Acta medica Iugoslavica最新文献_第6页

[Maprotiline and the heart rate]. [马普替林和心率]。

Acta medica Iugoslavica Pub Date : 1990-01-01

P Filaković, J Barkić, N Mandić

{"title":"[Maprotiline and the heart rate].","authors":"P Filaković, J Barkić, N Mandić","doi":"","DOIUrl":"","url":null,"abstract":"The increased heart rate is a frequent, seldom clinically significant side-effect of antidepressants. There are different opinions about the Maprotiline influence on the heart rate, either about its very existence or the pathophysiological mechanism of its side-effect. The aim of this study was to test the Maprotiline influence on the heart rate of depressed patients and to compare the results with the results of other studies. The study was carried out in a group of 21 patients with a depressive involutional syndrome treated by fixed daily doses of 150 mg of Maprotiline. The heart rate was estimated in a small sample of examinees using the method of paired observations, as a part of the orthostatic cardiovascular tolerance testing by Schellong's method; this was done before the therapy and twice a week during four week of the application of Maprotiline. The increase in the heart rate in the basal reclining position was noticed in 20 patients. The average value was 16 beats per minute. The increase of the heart rate was not noticed immediately after the application of the first doses but after the latency of 8 days on average. While increasing in the basal reclining position, the orthostatic deviation of the heart rate did not significantly change during the therapy. At the end of the study the orthostatic deviation even showed a negative sign. The reclining of the patients at the end of Schellong's test discovered a frequent occurrence of the prolonged blood pressure return from higher to normal values. The results obtained confirm the thesis that the increased heart rate in the therapy with Maprotiline is due to its noradrenergic activity, in other words, to its ability to block the \"reuptake\" of noradrenalin in the synaptic cleft. The delay of the heart rate increase in the basal reclining position, a more frequent prolonged blood pressure return in the further phase of the study, and the therapeutic response delay in the treatment of depression are explained by the authors by the same mechanism: by the most probable existence of the pathological changes in the synapses.(ABSTRACT TRUNCATED AT 400 WORDS)","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 4","pages":"347-56"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13246697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contemporary possibilities of medicamentous prevention of cataract. 当代药物预防白内障的可能性。

Acta medica Iugoslavica Pub Date : 1990-01-01

M Kosanović, K Cupak

引用次数: 0

Ventilatory lung function changes in family members of asbestos workers. 石棉工人家庭成员通气肺功能的变化。

Acta medica Iugoslavica Pub Date : 1990-01-01

F Valić, D Beritić-Stahuljak, M Cigula

引用次数: 0

Vitamin E status in men and women aged 60-90 years. 60-90岁男性和女性的维生素E水平。

Acta medica Iugoslavica Pub Date : 1990-01-01

D Pokorn, B Accetto, A Prevorćnik

引用次数: 0

Immunological observations in Guillain-Barré syndrome. 格林-巴罗综合征的免疫学观察。

Acta medica Iugoslavica Pub Date : 1990-01-01

J Sepcić, M Morović, D Rukavina, D Sepić-Grahovac

引用次数: 0

Effects of reducing diet and increased leisure time physical activity on hypertension associated with obesity. 减少饮食和增加闲暇时间体力活动对肥胖相关高血压的影响。

Acta medica Iugoslavica Pub Date : 1990-01-01

M Pecelj-Gec, J Jorga, S Rsumović, L Neradović-Mladenovski, G Zbutega-Milosević

{"title":"Effects of reducing diet and increased leisure time physical activity on hypertension associated with obesity.","authors":"M Pecelj-Gec, J Jorga, S Rsumović, L Neradović-Mladenovski, G Zbutega-Milosević","doi":"","DOIUrl":"","url":null,"abstract":"The study examined the effects of energy restriction and increased leisure time physical activity on the body mass, body fat, and blood pressure. A group of moderately obese women (120-160% of ideal body mass) referred to the Dietetic Unit as out-patients, were assigned to a reducing diet and increased activities. The diet provided an average of 4.18 MJ (bout 1000 kcalories), with a reduced salt intake of 0.5 g per day, enriched with cellulose and supplemented by trace elements and vitamins. Increased leisure time activities consisted in one-hour walking a day at the least and ten-minute light gymnastics. The average reduction in the blood pressure obtained in the study was 19 mmHg systolic and 10 mmHg diastolic in the non-exercising group. The exercised subjects had a greater reduction in the systolic (23 mmHg) and diastolic (11 mmHg) blood pressures. The significant correlation was not found between the body mass loss and the blood pressure decrease. It was observed that the normal blood pressure was achieved in about two thirds of the patients when they had lost 9 to 132 percent of their body mass, indicating that the achievement of a desirable body mass is not essential for the sizeable reduction in the blood pressure. Although this study demonstrates that a combined nutritional-physical activity intervention program may be effective in reducing a high blood pressure, it does not show a distinction between the body mass loss and physical activity as mediating factors.","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 4","pages":"367-76"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13247296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the magnitude of socio-medical problems of rheumatic diseases in adult urban population. 评估成人城市人口风湿病的社会医学问题的严重程度。

