025-11254-y

Hadeel Alyenbaawi, Mohammed Alsaweed, Qazi Mohammad Sajid Jamal, Mohammad Rehan Asad, Syed Mohd Danish Rizvi, Fuzail Ahmad, Mehnaz Kamal, Danish Iqbal

{"title":"Computational mechanistic insight of fungal metabolites for novel acetylcholinesterase inhibitors.","authors":"Hadeel Alyenbaawi, Mohammed Alsaweed, Qazi Mohammad Sajid Jamal, Mohammad Rehan Asad, Syed Mohd Danish Rizvi, Fuzail Ahmad, Mehnaz Kamal, Danish Iqbal","doi":"10.1007/s11030-025-11254-y","DOIUrl":"https://doi.org/10.1007/s11030-025-11254-y","url":null,"abstract":"Activity of acetylcholinesterase (AChE) enzyme elevation has been frequently observed in Alzheimer's disease (AD) and plays a key role in disease progression. Therefore, its inhibition is considered a crucial therapeutic step in the management of cognitive defects associated with AD. In this study, we screened a library of fungal metabolites using molecular docking, molecular dynamics, and PCA to identify metabolic compounds that effectively worked against AChE. An extensive database of 19,667 fungal metabolites was methodically filtered to identify compounds with drug-like properties that are suitable for neurological disorders. Of all metabolites, only four compounds inhibited AChE better than donepezil. Mangrovamide F was the most effective against AChE, followed by Libertellenone M, Tricholopardin A, and Aspeterreurone A (ΔG: -12.6 ± 0.2, -12.3 ± 0.2, -12.2 ± 0.2, -11.8 ± 0.1 kcal/mol, respectively). Aspeterreurone A had the highest LD50 dose (39,800 mg/kg), followed by Tricholopardin A (8350 mg/kg), Mangrovamide F (707 mg/kg), and Libertellenone M (190 mg/kg). Over the course of the 200-ns simulation, the protein in the AChE-fungal metabolite complexes stabilized and fluctuated within the permissible range. The most important residue, TRP86, in the AChE protein often interacts with all the best-hit ligands primarily through hydrophobic interactions, for the longest period with Libertellenone M, followed by Tricholopardin A, Mangrovamide F, Donepezil, and Aspeterreurone A. According to our PCA data, Mangrovamide F (44.61%) had the highest eigenvalue rank, followed by Libertellenone M (27.49%), Aspeterreurone A (23%), and Tricholopardin A (20.02%). Mangrovamide F and Tricholopardin A were found to be the best inhibitors of AChE enzyme with acceptable LD50 and have less toxicity. Further in vitro and in vivo works regarding the therapeutic effects of these fungal compounds could elaborate our findings.","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and antifungal properties of the new semiselenoglycolurils. 新型半乙烯基糖色素的合成及抗真菌性能研究。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-21 DOI: 10.1007/s11030-025-11243-1

Vladimir V Baranov, Anton A Galochkin, Vera A Alferova, Anton P Tyurin, Anna L Alekseenko, Sergei V Popkov, Sabrie M Shakir-Alieva, Yuri A Strelenko, Natalya G Kolotyrkina, Angelina N Kravchenko

引用次数: 0

Development of a novel multi-epitope vaccine against Ureaplasma urealyticum infection through reverse vaccinology approach. 利用反向疫苗学方法研制抗解脲支原体感染的新型多表位疫苗。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-19 DOI: 10.1007/s11030-025-11234-2

Linglan Xu, Nan Xie, Yiqin Liu, Hongmei Tang, Jinjiang He, Zhen He, Kang Zheng, Ranhui Li

{"title":"Development of a novel multi-epitope vaccine against Ureaplasma urealyticum infection through reverse vaccinology approach.","authors":"Linglan Xu, Nan Xie, Yiqin Liu, Hongmei Tang, Jinjiang He, Zhen He, Kang Zheng, Ranhui Li","doi":"10.1007/s11030-025-11234-2","DOIUrl":"10.1007/s11030-025-11234-2","url":null,"abstract":"Ureaplasma urealyticum (U. urealyticum) is a sexually transmitted pathogen often causing urogenital tract disorders. The growing challenge of multidrug-resistant strains poses a significant risk for the treatment of U. urealyticum infections. To date, no licensed vaccines are available, and previous attempts to create secure and efficient prophylaxis have been failed. Recent studies have adopted an immunoinformatic strategy based on reverse vaccinology to detect antigenic proteins which are appropriate for the creation of a multi-epitope vaccine. The multi-epitope subunit vaccine, incorporating eleven T-cell and seven B-cell epitopes along with the adjuvant, exhibited strong antigenicity and did not induce allergic responses. Moreover, molecular docking as well as dynamic simulations were utilized to investigate the interaction within the vaccine-adjuvant complex. The prospective effectiveness of the vaccine was verified via immune simulation experiments. Therefore, the vaccine developed in this study represents an effective multi-epitope solution for immunization against U. urealyticum, waiting for further experimental analysis.","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1,8-naphthalimide-based DNA intercalators and anticancer agents: a systematic review. 1,8-萘酰亚胺基DNA插入剂和抗癌剂：系统综述。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-18 DOI: 10.1007/s11030-025-11251-1

