TMR整合医学最新文献

{"title":"Study on intestinal flora of acupoint catgut embedding intervention in female patients with abdominal obesity: Study protocol for a randomized controlled trial","authors":"Qifu Li, Jialei Feng, Xinghe Zhang, X. Zeng, Si-Qi Zhao, Mengke Kong, Yunqiu Zheng, Chonghui Xing, Taipin Guo","doi":"10.21203/rs.3.rs-847319/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-847319/v1","url":null,"abstract":"\u0000 Background\u0000\u0000With high morbidity, and many complications, obesity has become a global public health problem, and attracted extensive attention from the medical community. Previous studies have suggested that acupoint catgut embedding (ACE) is a safe and effective therapy for abdominal obesity (AO). However, the investigation of its mechanisms remains limited. The purpose of this study is to observe the effect of ACE intervention in AO on the intestinal flora, to reveal its site of action and therapeutic mechanisms, and provide further theoretical support for ACE in the clinical treatment of AO.\u0000Methods/design:\u0000\u0000A total of 60 eligible female participants diagnosed with AO will be recruited in this study. They will be blinded to group assignment and randomized to either ACE group, sham ACE group, and waiting list (WL) group, with 20 patients in each group. Each patient in the two ACE-based groups will receive one ACE treatment per week for 12 consecutive weeks. This study will focus on analyzing the intestinal flora changes elicited by ACE treatment. The body mass index (BMI), waist circumference (WC), body weight (BW), blood pressure (BP), heart rate (HR), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), visual analogue score (VAS) of appetite, and the Gastrointestinal Symptom Rating Scale (GSRS) will be used to evaluate the clinical efficacy of ACE treatment by making assessments before and after treatment. High-throughput 16S ribosomal ribonucleic acid (rRNA) gene sequencing will be used to detect changes in the intestinal flora composition before and after treatment. The repeated measures analysis of variance (3 groups × 2-time points ANOVA) will be employed to analyze numerical variables of the clinical and intestinal flora data generated in the study.\u0000Discussion\u0000\u0000The results of this trial are expected to further confirm that ACE can effectively relieve AO and verify the intervention mechanisms of ACE on intestinal flora in patients with AO.\u0000Trial registration:\u0000\u0000Chinese Clinical Trial Registry, ChiCTR2100048853. Registered on July 19, 2021. https://www.chictr.org.cn/showproj.aspx?proj=130531","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43022630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medico-ethnobotanical studies of Odisha state, India for urogenital disorders: a review","authors":"S. Rani, J. Dash, Sarita Das","doi":"10.53388/tmrim202105028","DOIUrl":"https://doi.org/10.53388/tmrim202105028","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cinnamomum camphora: a long history for epidemics control","authors":"Rakhi Mishra, B. Dwivedi","doi":"10.53388/tmrim202105031","DOIUrl":"https://doi.org/10.53388/tmrim202105031","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupoint rules of acupuncture for functional dyspepsia treatment based on complex network analysis","authors":"Xinyuan Zhang, Yihua Fan, Gu Ling, HaiHang Dong, Xin Zhao, Xinju Li, Xu Wang","doi":"10.53388/tmrim202105027","DOIUrl":"https://doi.org/10.53388/tmrim202105027","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excellent response to acupuncture treatment in a case of intractable glossopharyngeal neuralgia due to vascular tortuosity: a case report","authors":"Mehdy Ghaeminia, S. Zareisedehizadeh, A. Razmkon","doi":"10.53388/tmrim202105029","DOIUrl":"https://doi.org/10.53388/tmrim202105029","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Plasma cell variant Castleman Disease","authors":"Qiaofeng Su, Zhen Lei, Weiyi Yang, Shu He, Yanli Luo","doi":"10.53388/tmrim202105023","DOIUrl":"https://doi.org/10.53388/tmrim202105023","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of nutritional ketosis and hyperoxygenation therapy—promising ground for integrative cancer treatment: a systematic review","authors":"S. John","doi":"10.53388/tmrim202105024","DOIUrl":"https://doi.org/10.53388/tmrim202105024","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network pharmacology approach to explore the mechanism of Kangguan decoction in the treatment of coronavirus disease 2019 with preliminary verification","authors":"Weilong Jiang, Yufeng Zhang, Mengying Liu, Suyan Zhang, Junxian Xu, Min Li, H. Xue, L. Tian, Xu-dong Han","doi":"10.53388/TMRIM202105025","DOIUrl":"https://doi.org/10.53388/TMRIM202105025","url":null,"abstract":"Objective: To explore the mechanism of Kangguan decoction in the treatment of coronavirus disease 2019 (COVID-19) and then perform preliminary verification. Methods: The effective compounds and target genes of Kangguan decoction were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. COVID-19 related target genes were searched in the GeneCards database. The active target genes of Kangguan decoction acting on COVID-19 were identified to perform GO function enrichment and KEGG pathway enrichment analysis. The compound-target network and protein-protein interaction were constructed;Molecular docking simulations of macromolecular protein target receptors and their corresponding compounds were performed. The clinical data of COVID-19 patients were retrieved from their electronic medical records of Nantong Third People's Hospital. Results: We screened out 137 effective compounds and 274 effective target genes of Kangguan decoction from TCMSP. The active target genes of Kangguan decoction were compared with the COVID-19 related target genes, and 63 active target genes for Kangguan decoction acting on COVID-19 were identified. GO function enrichment and KEGG pathway enrichment analysis were performed. The compound-target network and PPI network were constructed and the key compounds and key targets were selected to construct a key compound-target network. Finally, the binding of the target and its corresponding components was verified by molecular docking and two clinical cases with obvious clinical efficacy after Kangguan decoction application were demonstrated. Conclusion: The pharmacological mechanism of Kangguan decoction acting on COVID-19 has been explored, and the active compounds and targets of Kangguan decoction acting on COVID-19 and clinical efficacy for Kangguan decoction treating COVID-19 patients have been preliminarily verified.","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing people at risk of developing type 2 diabetes in Freetown, Sierra Leone","authors":"M. Ghazzawi, V. Thurtle, Joe Sam","doi":"10.53388/tmrim202105034","DOIUrl":"https://doi.org/10.53388/tmrim202105034","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of determining innate Mizaj (temperament) based on facial characteristics: a comparative study","authors":"Hamidreza Sheikh, R. Mirkazemi, Maryam Monfared, Hossein Kheirandish, Mehdinezhad Vali, F. Ghadimi, Maryam Ladani","doi":"10.53388/tmrim202105030","DOIUrl":"https://doi.org/10.53388/tmrim202105030","url":null,"abstract":"","PeriodicalId":70680,"journal":{"name":"TMR整合医学","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}