Acta medica Iugoslavica Pub Date : 1990-01-01

A Sućur

{"title":"Evaluating the magnitude of socio-medical problems of rheumatic diseases in adult urban population.","authors":"A Sućur","doi":"","DOIUrl":"","url":null,"abstract":"In the course of 1982 and 1983 a study was carried out on the prevalence of rheumatic symptoms and the identification of rheumatic diseases in the urban population of the Zagreb commune of Medvescak. The representative sample consisted of 5% of the adult population of both sexes, amounting to 1999 examinees. Rheumatic symptoms were found in 59.6%; in 41.6% of women and 18 of men. The prevalence of the most frequent rheumatic disease and the influence of age and sex on the frequency of the onset of symptoms were determined. By random sampling, of the 1191 surveyed with symptoms (42%), 500 were invited for a rheumatological examination; 238 responded (47.6%). Persons with rheumatic, symptoms who did not respond to the invitation were also interviewed in order to find out the reason for their not coming to the examination. Rheumatic changes were found in 86% of the examined. Most frequently diagnosed were different locations of degenerative changes of the joints (48.3% of all diagnoses). The magnitude of the problem of rheumatic diseases was assessed, the estimates being drawn on the basis of complex probability. Based on the results and estimates, it was concluded that 35% of the observed adult population suffered from diseases of the locomotor system and that they needed treatment but that only half of them were being treated (16%). The overall magnitude of the problem of rheumatic diseases appeared to be within the expected limits, with a high percentage of degenerative diseases of the joints.","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 4","pages":"407-14"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13247300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Correlation analysis of pulmonary shunt after resection the lung]. 【肺切除术后肺分流的相关分析】。

Acta medica Iugoslavica Pub Date : 1990-01-01

B Maldini, V Majerić-Kogler

引用次数: 0

Combined technique of argon-laser and neodymium-YAG laser photocoagulation for narrow-or closed-angle glaucoma. 氩激光与钕yag激光联合光凝治疗窄角或闭角青光眼。

Acta medica Iugoslavica Pub Date : 1990-01-01

M Striga, T Curković, Z Vukas

引用次数: 0

Erythropoiesis in paroxysmal nocturnal hemoglobinuria. 阵发性夜间血红蛋白尿的红细胞生成。

Acta medica Iugoslavica Pub Date : 1990-01-01

R Ruvidić, L Biljanović-Paunović, S Pendić, A Mijović, D Bosković, V Pavlović-Kentera

{"title":"Erythropoiesis in paroxysmal nocturnal hemoglobinuria.","authors":"R Ruvidić, L Biljanović-Paunović, S Pendić, A Mijović, D Bosković, V Pavlović-Kentera","doi":"","DOIUrl":"","url":null,"abstract":"Ten patients with paroxysmal nocturnal hemoglobinuria were studied. The diagnosis was made on the basis of hemolytic anemia, a positive Ham test and hemosiderinuria. Six patients had primary paroxysmal nocturnal hemoglobinuria evolved from aplastic anemia. These four patients also had a milder form of the disease, Over long periods of the follow-up, large variations of hemoglobin values and red blood cell counts were observed. Both absolute and percent reticulocyte counts were increased. Erythroblast counts in the bone marrow were 3-5 times higher than normal. Reticulocyte counts in the bone marrow were 3-5 times higher than normal. Reticulocyte counts showed wide variations but substantially smaller than those in autoimmune hemolytic anemias. Serum iron was either normal or increased, while the bone marrow iron store was high or low. However, the finding of urinary hemosiderin in all cases spoke against depletion of iron stores. The red blood cell life span was moderately shortened. Kinetic studies with 59Fe showed a high red blood cell iron incorporation, while the curves frequently had irregular shapes (broken curve) or an early, abrupt fall. Studies of late erythroid progenitors (CFU-E) indicated that this compartment was preserved. Even after long observation periods was no stem cell pool depletion due to an increased red blood cell demand observed.","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 5","pages":"447-56"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13232720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0