Aeyaz Ahmad Bhat, Amel Gacem, Maytham T Qasim, Nuha Almulla, Khursheed Muzammil, Manar G Shalabi

引用次数: 0

Unraveling the binding mechanism of olanzapine with human serum transferrin: a multispectroscopic and computational investigation. 揭示奥氮平与人血清转铁蛋白的结合机制：多光谱和计算研究。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-18 DOI: 10.1007/s11030-025-11233-3

Aleksandar Djurović, Emina Mrkalić, Žiko Milanović, Marina Ćendić Serafinović, Jadranka Odović, Dragan Milovanović, Ratomir Jelić

{"title":"Unraveling the binding mechanism of olanzapine with human serum transferrin: a multispectroscopic and computational investigation.","authors":"Aleksandar Djurović, Emina Mrkalić, Žiko Milanović, Marina Ćendić Serafinović, Jadranka Odović, Dragan Milovanović, Ratomir Jelić","doi":"10.1007/s11030-025-11233-3","DOIUrl":"https://doi.org/10.1007/s11030-025-11233-3","url":null,"abstract":"The interaction between olanzapine (OLZ) and human serum transferrin (Tf), both in the absence and presence of Fe3⁺, was analyzed using multispectroscopic methods, molecular docking, and molecular dynamics simulations under physiological conditions. Spectroscopic results confirmed OLZ's strong affinity for Tf, driven by static interactions complemented by minor dynamic effects. The values of the binding constants, Ka (2.48 × 108, 4.73 × 107, 1.13 × 107 at 296, 303 and 310 K, respectively) indicate that OLZ-Tf complex is more stable at lower temperatures. Negative thermodynamic parameter values (enthalpy, ΔH0 = -168.46 kJmol-1; entropy, ΔS0 = -408.63 JK-1 mol-1; and free energy, ΔG0 = -47.50 kJmol-1) suggest an exothermic and spontaneous binding process dominated by hydrogen bonding and van der Waals forces. Structural changes in Tf upon OLZ binding confirmed by spectroscopic measurements. Results of molecular docking revealed that OLZ exhibits a stronger binding affinity for apotransferrin (Fe3+-free Tf) than for holo-transferrin (iron-bound Tf), with preferential interaction in the N-lobe. The effect of Fe3+ on OLZ-Tf interactions was examined, confirming that iron modulates the binding mechanism. Molecular dynamics (MD) simulations supported these findings, showing OLZ stabilizes Tf's structure while maintaining its flexibility for transport. These results suggest that OLZ can bind to Tf and influence OLZ's bioavailability and pharmacokinetics, offering potential implications for drug design and clinical applications in altered iron homeostasis.","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemometric modeling, inverse docking, and molecular simulations-driven design for multilayered prioritization of novel leishmanicidal agents based on a 2-aminobenzimidazole scaffold. 基于2-氨基苯并咪唑支架的新型利什曼尼毒剂多层优先级的化学计量学建模、逆对接和分子模拟驱动设计。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-16 DOI: 10.1007/s11030-025-11228-0

Arpita Biswas, Arnab Bhattacharjee, Supratik Kar, Probir Kumar Ojha

{"title":"Chemometric modeling, inverse docking, and molecular simulations-driven design for multilayered prioritization of novel leishmanicidal agents based on a 2-aminobenzimidazole scaffold.","authors":"Arpita Biswas, Arnab Bhattacharjee, Supratik Kar, Probir Kumar Ojha","doi":"10.1007/s11030-025-11228-0","DOIUrl":"https://doi.org/10.1007/s11030-025-11228-0","url":null,"abstract":"Leishmaniasis, a major neglected tropical disease (NTD), affects millions of people globally. Current treatments are plagued by infection relapse, high toxicity, and lengthy regimens. A contemporary study investigated the 2-aminobenzimidazole scaffold for leishmanicidal activity but it was found to be associated with poor exposure and lack of efficacy in vivo. This inspired us to develop a QSAR model of leishmanicidal activity leveraging the reported in vivo leishmanicidal activity data toward Leishmania infantum. Interpretable 2D molecular descriptors were employed so that the key leishmanicidal structural features could be utilized to develop the novel molecules. The QSAR model highlighted key structural features associated with leishmanicidal activity, including hydrophobicity, aromatic ring, hydrogen bond acceptor/donor, as well as hetero-atoms (nitrogen, fluorine, etc.) that enhance activity. Various categories of drugs from DrugBank were screened using the developed QSAR model, followed by inverse docking against the putative protein targets for leishmaniasis, to identify the plausible target of the parent leads. QSAR-guided structural modifications were undertaken to generate potential analogs of the top five parent leads. The analogs were checked for their ADMET profiles, and the protein-ligand interactions stability of the top candidates (DB03231-A6 and DB12269-A4) was assessed by 300 ns molecular dynamics simulation. Free energy landscapes (FEL) of the apo and bound target receptor were constructed to further streamline the prioritized analogs. Upon cumulative retrospection, an analog of DB12269 (N-{5-[2-amino-4-fluro-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-4,6-difluoropyrid-3yl}-2-(5-chloropyrazin-2-yl)acetamide) is proposed for further wet lab validation studies for prospective application against leishmaniasis.","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational theranostics strategy for pancreatic ductal adenocarcinoma. 胰腺导管腺癌的计算治疗策略。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-16 DOI: 10.1007/s11030-025-11241-3

