ACS Symposium Series最新文献

{"title":"Advancements in Wastewater Treatment: Application of Immobilized Enzyme Systems","authors":"Zaheer Ud Din Sheikh, Preeti Verma, Pankaj Mehta, Deepak Pathania, Anita Singh","doi":"10.1021/bk-2025-1508.ch007","DOIUrl":"https://doi.org/10.1021/bk-2025-1508.ch007","url":null,"abstract":"This chapter explores the applications of immobilized enzymes in wastewater treatment. The chapter begins with an introduction to the utilization of enzymes in wastewater treatment, highlighting their potential for efficient and environmentally friendly pollutant degradation. It then delves into various enzyme immobilization techniques, detailing the different types of immobilized enzyme systems and their mechanisms of action. The factors influencing the effectiveness of these systems in wastewater treatment are discussed, along with the advantages of using immobilized enzymes, such as reusability, increased stability, enhanced catalytic activity, reduced operational cost, and significant environmental benefits. The chapter also provides an overall view of the practical applications of immobilized enzymes in wastewater treatment. The final sections mark the problems associated with the high cost of enzyme production, the need for more studies on real wastewater and pilot-scale applications, the integration of catalytic degradation with enzymatic methods, concerns about the toxicity of biodegradation products, and the inactivation of enzymes under harsh operational conditions. The chapter concludes with a discussion on future directions, emphasizing the importance of optimizing immobilization techniques and developing novel support materials to enhance the stability and effectiveness of immobilized enzyme systems in wastewater treatment.","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"1 1","pages":"147-170"},"PeriodicalIF":0.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzyme Immobilization with Nanomaterials: Applications and Challenges","authors":"","doi":"10.1021/bk-2025-1508","DOIUrl":"https://doi.org/10.1021/bk-2025-1508","url":null,"abstract":"","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147888924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery and Chemical Development of BI 1181181 MZ: A Bis-Spirocyclic BACE-1 Inhibitor for the Treatment of Alzheimer’s Disease","authors":"Shankar Venkatraman, Jonathan T. Reeves","doi":"10.1021/bk-2025-1505.ch002","DOIUrl":"https://doi.org/10.1021/bk-2025-1505.ch002","url":null,"abstract":"A doubly spirocyclic motif was identified using novel structure-based design technology, and SAR based on molecular modeling and pKa modulation as well as metabolite analysis led to the clinical candidate BI 1181181 MZ, a potent and selective BACE1 inhibitor for the treatment of Alzheimer’s disease. Process research addressed key safety and scalability issues in the medicinal chemistry route and led to the design of a robust synthesis that supported development work packages.","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"1 1","pages":"59-95"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of Macrocyclic Metal Complexes as Anticancer Agents","authors":"Waseem A. Wani, Afzal Hussain, Samira Amir, Mohamed F. Alajmi, Akhtar H. Malik, Azharudin Khursheed, Waheed Ahmad Khanday","doi":"10.1021/bk-2025-1492.ch001","DOIUrl":"https://doi.org/10.1021/bk-2025-1492.ch001","url":null,"abstract":"Cancer is a terrifying disease that causes the death of approximately 10 million people annually. It involves several physiological systems, which complicates its treatment and management. Methods such as radiation therapy, hormone therapy, bone marrow transplantation, surgery, immunotherapy, chemotherapy, and monoclonal antibody therapy are used for the treatment and management of cancer. Due to the metastatic nature of most cancers, chemotherapy is one of the most common methods of treatment. Several anticancer drugs with varying success rates are currently available on the market. Transition metal complexes (metallodrugs) have made a name for themselves in inorganic medicinal chemistry as they provide multi-purpose platforms for anticancer drug design and development. Among the different classes of metallodrugs, transition metal complexes of macrocyclic ligands are important for the development of anticancer drugs. This chapter highlights the need for different types of anticancer drugs and the importance of the emergence of metals and metal complexes in the treatment of cancer.","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"1 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Sampling of Heavy Metals from Air, Water, and Soil Samples","authors":"Pooja Dharni Dhar Singh, Z. V. P. Murthy, Suresh Kumar Kailasa","doi":"10.1021/bk-2023-1456.ch009","DOIUrl":"https://doi.org/10.1021/bk-2023-1456.ch009","url":null,"abstract":"Heavy metals have been detected in environmental samples (air, water, and soil) due to their discharge from various industries. Heavy metals present in air, water, and soil cause serious health issues and ecological toxicity. Various sampling procedures have been used for environmental sampling of heavy metals (Fe, Mn, Co, Pb, Hg, Zn, Ni, Cr, As, Cu, and Cd) from environmental samples prior to their identification by various analytical instruments. This chapter overviews the environmental sampling procedures, including digestion (ultraviolet-, microwave-, and ultrasound-assisted methods and wet and dry ashing methods), extraction approaches (liquid, acid, and solid phase, pressurized solvent extraction, and supercritical), and miniaturized sample preparations for heavy metals from air, water and soil samples prior to their analyses by various analytical techniques.","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"1 1","pages":"137-165"},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recycling of Polyurethanes","authors":"Devesh Sane, Apurv Gadekar, Vandana Jamdar, Anagha Sabnis","doi":"10.1021/bk-2023-1452.ch009","DOIUrl":"https://doi.org/10.1021/bk-2023-1452.ch009","url":null,"abstract":"Polyurethanes contribute to the sixth largest class of polymers produced on the planet. The versatility of this polymer boosts its production and so does the waste generated from it. The best approach to tackle with the problem of landfilling and burning of waste has been best addressed through recycling technologies. The easiest and most widely used technologies are mechanical recycling followed by thermochemical recycling which are usually used for materials not having much market value or possibility of creation of one. Chemical recycling involves technically complex procedures and hence is often not applied on a large scale. Use of different chemical reactions other than the ones that are commonly used is widely being studied on the lab scale. Biodegradation has emerged as a new method for degradation of PU but the time and special conditions required limits its scalability. This chapter tries to bring forward the newer developments in the field of PU recycling with the revision of past technologies. It is observed that many new recycling technologies have the ability to lead us to a sustainable future.","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"1 1","pages":"161-179"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Analytical Characterization of Beads from an Andean<i>Chullpa</i>Funerary Assemblage","authors":"Heather Walder, Adelphine Bonneau, Benjamin Carter, Ruth Ann Armitage, William A. Lovis","doi":"10.1021/bk-2023-1446.ch003","DOIUrl":"https://doi.org/10.1021/bk-2023-1446.ch003","url":null,"abstract":"In 1890, the U.S. Consul to Chile sent Michigan Agricultural College (now Michigan State University) the mummified remains of a young Andean girl interred in a chullpa tomb, reputedly located south of La Paz, Bolivia. She was accompanied by a group of funerary objects, and the documentation indicated that she dated from the 15th century CE and was from the Inca culture. She was repatriated to Bolivia in January 2019. During and following repatriation minimally destructive analyses were undertaken on the funerary objects that had been associated with the interment. The estimated age of 1400-1500 CE was corroborated by a series of AMS ages on maize, leather, and gourd. However, a series of small ~2.5 mm black and red beads gave the appearance of European manufactured glass “seed” beads common in the context of colonial exchange. If the beads were glass, and European in origin, it would question the chronological homogeneity and therefore the integrity of the funerary assemblage since they would likely postdate ca. 1533 CE. Microscopic observations revealed morphological characteristics consistent with fine sedimentary rock, or fine ceramic paste, but could not conclusively eliminate the possibility of weathered and altered vitreous material such as glass. To explore the chemical composition of the beads one of each color – limited by the sensitive nature of the assemblage – was subjected to a series of analyses. SEM-EDS (scanning electron microscopy coupled to X-ray energy dispersive spectroscopy), LA-ICP-MS (laser ablation - inductively coupled plasma – mass spectrometry), Raman microspectroscopy, and DART-MS (direct analysis in real time – mass spectrometry) were deployed. Results of the analysis revealed that the beads were fine sedimentary stone or ceramic, and exhibited an organic coating potentially for coloration, or later museum curation. Therefore, glass was eliminated as the material of manufacture. The most parsimonious interpretation of the beads analyzed seems to be Indigenous Inka manufacture, as small, stone beads have been identified in Inka and other pre-Colombian contexts.","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"1 1","pages":"65-85"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface Modified Carbon Nanotubes Volume 2: Industrial Applications","authors":"","doi":"10.1021/bk-2022-1425","DOIUrl":"https://doi.org/10.1021/bk-2022-1425","url":null,"abstract":"","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78638647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface Modified Carbon Nanotubes Volume 1: Fundamentals, Synthesis and Recent Trends","authors":"","doi":"10.1021/bk-2022-1424","DOIUrl":"https://doi.org/10.1021/bk-2022-1424","url":null,"abstract":"","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72850896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanozymes: Design, Synthesis, and Applications","authors":"","doi":"10.1021/bk-2022-1422","DOIUrl":"https://doi.org/10.1021/bk-2022-1422","url":null,"abstract":"","PeriodicalId":7028,"journal":{"name":"ACS Symposium Series","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87280195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}