Pradnya Kamble, Tanmaykumar Varma, Rajender Kumar, Prabha Garg

{"title":"Computational theranostics strategy for pancreatic ductal adenocarcinoma.","authors":"Pradnya Kamble, Tanmaykumar Varma, Rajender Kumar, Prabha Garg","doi":"10.1007/s11030-025-11241-3","DOIUrl":"https://doi.org/10.1007/s11030-025-11241-3","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is a formidable challenge in modern medicine, characterized by its insidious progression, early systemic metastasis, and alarmingly low survival rates. Given its clinical challenges, improving detection strategies for PDAC remains a critical area of research. This study has used advanced computational approaches to predict pancreatic adenocarcinoma-associated target genes using transcriptomics datasets. Predictive machine learning models were trained using the identified gene signatures, highlighting their potential relevance for future research into diagnostic strategies for PDAC. A total of thirteen differentially expressed genes (DEGs) associated with PDAC were identified, of which twelve were upregulated (CEACAM5, CEACAM6, CTSE, GALNT5, LAMB3, LAMC2, SLC6A14, TMPRSS4, TSPAN1, ITGA2, ITGB6, and POSTN) and one was down regulated (IAPP). These DEGs are all linked to cancer-associated pathways and potentially play a role in the growth and development of cancer. Furthermore, virtual screening evaluated the upregulated SLC6A14 gene-encoded protein for therapeutic repurposing, revealing promising candidates for PDAC treatment. This study offers exploratory insights into gene expression patterns and molecular biomarkers that may inform future research to improve PDAC prognosis and therapeutic development and provide the repurposed drug candidate for further exploration.","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and synthesis of 2-amino-4-(trifluoromethyl)pyrimidine derivatives as potential Werner-dependent antiproliferative agents. 设计和合成2-氨基-4-（三氟甲基）嘧啶衍生物作为潜在的werner依赖性抗增殖剂。

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-06-15 DOI: 10.1007/s11030-025-11225-3

Chang You, Shijiao Wei, Jia Yu, Guangcan Xu, Huimin Li, Xinyu Liu, Menghan Wang, Xueling Meng, Youyin Xu, Gang Yu, Heng Luo, Bixue Xu

{"title":"Design and synthesis of 2-amino-4-(trifluoromethyl)pyrimidine derivatives as potential Werner-dependent antiproliferative agents.","authors":"Chang You, Shijiao Wei, Jia Yu, Guangcan Xu, Huimin Li, Xinyu Liu, Menghan Wang, Xueling Meng, Youyin Xu, Gang Yu, Heng Luo, Bixue Xu","doi":"10.1007/s11030-025-11225-3","DOIUrl":"https://doi.org/10.1007/s11030-025-11225-3","url":null,"abstract":"To uncover novel inhibitors of Werner (WRN) helicase, this study adopted the scaffold-hopping strategy to design and synthesize 24 novel 2-amino-4-(trifluoromethyl)pyrimidine derivatives. The MTT assay was employed to evaluate the anticancer activity of target compounds against microsatellite instability-high (MSI-H) cell lines (HCT116 and LNCaP) and microsatellite stability (MSS) cell lines (SW620 and PC3). Some compounds demonstrated significant inhibitory activity against all four cancer cell lines. Specifically, compounds 11c, 11f, 11 g, 11 h, and 11 l exhibited greater inhibitory effect toward MSI-H cells (HCT116 and LNCaP) compared to MSS cells (SW620 and PC3). The most active compound 11 g exhibited excellent cellular selectivity, with IC50 values of 1.52 and 1.72 μM against MSI-H cell lines (HCT116 and LNCaP), respectively, while the IC50 values of 11 g against MSS cell lines (SW620 and PC3) were 4.24 and 2.78 μM, respectively, followed by the compound 11 h, whose IC50 values against HCT116, LNCaP, SW620, and PC3 cell lines were 2.22, 1.6, 2.37, and 3.21 µM, respectively. The results of apoptosis induction and cell cycle arrest experiments indicate that compounds 11 g and 11 h induced early apoptosis in HCT116 cells, and G2/M phase cell cycle arrest. This finding was further validated through molecular docking analysis and cellular thermal migration and enzyme activity experiments. The results of WRN helicase inhibition assays showed that the IC50 value of compound 11 g was 6.61 µM. In summary, our study identifies 2-amino-4-(trifluoromethyl)pyrimidine derivative 11 g as potential WRN-dependent anticancer agents.","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0